FI118536B - Monoklonaalinen anti-alfaV-integriinivasta-aine - Google Patents

Monoklonaalinen anti-alfaV-integriinivasta-aine Download PDF

Info

Publication number: FI118536B
Authority: FI; Finland
Prior art keywords: sequence; cells; cell; antibody; monoclonal antibody
Prior art date: 1994-12-20

Application number

FI956112A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI956112L (fi

FI956112A0 (fi

Inventor

Francesc Mitjans

Jaume Piulats

Elisabet Rosell

Jaume Adan

Simon Goodman

Diane Hahn

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-20

Filing date

1995-12-19

Publication date

2007-12-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8216547&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI118536(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-12-19 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1995-12-19 Publication of FI956112A0 publication Critical patent/FI956112A0/fi

1996-06-21 Publication of FI956112L publication Critical patent/FI956112L/fi

2007-12-14 Application granted granted Critical

2007-12-14 Publication of FI118536B publication Critical patent/FI118536B/fi

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230000000737 periodic effect Effects 0.000 description 1
230000008823 permeabilization Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
108010083476 phenylalanyltryptophan Proteins 0.000 description 1
238000000053 physical method Methods 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
238000003752 polymerase chain reaction Methods 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000013641 positive control Substances 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
230000003334 potential effect Effects 0.000 description 1
238000011533 pre-incubation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
108010031719 prolyl-serine Proteins 0.000 description 1
108010079317 prolyl-tyrosine Proteins 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
238000001525 receptor binding assay Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000010076 replication Effects 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
102220049163 rs35498994 Human genes 0.000 description 1
208000005687 scabies Diseases 0.000 description 1
230000007017 scission Effects 0.000 description 1
230000035939 shock Effects 0.000 description 1
201000000849 skin cancer Diseases 0.000 description 1
230000008470 skin growth Effects 0.000 description 1
229910000679 solder Inorganic materials 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000000392 somatic effect Effects 0.000 description 1
230000009870 specific binding Effects 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
210000004989 spleen cell Anatomy 0.000 description 1
230000007480 spreading Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
210000000130 stem cell Anatomy 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
210000004243 sweat Anatomy 0.000 description 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
210000000115 thoracic cavity Anatomy 0.000 description 1
108010072986 threonyl-seryl-lysine Proteins 0.000 description 1
239000003634 thrombocyte concentrate Substances 0.000 description 1
230000009772 tissue formation Effects 0.000 description 1
238000000954 titration curve Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000007704 transition Effects 0.000 description 1
102000035160 transmembrane proteins Human genes 0.000 description 1
108091005703 transmembrane proteins Proteins 0.000 description 1
108010002164 tyrosine receptor Proteins 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
108010073969 valyllysine Proteins 0.000 description 1
230000006459 vascular development Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
108010047303 von Willebrand Factor Proteins 0.000 description 1
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
108010027345 wheylin-1 peptide Proteins 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Engineering & Computer Science (AREA)
Hematology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

FI956112A 1994-12-20 1995-12-19 Monoklonaalinen anti-alfaV-integriinivasta-aine FI118536B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94120165		1994-12-20
EP94120165		1994-12-20

Publications (3)

Publication Number	Publication Date
FI956112A0 FI956112A0 (fi)	1995-12-19
FI956112L FI956112L (fi)	1996-06-21
FI118536B true FI118536B (fi)	2007-12-14

Family

ID=8216547

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI956112A FI118536B (fi)	1994-12-20	1995-12-19	Monoklonaalinen anti-alfaV-integriinivasta-aine

Country Status (26)

Country	Link
US (1)	US5985278A (sk)
EP (1)	EP0719859B1 (sk)
JP (1)	JP3898245B2 (sk)
KR (1)	KR100450368B1 (sk)
CN (1)	CN1117763C (sk)
AR (1)	AR001778A1 (sk)
AT (1)	ATE244306T1 (sk)
AU (1)	AU710234B2 (sk)
BR (1)	BR9505980B1 (sk)
CA (1)	CA2165573C (sk)
CO (1)	CO4480042A1 (sk)
CZ (1)	CZ290477B6 (sk)
DE (1)	DE69531187T2 (sk)
DK (1)	DK0719859T3 (sk)
ES (1)	ES2202336T3 (sk)
FI (1)	FI118536B (sk)
HU (1)	HU221061B1 (sk)
NO (1)	NO321186B1 (sk)
PL (1)	PL182961B1 (sk)
PT (1)	PT719859E (sk)
RU (1)	RU2205223C2 (sk)
SI (1)	SI0719859T1 (sk)
SK (1)	SK284932B6 (sk)
TR (1)	TR199501614A2 (sk)
UA (1)	UA40621C2 (sk)
ZA (1)	ZA9510806B (sk)

