FI113741B - Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi - Google Patents

Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi Download PDF

Info

Publication number: FI113741B
Authority: FI; Finland
Prior art keywords: product; milk; fermentation; casein; peptides
Prior art date: 1999-11-01

Application number

FI992360A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI19992360A (fi

Inventor

Olli Tossavainen

Annika Maeyrae-Maekinen

Tarja Suomalainen

Janne Sahlsten

Original Assignee

Valio Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-01

Filing date

1999-11-01

Publication date

2004-06-15

1999-11-01 Priority to FI992360A priority Critical patent/FI113741B/fi

1999-11-01 Application filed by Valio Oy filed Critical Valio Oy

2000-10-30 Priority to PT00972941T priority patent/PT1226267E/pt

2000-10-30 Priority to CNB008153930A priority patent/CN1197956C/zh

2000-10-30 Priority to AT00972940T priority patent/ATE285470T1/de

2000-10-30 Priority to NZ518493A priority patent/NZ518493A/xx

2000-10-30 Priority to JP2001535586A priority patent/JP4172681B2/ja

2000-10-30 Priority to DE60016959T priority patent/DE60016959T2/de

2000-10-30 Priority to HU0203185A priority patent/HUP0203185A3/hu

2000-10-30 Priority to ES00972941T priority patent/ES2220557T3/es

2000-10-30 Priority to PCT/FI2000/000942 priority patent/WO2001032905A1/en

2000-10-30 Priority to JP2001535518A priority patent/JP3695648B2/ja

2000-10-30 Priority to KR1020027005619A priority patent/KR100704441B1/ko

2000-10-30 Priority to AU11498/01A priority patent/AU777795B2/en

2000-10-30 Priority to EEP200200230A priority patent/EE05461B1/xx

2000-10-30 Priority to ES00972940T priority patent/ES2234686T3/es

2000-10-30 Priority to AU11499/01A priority patent/AU769432B2/en

2000-10-30 Priority to PT00972940T priority patent/PT1226230E/pt

2000-10-30 Priority to EP00972941A priority patent/EP1226267B1/en

2000-10-30 Priority to PL355670A priority patent/PL204119B1/pl

2000-10-30 Priority to PL00364790A priority patent/PL364790A1/xx

2000-10-30 Priority to CA002387738A priority patent/CA2387738C/en

2000-10-30 Priority to DK00972940T priority patent/DK1226230T3/da

2000-10-30 Priority to RU2002114359/13A priority patent/RU2276689C2/ru

2000-10-30 Priority to HU0203256A priority patent/HU226200B1/hu

2000-10-30 Priority to EEP200200231A priority patent/EE200200231A/xx

2000-10-30 Priority to DK00972941T priority patent/DK1226267T3/da

2000-10-30 Priority to RU2002114327/13A priority patent/RU2270855C2/ru

2000-10-30 Priority to US10/111,914 priority patent/US6890529B1/en

2000-10-30 Priority to PCT/FI2000/000941 priority patent/WO2001032836A1/en

2000-10-30 Priority to CZ20021369A priority patent/CZ294146B6/cs

2000-10-30 Priority to NZ518470A priority patent/NZ518470A/xx

2000-10-30 Priority to US10/111,942 priority patent/US6972282B1/en

2000-10-30 Priority to KR1020027005618A priority patent/KR100718709B1/ko

2000-10-30 Priority to CA002388354A priority patent/CA2388354A1/en

2000-10-30 Priority to DE60010742T priority patent/DE60010742T2/de

2000-10-30 Priority to CNB008153353A priority patent/CN1164761C/zh

2000-10-30 Priority to EP00972940A priority patent/EP1226230B1/en

2000-10-30 Priority to AT00972941T priority patent/ATE266735T1/de

2000-10-30 Priority to CZ20021431A priority patent/CZ302271B6/cs

2001-05-02 Publication of FI19992360A publication Critical patent/FI19992360A/fi

2002-04-22 Priority to ZA200203179A priority patent/ZA200203179B/xx

2002-04-22 Priority to ZA200203172A priority patent/ZA200203172B/xx

2002-04-29 Priority to HR20020378A priority patent/HRP20020378B1/xx

2002-04-29 Priority to HR20020377A priority patent/HRP20020377B1/xx

2002-04-30 Priority to NO20022062A priority patent/NO20022062L/no

2002-04-30 Priority to NO20022061A priority patent/NO330951B1/no

2004-06-15 Application granted granted Critical

2004-06-15 Publication of FI113741B publication Critical patent/FI113741B/fi

Links

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Classifications

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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
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- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
- A—HUMAN NECESSITIES
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- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
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- A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
- A23C9/1427—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by dialysis, reverse osmosis or hyperfiltration, e.g. for concentrating or desalting
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/147—Helveticus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus

