[go: up one dir, main page]

ES2066896T3 - Forma oral de farmaco de lipidos. - Google Patents

Forma oral de farmaco de lipidos.

Info

Publication number
ES2066896T3
ES2066896T3 ES90106947T ES90106947T ES2066896T3 ES 2066896 T3 ES2066896 T3 ES 2066896T3 ES 90106947 T ES90106947 T ES 90106947T ES 90106947 T ES90106947 T ES 90106947T ES 2066896 T3 ES2066896 T3 ES 2066896T3
Authority
ES
Spain
Prior art keywords
solid component
lipid
lipids
semi
oral form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90106947T
Other languages
English (en)
Inventor
Rainer K Dr Liedtke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmed GmbH
Original Assignee
Pharmed GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmed GmbH filed Critical Pharmed GmbH
Application granted granted Critical
Publication of ES2066896T3 publication Critical patent/ES2066896T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PARA MEJORAR LA RESORCION DE SUSTANCIAS ACTIVAS, QUE DESPUES DE LA APLICACION ORAL NO ADOPTEN UNA FORMA FACILMENTE ASIMILABLE, SE PREPARA EL MEDICAMENTO ORAL CON LIPIDOS POR MEDIO DE LA COMBINACION DE COMPONENTES LIPOFILOS SEMISOLIDOS CON UN COMPONENTE SOLIDO SOLUBLE EN AGUA. EL COMPONENTE SEMISOLIDO ES UNA MEZCLA HOMOGENEA DE LIPIDOS EN FORMA DE GRASA DURA CON PROPIEDADES DE FUSION REVERSIBLES, QUE A LA TEMPERATURA DEL CUERPO ES LIQUIDA EN UN 95 %. EL COMPONENTE SOLIDO ES UNA ENVOLVENTE SOLUBLE EN AGUA DE GELATINA O ALMIDON.
ES90106947T 1989-06-19 1990-04-11 Forma oral de farmaco de lipidos. Expired - Lifetime ES2066896T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3919982A DE3919982A1 (de) 1989-06-19 1989-06-19 Orale lipidarzneiform

Publications (1)

Publication Number Publication Date
ES2066896T3 true ES2066896T3 (es) 1995-03-16

Family

ID=6383046

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90106947T Expired - Lifetime ES2066896T3 (es) 1989-06-19 1990-04-11 Forma oral de farmaco de lipidos.

Country Status (6)

Country Link
US (1) US5120710A (es)
EP (1) EP0403748B1 (es)
JP (1) JPH0334922A (es)
AT (1) ATE117547T1 (es)
DE (2) DE3919982A1 (es)
ES (1) ES2066896T3 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109118A (en) * 1989-07-06 1992-04-28 Yutaka Mizushima Modified biologically active proteins
WO1992014479A1 (en) * 1991-02-19 1992-09-03 Tsumura & Co. Composition for rectal administration of difficultly absorbable peptide
US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
ES2136620T3 (es) * 1991-04-19 1999-12-01 Lds Technologies Inc Formulaciones de microemulsiones convertibles.
DE4208552A1 (de) * 1992-03-17 1993-09-23 Liedtke Pharmed Gmbh Topische arzneiformen mit insulin
SE9300937L (sv) * 1993-03-19 1994-09-20 Anne Fjellestad Paulsen Komposition för oral administrering av peptider
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
GB2281697A (en) * 1993-09-14 1995-03-15 Euro Celtique Sa Laxative compositions in capsules
FR2712823B1 (fr) * 1993-11-25 1996-02-23 Scherer Sa Rp Capsule molle de gélatine renfermant un mélange à forte teneur en eau.
JPH08208510A (ja) * 1994-11-03 1996-08-13 F Hoffmann La Roche Ag インターフェロン組成物
US5629021A (en) * 1995-01-31 1997-05-13 Novavax, Inc. Micellar nanoparticles
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
DE19546159A1 (de) 1995-12-11 1997-06-12 Liedtke Pharmed Gmbh Methode und Zusammensetzung einer topisch wirksamen Therapie postoperativer und posttraumatischer Wundschmerzen
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
IL117773A (en) * 1996-04-02 2000-10-31 Pharmos Ltd Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
US5726154A (en) * 1996-06-28 1998-03-10 University Of Utah Research Foundation Stabilization and oral delivery of calcitonin
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6455066B1 (en) 2000-03-10 2002-09-24 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
US7670626B2 (en) * 2001-07-02 2010-03-02 Merrion Research Iii Limited Delivery of a bioactive material
DE102006001554A1 (de) * 2006-01-05 2007-07-12 Ipc Process-Center Gmbh & Co. Micropellets für die Herstellung von Tiernahrungspellets
JP5156458B2 (ja) * 2008-03-31 2013-03-06 理研ビタミン株式会社 ソフトカプセル充填用液状組成物
WO2009041105A1 (ja) * 2007-09-27 2009-04-02 Riken Vitamin Co., Ltd. ソフトカプセル充填用液状組成物
US20100080773A1 (en) * 2008-09-26 2010-04-01 Sdg, Inc. Orally Bioavailable Lipid-Based Constructs
US8962015B2 (en) 2007-09-28 2015-02-24 Sdg, Inc. Orally bioavailable lipid-based constructs
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
CA3122934A1 (en) 2011-03-11 2012-09-20 Beth Israel Deaconess Medical Center, Inc. Fusion protein comprising a fragment of cd40 and method of producing same
WO2013003803A1 (en) 2011-06-29 2013-01-03 Avidas Pharmaceuticals Llc Topical formulations including lipid microcapsule delivery vehicles and their uses
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2017040932A1 (en) 2015-09-04 2017-03-09 Primatope Therapeutics Inc. Humanized anti-cd40 antibodies and uses thereof
EP3544614A4 (en) 2016-11-28 2020-08-05 Lipocine Inc. ORAL TESTOSTERONE UNDECANOATE THERAPY
EP3595701A4 (en) 2017-03-13 2021-01-06 SDG, Inc. FAT-BASED NANOPARTICLES WITH IMPROVED STABILITY
US11077173B2 (en) 2017-03-13 2021-08-03 Sdg, Inc. Lipid-based nanoparticles and methods using same
AU2019308326A1 (en) 2018-07-20 2021-03-18 Lipocine Inc. Liver disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5257313A (en) * 1975-11-07 1977-05-11 Yamanouchi Pharmaceut Co Ltd Manufacture of micellar insuline emulsion preparations
US4202888A (en) * 1976-07-12 1980-05-13 Kali-Chemie Pharma Gmbh. Readily enterally absorbable pharmaceutical compositions of cardiac glycosides and preparation thereof
DE2631214A1 (de) * 1976-07-12 1978-01-26 Kali Chemie Pharma Gmbh Verfahren zur erhoehung der loeslichkeit von schwerloeslichen arzneistoffen zum zwecke deren applikation in gelatinekapseln
BE861612A (fr) * 1977-12-07 1978-06-07 Kali Chemie Pharma Gmbh Preparations fortement resorbables par voie enterale de medicaments peu resorbables de nature et procede pour la preparation de celles-ci
JPS5517328A (en) * 1978-07-21 1980-02-06 Tanabe Seiyaku Co Ltd Insulin-containing emulsion and its preparation
DE3171774D1 (en) * 1980-03-31 1985-09-19 Teijin Ltd Pharmaceutical composition for intrarectal administration, and suppository prepared therefrom
GB2118040A (en) * 1982-02-15 1983-10-26 Hoechst Uk Ltd Oral anti-diabetic preparation
EP0088046B1 (de) * 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
DE3237814A1 (de) * 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
IL77186A0 (en) * 1985-11-29 1986-04-29 Touitou Elka Pharmaceutical insulin composition
CA1257199A (en) * 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
IL87219A0 (en) * 1987-08-07 1988-12-30 Abbott Lab Erythromycin formulations for oral administration

