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ES8606412A1 - Un procedimiento para preparar un peptido sintetico - Google Patents

Un procedimiento para preparar un peptido sintetico

Info

Publication number
ES8606412A1
ES8606412A1 ES543235A ES543235A ES8606412A1 ES 8606412 A1 ES8606412 A1 ES 8606412A1 ES 543235 A ES543235 A ES 543235A ES 543235 A ES543235 A ES 543235A ES 8606412 A1 ES8606412 A1 ES 8606412A1
Authority
ES
Spain
Prior art keywords
arg
leu
ala
ser
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543235A
Other languages
English (en)
Other versions
ES543235A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of ES543235A0 publication Critical patent/ES543235A0/es
Publication of ES8606412A1 publication Critical patent/ES8606412A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Dental Preparations (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR UN PEPTIDO SINTETICO. COMPRENDE: A) FORMAR UN PEPTIDO QUE TENGA AL MENOS UN GRUPO PROTECTOR DE FORMULA (II) EN DONDE X, X1, X2, X3, X4, X5, X6, X7 Y X8 SON CADA UNO H O UN GRUPO PROTECTOR Y R9 ES UN GRUPO PROTECTOR O UN ENLACE DE ANCLAJE AL SOPORTE DE RESINA O ES DES-X9, EN CUYO CASO EL RESIDUO EN EL EXTREMO TERMINAL C TIENE UN RESTO CARBOXI QUE ES Y; B) ESCINDIR EL GRUPO O GRUPOS PROTECTORES O EL ENLACE DE ANCLAJE DEL PEPTIDO DE FORMULA (II) PARA OBTENER UN PEPTIDO SINTETICO DE FORMULA (I); Y C) SI SE DESEA, CONVERTIR EL PEPTIDO RESULTANTE DE LA SECUENCIA DE FORMULA (I) EN UNA DE SUS SALES NO TOXICAS. TIENE APLICACIONES FARMACEUTICAS POR PROMOVER LA LIBERACION DE LA HORMONA DEL CRECIMIENTO POR LA GLANDULA PITUITARIA.
ES543235A 1984-05-18 1985-05-17 Un procedimiento para preparar un peptido sintetico Expired ES8606412A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/611,844 US4528190A (en) 1983-10-25 1984-05-18 GRF Analogs IV

Publications (2)

Publication Number Publication Date
ES543235A0 ES543235A0 (es) 1986-04-01
ES8606412A1 true ES8606412A1 (es) 1986-04-01

Family

ID=24450622

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543235A Expired ES8606412A1 (es) 1984-05-18 1985-05-17 Un procedimiento para preparar un peptido sintetico

Country Status (25)