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Polymers & Plastics (AREA)
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Bioinformatics & Cheminformatics (AREA)
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Biotechnology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
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Proteomics, Peptides & Aminoacids (AREA)
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General Chemical & Material Sciences (AREA)
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Tropical Medicine & Parasitology (AREA)
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Mycology (AREA)
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Water Supply & Treatment (AREA)
Heart & Thoracic Surgery (AREA)
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Pharmacology & Pharmacy (AREA)
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Public Health (AREA)
Cardiology (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

FI992360A 1999-11-01 1999-11-01 Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi FI113741B (fi)

Priority Applications (45)

Application Number	Priority Date	Filing Date	Title
FI992360A FI113741B (fi)	1999-11-01	1999-11-01	Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
HU0203256A HU226200B1 (en)	1999-11-01	2000-10-30	Process for producing a product containing antihypertensive tripeptides
AT00972940T ATE285470T1 (de)	1999-11-01	2000-10-30	Lactobacillus helveticus, welches blutdrucksenkende di- und tripeptide herstellt
NZ518493A NZ518493A (en)	1999-11-01	2000-10-30	Lactobacillus helvetius producing antihypertensive DI- and tripeptides
JP2001535586A JP4172681B2 (ja)	1999-11-01	2000-10-30	抗高血圧性トリペプチドを含有する産物をつくる方法
DE60016959T DE60016959T2 (de)	1999-11-01	2000-10-30	Lactobacillus helveticus, welches blutdrucksenkende di- und tripeptide herstellt
HU0203185A HUP0203185A3 (en)	1999-11-01	2000-10-30	Lactobacillus helvetius producing antihypertensive di- and tripeptides
ES00972941T ES2220557T3 (es)	1999-11-01	2000-10-30	Procedimiento de fabricacion de un producto que contiene tripeptidos antihipertensores.
PCT/FI2000/000942 WO2001032905A1 (en)	1999-11-01	2000-10-30	Process for producing a product containing antihypertensive tripeptides
JP2001535518A JP3695648B2 (ja)	1999-11-01	2000-10-30	抗高血圧性ジペプチドおよびトリペプチドを産生するＬａｃｔｏｂａｃｉｌｌｕｓｈｅｌｖｅｔｉｃｕｓ
KR1020027005619A KR100704441B1 (ko)	1999-11-01	2000-10-30	항고혈압성 디펩타이드 및 트리펩타이드를 생산하는락토바실러스 헬베티쿠스
AU11498/01A AU777795B2 (en)	1999-11-01	2000-10-30	Lactobacillus helveticus producing antihypertensive di- and tripeptides
CNB008153930A CN1197956C (zh)	1999-11-01	2000-10-30	产生抗高血压二和三肽的瑞士乳杆菌
ES00972940T ES2234686T3 (es)	1999-11-01	2000-10-30	Lactobacillus helveticus que produce dipeptidos y tripeptidos antihipertensivos.
AU11499/01A AU769432B2 (en)	1999-11-01	2000-10-30	Process for producing a product containing antihypertensive tripeptides
PT00972940T PT1226230E (pt)	1999-11-01	2000-10-30	Lactobacillus helvetius produtor de di e tripeptidos antihipertensores
EP00972941A EP1226267B1 (en)	1999-11-01	2000-10-30	Process for producing a product containing antihypertensive tripeptides
PL355670A PL204119B1 (pl)	1999-11-01	2000-10-30	Sposób wytwarzania produktu zawierającego trójpeptydy przeciw nadciśnieniu, produkt zawierający te trójpeptydy, produkt zawierający te trójpeptydy do zastosowania jako czynnik przeciw nadciścnieniu, produkt do zastosowania w wytwarzaniu substancji jadalnych, produkt do zastosowania w przemyśle i produkt jadalny
PL00364790A PL364790A1 (en)	1999-11-01	2000-10-30	Lactobacillus helvetius producing antihypertensive di- and tripeptides