Also Published As

Publication number Publication date
ATE117547T1 (de) 1995-02-15
DE59008336D1 (de) 1995-03-09
US5120710A (en) 1992-06-09
DE3919982A1 (de) 1990-12-20
EP0403748B1 (de) 1995-01-25
EP0403748A3 (de) 1992-07-08
EP0403748A2 (de) 1990-12-27
JPH0334922A (ja) 1991-02-14

Similar Documents

Publication Publication Date Title
ES2066896T3 (es) Forma oral de farmaco de lipidos.
BR0108354A (pt) Carboidratos antiadesivos
ATE72990T1 (de) Pharmazeutische zusammensetzung vom fluessig/gel- phasenuebergangstyp.
PL261349A1 (en) Method of obtaining an incorporative complex of 7-isopropoxyisoflavone with cyclodextrin
AU668447B2 (en) Reversible, thermally gelling water-base medicinal composition
ES2128369T3 (es) Procedimiento para la fabricacion de formas farmaceuticas solidas con liberacion prolongada en dos etapas.
PT768867E (pt) Forma de dosagem para a administracao de droga em formulacao liquida
AR007649A1 (es) Composicion de relleno para forma de dosis farmaceutica de gelatina blanda y forma de dosis farmaceutica que la comprende
KR900015715A (ko) 약물을 함유하는 동결건조 제형물의 제조방법
DE59307073D1 (de) Peptidarzneistoffe enthaltende pellets und ihre herstellung sowie deren verwendung
KR890003379A (ko) 항-아테롬성 동맥경화제로서의 독사조신
ES2019595B3 (es) Empleo de glicofurol para licuacion de preparaciones medicas, para el llenado en capsulas de gelatina blanda
JPS6434909A (en) Cosmetic
IL97607A0 (en) Retinoids,their manufacture and pharmaceutical compositions containing them
ATE65395T1 (de) Acetylcystein enthaltendes, festes, wasserloeslisches arzneimittel.
AU4478485A (en) 2-phenoxymethyl-imidazoline derivatives
NO871620D0 (no) Guar-mel.
EP0391852A3 (en) Pharmaceutical compositions
Selye Prevention of cardiac necrosis by amiloride
AR023668A1 (es) Nuevos derivados de benzoilguanidina con ventajosas propiedades, procedimiento para su preparacion y su utilizacion en la preparacion de medicamentos
ES2144532T3 (es) Relleno de capsula de gelatina que puede formar espuma.
KR880012518A (ko) 나프탈-아세트산 유도체를 함유하는 진통 및 소염제약 조성물
IT8720271A0 (it) Nuovi derivati dell'ergolene, composizioni farmaceutiche che licontengono e procedimento per lapreparazione dei medesimi.
FR2594335B1 (fr) Derives de 5-(2-piperazinoethyl)-thiazole en tant que medicaments utiles en urologie
ES2058316T3 (es) Procedimiento para la obtencion de un medicamento antitusigeno.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 403748

Country of ref document: ES