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ES2195190T3 - Dispositivo y metodo para mejorar el flujo de agente transdermico. - Google Patents

Dispositivo y metodo para mejorar el flujo de agente transdermico.

Info

Publication number
ES2195190T3
ES2195190T3 ES97951729T ES97951729T ES2195190T3 ES 2195190 T3 ES2195190 T3 ES 2195190T3 ES 97951729 T ES97951729 T ES 97951729T ES 97951729 T ES97951729 T ES 97951729T ES 2195190 T3 ES2195190 T3 ES 2195190T3
Authority
ES
Spain
Prior art keywords
improving
agent flow
transdermal agent
skin
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97951729T
Other languages
English (en)
Inventor
Felix Theeuwes
Armand P Neukermans
Michel J N Cormier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2195190T3 publication Critical patent/ES2195190T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN DISPOSITIVO DE ADMINISTRACION O MUESTREO (2) DE UN AGENTE, QUE COMPRENDE UN ELEMENTO (6) QUE TIENE VARIAS LAMINAS (4) PARA PERFORAR LA PIEL Y UN MEDIO DE CONEXION (65) QUE CUBRE, POR LO MENOS, UNA PARTE DEL LADO QUE ESTA EN CONTACTO CON LA PIEL (48) DEL ELEMENTO (6) PARA INCREMENTAR EL FLUJO TRANSDERMICO DE UN AGENTE.
ES97951729T 1996-12-20 1997-12-16 Dispositivo y metodo para mejorar el flujo de agente transdermico. Expired - Lifetime ES2195190T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3344096P 1996-12-20 1996-12-20

Publications (1)

Publication Number Publication Date
ES2195190T3 true ES2195190T3 (es) 2003-12-01

Family

ID=21870407

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97951729T Expired - Lifetime ES2195190T3 (es) 1996-12-20 1997-12-16 Dispositivo y metodo para mejorar el flujo de agente transdermico.

Country Status (11)