CA002387738A CA2387738C (en)	1999-11-01	2000-10-30	Process for producing a product containing antihypertensive tripeptides
DK00972940T DK1226230T3 (da)	1999-11-01	2000-10-30	Lactobacillus helveticus, der producerer antihypertensive di- og tripeptider
RU2002114359/13A RU2276689C2 (ru)	1999-11-01	2000-10-30	Способ получения продукта, содержащего гипотензивные пептиды, продукт, полученный способом, и пищевой продукт
PT00972941T PT1226267E (pt)	1999-11-01	2000-10-30	Processo para produzir um produto tripeptidos anti-hipertensores
EEP200200230A EE05461B1 (et)	1999-11-01	2000-10-30	Antihpertensiivseid tripeptiide sisaldava toote valmistamise meetod
KR1020027005618A KR100718709B1 (ko)	1999-11-01	2000-10-30	항고혈압 트리펩타이드를 함유하는 제품의 생산 방법
RU2002114327/13A RU2270855C2 (ru)	1999-11-01	2000-10-30	Штамм бактерий lactobacillus helveticus lbk-16 h, используемый для получения пробиотика, бактериальный пробиотический препарат и пищевой продукт
US10/111,914 US6890529B1 (en)	1999-11-01	2000-10-30	Lactobacillus helveticus producing antihypertensive di- and tripeptides
PCT/FI2000/000941 WO2001032836A1 (en)	1999-11-01	2000-10-30	Lactobacillus helvetius producing antihypertensive di- and tripeptides
CZ20021369A CZ294146B6 (cs)	1999-11-01	2000-10-30	Lactobacillus helveticus LBK@�@ H a jeho použitíŹ bakteriální preparát a jedlý produkt
NZ518470A NZ518470A (en)	1999-11-01	2000-10-30	Process for producing a product containing antihypertensive peptides and the product formed by this process
US10/111,942 US6972282B1 (en)	1999-11-01	2000-10-30	Process for producing a product containing antihypertensive tripeptides
DK00972941T DK1226267T3 (da)	1999-11-01	2000-10-30	Fremgangsmåde til fremstilling af et produkt, der indeholder antihypertensive tripeptider
CA002388354A CA2388354A1 (en)	1999-11-01	2000-10-30	Lactobacillus helvetius producing antihypertensive di- and tripeptides
DE60010742T DE60010742T2 (de)	1999-11-01	2000-10-30	Verfahren zur herstellung eines produktes, welches gegen bluthochdruck gerichtete tripeptide enthält
CNB008153353A CN1164761C (zh)	1999-11-01	2000-10-30	生产含抗高血压三肽产品的方法
EP00972940A EP1226230B1 (en)	1999-11-01	2000-10-30	Lactobacillus helveticus producing antihypertensive di- and tripeptides
AT00972941T ATE266735T1 (de)	1999-11-01	2000-10-30	Verfahren zur herstellung eines produktes, welches gegen bluthochdruck gerichtete tripeptide enthält
CZ20021431A CZ302271B6 (cs)	1999-11-01	2000-10-30	Zpusob výroby produktu obsahujícího antihypertenzivní tripeptidy
EEP200200231A EE200200231A (xx)	1999-11-01	2000-10-30	Antih�pertensiivseid di- ja tripeptiide produtseeriv Lactobacillus helveticus
ZA200203179A ZA200203179B (en)	1999-11-01	2002-04-22	Process for producing a product containing antihypertensive tripeptides.
ZA200203172A ZA200203172B (en)	1999-11-01	2002-04-22	Lactobacillus helveticus producing antihypertensive di- and tripeptides.
HR20020378A HRP20020378B1 (en)	1999-11-01	2002-04-29	Lactobacillus helvetius producing antihypertensive di- and tripeptides
HR20020377A HRP20020377B1 (en)	1999-11-01	2002-04-29	Process for producing a product containing antihypertensive tripeptides
NO20022062A NO20022062L (no)	1999-11-01	2002-04-30	Lactobacillus helveticus som produserer antihypertensive di- og tripeptider
NO20022061A NO330951B1 (no)	1999-11-01	2002-04-30	Fremgangsmate for a fremstille produkter inneholdende antihypertensive tripeptider og produkter inneholdende disse

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI992360A FI113741B (fi)	1999-11-01	1999-11-01	Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
FI992360		1999-11-01

Publications (2)

Publication Number	Publication Date
FI19992360A FI19992360A (fi)	2001-05-02
FI113741B true FI113741B (fi)	2004-06-15

