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ES8602404A1 - Metodo de producir complejos solubles en agua de principios activos insolubles en agua y fosfolipidos - Google Patents

Metodo de producir complejos solubles en agua de principios activos insolubles en agua y fosfolipidos

Info

Publication number
ES8602404A1
ES8602404A1 ES542478A ES542478A ES8602404A1 ES 8602404 A1 ES8602404 A1 ES 8602404A1 ES 542478 A ES542478 A ES 542478A ES 542478 A ES542478 A ES 542478A ES 8602404 A1 ES8602404 A1 ES 8602404A1
Authority
ES
Spain
Prior art keywords
water
production
same
water soluble
soluble drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES542478A
Other languages
English (en)
Other versions
ES542478A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GC Biopharma Corp
Original Assignee
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13245333&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8602404(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Green Cross Corp Korea filed Critical Green Cross Corp Korea
Publication of ES8602404A1 publication Critical patent/ES8602404A1/es
Publication of ES542478A0 publication Critical patent/ES542478A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

METODO DE PRODUCCION DE COMPLEJOS SOLUBLES EN AGUA CON PRINCIPIOS ACTIVOS INSOLUBLES EN AGUA Y FOSFOLIPIDOS. COMPRENDE LA DISOLUCION DE UN PRINCIPIO ACTIVO INSOLUBLE EN AGUA Y UN FOSFOLIPIDO EN UN DISOLVENTE ORGANICO; ELIMINACION DEL DISOLVENTE PARA PRODUCIR UNA PELICULA DE FOSFOLIPIDO QUE CONTIENE EL PRINCIPIO ACTIVO; SUSPENSION DE LA PELICULA FORMADA EN UNA DISOLUCION ACUOSA; TRATAMIENTO DE DICHA PELICULA CON ULTRASONIDOS, SEGUIDO DE LA CENTRIFUGACION DE LA SUSPENSION RESULTANTE; Y RECUPERACION DE LA CAPA MAS INFERIOR DEL SEDIMENTO RESULTANTE QUE CONTIENE EL COMPLEJO FORMADO, SOLUBLE EN AGUA. TIENE APLICACIONES PARA LA SOLUBILIZACION DE PRINCIPIOS ACTIVOS EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS.
ES542478A 1984-03-31 1985-03-29 Metodo de producir complejos solubles en agua de principios activos insolubles en agua y fosfolipidos Granted ES542478A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59063994A JPS60208910A (ja) 1984-03-31 1984-03-31 水難溶性薬物・リン脂質複合体の製造方法

Publications (2)

Publication Number Publication Date
ES8602404A1 true ES8602404A1 (es) 1985-12-16
ES542478A0 ES542478A0 (es) 1985-12-16

Family

ID=13245333

Family Applications (1)

Application Number Title Priority Date Filing Date
ES542478A Granted ES542478A0 (es) 1984-03-31 1985-03-29 Metodo de producir complejos solubles en agua de principios activos insolubles en agua y fosfolipidos

Country Status (7)

Country Link
US (1) US4687762A (es)
EP (1) EP0161445B1 (es)
JP (1) JPS60208910A (es)
KR (1) KR890000115B1 (es)
CA (1) CA1238853A (es)
DE (1) DE3565049D1 (es)
ES (1) ES542478A0 (es)