Country Link
EP (1) EP0957972B1 (es)
JP (1) JP4153999B2 (es)
KR (1) KR100453132B1 (es)
CN (1) CN1133472C (es)
AT (1) ATE234649T1 (es)
AU (1) AU722574B2 (es)
CA (1) CA2271167C (es)
DE (1) DE69720057T2 (es)
DK (1) DK0957972T3 (es)
ES (1) ES2195190T3 (es)
WO (1) WO1998028037A1 (es)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3316820B2 (ja) 1995-12-28 2002-08-19 シィグナス インコーポレィティド 被験者の生理的分析物の継続モニタリング装置及び方法
EP1911488A3 (en) 1997-12-11 2008-12-03 Alza Corporation Device for enhancing transdermal agent flux
CN1170603C (zh) * 1997-12-11 2004-10-13 阿尔扎有限公司 增强透皮物剂流量的装置
ES2314995T3 (es) * 1997-12-11 2009-03-16 Alza Corporation Dispositivo para mejorar el flujo de agentes tansdermicos.
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
EP1109594B1 (en) * 1998-08-31 2004-10-27 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US6558670B1 (en) 1999-04-19 2003-05-06 Smithkline Beechman Biologicals S.A. Vaccine adjuvants
HK1044484B (en) 1999-04-19 2005-07-29 Smithkline Beecham Biologicals S.A. Adjuvant composition containing saponin and immunostimulatory oligonucleotide
DE60044084D1 (de) * 1999-06-04 2010-05-12 Georgia Tech Res Inst Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
CN100402105C (zh) * 1999-06-08 2008-07-16 奥尔蒂治疗学公司 采用薄膜组织界面装置在生物膜中制作微孔的设备及方法
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
WO2001041863A1 (en) 1999-12-10 2001-06-14 Alza Corporation Device and method for enhancing microprotrusion skin piercing
PT1239917E (pt) * 1999-12-10 2005-08-31 Alza Corp Dispositivo de tratamento cutaneo para administracao transdermica prolongada de um medicamento
US6622035B1 (en) * 2000-01-21 2003-09-16 Instrumentarium Corp. Electrode for measurement of weak bioelectrical signals
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
MXPA03001694A (es) * 2000-08-24 2004-11-01 Johnson & Johnson Metodo para toma de muestra transdermal de acido nucleico.
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
DK1335711T3 (da) 2000-09-08 2007-11-26 Alza Corp Transdermal indretning
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
PL360998A1 (en) * 2000-10-13 2004-09-20 Alza Corporation Apparatus and method for piercing skin with microprotrusions
JP4104975B2 (ja) 2000-10-13 2008-06-18 アルザ・コーポレーシヨン 衝撃適用装置用の微小突起部材保持器
HUP0303583A2 (en) 2000-10-13 2004-01-28 Alza Corp Microblade array impact applicator
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US20050019340A1 (en) 2000-10-18 2005-01-27 Nathalie Garcon Vaccines
HUP0302924A2 (en) 2000-10-26 2003-12-29 Alza Corp Transdermal drug delivery devices having coated microprotrusions
US9302903B2 (en) 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US7027478B2 (en) 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
WO2002074173A1 (en) 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
CN101129327A (zh) * 2001-04-20 2008-02-27 阿尔扎公司 具有包含有益药剂的涂层的微小突出物阵列
EP3251722B1 (en) 2001-04-20 2020-06-17 ALZA Corporation Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
WO2003024507A2 (en) 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
AU2002330083A1 (en) 2001-09-21 2003-04-01 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
AU2003220143A1 (en) * 2002-03-11 2003-09-29 Altea Therapeutics Corporation Transdermal integrated actuator device, methods of making and using same
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
BRPI0412029A (pt) 2003-06-30 2006-09-05 Alza Corp formulações para microprojeções revestidas contendo contra-ìons não-voláteis
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
KR20060108682A (ko) * 2003-10-24 2006-10-18 알자 코포레이션 경피 약물 전달을 증대시키기 위한 전처리 방법 및 장치
WO2005044139A2 (en) 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
ATE539687T1 (de) 2003-10-31 2012-01-15 Alza Corp Selbstbetätigter applikator für eine mikroprojektionsanordnung
CA2546280A1 (en) * 2003-11-13 2005-06-09 Alza Corporation Composition and apparatus for transdermal delivery