Family

ID=8555541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI992360A FI113741B (fi)	1999-11-01	1999-11-01	Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi

Country Status (23)

Country	Link
US (2)	US6890529B1 (no)
EP (2)	EP1226267B1 (no)
JP (2)	JP4172681B2 (no)
KR (2)	KR100704441B1 (no)
CN (2)	CN1197956C (no)
AT (2)	ATE285470T1 (no)
AU (2)	AU777795B2 (no)
CA (2)	CA2388354A1 (no)
CZ (2)	CZ302271B6 (no)
DE (2)	DE60016959T2 (no)
DK (2)	DK1226267T3 (no)
EE (2)	EE05461B1 (no)
ES (2)	ES2234686T3 (no)
FI (1)	FI113741B (no)
HR (2)	HRP20020378B1 (no)
HU (2)	HU226200B1 (no)
NO (2)	NO330951B1 (no)
NZ (2)	NZ518470A (no)
PL (2)	PL364790A1 (no)
PT (2)	PT1226230E (no)
RU (2)	RU2276689C2 (no)
WO (2)	WO2001032905A1 (no)
ZA (2)	ZA200203179B (no)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI113741B (fi) *	1999-11-01	2004-06-15	Valio Oy	Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
FI112031B (fi)	2002-02-25	2003-10-31	Valio Oy	Biologisesti aktiivisen tuotteen uusi käyttö
ES2540926T3 (es)	2002-06-04	2015-07-14	Dsm Ip Assets B.V.	Hidrolizado de proteínas rico en tripéptidos
CN100451127C (zh) *	2002-08-09	2009-01-14	科·汉森有限公司	制备具有抗高血压特性的肽的方法
JP2006512912A (ja) *	2003-01-06	2006-04-20	ユニリーバー・ナームローゼ・ベンノートシヤープ	トリペプチドｖｐｐおよび／またはｉｐｐを含む発酵乳製品
TWI411441B (zh) *	2003-03-18	2013-10-11	Suntory Holdings Ltd	血管收縮素轉化酶抑制性肽類
US7718171B2 (en)	2003-04-07	2010-05-18	Chr. Hansen A/S	Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
AU2004237455B2 (en) *	2003-05-05	2007-08-02	Dsm Ip Assets B.V.	Hydrolysed casein product comprising tripeptides IPP and/ or VPP
JP2007529206A (ja) *	2004-03-19	2007-10-25	カンピーナネーダーランドホールディングビー．ブイ．	アンジオテンシン−ｉ−変換酵素阻害特性を有する食品成分及び食品の調製方法、並びにその方法により得られる製品
EP1736164A4 (en) *	2004-03-31	2009-06-24	Calpis Co Ltd	AGENT TO PREVENT OR REMOVE HEPATOPATHY AND FUNCTIONAL FEED TO PREVENT OR DELETE HEPATOPATHY
US7862808B2 (en)	2004-07-01	2011-01-04	Mead Johnson Nutrition Company	Method for preventing or treating respiratory infections and acute otitis media in infants using Lactobacillus rhamnosus LGG and Bifidobacterium lactis Bb-12
JP4723501B2 (ja) *	2004-07-05	2011-07-13	カルピス株式会社	ペプチド混合物の製造法、抗高血圧ペプチド含有発酵乳の製造法及び抗高血圧ペプチド製剤の製造法
EA011865B1 (ru) *	2004-07-12	2009-06-30	ДСМ Ай Пи ЭССЕТС Б.В.	Протеиновые гидролизаты, снижающие давление крови
EP1685764A1 (en)	2005-01-27	2006-08-02	Globus Egg Sciences B.V.	Anti-hypertensive functional food products
DK1796480T3 (da)	2004-09-03	2012-02-13	Chr Hansen As	Fermenterede mælkeproteiner, der omfatter receptor-ligand, og anvendelser deraf
FR2876874B1 (fr) *	2004-10-22	2007-02-16	Gervais Danone Sa	Protection d'ingredients alimentaires bioactifs par l'utilisation d'ingredients leurres
FR2876876B1 (fr) *	2004-10-22	2007-02-16	Gervais Danone Sa	Protection d'ingredients alimentaires bioactifs par l'utilisation de microorganismes presentant une capacite de metabolisation reduite
US7879804B2 (en) *	2004-12-22	2011-02-01	Dsm Ip Assets B.V.	Blood pressure lowering peptides in a single enzymatic step
