FI112359B - D-vitamiinin amidijohdannaiset - Google Patents

D-vitamiinin amidijohdannaiset Download PDF

Info

Publication number: FI112359B
Authority: FI; Finland
Prior art keywords: formula; group; oleic acid; compound; secochola
Prior art date: 1994-03-23

Application number

FI963754A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI963754L (fi

FI963754A0 (fi

Inventor

Robert Henry Hesse

Sundara Katugam Srinivas Setty

Original Assignee

Res Inst Medicine Chem

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-23

Filing date

1996-09-20

Publication date

2003-11-28

1996-09-20 Application filed by Res Inst Medicine Chem filed Critical Res Inst Medicine Chem

1996-09-20 Publication of FI963754L publication Critical patent/FI963754L/fi

1996-09-20 Publication of FI963754A0 publication Critical patent/FI963754A0/fi

2003-11-28 Application granted granted Critical

2003-11-28 Publication of FI112359B publication Critical patent/FI112359B/fi

Links

-1 Vitamin D amide Chemical class 0.000 title claims abstract description 35
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title claims abstract description 20
239000011710 vitamin D Substances 0.000 title claims abstract description 19
235000019166 vitamin D Nutrition 0.000 title claims abstract description 18
229940046008 vitamin d Drugs 0.000 title claims abstract description 18
229930003316 Vitamin D Natural products 0.000 title claims abstract description 17
150000001875 compounds Chemical class 0.000 claims abstract description 144
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 50
229910052701 rubidium Inorganic materials 0.000 claims abstract description 22
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 19
150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 17
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 13
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 9
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 7
125000003118 aryl group Chemical group 0.000 claims abstract description 5
125000000623 heterocyclic group Chemical group 0.000 claims abstract description 5
125000001931 aliphatic group Chemical group 0.000 claims abstract description 4
125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 3
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 86
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238000002360 preparation method Methods 0.000 claims description 36
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 33
238000006243 chemical reaction Methods 0.000 claims description 32
238000000034 method Methods 0.000 claims description 28
238000004519 manufacturing process Methods 0.000 claims description 16
238000011282 treatment Methods 0.000 claims description 16
125000000217 alkyl group Chemical group 0.000 claims description 10
238000006317 isomerization reaction Methods 0.000 claims description 10
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
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125000005842 heteroatom Chemical group 0.000 claims description 3
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229960001319 parathyroid hormone Drugs 0.000 claims description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
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125000003710 aryl alkyl group Chemical group 0.000 claims 1
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125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
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208000005368 osteomalacia Diseases 0.000 claims 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
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230000000694 effects Effects 0.000 abstract description 29
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125000002947 alkylene group Chemical group 0.000 abstract description 3
238000000926 separation method Methods 0.000 abstract description 2
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YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 48
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125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 40
238000005481 NMR spectroscopy Methods 0.000 description 38
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239000011541 reaction mixture Substances 0.000 description 23
FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 22
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 21
229910052710 silicon Inorganic materials 0.000 description 16
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 14
PBGGNZZGJIKBMJ-UHFFFAOYSA-N di(propan-2-yl)azanide Chemical compound CC(C)[N-]C(C)C PBGGNZZGJIKBMJ-UHFFFAOYSA-N 0.000 description 14
VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 14
150000001408 amides Chemical class 0.000 description 13
VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 description 12
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
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229920006395 saturated elastomer Polymers 0.000 description 10
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OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 9
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239000011575 calcium Substances 0.000 description 9
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150000002148 esters Chemical class 0.000 description 9
210000004027 cell Anatomy 0.000 description 8
UZBQIPPOMKBLAS-UHFFFAOYSA-N diethylazanide Chemical compound CC[N-]CC UZBQIPPOMKBLAS-UHFFFAOYSA-N 0.000 description 8
235000019441 ethanol Nutrition 0.000 description 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
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GKIRPKYJQBWNGO-OCEACIFDSA-N clomifene Chemical compound C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(\Cl)C1=CC=CC=C1 GKIRPKYJQBWNGO-OCEACIFDSA-N 0.000 description 5
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ZKWFSTHEYLJLEL-UHFFFAOYSA-N morpholine-4-carboxamide Chemical compound NC(=O)N1CCOCC1 ZKWFSTHEYLJLEL-UHFFFAOYSA-N 0.000 description 5
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125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
238000005822 methylenation reaction Methods 0.000 description 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
229960005181 morphine Drugs 0.000 description 1
BRTGHGKBYNOAPI-UHFFFAOYSA-N n,n-dicyclopropylacetamide Chemical compound C1CC1N(C(=O)C)C1CC1 BRTGHGKBYNOAPI-UHFFFAOYSA-N 0.000 description 1
JKWKFBUUNGGYBP-UHFFFAOYSA-N n-cyclopropylcyclopropanamine Chemical compound C1CC1NC1CC1 JKWKFBUUNGGYBP-UHFFFAOYSA-N 0.000 description 1
PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
229910000510 noble metal Inorganic materials 0.000 description 1
230000000269 nucleophilic effect Effects 0.000 description 1
150000007530 organic bases Chemical group 0.000 description 1
150000002916 oxazoles Chemical class 0.000 description 1
238000007248 oxidative elimination reaction Methods 0.000 description 1
230000000849 parathyroid Effects 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
150000004965 peroxy acids Chemical class 0.000 description 1
239000006187 pill Substances 0.000 description 1
LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical compound NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 description 1
125000003386 piperidinyl group Chemical group 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
239000012286 potassium permanganate Substances 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical class CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
125000003072 pyrazolidinyl group Chemical group 0.000 description 1
125000003226 pyrazolyl group Chemical group 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
206010037844 rash Diseases 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000027425 release of sequestered calcium ion into cytosol Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
230000007017 scission Effects 0.000 description 1
229940082569 selenite Drugs 0.000 description 1
229910000077 silane Inorganic materials 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
235000020374 simple syrup Nutrition 0.000 description 1
230000009759 skin aging Effects 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
229960002920 sorbitol Drugs 0.000 description 1
230000000707 stereoselective effect Effects 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
125000005207 tetraalkylammonium group Chemical group 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 description 1
JABYJIQOLGWMQW-UHFFFAOYSA-N undec-4-ene Chemical compound CCCCCCC=CCCC JABYJIQOLGWMQW-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
150000004799 α-ketoamides Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Psychiatry (AREA)
Nutrition Science (AREA)
Reproductive Health (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI963754A 1994-03-23 1996-09-20 D-vitamiinin amidijohdannaiset FI112359B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9405715		1994-03-23
GB9405715A GB9405715D0 (en)	1994-03-23	1994-03-23	Chemical compounds
PCT/GB1995/000658 WO1995025718A1 (en)	1994-03-23	1995-03-23	Vitamin-d amide derivatives
GB9500658		1995-03-23