EP1694400A1 (en) * 2003-11-28 2006-08-30 Acrux DDS Pty Ltd Method and system for rapid transdermal administration
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
TW200616660A (en) * 2004-08-11 2006-06-01 Alza Corp Apparatus and method for transdermal delivery of natriuretic peptides
EP2181714A3 (en) 2004-09-22 2010-06-23 GlaxoSmithKline Biologicals S.A. Immunogenic composition for use in vaccination against staphylococcei
US20060182789A1 (en) * 2005-02-16 2006-08-17 Mahmoud Ameri Apparatus and method for transdermal delivery of epoetin-based agents
CA2602814A1 (en) * 2005-03-28 2006-10-05 Alza Corporation Microprojections with capillary control features and method
EP1896115B2 (en) 2005-06-27 2020-01-22 3M Innovative Properties Company Microneedle cartridge assembly
US7432069B2 (en) 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
KR101441368B1 (ko) 2005-12-22 2014-09-24 글락소스미스클라인 바이오로지칼즈 에스.에이. 폐렴구균 다당류 컨쥬게이트 백신
EP1981547B1 (en) 2005-12-28 2015-09-30 Alza Corporation Stable therapeutic formulations
SG170090A1 (en) 2006-03-30 2011-04-29 Glaxosmithkline Biolog Sa Immunogenic composition
WO2007124393A2 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Molded articles comprising microneedle arrays
DE102006028987A1 (de) * 2006-06-24 2007-12-27 Lts Lohmann Therapie-Systeme Ag Ultraschallverstärktes transdermales therapeutisches System
PL2086582T3 (pl) 2006-10-12 2013-04-30 Glaxosmithkline Biologicals Sa Kompozycja zawierająca adiuwant w postaci emulsji typu olej w wodzie
DK2086582T3 (da) 2006-10-12 2013-02-04 Glaxosmithkline Biolog Sa Vaccine omfattende en olie-i-vand-emulsionsadjuvans
JP2010525881A (ja) 2007-04-27 2010-07-29 エコー セラピューティクス， インコーポレイテッド 被検体の検知または経皮的薬物送達のための皮膚透過装置
WO2008137747A1 (en) 2007-05-02 2008-11-13 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
WO2008139648A1 (ja) 2007-05-15 2008-11-20 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルのコーティング方法
DK2167121T3 (en) 2007-06-26 2015-11-23 Glaxosmithkline Biolog Sa A vaccine comprising Streptococcus pneumoniae kapselpolysaccharidkonjugater
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
US8883015B2 (en) 2008-02-07 2014-11-11 The University Of Queensland Patch production
GB0802447D0 (en) 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
HUE026586T2 (hu) 2008-04-16 2016-06-28 Glaxosmithkline Biologicals Sa Vakcina
AU2009250341A1 (en) * 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
US8962026B2 (en) 2008-09-26 2015-02-24 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
WO2010057197A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
EP2383013A4 (en) 2008-12-26 2012-11-28 Hisamitsu Pharmaceutical Co MICRO NEEDLE DEVICE
JP5709530B2 (ja) 2009-01-30 2015-04-30 久光製薬株式会社 マイクロニードルデバイス
JP5615814B2 (ja) 2009-06-10 2014-10-29 久光製薬株式会社 マイクロニードルデバイス
JP6110140B2 (ja) 2009-06-16 2017-04-05 ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン ナノエマルションワクチン
KR101686692B1 (ko) 2009-07-23 2016-12-14 히사미쓰 세이야꾸 가부시키가이샤 마이크로니들 어레이
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
PH12012501667B1 (en) 2010-02-24 2022-03-09 Hisamitsu Pharmaceutical Co Micro-needle device and preparation method
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
WO2011148994A1 (ja) 2010-05-28 2011-12-01 久光製薬株式会社 微小突起付きアレイを有するデバイス
KR101759370B1 (ko) 2010-05-28 2017-07-18 히사미쓰 세이야꾸 가부시키가이샤 미소 돌기가 형성된 어레이
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
US20130323293A1 (en) 2011-02-24 2013-12-05 Takuya Umemoto Glp-1 analogue composition for microneedle devices
US8696637B2 (en) * 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
US20140072622A1 (en) 2011-05-17 2014-03-13 Glaxosmithkline Biologicals S.A. Vaccine against streptococcus pneumoniae
EP2765927B1 (en) 2011-10-12 2021-02-24 Vaxxas Pty Limited Delivery device
KR102022574B1 (ko) 2011-10-12 2019-09-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 통합된 마이크로니들 어레이 전달 시스템