EP1879465A1 (en) *	2005-02-09	2008-01-23	Unilever N.V.	Composition comprising peptide
EA016396B1 (ru) *	2005-02-24	2012-04-30	ДСМ АйПи АССЕТС Б.В.	Способ получения пептидного гидролизата, содержащего ipp, и применение указанного гидролизата для производства функционального пищевого продукта, предназначенного для поддержания здоровья сердечно-сосудистой системы
US7303745B2 (en)	2005-04-15	2007-12-04	Bristol-Myers Squibb Company	Method for preventing or treating the development of respiratory allergies
CN104450647A (zh)	2005-11-28	2015-03-25	帝斯曼知识产权资产管理有限公司	产生清洁味道的酶制剂
CA2642539C (en) *	2006-02-14	2013-01-08	Calpis Co., Ltd.	Agent for preventing arteriosclerosis, agent for suppressing vascular intimal thickening and agent for improving vascular endothelial function
JPWO2007094340A1 (ja) *	2006-02-14	2009-07-09	カルピス株式会社	血管拡張剤
ATE548445T1 (de) *	2006-02-20	2012-03-15	Gervais Danone Sa	Laktose nicht fermentierende lactobacillus helveticus
EP1820850B1 (fr) *	2006-02-20	2009-02-25	Compagnie Gervais Danone	Nouvelles souches de lactobacillus helveticus
ES2320482T3 (es) *	2006-02-20	2009-05-22	Compagnie Gervais Danone	Nuevas cepas de lactobacillus helveticus.
CN100370019C (zh) *	2006-04-21	2008-02-20	江南大学	一种具有抗高血压作用的植物乳杆菌cw006
EP2040732A4 (en)	2006-05-15	2009-08-19	Valio Ltd	NEW USE OF THERAPEUTICALLY USEFUL PEPTIDES
RU2457852C2 (ru) *	2006-05-15	2012-08-10	Валио Лтд	Новое применение терапевтически эффективных пептидов
US20100021444A1 (en) *	2006-09-04	2010-01-28	Snow Brand Milk Products Co., Ltd.	Blood-adiponectin-concentration increase-accelerator and/or decrease-inhibitor thereof and visceral fat accumulation inhibitor
PL1915913T3 (pl)	2006-10-23	2016-06-30	Nestec Sa	Modulowanie smaku oraz aromatu w mlecznych produktach poprzez biotransformację
ES2351230T3 (es) *	2007-02-02	2011-02-01	May, Amadeus Alexander	Producto con microorganismos prebióticos vivos.
US11759477B2 (en)	2007-02-26	2023-09-19	Heartbeet Ltd.	Compositions of nitrates and methods of use thereof
US10842813B2 (en)	2007-02-26	2020-11-24	Heartbeet Ltd	Compositions of nitrates and methods of use thereof
CN101678071A (zh) *	2007-03-27	2010-03-24	卡尔皮斯株式会社	肾衰竭预防剂
EP2303030A1 (en) *	2008-06-12	2011-04-06	Nestec S.A.	Lactobacillus helveticus strains for producing hypotensive peptides
DE102008032828A1 (de)	2008-07-02	2010-01-07	Technische Universität Dresden	Tryptophanhaltige Peptide aus alpha-Lactalbumin mit blutdrucksenkender und vasoprotektiver Wirkung für biofunktionelle Lebensmittel
FI122531B (fi) *	2009-09-30	2012-03-15	Valio Oy	Juusto ja menetelmä sen valmistamiseksi
RU2453593C1 (ru) *	2011-04-21	2012-06-20	Общество с ограниченной ответственностью "Бифилюкс"	Штамм lactobacillus helveticus, используемый для получения продукции, содержащей лактобактерии
CN102786580A (zh) *	2012-07-17	2012-11-21	上海交通大学	抗高血压活性肽ivp
CN102786579B (zh) *	2012-07-17	2014-07-09	上海交通大学	抗高血压活性肽vip
