DE69510189D1 - Vitamin-d-amid derivate - Google Patents
Vitamin-d-amid derivateInfo
- Publication number
- DE69510189D1 DE69510189D1 DE69510189T DE69510189T DE69510189D1 DE 69510189 D1 DE69510189 D1 DE 69510189D1 DE 69510189 T DE69510189 T DE 69510189T DE 69510189 T DE69510189 T DE 69510189T DE 69510189 D1 DE69510189 D1 DE 69510189D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- group
- sec
- alpha
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000000125 calcaemic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- -1 cyclohexylidene moiety Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9405715A GB9405715D0 (en) | 1994-03-23 | 1994-03-23 | Chemical compounds |
| PCT/GB1995/000658 WO1995025718A1 (en) | 1994-03-23 | 1995-03-23 | Vitamin-d amide derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69510189D1 true DE69510189D1 (de) | 1999-07-15 |
| DE69510189T2 DE69510189T2 (de) | 1999-11-11 |
Family
ID=10752346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69510189T Expired - Fee Related DE69510189T2 (de) | 1994-03-23 | 1995-03-23 | Vitamin-d-amid derivate |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5811562A (de) |
| EP (1) | EP0751932B1 (de) |
| JP (1) | JP3790544B2 (de) |
| KR (1) | KR100361556B1 (de) |
| CN (1) | CN1073557C (de) |
| AT (1) | ATE181063T1 (de) |
| AU (1) | AU685249B2 (de) |
| CA (1) | CA2185813A1 (de) |
| CZ (1) | CZ290304B6 (de) |
| DE (1) | DE69510189T2 (de) |
| DK (1) | DK0751932T3 (de) |
| ES (1) | ES2132651T3 (de) |
| FI (1) | FI112359B (de) |
| GB (1) | GB9405715D0 (de) |
| GR (1) | GR3031084T3 (de) |
| HU (1) | HUT75520A (de) |
| IL (1) | IL113113A (de) |
| NO (1) | NO309188B1 (de) |
| NZ (1) | NZ282453A (de) |
| WO (1) | WO1995025718A1 (de) |
| ZA (1) | ZA952377B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19619036A1 (de) * | 1996-04-30 | 1997-11-13 | Schering Ag | Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| US6043385A (en) * | 1997-12-16 | 2000-03-28 | Hoffman-La Roche Inc. | Vitamin D derivatives |
| DE19935771A1 (de) * | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
| AU2005201074B2 (en) * | 1999-08-17 | 2007-10-18 | Battelle Memorial Institute | A Chemical reactor and method for gas phase reactant catalytic reactions |
| DE60021086T2 (de) * | 1999-08-17 | 2006-05-04 | Battelle Memorial Institute, Richland | Chemischer reaktor und verfahren zur katalytischen gasphasenreaktionen |
| US6358939B1 (en) | 1999-12-21 | 2002-03-19 | Northern Lights Pharmaceuticals, Llc | Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease |
| US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
| AU2001296542B2 (en) | 2000-10-02 | 2007-10-25 | Emory University | Triptolide analogs for the treatment of autoimmune and inflammatory disorders |
| EA201691980A1 (ru) | 2009-01-27 | 2017-07-31 | БЕРГ ЭлЭлСи | Способы уменьшения побочных эффектов, связанных с химиотерапией |
| KR101880032B1 (ko) | 2009-08-14 | 2018-07-20 | 베르그 엘엘씨 | 탈모증 치료용 비타민 ｄ3 및 이의 유사체들 |
| CA2913543C (en) | 2013-05-29 | 2024-01-09 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3282811B2 (ja) * | 1991-11-07 | 2002-05-20 | リサーチ・インステイテユート・フオア・メデイシン・アンド・ケミストリー | 化学的化合物 |