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ES2311131T3 (es) *	1997-08-08	2009-02-01	The Regents Of The University Of California	Tratamiento de la fibrosis hepatico con anticuerpos contra la integrina alfa-v-beta6.
ATE322508T1 (de) *	1998-01-23	2006-04-15	Merck Patent Gmbh	Verwendung des antikörpers 271.14d9.f8 (dsm acc2331) um die bindung zwischen alphavbeta6- integrin und fibronectin in vitro zu hemmen
US6160099A (en) *	1998-11-24	2000-12-12	Jonak; Zdenka Ludmila	Anti-human αv β3 and αv β5 antibodies
US6521593B1 (en) *	1999-02-01	2003-02-18	Childrens Hospital Los Angeles	Methods for inhibiting brain tumor growth
US7064180B2 (en)	2000-07-31	2006-06-20	The General Hospital Corporation	High affinity integrin polypeptides and uses thereof
US7153944B2 (en) *	2000-07-31	2006-12-26	The General Hospital Corporation	High affinity integrin polypeptides and uses thereof
US7323552B2 (en) *	2000-07-31	2008-01-29	The General Hospital Corporation	Variant integrin polypeptides and uses thereof
US7288390B2 (en)	2000-08-07	2007-10-30	Centocor, Inc.	Anti-dual integrin antibodies, compositions, methods and uses
US7163681B2 (en)	2000-08-07	2007-01-16	Centocor, Inc.	Anti-integrin antibodies, compositions, methods and uses
AU2002306651B2 (en) *	2001-03-02	2007-12-13	Medimmune, Llc	Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav Beta3 antagonists
PT1381384E (pt)	2001-04-24	2011-09-01	Merck Patent Gmbh	Terapia de combinação usando agentes anti-angiogénicos e tnfa
AU2002312566A1 (en) *	2001-07-09	2003-01-29	Elan Pharmaceuticals, Inc.	Methods of inhibiting amyloid toxicity
US7829087B2 (en) *	2001-07-09	2010-11-09	Elan Pharmaceuticals, Inc.	Methods of treating cognitive impairment
US20050084489A1 (en) *	2002-03-04	2005-04-21	Wilder Ronald L.	Methods of preventing or treating disorders by administering and integrin alphanubeta3 antagonist in combination with an HMG-CoA reductase inhibitor or a bisphosphonate
AU2003217930A1 (en) *	2002-03-04	2003-09-22	Medimmune, Llc	The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
US7465449B2 (en) *	2002-03-13	2008-12-16	Biogen Idec Ma Inc.	Anti-αvβ6 antibodies
CN100509851C (zh) *	2002-03-13	2009-07-08	拜奥根Idec马萨诸塞公司	抗αvβ6抗体
WO2003087340A2 (en) *	2002-04-12	2003-10-23	Raven Biotechnologies, Inc.	Antibodies that bind to integrin alpha-v-beta-6 and methods of use thereof
EP1499352A4 (en)	2002-04-12	2006-10-11	Medimmune Inc	ANTI-INTERLEUKIN-9 RECOMBINANT ANTIBODIES
JP2006516635A (ja) *	2003-01-30	2006-07-06	メディミューン，インコーポレーテッド	インテグリンαｖβ３アンタゴニストの使用
KR20120035234A (ko)	2003-04-11	2012-04-13	메디뮨 엘엘씨	재조합 ｉｌ?９ 항체 및 그의 용도
US7351739B2 (en) *	2004-04-30	2008-04-01	Wellgen, Inc.	Bioactive compounds and methods of uses thereof
JP2008518023A (ja)	2004-10-27	2008-05-29	メディミューン，インコーポレーテッド	同族抗原に対する親和性を改変することによる抗体特異性の調節
CN102875681A (zh)	2005-07-08	2013-01-16	拜奥根Idec马萨诸塞公司	抗-αvβ6抗体及其用途
NZ615012A (en) *	2006-03-21	2015-11-27	Genentech Inc	Combinatorial therapy involving alpha5beta1 antagonists
WO2008008315A2 (en)	2006-07-10	2008-01-17	Biogen Idec Ma Inc.	Compositions and methods for inhibiting growth of smad4-deficient cancers
US8637469B2 (en)	2006-07-11	2014-01-28	Roy C. Levitt	Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors
CA3177366A1 (en)	2006-08-10	2008-02-21	Roy C. Levitt	Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