RU2580052C1 (ru) *	2014-12-24	2016-04-10	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет"	Штамм lactobacillus helveticus вкпм в-11176, полученный на доступных питательных средах
RU2577112C1 (ru) *	2014-12-25	2016-03-10	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет"	Штамм lactobacillus helveticus вкпм в-11175, полученный на доступных питательных средах
EP3547841B1 (en)	2016-12-02	2020-11-11	Fairlife, LLC	Non-browning lactose-free milk powder and methods of making same
RU2685912C1 (ru) *	2018-03-14	2019-04-23	Федеральное государственное автономное научное учреждение "Научно-исследовательский институт хлебопекарной промышленности"	Штамм бактерий lactobacillus amylolyticus, используемый для приготовления термофильной заквашенной заварки
RU2728171C2 (ru) *	2018-11-08	2020-07-28	Общество с ограниченной ответственностью "Инновационные биотехнологии" (ООО "Инбиотех")	Штамм бактерий Lactobacillus helveticus T-5068, используемый в качестве закваски прямого внесения для приготовления кисломолочных продуктов
CN109517763B (zh) *	2018-12-27	2022-03-22	内蒙古农业大学	瑞士乳杆菌h11及其应用
TWI713972B (zh) *	2019-01-14	2020-12-21	大江生醫股份有限公司	改善呼吸道健康之益生菌株及其組合物與用途
WO2021195718A1 (en) *	2020-04-02	2021-10-07	Ahtesh Fatah Bashir	Milk fermentation process
CN112029784A (zh) *	2020-09-16	2020-12-04	内蒙古农业大学	一个与蛋白水解能力相关的基因及基于该基因的高蛋白水解能力瑞士乳杆菌的筛选方法
KR102684805B1 (ko)	2023-12-20	2024-07-12	푸른하늘환경주식회사	우수 유출수의 정화 처리 장치
KR102687298B1 (ko)	2023-12-20	2024-07-22	푸른하늘환경주식회사	비점오염물질 저감 및 우수 정화 장치
CN117986337B (zh) *	2024-02-02	2024-08-16	杭州御寿生物科技有限公司	一种提高免疫力的益生菌组合物以及在治疗疾病中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2483748A1 (fr) *	1980-06-06	1981-12-11	Corning Glass Works	Procede d'hydrolyse du lactose contenu dans les lactoserums a l'aide de lactase immobilisee
JPS6153216A (ja)	1984-08-23	1986-03-17	Rikagaku Kenkyusho	高血圧症予防治療剤
JP2782142B2 (ja) *	1992-07-23	1998-07-30	カルピス株式会社	アンジオテンシン変換酵素阻害剤及びその製造法
JP2782153B2 (ja) *	1992-11-09	1998-07-30	カルピス株式会社	アンジオテンシン変換酵素阻害ペプチドの製造法
JP2824821B2 (ja)	1993-11-04	1998-11-18	カルピス株式会社	乳酸菌及び発酵乳製品
GB2294191B (en)	1994-10-06	1997-10-01	Waterford Creamery Ltd	Cheese manufacture
JP3782837B2 (ja) *	1995-04-10	2006-06-07	カルピス株式会社	血圧降下剤及びその製造法
JPH09188694A (ja)	1996-01-10	1997-07-22	Otsuka Shokuhin Kk	ペプチド、アンジオテンシン変換酵素阻害組成物及びその製法
JP3746556B2 (ja)	1996-02-09	2006-02-15	カルピス株式会社	プラスミド及びプラスミドベクター
US5854029A (en)	1996-08-02	1998-12-29	Calpis Co., Ltd.	Method for preparing antihypertensive agent
JP4727770B2 (ja) *	1997-09-26	2011-07-20	カルピス株式会社	尿中カテコールアミン低下、尿中ノルアドレナリン低下、尿中ドーパミン低下及びＦｉｓｃｈｅｒ比低下の少なくとも１つの軽減剤
JP3028411B2 (ja)	1997-09-26	2000-04-04	カルピス株式会社	トリペプチド高生産性ラクトバチルス・ヘルベチカス乳酸菌
FI104783B (fi) *	1998-02-12	2000-04-14	Valio Oy	Herasuolajauhe, menetelmä sen valmistamiseksi ja sen käyttö
FI113741B (fi) *	1999-11-01	2004-06-15	Valio Oy	Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
US6514941B1 (en) *	1999-12-10	2003-02-04	Campina Melkunie B.V.	Method of preparing a casein hydrolysate enriched in anti-hypertensive peptides

