ES2174757B1 - Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares. - Google Patents
Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares.Info
- Publication number
- ES2174757B1 ES2174757B1 ES200100818A ES200100818A ES2174757B1 ES 2174757 B1 ES2174757 B1 ES 2174757B1 ES 200100818 A ES200100818 A ES 200100818A ES 200100818 A ES200100818 A ES 200100818A ES 2174757 B1 ES2174757 B1 ES 2174757B1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- hydrogen
- trifluoromethyl
- fluorine
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 230000002265 prevention Effects 0.000 title abstract 3
- 230000002062 proliferating effect Effects 0.000 title abstract 3
- 230000001413 cellular effect Effects 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- -1 methoxy, trifluoromethoxy, methylsulfonyl Chemical group 0.000 abstract 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 8
- 229910052731 fluorine Inorganic materials 0.000 abstract 6
- 239000011737 fluorine Substances 0.000 abstract 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 5
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 5
- 229910052801 chlorine Inorganic materials 0.000 abstract 5
- 239000000460 chlorine Substances 0.000 abstract 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 2
- 150000003219 pyrazolines Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000005599 alkyl carboxylate group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000003857 carboxamides Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Empleo de derivados de pirazolinas en la elaboración de un medicamento para la prevención y/o el tratamiento de enfermedades proliferativas celulares. Los derivados de pirazolina (I), donde R1 es hidrógeno, metilo, fluorometilo, difluorometilo, trifluorometilo, ácido carboxílico, carboxilato de alquilo inferior de 1 a 4 átomos de carbono, carboxamida o ciano, R2 es hidrógeno o metilo, R3, R4, R7 y R8, independientemente son hidrógeno, cloro, flúor, metilo, trifluorometilo o metoxi, R5 y R6, independientemente entre sí, son hidrógeno, cloro, flúor, metilo, trifluorometilo, metoxi, trifluorometoxi, metilsulfonilo, aminosulfonilo o acetilaminosulfonilo, con la condición de que uno de los sustituyentes R5 o R6 es un grupo metilsulfonilo, aminosulfonilo o acetilaminosulfonilo, y con la condición de que cuando R1 es metilo, entonces R2 es hidrógeno o metilo, R3 y R8, independientemente, son hidrógeno, cloro, flúor, metilo, o trifluorometilo, R4 es hidrógeno, flúor, metilo, trifluorometilo o metoxi, R5 es flúor, trifluorometilo, trifluorometoxi, metilsulfonilo, aminosulfonilo o acetilaminosulfonilo, R6 es hidrógeno, cloro, flúor, metilo, trifluorometilo, metoxi, trifluorometoxi, metilsulfonilo, aminosulfonilo o acetilaminosulfonilo, con la condición de que uno de los sustituyentes R5 o R6 es un grupo metilsulfonilo, aminosulfonilo o acetilaminosulfonilo, y R7 representa un átomo de hidrógeno, cloro, flúor, un grupo metilo, trifluorometilo o metoxi; son útiles para la prevención o el tratamiento de enfermedades proliferativas celulares.