US20090196913A1 (en) *	2007-05-11	2009-08-06	Ken Shi Kun Huang	Anti-Alpha-V Immunoliposome Composition, Methods, and Uses
US20090175784A1 (en) *	2007-05-11	2009-07-09	Joshua Goldstein	Anti-Alpha V Immunoliposome Composition, Methods, and Uses
WO2009010290A2 (en) *	2007-07-17	2009-01-22	Merck Patent Gmbh	Engineered anti-alpha v- integrin hybrid antibodies
US7973138B2 (en)	2007-09-26	2011-07-05	Genentech, Inc.	Antibodies
CA2747937C (en)	2008-12-23	2019-02-26	Merck Patent Gmbh	Biomarkers for inhibitors with anti-angiogenic activity
CN102365297B (zh)	2009-03-25	2014-10-29	霍夫曼-拉罗奇有限公司	新型抗-α5β1抗体及其应用
US20120263739A1 (en)	2009-11-13	2012-10-18	Merck Patent Gmbh	Anti integrin antibodies linked to nanoparticles loaded with chemotherapeutic agents
WO2011103490A2 (en) *	2010-02-18	2011-08-25	The Regents Of The University Of California	INTEGRIN αVβ8 NEUTRALIZING ANTIBODY
WO2012027745A1 (en) *	2010-08-27	2012-03-01	University Of Miami	Treatment of renal diseases
WO2012107211A1 (en)	2011-02-11	2012-08-16	Merck Patent Gmbh	Anti-alpha-v integrin antibody for the treatment of prostate cancer
US20130066055A1 (en)	2011-04-21	2013-03-14	Bayer Intellectual Property Gmbh	New binder-drug conjugates (adcs) and use thereof
BR112014003501B1 (pt) *	2011-08-17	2022-02-08	The Regents Of The University Of California	Anticorpo humanizado que se liga especificamente à integrina alfa-v beta-8, seu uso na redução da sinalização de tgfbeta, composição farmacêutica, bem como método para detectar a presença de uma célula que expressa alfa-v beta-8
US10035859B2 (en)	2013-03-15	2018-07-31	Biogen Ma Inc.	Anti-alpha V beta 6 antibodies and uses thereof
WO2014143739A2 (en)	2013-03-15	2014-09-18	Biogen Idec Ma Inc.	Anti-alpha v beta 6 antibodies and uses thereof
PE20160996A1 (es)	2013-12-23	2016-11-09	Bayer Pharma AG	Conjugados de farmacos anticuerpo (adcs) con inhibidores de ksp
JP7372025B2 (ja)	2014-09-17	2023-10-31	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	固形がんおよび／またはその転移を処置する方法、そのための薬剤、ならびに固形がんおよび／またはその転移処置の臨床転帰を予測する方法
KR20170055540A (ko)	2014-09-17	2017-05-19	메르크 파텐트 게엠베하	뼈 전이 질환 치료 방법, 그에 따른 약제, 및 뼈 전이 질환 치료의 임상 결과 예측 방법
AU2016282723B2 (en)	2015-06-22	2021-09-23	Bayer Pharma Aktiengesellschaft	Antibody drug conjugates (ADCs) and antibody prodrug conjugates (APDCs) with enzymatically cleavable groups
US10973923B2 (en)	2015-06-23	2021-04-13	Bayer Pharma Aktiengesellschaft	Site specific homogeneous with KSP inhibitors
WO2017060322A2 (en)	2015-10-10	2017-04-13	Bayer Pharma Aktiengesellschaft	Ptefb-inhibitor-adc
US20190144547A1 (en)	2015-11-23	2019-05-16	Merck Patent Gmbh	Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders
SG10202008909VA (en)	2016-03-24	2020-10-29	Bayer Pharma AG	Prodrugs of cytotoxic active agents having enzymatically cleavable groups
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EP3510407A1 (en)	2016-09-08	2019-07-17	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for diagnosing and treating nephrotic syndrome
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KR20190099250A (ko)	2016-12-21	2019-08-26	바이엘 악티엔게젤샤프트	효소적으로 절단가능한 기를 갖는 세포독성 활성제의 전구약물
KR102628678B1 (ko)	2016-12-21	2024-01-25	바이엘 파마 악티엔게젤샤프트	효소적으로 절단가능한 기를 갖는 항체 약물 접합체 (adc)
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CN117143241B (zh) *	2023-10-26	2024-02-23	迈威(上海)生物科技股份有限公司	与人整合素蛋白itgav/itgb8特异性结合的单克隆抗体