1999
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Publication number	Publication date
AU1149901A (en)	2001-05-14
EE200200230A (et)	2003-06-16
EE200200231A (xx)	2003-06-16
NO20022062L (no)	2002-06-28
NO20022062D0 (no)	2002-04-30
DE60010742T2 (de)	2005-05-12
PL355670A1 (en)	2004-05-04
HRP20020378A2 (en)	2003-08-31
JP3695648B2 (ja)	2005-09-14
CN1164761C (zh)	2004-09-01
NO20022061D0 (no)	2002-04-30
JP4172681B2 (ja)	2008-10-29
EP1226230A1 (en)	2002-07-31
EP1226267A1 (en)	2002-07-31
CZ20021431A3 (cs)	2002-08-14
PL204119B1 (pl)	2009-12-31
NO20022061L (no)	2002-06-28
EP1226267B1 (en)	2004-05-12
ES2234686T3 (es)	2005-07-01
DE60016959T2 (de)	2005-12-22
HRP20020377A2 (en)	2003-08-31
AU777795B2 (en)	2004-10-28
CA2388354A1 (en)	2001-05-10
DK1226230T3 (da)	2005-04-04
NZ518493A (en)	2003-03-28
CZ302271B6 (cs)	2011-01-19
CN1197956C (zh)	2005-04-20
CZ294146B6 (cs)	2004-10-13
US6972282B1 (en)	2005-12-06
PL364790A1 (en)	2004-12-13
KR100718709B1 (ko)	2007-05-16
CN1387564A (zh)	2002-12-25
CA2387738C (en)	2008-09-16
ZA200203179B (en)	2003-07-22
HUP0203256A3 (en)	2005-11-28
WO2001032905A1 (en)	2001-05-10
WO2001032836A1 (en)	2001-05-10
ES2220557T3 (es)	2004-12-16
JP2003513636A (ja)	2003-04-15
CZ20021369A3 (cs)	2002-07-17
RU2270855C2 (ru)	2006-02-27
KR20020064895A (ko)	2002-08-10
KR20020060220A (ko)	2002-07-16
FI19992360A (fi)	2001-05-02
AU1149801A (en)	2001-05-14
NZ518470A (en)	2003-03-28
CA2387738A1 (en)	2001-05-10
ATE266735T1 (de)	2004-05-15
HUP0203256A2 (hu)	2003-01-28
EE05461B1 (et)	2011-08-15
CN1387577A (zh)	2002-12-25
HUP0203185A3 (en)	2005-07-28
ATE285470T1 (de)	2005-01-15
ZA200203172B (en)	2003-09-23
RU2276689C2 (ru)	2006-05-20
HU226200B1 (en)	2008-06-30
PT1226230E (pt)	2005-04-29
DK1226267T3 (da)	2004-09-20
KR100704441B1 (ko)	2007-04-24
DE60016959D1 (de)	2005-01-27
AU769432B2 (en)	2004-01-29
HRP20020377B1 (en)	2005-06-30
HRP20020378B1 (en)	2005-06-30
DE60010742D1 (de)	2004-06-17
HUP0203185A2 (hu)	2003-01-28
EP1226230B1 (en)	2004-12-22
NO330951B1 (no)	2011-08-22
PT1226267E (pt)	2004-08-31
US6890529B1 (en)	2005-05-10
JP2003513621A (ja)	2003-04-15

Publication	Publication Date	Title
FI113741B (fi)	2004-06-15	Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
Takano	2002	Anti-hypertensive activity of fermented dairy products containing biogenic peptides
JP5888701B2 (ja)	2016-03-22	高タンパク質分解活性を有するラクトバチルス・ヘルベティカス菌
JP2011504363A (ja)	2011-02-10	改良された生理活性ペプチドの生成
MXPA05007267A (es)	2005-09-08	Producto de leche fermentada que comprende tripeptidos val-pro-pro (vpp) e ile-pro-pro (ipp).
WO2013046031A2 (en)	2013-04-04	Lactococcus lactis strains, and bacterial preparations thereof, for the production of bioactive peptides having anti-hypertensive and cholesterol-lowering effects in mammals; nutritional and therapeutic products produced therefrom
FI112031B (fi)	2003-10-31	Biologisesti aktiivisen tuotteen uusi käyttö
FI120267B (fi)	2009-08-31	Menetelmä terapeuttisesti käyttökelpoisten peptidien valmistamiseksi
JP4268785B2 (ja)	2009-05-27	カルシウム吸収促進及びリン酸カルシウム結晶成長促進剤
Acharya	2014	Production of functional food, Fruit ravioli with antihypertensive peptides

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