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200100818A ES2174757B1 (es) | 2001-04-06 | 2001-04-06 | Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares. |
| IL15826902A IL158269A0 (en) | 2001-04-06 | 2002-03-21 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases |
| CNB028098935A CN1299682C (zh) | 2001-04-06 | 2002-03-21 | 吡唑啉衍生物在用于预防和/或治疗细胞增殖疾病的药物制备中的用途 |
| EP04030751A EP1516621A3 (en) | 2001-04-06 | 2002-03-21 | Use of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of cell proliferation diseases |
| UA2003119998A UA75402C2 (en) | 2001-04-06 | 2002-03-21 | Use of pyrazoline derivative for the preparation of medicament for prevention or treatment of proliferative cellular diseases |
| RU2003132457/15A RU2305545C2 (ru) | 2001-04-06 | 2002-03-21 | Применение производных пиразолина при получении лечебного средства для предупреждения и/или лечения болезней, связанных с пролиферацией клеток |
| ES02714233T ES2264723T3 (es) | 2001-04-06 | 2002-03-21 | Uso de derivados de pirazolina en la preparacion de un medicamento para la prevencion y/o el tratamiento de enfermedades proliferativas celulares. |
| PL02365220A PL365220A1 (en) | 2001-04-06 | 2002-03-21 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases |
| DK02714233T DK1384477T3 (da) | 2001-04-06 | 2002-03-21 | Anvendelse af pyrazolinderivater ved fremstilling af et medikament til forebyggelse og/eller behandling af proliferative cellesygdomme |
| KR10-2003-7013062A KR20040025912A (ko) | 2001-04-06 | 2002-03-21 | 세포 증식 질환의 예방 및/또는 치료를 위한 약물의제조에서 피라졸린 유도체의 용도 |
| BR0208805-3A BR0208805A (pt) | 2001-04-06 | 2002-03-21 | Uso de um derivado de pirazolina |
| AT02714233T ATE326966T1 (de) | 2001-04-06 | 2002-03-21 | Verwendung von pyrazolinderivativen bei der herstellung eines medikaments zur prävention und/oder behandlung von proliferativen zellerkrankungen |
| US10/312,193 US20040034082A1 (en) | 2001-04-06 | 2002-03-21 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases |
| DE60211681T DE60211681T2 (de) | 2001-04-06 | 2002-03-21 | Verwendung von pyrazolinderivativen bei der herstellung eines medikaments zur prävention und/oder behandlung von proliferativen zellerkrankungen |
| CA2442974A CA2442974C (en) | 2001-04-06 | 2002-03-21 | Use of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of cell proliferation diseases |
| HU0400918A HUP0400918A3 (en) | 2001-04-06 | 2002-03-21 | Utilization of pyrazoline derivatives in the preparation of pharmaceutical compositions for the prevention and/or treatment of proliferative cell diseases |
| EP02714233A EP1384477B1 (en) | 2001-04-06 | 2002-03-21 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases |
| PCT/ES2002/000137 WO2002080909A1 (es) | 2001-04-06 | 2002-03-21 | Empleo de derivados de pirazolinas en la elaboración de un medicamento para la prevención y/o el tratamiento de enfermedades proliferativas celulares |
| CNA2005100713090A CN1698602A (zh) | 2001-04-06 | 2002-03-21 | 吡唑啉衍生物在用于预防和/或治疗细胞增殖疾病的药物制备中的用途 |
| SI200230345T SI1384477T1 (sl) | 2001-04-06 | 2002-03-21 | Uporaba derivatov pirazolina pri pripravi zdravila za preprecevanje in/ali zdravljenje proliferatnih celicnih bolezni |
| MXPA03009124A MXPA03009124A (es) | 2001-04-06 | 2002-03-21 | Empleo de derivados de pirazolinas en la elaboracion de un medicamento para la prevencion y/o el tratamiento de enfermedades proliferativas celulares. |
| AU2002246152A AU2002246152B2 (en) | 2001-04-06 | 2002-03-21 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases |
| NZ529304A NZ529304A (en) | 2001-04-06 | 2002-03-21 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases |
| JP2002578948A JP4451599B2 (ja) | 2001-04-06 | 2002-03-21 | 細胞増殖疾患の予防及び／又は治療薬の調製におけるピラゾリン誘導体の使用 |
| PT02714233T PT1384477E (pt) | 2001-04-06 | 2002-03-21 | Utilizacao de derivados de pirazolina na preparacao de um medicamento para a prevencao e/ou tratamento de doencas proliferativas celulares |
| ZA200308626A ZA200308626B (en) | 2001-04-06 | 2002-03-21 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of poroliferative cell diseases. |
| IS6973A IS6973A (is) | 2001-04-06 | 2003-10-03 | Notkun pýrasólínafleiða í framleiðslu á lyfi til að fyrirbyggja og/eða meðhöndla frumufjölgunarsjúkdóma |