Publications (3)

Publication Number	Publication Date
FI963754L FI963754L (fi)	1996-09-20
FI963754A0 FI963754A0 (fi)	1996-09-20
FI112359B true FI112359B (fi)	2003-11-28

Family

ID=10752346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI963754A FI112359B (fi)	1994-03-23	1996-09-20	D-vitamiinin amidijohdannaiset

Country Status (21)

Country	Link
US (1)	US5811562A (ja)
EP (1)	EP0751932B1 (ja)
JP (1)	JP3790544B2 (ja)
KR (1)	KR100361556B1 (ja)
CN (1)	CN1073557C (ja)
AT (1)	ATE181063T1 (ja)
AU (1)	AU685249B2 (ja)
CA (1)	CA2185813A1 (ja)
CZ (1)	CZ290304B6 (ja)
DE (1)	DE69510189T2 (ja)
DK (1)	DK0751932T3 (ja)
ES (1)	ES2132651T3 (ja)
FI (1)	FI112359B (ja)
GB (1)	GB9405715D0 (ja)
GR (1)	GR3031084T3 (ja)
HU (1)	HUT75520A (ja)
IL (1)	IL113113A (ja)
NO (1)	NO309188B1 (ja)
NZ (1)	NZ282453A (ja)
WO (1)	WO1995025718A1 (ja)
ZA (1)	ZA952377B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6043385A (en) *	1997-12-16	2000-03-28	Hoffman-La Roche Inc.	Vitamin D derivatives
DE19935771A1 (de) *	1999-07-23	2001-02-01	Schering Ag	Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
AU2005201074B2 (en) *	1999-08-17	2007-10-18	Battelle Memorial Institute	A Chemical reactor and method for gas phase reactant catalytic reactions
WO2001012312A2 (en) *	1999-08-17	2001-02-22	Battelle Memorial Institute	Chemical reactor and method for catalytic gas phase reactions
US6358939B1 (en)	1999-12-21	2002-03-19	Northern Lights Pharmaceuticals, Llc	Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en)	1999-12-21	2006-01-24	Wisconsin Alumni Research Foundation	Treating vitamin D responsive diseases
DE60142313D1 (de)	2000-10-02	2010-07-15	Univ Emory	Triptolid-analoga zur behandlung von autoimmunkranheiten und entzündungen
US20100196308A1 (en)	2009-01-27	2010-08-05	Jimenez Joaquin J	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
BR112012003372A2 (pt)	2009-08-14	2019-09-24	Berg Biosystems Llc	vitamina d3 e análogos da mesma para o tratamento de alopecia.
NZ714801A (en)	2013-05-29	2021-07-30	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin d

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK281302B6 (sk) *	1991-11-07	2001-02-12	Research Institute For Medicine And Chemistry	Amidové deriváty vitamínu d, spôsob ich výroby, ich použitie a farmaceutické kompozície s ich obsahom
GB9206648D0 (en) *	1992-03-26	1992-05-06	Leo Pharm Prod Ltd	Chemical compounds
DE4234382A1 (de) *	1992-10-06	1994-04-07	Schering Ag	25-Carbonsäure-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
GB9309422D0 (en) *	1993-05-07	1993-06-23	Res Inst Medicine Chem	Chemical compounds