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US5171566A (en) * 1986-05-16 1992-12-15 The Green Cross Corporation Flurbiprofen derivative ophthalmic preparation
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
IT1201149B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1201151B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono
US6406713B1 (en) * 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US4828837A (en) * 1987-03-30 1989-05-09 Liposome Technology, Inc. Non-crystalline minoxidil composition, its production and application
US5030442A (en) * 1987-03-30 1991-07-09 Liposome Technology, Inc. Non-crystalline minoxidil composition
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
JP2926749B2 (ja) 1989-04-25 1999-07-28 吉富製薬株式会社 プロスタグランジン含有液状組成物
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
GB9126209D0 (en) * 1991-12-10 1992-02-12 Orion Yhtymae Oy Drug formulations for parenteral use
DE4309579C3 (de) * 1993-03-24 2000-01-27 Sanol Arznei Schwarz Gmbh Pharmazeutische Zusammensetzung in Form einer Packung
WO1997014407A1 (en) * 1995-10-17 1997-04-24 Research Triangle Pharmaceuticals Insoluble drug delivery
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
GB9625589D0 (en) 1996-12-10 1997-01-29 Boots Co Plc Therapeutic agents
IL137734A0 (en) * 1998-02-11 2001-10-31 Res Triangle Pharm Ltd Method and composition for treatment of inflammatory conditions
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
AU764001B2 (en) 1998-05-29 2003-08-07 Skyepharma Canada Inc. Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
WO2000010531A1 (en) 1998-08-19 2000-03-02 Rtp Pharma Inc. Injectable aqueous dispersions of propofol
RU2233654C2 (ru) 1998-11-20 2004-08-10 Ртп Фарма Инк. Диспергируемые стабилизированные фосфолипидом микрочастицы
JP2003509453A (ja) * 1999-09-21 2003-03-11 アールティーピー・ファーマ・インコーポレーテッド 生物学的に活性な物質の、表面改質された粒状組成物
EP1276465B1 (en) 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
US6761901B1 (en) * 2000-05-02 2004-07-13 Enzrel Inc. Liposome drug delivery
US20020037877A1 (en) * 2000-07-26 2002-03-28 Alcon Universal Ltd. Pharmaceutical suspension compositions lacking a polymeric suspending agent
AU8847101A (en) 2000-08-31 2002-03-13 Rtp Pharma Inc Milled particles
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
US20040092186A1 (en) * 2000-11-17 2004-05-13 Patricia Wilson-Nguyen Textile electronic connection system
WO2002085414A2 (en) * 2000-12-19 2002-10-31 The Board Of Regents Of The University Of Texas System Nsaid formulations comprising lecithin oils for protecting the gastrointestinal tract and providing enhanced therapeutic activity
US20100173876A1 (en) * 2000-12-19 2010-07-08 The Board Of Regents Of The University Of Texas System Oil-based nsaid compositions and methods for making and using same
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
ATE357216T1 (de) * 2001-02-22 2007-04-15 Jagotec Ag Fibrat-statin kombinationen mit verminderten von der nahrungsaufnahme abhängigen auswirkungen
WO2003059288A2 (en) * 2002-01-09 2003-07-24 Enzrel, Inc. Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds
DE10234784A1 (de) * 2002-07-30 2004-02-19 Günenthal GmbH Intravenös applizierbare, pharmazeutische Darreichungsform
US7838034B2 (en) 2002-07-30 2010-11-23 Grunenthal Gmbh Intravenous pharmaceutical form of administration
DE10255285A1 (de) * 2002-11-26 2004-06-03 Mcs Micro Carrier Systems Gmbh Selbst formende Phospholipid-Gele
US20130085146A1 (en) * 2003-01-14 2013-04-04 Rodney J.Y. Ho Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues
AU2005295874B2 (en) * 2004-10-12 2011-01-27 The Board Of Regents Of The University Of Texas System Purified phospholipid-non-steroidal anti-inflammatory drug associated compositions and methods for preparing and using same
JP5558712B2 (ja) * 2005-08-02 2014-07-23 ドロサファーム アクチェンゲゼルシャフト インドメタシン及び／又はアセメタシンを含む医薬組成物
US20080213339A1 (en) * 2005-08-02 2008-09-04 Roger Imboden Pharmaceutical Composition Containing Indometacin and/or Acemetacin
JPWO2009125858A1 (ja) * 2008-04-07 2011-08-04 静岡県公立大学法人 ２−インドリノン誘導体を含有する脂質分散体製剤
MX340951B (es) 2011-09-29 2016-07-29 Plx Pharma Inc Portadores dependientes del ph para la liberacion dirigida de productos farmaceuticos a lo largo del tracto gastrointestinal, composiciones de los mismos, y fabricación y uso de las mismas.
KR101751533B1 (ko) * 2012-09-14 2017-06-28 주식회사 아미팜 포스파티딜콜린 및 바이페닐-디메틸-디카르복실레이트를 포함하는 간 질환 예방 또는 치료용 조성물
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
MX2022011743A (es) 2020-03-26 2022-12-08 Plx Opco Inc Portadores farmaceuticos con capacidad de reconstitucion dependiente del ph y metodos para elaborar y usar los mismos.

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FR2374910A1 (fr) * 1976-10-23 1978-07-21 Choay Sa Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations
DE2656333C2 (de) * 1976-12-13 1985-08-08 Karl Prof. Dr.med. 7302 Ostfildern Theurer Verfahren zur Herstellung von Liposomen, welche Arzneistoffe enthalten
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
US4196202A (en) * 1977-12-20 1980-04-01 Taiji Okada Carcinostatic composition containing 3-N-o-toluyl-5-fluorouracil producing the same
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Also Published As

Publication number Publication date
JPS60208910A (ja) 1985-10-21
CA1238853A (en) 1988-07-05
ES542478A0 (es) 1985-12-16
EP0161445A1 (en) 1985-11-21
JPH0534334B2 (es) 1993-05-21
DE3565049D1 (en) 1988-10-27
EP0161445B1 (en) 1988-09-21
KR890000115B1 (ko) 1989-03-08
US4687762A (en) 1987-08-18
KR850006129A (ko) 1985-10-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603