Country Link
US (1) US4528190A (es)
EP (1) EP0161852B1 (es)
JP (1) JPH0689036B2 (es)
KR (1) KR910000379B1 (es)
AT (1) ATE73823T1 (es)
AU (1) AU578467B2 (es)
CA (1) CA1271299A (es)
DD (1) DD236536A5 (es)
DE (1) DE3585634D1 (es)
DK (1) DK162103C (es)
EG (1) EG17394A (es)
ES (1) ES8606412A1 (es)
FI (1) FI92210C (es)
GR (1) GR851207B (es)
HU (1) HU197759B (es)
IE (1) IE57813B1 (es)
IL (1) IL75088A (es)
MX (1) MX157381A (es)
NO (1) NO168043C (es)
NZ (1) NZ212113A (es)
PH (1) PH20976A (es)
PT (1) PT80450B (es)
SU (1) SU1530097A3 (es)
YU (1) YU46153B (es)
ZA (1) ZA852919B (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728726A (en) * 1982-10-04 1988-03-01 The Salk Institute For Biological Studies GRF analogs IIIb
US4732972A (en) * 1983-03-07 1988-03-22 Hoffmann-La Roche Inc. Polypeptides having growth hormone releasing activity
US4649131A (en) * 1984-09-24 1987-03-10 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
CA1271600A (en) * 1985-01-07 1990-07-10 David Howard Coy Growth hormone-releasing peptides and method of treating mammals therewith
EP0193910A3 (en) * 1985-03-06 1988-11-23 Sumitomo Pharmaceuticals Company, Limited Synthesis of a derivative of grf and intermediate peptides
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
US4689318A (en) * 1985-08-29 1987-08-25 The Salk Institute For Biological Studies GRF analogs
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
FR2599038B1 (fr) * 1986-05-26 1990-06-29 Sanofi Sa Procede de preparation de nonacosapeptides et peptides intermediaires
DE3742633A1 (de) * 1987-12-16 1989-06-29 Hoechst Ag Peptide mit beeinflussender wirkung auf die hypophyse von saeugern
US5565606A (en) * 1986-10-21 1996-10-15 Hoechst Aktiengesellschaft Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
US4843064A (en) * 1987-01-13 1989-06-27 The Salk Institute For Biological Studies GRF analogs V
IL84758A (en) * 1987-01-13 1992-03-29 Salk Inst For Biological Studi Peptides stimulating the release of pituitary growth hormone in fish and amphibians,and pharmaceutical compositions containing them
US4914189A (en) * 1987-02-05 1990-04-03 The Adminstrators Of The Tulane Educational Fund Synthetic GHRH analogs
EP0289186A3 (en) * 1987-04-23 1990-04-04 International Minerals And Chemical Corporation Process for increasing the growth rate and enhancing the feed efficiency of meat producing livestock
US5112808A (en) * 1987-05-11 1992-05-12 American Cyanamid Company Alkylated hormone-releasing peptides and method of treatig mammals therewith
IL86102A (en) * 1987-05-11 1994-04-12 Univ Tulane Alkylated peptides that release growth hormone and their use
US5002931A (en) * 1987-05-22 1991-03-26 The Salk Institute For Biological Studies GRF analogs VII
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US4801456A (en) * 1987-07-09 1989-01-31 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
USRE33699E (en) * 1987-07-09 1991-09-24 International Minerals & Chemical Corp. Growth hormone-releasing factor analogs
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
EP0307860B1 (en) * 1987-09-18 1994-06-08 F. Hoffmann-La Roche Ag Cyclic GRF-analogs
ATE122357T1 (de) * 1988-01-28 1995-05-15 Polygen Holding Corp Polypeptide mit hormonwachstumsbefreiender wirkung.
US5043322A (en) * 1988-07-22 1991-08-27 The Salk Institute For Biological Studies Cyclic GRF analogs
US5023322A (en) * 1988-08-31 1991-06-11 Mta Kutatas-Es Szervezetelemzo Intezete Analogs of growth hormone releasing factor (GRF) and a method for the preparation thereof
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
US5716937A (en) * 1989-12-13 1998-02-10 The General Hospital Corporation Method for treating cardiac malfunction
IL98638A (en) * 1990-06-29 1995-07-31 Hoffmann La Roche Analogs of the factor that releases human growth hormone, their preparation and pharmaceutical preparations that contain them
ATE119916T1 (de) * 1990-12-10 1995-04-15 Hoffmann La Roche Verfahren zur enzymatischen herstellung von grf(1-44)nh2.
WO1992018531A1 (en) * 1991-04-09 1992-10-29 F. Hoffmann-La Roche Ag Growth hormone releasing factor analogs
ZA922746B (en) * 1991-04-26 1992-12-30 Lilly Co Eli Superactive grf analogs
US5246920A (en) * 1992-06-15 1993-09-21 University Of South Florida Treatment of hyperprolactinemia
US5811074A (en) * 1992-06-29 1998-09-22 University Of South Florida Method of diagnosing pituitary dependent growth hormone deficiency
GB9324691D0 (en) * 1993-12-01 1994-01-19 Hafslund Nycomed As Peptide compounds
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
CN1491233A (zh) * 2001-02-02 2004-04-21 康久化学公司 长效生长激素释放因子衍生物
RU2005111253A (ru) * 2002-09-18 2005-11-20 Сантр Оспиталье Де Л` Юниверсите Де Монреаль (Схюм) (Ca) Аналоги ghrh
US20090088380A1 (en) * 2007-07-12 2009-04-02 Pierrette Gaudreau Ghrh analogs and therapeutic uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563352A (en) * 1982-10-04 1986-01-07 The Salk Institute For Biological Studies Human pancreatic GRF
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4518586A (en) * 1983-01-13 1985-05-21 The Salk Institute For Biological Studies GRF Analogs III
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides

Also Published As

Publication number Publication date
NO851947L (no) 1985-11-19
PT80450A (en) 1985-06-01
PH20976A (en) 1987-06-15
FI92210B (fi) 1994-06-30
KR850008681A (ko) 1985-12-21
FI851842A0 (fi) 1985-05-09
FI92210C (fi) 1994-10-10
NO168043C (no) 1992-01-08
DK162103C (da) 1992-02-17
ATE73823T1 (de) 1992-04-15
KR910000379B1 (ko) 1991-01-24
DK220685A (da) 1985-11-19
EG17394A (en) 1992-12-30
YU46153B (sh) 1993-05-28
PT80450B (pt) 1987-08-19
NO168043B (no) 1991-09-30
IL75088A0 (en) 1985-09-29
DD236536A5 (de) 1986-06-11
SU1530097A3 (ru) 1989-12-15
ES543235A0 (es) 1986-04-01
US4528190A (en) 1985-07-09
EP0161852A3 (en) 1988-10-26
NZ212113A (en) 1988-05-30
AU4248885A (en) 1985-11-21
ZA852919B (en) 1986-11-26
FI851842L (fi) 1985-11-19
IE57813B1 (en) 1993-04-21
JPS60260595A (ja) 1985-12-23
GR851207B (es) 1985-11-25
IL75088A (en) 1988-12-30
JPH0689036B2 (ja) 1994-11-09
MX157381A (es) 1988-11-18
YU77185A (en) 1988-04-30
IE851087L (en) 1985-11-18
DK220685D0 (da) 1985-05-17
DK162103B (da) 1991-09-16
DE3585634D1 (de) 1992-04-23
EP0161852B1 (en) 1992-03-18
HU197759B (en) 1989-05-29
AU578467B2 (en) 1988-10-27
CA1271299A (en) 1990-07-03
EP0161852A2 (en) 1985-11-21
HUT37633A (en) 1986-01-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009