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EP0633945B1 (en) *	1992-04-03	1998-12-30	Genentech, Inc.	ANTIBODIES TO ALPHAvBETA3 INTEGRIN
US5753230A (en) *	1994-03-18	1998-05-19	The Scripps Research Institute	Methods and compositions useful for inhibition of angiogenesis

1995
- 1995-12-06 PT PT95119233T patent/PT719859E/pt unknown
- 1995-12-06 DE DE69531187T patent/DE69531187T2/de not_active Expired - Lifetime
- 1995-12-06 AT AT95119233T patent/ATE244306T1/de active
- 1995-12-06 DK DK95119233T patent/DK0719859T3/da active
- 1995-12-06 ES ES95119233T patent/ES2202336T3/es not_active Expired - Lifetime
- 1995-12-06 EP EP95119233A patent/EP0719859B1/en not_active Expired - Lifetime
- 1995-12-06 SI SI9530683T patent/SI0719859T1/xx unknown
- 1995-12-13 CZ CZ19953288A patent/CZ290477B6/cs not_active IP Right Cessation
- 1995-12-13 AU AU40421/95A patent/AU710234B2/en not_active Ceased
- 1995-12-18 CA CA2165573A patent/CA2165573C/en not_active Expired - Fee Related
- 1995-12-18 JP JP32887795A patent/JP3898245B2/ja not_active Expired - Fee Related
- 1995-12-19 ZA ZA9510806A patent/ZA9510806B/xx unknown
- 1995-12-19 RU RU95121105/13A patent/RU2205223C2/ru not_active IP Right Cessation
- 1995-12-19 HU HU9503638A patent/HU221061B1/hu not_active IP Right Cessation
- 1995-12-19 SK SK1592-95A patent/SK284932B6/sk not_active IP Right Cessation
- 1995-12-19 PL PL95311926A patent/PL182961B1/pl unknown
- 1995-12-19 UA UA95125376A patent/UA40621C2/uk unknown
- 1995-12-19 US US08/574,699 patent/US5985278A/en not_active Expired - Lifetime
- 1995-12-19 FI FI956112A patent/FI118536B/fi not_active IP Right Cessation
- 1995-12-19 CN CN95120901A patent/CN1117763C/zh not_active Expired - Fee Related
- 1995-12-19 NO NO19955167A patent/NO321186B1/no not_active IP Right Cessation
- 1995-12-20 TR TR95/01614A patent/TR199501614A2/xx unknown
- 1995-12-20 KR KR1019950052440A patent/KR100450368B1/ko not_active Expired - Fee Related
- 1995-12-20 AR AR33473095A patent/AR001778A1/es active IP Right Grant
- 1995-12-20 BR BRPI9505980-6A patent/BR9505980B1/pt not_active IP Right Cessation
- 1995-12-20 CO CO95060553A patent/CO4480042A1/es unknown

Also Published As

Publication number	Publication date
DE69531187T2 (de)	2004-04-22
AU4042195A (en)	1996-06-27
CA2165573C (en)	2011-03-29
DE69531187D1 (de)	2003-08-07
FI956112L (fi)	1996-06-21
ATE244306T1 (de)	2003-07-15
SK284932B6 (sk)	2006-02-02
BR9505980A (pt)	1997-12-23
UA40621C2 (uk)	2001-08-15
JPH08231597A (ja)	1996-09-10
RU2205223C2 (ru)	2003-05-27
HUT74828A (en)	1997-02-28
BR9505980B1 (pt)	2010-02-23
AU710234B2 (en)	1999-09-16
CZ328895A3 (en)	1996-09-11
KR100450368B1 (ko)	2005-01-31
DK0719859T3 (da)	2003-10-20
KR960022562A (ko)	1996-07-18
EP0719859A1 (en)	1996-07-03
CO4480042A1 (es)	1997-07-09
AR001778A1 (es)	1997-12-10
PT719859E (pt)	2003-11-28
US5985278A (en)	1999-11-16
FI956112A0 (fi)	1995-12-19
PL182961B1 (pl)	2002-05-31
NO955167L (no)	1996-06-21
ZA9510806B (en)	1996-05-30
JP3898245B2 (ja)	2007-03-28
NO321186B1 (no)	2006-04-03
CN1139115A (zh)	1997-01-01
NO955167D0 (no)	1995-12-19
HU9503638D0 (en)	1996-02-28
EP0719859B1 (en)	2003-07-02
CZ290477B6 (cs)	2002-07-17
ES2202336T3 (es)	2004-04-01
HU221061B1 (hu)	2002-07-29
SK159295A3 (en)	1996-07-03
CA2165573A1 (en)	1996-06-21
PL311926A1 (en)	1996-06-24
TR199501614A2 (tr)	1996-07-21
CN1117763C (zh)	2003-08-13
SI0719859T1 (en)	2003-12-31

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