1994
- 1994-03-23 GB GB9405715A patent/GB9405715D0/en active Pending
1995
- 1995-03-23 JP JP52450395A patent/JP3790544B2/ja not_active Expired - Fee Related
- 1995-03-23 NZ NZ282453A patent/NZ282453A/en unknown
- 1995-03-23 EP EP95912345A patent/EP0751932B1/en not_active Expired - Lifetime
- 1995-03-23 CA CA002185813A patent/CA2185813A1/en not_active Abandoned
- 1995-03-23 IL IL11311395A patent/IL113113A/en not_active IP Right Cessation
- 1995-03-23 KR KR1019960705257A patent/KR100361556B1/ko not_active Expired - Fee Related
- 1995-03-23 ZA ZA952377A patent/ZA952377B/xx unknown
- 1995-03-23 CN CN95192735A patent/CN1073557C/zh not_active Expired - Fee Related
- 1995-03-23 DE DE69510189T patent/DE69510189T2/de not_active Expired - Fee Related
- 1995-03-23 CZ CZ19962660A patent/CZ290304B6/cs unknown
- 1995-03-23 AU AU19560/95A patent/AU685249B2/en not_active Ceased
- 1995-03-23 DK DK95912345T patent/DK0751932T3/da active
- 1995-03-23 ES ES95912345T patent/ES2132651T3/es not_active Expired - Lifetime
- 1995-03-23 US US08/704,613 patent/US5811562A/en not_active Expired - Fee Related
- 1995-03-23 WO PCT/GB1995/000658 patent/WO1995025718A1/en active IP Right Grant
- 1995-03-23 HU HU9602572A patent/HUT75520A/hu unknown
- 1995-03-23 AT AT95912345T patent/ATE181063T1/de not_active IP Right Cessation
1996
- 1996-09-20 FI FI963754A patent/FI112359B/fi not_active IP Right Cessation
- 1996-09-20 NO NO963949A patent/NO309188B1/no unknown
1999
- 1999-08-26 GR GR990402167T patent/GR3031084T3/el unknown

Also Published As

Publication number	Publication date
DK0751932T3 (da)	1999-11-15
KR100361556B1 (ko)	2003-02-17
KR970701692A (ko)	1997-04-12
FI963754L (fi)	1996-09-20
EP0751932A1 (en)	1997-01-08
ZA952377B (en)	1996-02-07
EP0751932B1 (en)	1999-06-09
JP3790544B2 (ja)	2006-06-28
NZ282453A (en)	1997-04-24
JPH09510472A (ja)	1997-10-21
US5811562A (en)	1998-09-22
GB9405715D0 (en)	1994-05-11
CN1149288A (zh)	1997-05-07
HUT75520A (en)	1997-05-28
CA2185813A1 (en)	1995-09-28
HU9602572D0 (en)	1996-11-28
AU685249B2 (en)	1998-01-15
ATE181063T1 (de)	1999-06-15
WO1995025718A1 (en)	1995-09-28
IL113113A (en)	2001-03-19
NO309188B1 (no)	2000-12-27
AU1956095A (en)	1995-10-09
NO963949D0 (no)	1996-09-20
DE69510189D1 (de)	1999-07-15
CN1073557C (zh)	2001-10-24
ES2132651T3 (es)	1999-08-16
CZ290304B6 (cs)	2002-07-17
CZ266096A3 (en)	1997-06-11
DE69510189T2 (de)	1999-11-11
IL113113A0 (en)	1995-06-29
FI963754A0 (fi)	1996-09-20
GR3031084T3 (en)	1999-12-31
NO963949L (no)	1996-11-22

Publication	Publication Date	Title
JP3703099B2 (ja)	2005-10-05	ビタミンｄアミド誘導体
KR100321415B1 (ko)	2002-11-13	비타민d유사체
FI112359B (fi)	2003-11-28	D-vitamiinin amidijohdannaiset
FI112360B (fi)	2003-11-28	Menetelmä terapeuttisesti käyttökelpoisten vitamiini D:n amiini- ja amidijohdannaisten valmistamiseksi
CZ288031B6 (cs)	2001-04-11	Amidové deriváty vitaminu D, způsob výroby a farmaceutické prostředky s jejich obsahem
WO1985002189A1 (en)	1985-05-23	1,25-dihdroxyvitamin d2 compounds and methods for their preparation
DE69612568T2 (de)	2001-09-06	17-seitenkette-alknyl- und 20-oxopregna-derivate von vitamin d, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon
WO1985001291A1 (en)	1985-03-28	1,23-dihydroxyvitamin d compounds
IE57947B1 (en)	1993-05-19	Side-chain unsaturated 1-hydroxyvitamin d compounds

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