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ES8106282A1 - Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas. - Google Patents

Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.

Info

Publication number
ES8106282A1
ES8106282A1 ES494302A ES494302A ES8106282A1 ES 8106282 A1 ES8106282 A1 ES 8106282A1 ES 494302 A ES494302 A ES 494302A ES 494302 A ES494302 A ES 494302A ES 8106282 A1 ES8106282 A1 ES 8106282A1
Authority
ES
Spain
Prior art keywords
same
preparing
organic sulfoxides
inhibiting compositions
enzyme inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494302A
Other languages
English (en)
Other versions
ES494302A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES494302A0 publication Critical patent/ES494302A0/es
Publication of ES8106282A1 publication Critical patent/ES8106282A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polymerisation Methods In General (AREA)
  • Indole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE PRECURSORES DE ALILSULFOXIDOS INHIBIDORES DE ENZIMAS DE FORMULA ESTRUCTURAL (I), DONDE R ES FENILO, FENILO SUSTITUIDO CON UN GRUPO ACEPTOR DE ELECTRONES, TRIHALOMETILO O UN HETEROCICLO AROMATICO DE CINCO O SEIS MIEMBROS; R ELEVADO A 1 ES HIDROGENO O AMINOMETILO; R CUADRADO Y R ELEVADO A 5 SON HIDROGENO; R CUBO ES UN GRUPO FACILMENTE SALIENTE, O R CUADRADO Y R CUBO JUNTOS FORMAN UN DOBLE ENLACE; R ELEVADO A 4 ES HIDROGENO O UN GRUPO ACEPTOR DE ELECTRONES; R ELEVADO A 6 ES HIDROGENO O -COOH, Y R ELEVADO A 7 ES -OH, NH2, -SH Y -CH2OH. CONSISTE EN OXIDAR UN TIO-DERIVADO AROMATICO DE FORMULA ESTRUCTURAL (II), DONDE R Y R ELEVADO A 1-7 TIENEN EL SIGNIFICADO SEÑALADO ANTERIORMENTE, CON LA EXCEPCION DE QUE CUALQUIERA DE LOS SUSTITUYENTES R ELEVADO A 1-7 QUE SEA SENSIBLE A LA OXIDACION VA PROVISTO DE UN GRUPO PROTECTOR. DESPUES DE LA OXIDACION DICHO GRUPO PROTECTOR ES SEPARADO. EL AGENTE OXIDANTE SE SELECCIONA ENTRE 1-CLOROBENZOTRIAZOL, CL2, BR2, NAIO4, CH3COONO2O UN PERACIDO. *FORMULA* N
ES494302A 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas. Expired ES8106282A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6660379A 1979-08-15 1979-08-15

Publications (2)

Publication Number Publication Date
ES494302A0 ES494302A0 (es) 1981-08-01
ES8106282A1 true ES8106282A1 (es) 1981-08-01

Family

ID=22070551

Family Applications (4)

Application Number Title Priority Date Filing Date
ES494305A Granted ES494305A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.
ES494302A Expired ES8106282A1 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.
ES494304A Expired ES8106284A1 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.
ES494303A Granted ES494303A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzimas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES494305A Granted ES494305A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES494304A Expired ES8106284A1 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzinas.
ES494303A Granted ES494303A0 (es) 1979-08-15 1980-08-14 Un procedimiento para la preparacion de precursores de alil sulfoxidos inhibidores de enzimas.

Country Status (9)

Country Link
EP (4) EP0025857B1 (es)
JP (4) JPS5643260A (es)
AT (4) ATE3545T1 (es)
DE (4) DE3063503D1 (es)
DK (4) DK350980A (es)
ES (4) ES494305A0 (es)
GR (4) GR69833B (es)
IE (4) IE50152B1 (es)
PT (4) PT71653B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2457296A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouveaux derives de vinyl-3 cephalosporines et leur preparation
US4553191A (en) * 1982-12-03 1985-11-12 Xerox Corporation Static eliminator
DE3469169D1 (en) * 1983-04-21 1988-03-10 Merck Frosst Canada Inc Leukotriene antagonists, their production and use and compositions containing them
US4609744A (en) * 1983-04-21 1986-09-02 Merck Frosst Canada Inc. 4-oxo-benzopyran carboxylic acids
FR2661909B1 (fr) * 1990-05-09 1997-08-14 Inst Nat Sante Rech Med Nouveaux composes agonistes du recepteur h3 de l'histamine a usage therapeutique, compositions pharmaceutiques agissant comme agonistes dudit recepteur et procede de preparation.
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
JP2003513065A (ja) * 1999-10-29 2003-04-08 ザ・ピコワー・インスティチュート・フォー・メディカル・リサーチ Ｍｉｆアンタゴニスト活性を有する化合物
WO2009049086A1 (en) * 2007-10-09 2009-04-16 Larry Sutton Broad spectrum beta-lactamase inhibitors
EP3441071A1 (en) 2013-03-12 2019-02-13 Gladius Pharmaceuticals Corporation Derivatized cephalosporins