JP2013153959A (ja) * 2012-01-30 2013-08-15 Toppan Printing Co Ltd 針状体の構造
CN103356243A (zh) * 2012-03-27 2013-10-23 马广 新型皮肤采样器
WO2014066663A1 (en) 2012-10-24 2014-05-01 Platelet Targeted Therapeutics, Llc Platelet targeted treatment
EP3027263A1 (en) 2013-07-30 2016-06-08 ZP Opco, Inc. Low-profile microneedle patch applicator
WO2015063611A2 (en) 2013-11-01 2015-05-07 University Of Oslo Albumin variants and uses thereof
CA2929126C (en) 2013-11-13 2020-01-07 University Of Oslo Outer membrane vesicles and uses thereof
EP3069138B1 (en) 2013-11-15 2019-01-09 Oslo Universitetssykehus HF Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof
ES2924988T3 (es) 2014-10-10 2022-10-13 Univ Michigan Regents Composiciones con nanoemulsiones para prevenir, inhibir o eliminar una enfermedad alérgica e inflamatoria
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
AR102548A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y uso
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
EP4226937A3 (en) 2015-03-05 2023-09-27 Northwestern University Non-neuroinvasive viruses and uses thereof
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3355981B1 (en) 2015-09-28 2025-11-19 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
US12076397B2 (en) 2016-05-10 2024-09-03 The Regents Of The University Of Michigan Emulsion adjuvant for intramuscular, intradermal and subcutaneous administration
WO2017201390A1 (en) 2016-05-19 2017-11-23 The Regents Of The University Of Michigan Novel adjuvant compositions
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
JP6685432B2 (ja) 2016-12-26 2020-04-22 久光製薬株式会社 マイクロニードルデバイス
EP3586906A4 (en) 2017-02-24 2020-12-30 Hisamitsu Pharmaceutical Co., Inc. MICRO-NEEDLE DEVICE
CN115923337A (zh) 2017-03-31 2023-04-07 瓦克萨斯私人有限公司 用于涂覆表面的设备和方法
AU2018285954A1 (en) 2017-06-13 2019-12-19 Vaxxas Pty Limited Quality control of substrate coatings
AU2018290298B2 (en) 2017-06-23 2024-03-28 Affinivax, Inc. Immunogenic compositions
EP4548954A3 (en) 2017-08-04 2025-07-30 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
JP2020533338A (ja) 2017-09-07 2020-11-19 ユニバーシティ オブ オスロＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｏｓｌｏ ワクチン分子
WO2019048936A1 (en) 2017-09-07 2019-03-14 University Of Oslo VACCINE MOLECULES
WO2019090238A1 (en) 2017-11-03 2019-05-09 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
ES2964349T3 (es) 2018-06-26 2024-04-05 Hisamitsu Pharmaceutical Co Dispositivo de microagujas y método para la fabricación del mismo
EP4134121A4 (en) * 2020-04-06 2024-05-08 Illon Co., Ltd. Cosmetic injector on which microneedles for inducing absorption of cosmetics are mounted, and manufacturing method therefor
WO2023039108A1 (en) 2021-09-08 2023-03-16 Affinivax, Inc. Coronavirus vaccine
WO2024229176A1 (en) 2023-05-04 2024-11-07 Affinivax, Inc. Rhizavidin variants
WO2025193903A1 (en) 2024-03-15 2025-09-18 Affinivax, Inc. Pneumococcal polysaccharide compositions and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
DK0521988T3 (da) 1990-03-30 1996-04-29 Alza Corp Anordning til iontoforetisk lægemiddeltilførsel
KR930702043A (ko) 1990-10-29 1993-09-08 에드워드 엘. 맨델 이온 영동 약물 전달 전극 및 그의 수화 방법
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
AU4256496A (en) * 1994-12-09 1996-06-26 Novartis Ag Transdermal system
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem

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DE69720057T2 (de) 2003-09-25
JP4153999B2 (ja) 2008-09-24
JP2001506904A (ja) 2001-05-29
EP0957972B1 (en) 2003-03-19
CN1133472C (zh) 2004-01-07
AU722574B2 (en) 2000-08-10
ATE234649T1 (de) 2003-04-15
KR100453132B1 (ko) 2004-10-15
DE69720057D1 (de) 2003-04-24
CN1233967A (zh) 1999-11-03
EP0957972A1 (en) 1999-11-24
WO1998028037A1 (en) 1998-07-02
CA2271167A1 (en) 1998-07-02
CA2271167C (en) 2007-01-09
KR20000053006A (ko) 2000-08-25
AU5529498A (en) 1998-07-17
DK0957972T3 (da) 2003-07-21

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