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ES8300104A1 - Un procedimiento para obtener derivados de benzopirano - Google Patents

Un procedimiento para obtener derivados de benzopirano

Info

Publication number
ES8300104A1
ES8300104A1 ES503091A ES503091A ES8300104A1 ES 8300104 A1 ES8300104 A1 ES 8300104A1 ES 503091 A ES503091 A ES 503091A ES 503091 A ES503091 A ES 503091A ES 8300104 A1 ES8300104 A1 ES 8300104A1
Authority
ES
Spain
Prior art keywords
group
procedure
alcohyl
obtaining
benzopyran derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503091A
Other languages
English (en)
Other versions
ES503091A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8084180A external-priority patent/JPS6054317B2/ja
Priority claimed from JP55182854A external-priority patent/JPS57106619A/ja
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Publication of ES503091A0 publication Critical patent/ES503091A0/es
Publication of ES8300104A1 publication Critical patent/ES8300104A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA OBTENER DERIVADOS DE BENZOPIRANO. SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I) CON UNA AMINA DE FORMULA NH2R1. SE OBTIENE EL COMPUESTO (II) EN QUE A ES UN ENLACE DIRECTO O EL ENLACE -O-CH2-; R1 SE SELECCIONA ENTRE C3-5; UN GRUPO HIDROXI-(ALCOHILODE C3-5, UN GRUPO ALCOHILAMINO INFERIOR-ALCOHILO INFERIOR, UN GRUPO NITRATO-(ALCOHILO C3-5) Y UN GRUPO FENIL-(ALCOHILO C1-5); R2 SE SELECCIONA ENTRE HIDROGENO, HALOGENO, OH, NO2, UN GRUPO CARBAMOILO U OTROS. R3 ES HIDROGENO O NO2; B ES UN ENLACE DIRECTO, UN ALCOHILENO DE C1-7 U OTROS. *FORMULA*.
ES503091A 1980-06-17 1981-06-16 Un procedimiento para obtener derivados de benzopirano Expired ES8300104A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8084180A JPS6054317B2 (ja) 1980-06-17 1980-06-17 新規ベンゾピラン誘導体
JP55182854A JPS57106619A (en) 1980-12-25 1980-12-25 Remedy for circulatory disease

Publications (2)

Publication Number Publication Date
ES503091A0 ES503091A0 (es) 1982-10-01
ES8300104A1 true ES8300104A1 (es) 1982-10-01

Family

ID=26421809

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503091A Expired ES8300104A1 (es) 1980-06-17 1981-06-16 Un procedimiento para obtener derivados de benzopirano

Country Status (16)

Country Link
US (1) US4394382A (es)
EP (1) EP0042299B1 (es)
KR (1) KR850000193B1 (es)
AU (1) AU543347B2 (es)
CA (1) CA1178598A (es)
CS (1) CS226731B2 (es)
DD (1) DD160453A5 (es)
DE (1) DE3166300D1 (es)
DK (1) DK154557C (es)
ES (1) ES8300104A1 (es)
FI (1) FI79307C (es)
IE (1) IE52067B1 (es)
NO (1) NO154495C (es)
PL (1) PL130537B1 (es)
SU (1) SU1212325A3 (es)
ZA (1) ZA814042B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5965076A (ja) * 1982-10-05 1984-04-13 Kowa Co 新規なキノリン誘導体
JPS60181083A (ja) * 1984-02-29 1985-09-14 Kowa Co 新規ラセミ体及びその変換方法
JPS60208973A (ja) * 1984-03-31 1985-10-21 Kowa Co 循環系疾患治療剤
GB8730051D0 (en) * 1987-12-23 1988-02-03 Beecham Group Plc Novel compounds
EP0901483B1 (en) * 1996-05-14 2003-07-09 Glaxo Group Limited Benzofurans and benzopyrans as chronobiological agents
JP4000505B2 (ja) 1999-12-01 2007-10-31 第一三共株式会社 緑内障を治療するための併用剤
PL375713A1 (en) 2002-08-19 2005-12-12 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
KR20050059274A (ko) * 2002-10-24 2005-06-17 코와 가부시키가이샤 신경섬유 재생 촉진제
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
TWI646091B (zh) * 2012-12-28 2019-01-01 日商衛斯克慧特股份有限公司 鹽類及晶形
CA2909442A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
KR20210116548A (ko) 2019-01-18 2021-09-27 아스트라제네카 아베 Pcsk9 억제제 및 이의 이용 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493998A (en) * 1975-06-03 1977-12-07 Beecham Group Ltd Propanolamine derivatives
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
DE2804625A1 (de) * 1978-02-03 1979-08-09 Thomae Gmbh Dr K Neue 4-acylamino-phenyl-aethanolamine
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AU7165281A (en) 1981-12-24
FI79307B (fi) 1989-08-31
DK154557B (da) 1988-11-28
FI79307C (fi) 1989-12-11
DD160453A5 (de) 1983-08-03
NO154495C (no) 1986-10-01
DK264181A (da) 1981-12-18
NO812042L (no) 1981-12-18
US4394382A (en) 1983-07-19
AU543347B2 (en) 1985-04-18
PL130537B1 (en) 1984-08-31
KR830006268A (ko) 1983-09-20
KR850000193B1 (ko) 1985-03-05
ES503091A0 (es) 1982-10-01
DK154557C (da) 1989-04-17
PL231734A1 (es) 1982-08-16
NO154495B (no) 1986-06-23
IE811312L (en) 1981-12-17
CA1178598A (en) 1984-11-27
ZA814042B (en) 1982-06-30
FI811856L (fi) 1981-12-18
IE52067B1 (en) 1987-06-10
EP0042299A1 (en) 1981-12-23
CS226731B2 (en) 1984-04-16
DE3166300D1 (en) 1984-10-31
SU1212325A3 (ru) 1986-02-15
EP0042299B1 (en) 1984-09-26

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