| NO20034470A NO20034470L (no) | 2001-04-06 | 2003-10-06 | Anvendelse av pyrazolin-derivater ved fremstilling av et medikament for forebygging og/eller behandling av proliferasjonssykdommer |
| MA27382A MA27019A1 (fr) | 2001-04-06 | 2003-11-05 | Utilisation des derives de la pyrazoline dans la preparation d'un medicament pour la prevention et/ou le traitement des maladies de la proliferation des cellules. |
| HK04110341A HK1067311A1 (en) | 2001-04-06 | 2004-12-30 | Utilization of pyrazoline derivatives in the preparation of a medicament for the prevention and/or treatment of proliferative cell diseases |
| CY20061101088T CY1105523T1 (el) | 2001-04-06 | 2006-08-03 | Χρηση παραγωγων της πυραζολινης κατα την παρασκευη ενος φαρμακου για την προληψη και/ή την υποβολη σε θεραπευτικη αγωγη ασθενειων πολλαπλασιασμου των κυτταρων |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200100818A ES2174757B1 (es) | 2001-04-06 | 2001-04-06 | Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2174757A1 ES2174757A1 (es) | 2002-11-01 |
| ES2174757B1 true ES2174757B1 (es) | 2003-11-01 |
Family
ID=8497370
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES200100818A Expired - Fee Related ES2174757B1 (es) | 2001-04-06 | 2001-04-06 | Empleo de derivados de firazolinas en la elaboracion de un medicamentopara la prevencion y/o el tratamiento de enfermedades proliferativas celulares. |
| ES02714233T Expired - Lifetime ES2264723T3 (es) | 2001-04-06 | 2002-03-21 | Uso de derivados de pirazolina en la preparacion de un medicamento para la prevencion y/o el tratamiento de enfermedades proliferativas celulares. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02714233T Expired - Lifetime ES2264723T3 (es) | 2001-04-06 | 2002-03-21 | Uso de derivados de pirazolina en la preparacion de un medicamento para la prevencion y/o el tratamiento de enfermedades proliferativas celulares. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20040034082A1 (es) |
| EP (2) | EP1516621A3 (es) |
| JP (1) | JP4451599B2 (es) |
| KR (1) | KR20040025912A (es) |
| CN (2) | CN1698602A (es) |
| AT (1) | ATE326966T1 (es) |
| AU (1) | AU2002246152B2 (es) |
| BR (1) | BR0208805A (es) |
| CA (1) | CA2442974C (es) |
| CY (1) | CY1105523T1 (es) |
| DE (1) | DE60211681T2 (es) |
| DK (1) | DK1384477T3 (es) |
| ES (2) | ES2174757B1 (es) |
| HK (1) | HK1067311A1 (es) |
| HU (1) | HUP0400918A3 (es) |
| IL (1) | IL158269A0 (es) |
| IS (1) | IS6973A (es) |
| MA (1) | MA27019A1 (es) |
| MX (1) | MXPA03009124A (es) |
| NO (1) | NO20034470L (es) |
| NZ (1) | NZ529304A (es) |
| PL (1) | PL365220A1 (es) |
| PT (1) | PT1384477E (es) |
| RU (1) | RU2305545C2 (es) |
| UA (1) | UA75402C2 (es) |
| WO (1) | WO2002080909A1 (es) |
| ZA (1) | ZA200308626B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005212833A1 (en) * | 2004-02-16 | 2005-08-25 | Laboratorios Del Dr. Esteve S.A. | Pyrazoline derivatives useful for the treatment of cancer |
| ES2238923B1 (es) * | 2004-02-16 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Nuevos derivados pirazolinicos sustituidos. |
| EP1637522A1 (en) * | 2004-09-16 | 2006-03-22 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds for reducing triglycerides in blood |
| EP1718619A1 (en) * | 2004-02-17 | 2006-11-08 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds for reducing triglycerides in blood |
| US7998996B2 (en) | 2004-02-17 | 2011-08-16 | Laboratorios Del Dr. Esteve S.A. | Substituted pyrazoline compounds for reducing triglycerides in blood |
| TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| WO2007009704A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes |
| WO2007009699A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A | Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases |
| EP1743636A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Combination of a substituted pyrazoline compound and a drug used in food-related disorders |
| EP1743639A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds for the treatment of coagulation related diseases |
| EP1743643A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | New formulations of substituted pyrazoline compounds |