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3419606A (en) * 1964-05-13 1968-12-31 Merck & Co Inc 4-(2-methylenealkanoyl)phenylsulfinyl alkanoic acids
CH496639A (fr) * 1968-01-05 1970-09-30 Pfizer & Co C Procédé de préparation des aryl halogénocarbonyl cétènes
CH568708A5 (es) * 1969-04-30 1975-11-14 Hoffmann La Roche
GB1357154A (en) * 1970-09-25 1974-06-19 Shell Int Research Alkylthio-nitro-aniline compounds and herbicidal 'ompositions containing them
GB1463077A (en) * 1973-04-19 1977-02-02 Glaxo Lab Ltd 7-substituted-ethyl-cephalosporin derivatives
US4049806A (en) * 1975-08-15 1977-09-20 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
JPS5253890A (en) * 1975-10-14 1977-04-30 Syntex Inc Production of cephalosporin type compound
US4155907A (en) * 1976-08-16 1979-05-22 The Dow Chemical Company Method for inhibiting ADP-induced platelet aggregation using phenylthioalkylamines
JPS5350326A (en) * 1976-10-18 1978-05-08 Kao Corp Herbicides
AU4091178A (en) * 1977-10-25 1980-04-24 Merck & Co Inc Substituted mercapto acid amides

Also Published As

Publication number Publication date
ES494304A0 (es) 1981-08-01
ES8106283A1 (es) 1981-08-01
IE50151B1 (en) 1986-02-19
DE3068110D1 (en) 1984-07-12
ES8106284A1 (es) 1981-08-01
EP0024639A1 (en) 1981-03-11
GR69833B (es) 1982-07-19
IE801706L (en) 1981-02-15
JPS5630960A (en) 1981-03-28
DE3065684D1 (en) 1983-12-29
PT71652A (en) 1980-09-01
EP0024639B1 (en) 1984-06-06
DE3064411D1 (en) 1983-09-01
ES8106285A1 (es) 1981-08-01
IE801705L (en) 1981-02-15
IE50150B1 (en) 1986-02-19
IE50225B1 (en) 1986-03-05
DE3063503D1 (en) 1983-07-07
PT71654B (en) 1982-01-22
PT71653B (en) 1982-01-21
DK350980A (da) 1981-02-16
JPS5630961A (en) 1981-03-28
GR69834B (es) 1982-07-19
ATE7785T1 (de) 1984-06-15
IE801708L (en) 1981-02-15
EP0026307B1 (en) 1983-11-23
GR69805B (es) 1982-07-12
ATE5403T1 (de) 1983-12-15
ATE4316T1 (de) 1983-08-15
IE801707L (en) 1981-02-15
GR69832B (es) 1982-07-19
ES494305A0 (es) 1981-08-01
ATE3545T1 (de) 1983-06-15
DK351280A (da) 1981-02-16
DK351180A (da) 1981-02-16
JPS5643260A (en) 1981-04-21
ES494302A0 (es) 1981-08-01
EP0025857A1 (en) 1981-04-01
EP0025857B1 (en) 1983-07-27
PT71651A (en) 1980-09-01
EP0026307A1 (en) 1981-04-08
ES494303A0 (es) 1981-08-01
PT71652B (en) 1982-01-21
JPS5663989A (en) 1981-05-30
PT71653A (en) 1980-09-01
IE50152B1 (en) 1986-02-19
DK351080A (da) 1981-02-16
PT71654A (en) 1980-09-01
EP0024347B1 (en) 1983-05-25
EP0024347A1 (en) 1981-03-04
PT71651B (en) 1982-01-21

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