| GB9206648D0 (en) * | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
| DE4234382A1 (de) * | 1992-10-06 | 1994-04-07 | Schering Ag | 25-Carbonsäure-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| GB9309422D0 (en) * | 1993-05-07 | 1993-06-23 | Res Inst Medicine Chem | Chemical compounds |
-
1994
- 1994-03-23 GB GB9405715A patent/GB9405715D0/en active Pending
-
1995
- 1995-03-23 ES ES95912345T patent/ES2132651T3/es not_active Expired - Lifetime
- 1995-03-23 CZ CZ19962660A patent/CZ290304B6/cs unknown
- 1995-03-23 NZ NZ282453A patent/NZ282453A/en unknown
- 1995-03-23 CN CN95192735A patent/CN1073557C/zh not_active Expired - Fee Related
- 1995-03-23 AT AT95912345T patent/ATE181063T1/de not_active IP Right Cessation
- 1995-03-23 AU AU19560/95A patent/AU685249B2/en not_active Ceased
- 1995-03-23 CA CA002185813A patent/CA2185813A1/en not_active Abandoned
- 1995-03-23 WO PCT/GB1995/000658 patent/WO1995025718A1/en active IP Right Grant
- 1995-03-23 ZA ZA952377A patent/ZA952377B/xx unknown
- 1995-03-23 KR KR1019960705257A patent/KR100361556B1/ko not_active Expired - Fee Related
- 1995-03-23 JP JP52450395A patent/JP3790544B2/ja not_active Expired - Fee Related
- 1995-03-23 US US08/704,613 patent/US5811562A/en not_active Expired - Fee Related
- 1995-03-23 HU HU9602572A patent/HUT75520A/hu unknown
- 1995-03-23 IL IL11311395A patent/IL113113A/en not_active IP Right Cessation
- 1995-03-23 EP EP95912345A patent/EP0751932B1/de not_active Expired - Lifetime
- 1995-03-23 DE DE69510189T patent/DE69510189T2/de not_active Expired - Fee Related
- 1995-03-23 DK DK95912345T patent/DK0751932T3/da active
-
1996
- 1996-09-20 NO NO963949A patent/NO309188B1/no unknown
- 1996-09-20 FI FI963754A patent/FI112359B/fi not_active IP Right Cessation
-
1999
- 1999-08-26 GR GR990402167T patent/GR3031084T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO963949L (no) | 1996-11-22 |
| HUT75520A (en) | 1997-05-28 |
| HU9602572D0 (en) | 1996-11-28 |
| EP0751932B1 (de) | 1999-06-09 |
| IL113113A (en) | 2001-03-19 |
| CZ266096A3 (en) | 1997-06-11 |
| ES2132651T3 (es) | 1999-08-16 |
| CA2185813A1 (en) | 1995-09-28 |
| US5811562A (en) | 1998-09-22 |
| ATE181063T1 (de) | 1999-06-15 |
| NO309188B1 (no) | 2000-12-27 |
| IL113113A0 (en) | 1995-06-29 |
| NZ282453A (en) | 1997-04-24 |
| JP3790544B2 (ja) | 2006-06-28 |
| CN1149288A (zh) | 1997-05-07 |
| KR100361556B1 (ko) | 2003-02-17 |
| FI963754L (fi) | 1996-09-20 |
| KR970701692A (ko) | 1997-04-12 |
| GR3031084T3 (en) | 1999-12-31 |
| EP0751932A1 (de) | 1997-01-08 |
| WO1995025718A1 (en) | 1995-09-28 |
| FI112359B (fi) | 2003-11-28 |
| ZA952377B (en) | 1996-02-07 |
| CZ290304B6 (cs) | 2002-07-17 |
| CN1073557C (zh) | 2001-10-24 |
| NO963949D0 (no) | 1996-09-20 |
| JPH09510472A (ja) | 1997-10-21 |
| DE69510189T2 (de) | 1999-11-11 |
| FI963754A0 (fi) | 1996-09-20 |
| AU1956095A (en) | 1995-10-09 |
| GB9405715D0 (en) | 1994-05-11 |
| DK0751932T3 (da) | 1999-11-15 |
| AU685249B2 (en) | 1998-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN |
|
| 8339 | Ceased/non-payment of the annual fee |