| EP1743637A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome |
| EP1749527A1 (en) * | 2005-07-15 | 2007-02-07 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds for the treatment of the lipid parameters of the metabolic syndrome |
| EP1749525A1 (en) * | 2005-07-15 | 2007-02-07 | Laboratorios Del Dr. Esteve, S.A. | Combination of substituted pyrazolines and anti-addictive agent |
| WO2007009702A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood |
| EP1746090A1 (en) * | 2005-07-15 | 2007-01-24 | Laboratorios del Dr. Esteve S.A. | Sustituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood |
| EP1749526A1 (en) * | 2005-07-15 | 2007-02-07 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds for the treatment of food disorders, including obesity or metabolic syndrome in patients with developed diabetes |
| WO2007009693A1 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr.Esteve, S.A | Combination of a substituted pyrazoline compound and a drug used in food-related disorders |
| EP1849776A1 (en) * | 2006-04-26 | 2007-10-31 | Laboratorios Del Dr. Esteve, S.A. | Azepane- or Azocane-substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1743890A1 (en) | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments |
| EP1743892A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1743889A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Sustituted pyrazoline compounds, having predetermined stereochemistry, for reducing triglycerides in blood |
| ES2326723B1 (es) * | 2005-07-15 | 2010-05-11 | Laboratorios Del Dr. Esteve, S.A. | Uso de compuestos de pirazol sustituidos y combinaciones de los mismos para el tratamiento del sindrome metabolico. |
| EP1849784A1 (en) * | 2006-04-26 | 2007-10-31 | Laboratorios Del Dr. Esteve, S.A. | Indoline-substituted pyrazoline compounds, their preparation and use as medicaments |
| ES2334967B1 (es) * | 2005-07-15 | 2010-10-21 | Laboratorios Del Dr. Esteve, S.A. | Compuestos de pirazolina sustituidos, con una estereoquimica predeterminada, para la reduccion de trigliceridos en sangre. |
| ES2319074B1 (es) * | 2005-07-15 | 2009-12-03 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de principios activos. |
| EP1743642A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds and their derivatives for the treatment of cannabinoid system-associated diseases |
| ES2327203B1 (es) * | 2005-07-15 | 2010-06-07 | Laboratorios Del Dr. Esteve, S.A. | Uso de compuestos de pirazolina sustituidos para el tratamiento de trastornos relacionados con la coagulacion. |
| ES2327379B1 (es) * | 2005-07-15 | 2010-05-28 | Laboratorios Del Dr. Esteve, S.A. | Compuestos de pirazolina indolinsustituidos, su preparacion y su uso como medicamentos. |
| US7897589B2 (en) | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| ES2326724B1 (es) * | 2005-07-15 | 2010-05-11 | Laboratorios Del Dr. Esteve, S.A. | Nuevas formulaciones de compuestos de pirazolina sustituidos. |
| WO2007009700A2 (en) * | 2005-07-15 | 2007-01-25 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazoline compounds for the treatment of the lipid parameters of the metabolic syndrome |
| KR101457637B1 (ko) * | 2012-10-24 | 2014-11-20 | 건국대학교 산학협력단 | 디히드로피라졸카르보티오아미드 유도체 및 그 제법 및 그 유도체를 포함하는 항암제 조성물 |
| CN103664785A (zh) * | 2013-11-04 | 2014-03-26 | 南京大学 | 一类新颖的二氢吡唑磺胺衍生物的合成及在抗癌药物中的应用 |
| WO2023043778A1 (en) * | 2021-09-14 | 2023-03-23 | Maverick Gold (Nv), Llc | Methods and systems for titling and trading alternative reserves |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5604253A (en) * | 1995-05-22 | 1997-02-18 | Merck Frosst Canada, Inc. | N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors |
| US5972986A (en) * | 1997-10-14 | 1999-10-26 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia |
| ES2137138B1 (es) * | 1998-05-29 | 2000-09-16 | Esteve Labor Dr | Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos. |
| AU771668C (en) * | 1999-06-16 | 2005-08-11 | Temple University - Of The Commonwealth System Of Higher Education | 1-(4-sulfamylaryl)-3-substituted-5-aryl-2-pyrazolines as inhibitors of cyclooxygenase-2 |
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