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ES477653A1 - Un procedimiento para la preparacion de nuevos derivados de aminoazucares. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de aminoazucares.

Info

Publication number
ES477653A1
ES477653A1 ES477653A ES477653A ES477653A1 ES 477653 A1 ES477653 A1 ES 477653A1 ES 477653 A ES477653 A ES 477653A ES 477653 A ES477653 A ES 477653A ES 477653 A1 ES477653 A1 ES 477653A1
Authority
ES
Spain
Prior art keywords
preparation
sugar derivatives
amino sugar
new amino
amylase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES477653A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES477653A1 publication Critical patent/ES477653A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/22Cyclohexane rings, substituted by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99Enzyme inactivation by chemical treatment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un procedimiento para la preparación de nuevos derivados de aminoazúcares, de Trestatina A, Trestatina B y Trestatina C y sus sales que poseen trehalosa como una característica estructura común y con las propiedades siguientes: a) análisis elemental Trestatina A: C46,72%, H7,13%, N2,08%, O43,28% Trestatina B: C46,27%, H7,04%, N1,65%, O44,69% Trestatina C: C47,55%, H7,15%, N2,29%, O42,66%
ES477653A 1978-02-14 1979-02-13 Un procedimiento para la preparacion de nuevos derivados de aminoazucares. Expired ES477653A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB583478 1978-02-14

Publications (1)

Publication Number Publication Date
ES477653A1 true ES477653A1 (es) 1980-03-01

Family

ID=9803510

Family Applications (1)

Application Number Title Priority Date Filing Date
ES477653A Expired ES477653A1 (es) 1978-02-14 1979-02-13 Un procedimiento para la preparacion de nuevos derivados de aminoazucares.

Country Status (26)

Country Link
US (1) US4273765A (es)
EP (1) EP0003616B1 (es)
JP (1) JPS54163511A (es)
AR (1) AR219150A1 (es)
AT (1) AT367451B (es)
AU (1) AU527318B2 (es)
CA (1) CA1121290A (es)
DE (2) DE2962165D1 (es)
DK (1) DK149599C (es)
ES (1) ES477653A1 (es)
FI (1) FI63062C (es)
FR (1) FR2416901A1 (es)
GR (1) GR72817B (es)
HU (1) HU181442B (es)
IE (1) IE47916B1 (es)
IL (1) IL56626A0 (es)
LU (1) LU80906A1 (es)
MC (1) MC1253A1 (es)
NL (1) NL7901182A (es)
NO (1) NO153011C (es)
NZ (1) NZ189625A (es)
PH (1) PH15084A (es)
PT (1) PT69218A (es)
SE (1) SE7901276L (es)
YU (1) YU41437B (es)
ZA (1) ZA79528B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056194B1 (en) * 1981-01-05 1984-09-12 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars, their production and use
JPS57146713A (en) * 1981-03-09 1982-09-10 Akira Endo Hypoglycemic
US4595678A (en) * 1982-03-19 1986-06-17 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars and pharmaceutical compositions containing same
US4678812A (en) * 1986-05-30 1987-07-07 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4762857A (en) * 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4885361A (en) * 1987-07-31 1989-12-05 Hoffmann-La Roche Inc. Sulfated oligosaccharides
WO1992010760A1 (en) * 1990-11-30 1992-06-25 Monoclonetics International, Incorporated Methods for the diagnosis of chronic lower back and cervical pain
TW381025B (en) * 1993-08-05 2000-02-01 Hoffmann La Roche Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
IL143225A (en) * 2000-05-24 2008-03-20 Pfizer Preparation of drugs containing α-amylase inhibitors to treat hyperacidity of the inner abdomen
US7022684B2 (en) * 2000-05-24 2006-04-04 Pfizer Inc. Treatment of rumen acidosis with α-amylase inhibitors
US7829552B2 (en) 2003-11-19 2010-11-09 Metabasis Therapeutics, Inc. Phosphorus-containing thyromimetics
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005308575A1 (en) * 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
EP2264179A1 (en) 2008-04-11 2010-12-22 Astellas Pharma Inc. Aminosugar compound and process for production thereof
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
EP2571860A1 (en) 2010-05-21 2013-03-27 Pfizer Inc 2-phenyl benzoylamides
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2828343A1 (en) 2011-03-04 2012-09-13 The Scripps Research Institute Edn3-like peptides and uses thereof
US20150050371A1 (en) 2012-03-09 2015-02-19 Biotropics Malaysia Berhad Extract Formulations of Rhodamnia Cinerea And Uses Thereof
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
RU2618628C1 (ru) 2013-04-17 2017-05-05 Пфайзер Инк. Производные N-пиперидин-3-илбензамида для лечения сердечно-сосудистых заболеваний
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
AU2015308350B2 (en) 2014-08-29 2020-03-05 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
KR20190065312A (ko) 2016-10-14 2019-06-11 테스 파마 에스.알.엘. 알파-아미노-베타-카복시뮤콘산 세미알데하이드 데카복실라제의 저해제
AU2019385644A1 (en) 2018-11-20 2021-06-03 Tes Pharma S.R.L. Inhibitors of α-Amino-β-carboxymuconic acid semialdehyde decarboxylase
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2064092C2 (de) * 1970-12-28 1983-06-01 Bayer Ag, 5090 Leverkusen Inhibitoren für Glykosidhydrolasen aus Actinomyceten
DE2347782C3 (de) * 1973-09-22 1979-10-11 Bayer Ag, 5090 Leverkusen Aminozuckerderivate, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US4062950A (en) * 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals
USRE29903E (en) 1975-03-19 1979-02-06 American Cyanamid Company Antibacterial antibiotics AM31α, AM31β and AM31γ
DE2614393C3 (de) * 1976-04-02 1980-04-03 Bayer Ag, 5090 Leverkusen Aminozucker-Derivate und diese Verbindungen enthaltende Arzneimittel

Also Published As

Publication number Publication date
AU527318B2 (en) 1983-02-24
FR2416901B1 (es) 1980-10-24
FR2416901A1 (fr) 1979-09-07
EP0003616A2 (de) 1979-08-22
DK149599C (da) 1987-06-01
AR219150A1 (es) 1980-07-31
HU181442B (en) 1983-07-28
ZA79528B (en) 1980-02-27
SE7901276L (sv) 1979-08-15
EP0003616A3 (en) 1979-09-05
DK149599B (da) 1986-08-04
EP0003616B1 (de) 1982-02-24
YU34879A (en) 1983-01-21
IE790274L (en) 1979-08-14
LU80906A1 (de) 1980-09-24
ATA108879A (de) 1981-11-15
YU41437B (en) 1987-06-30
FI63062C (fi) 1983-04-11
FI63062B (fi) 1982-12-31
AT367451B (de) 1982-07-12
AU4402879A (en) 1979-08-23
NZ189625A (en) 1981-05-01
DE2962165D1 (en) 1982-03-25
DE2905649A1 (de) 1979-08-16
IE47916B1 (en) 1984-07-25
PT69218A (en) 1979-03-01
NO153011C (no) 1986-01-02
NO153011B (no) 1985-09-23
NL7901182A (nl) 1979-08-16
US4273765A (en) 1981-06-16
IL56626A0 (en) 1979-05-31
NO790469L (no) 1979-08-15
PH15084A (en) 1982-07-02
JPS643877B2 (es) 1989-01-23
FI790486A (fi) 1979-08-15
GR72817B (es) 1983-12-06
JPS54163511A (en) 1979-12-26
CA1121290A (en) 1982-04-06
MC1253A1 (fr) 1980-01-14
DK61179A (da) 1979-08-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519