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ES2149883T3 - Sintesis quimica de taxol y de derivados de taxol. - Google Patents

Sintesis quimica de taxol y de derivados de taxol.

Info

Publication number
ES2149883T3
ES2149883T3 ES94923998T ES94923998T ES2149883T3 ES 2149883 T3 ES2149883 T3 ES 2149883T3 ES 94923998 T ES94923998 T ES 94923998T ES 94923998 T ES94923998 T ES 94923998T ES 2149883 T3 ES2149883 T3 ES 2149883T3
Authority
ES
Spain
Prior art keywords
taxol
derivatives
chemical synthesis
synthesis
tetraciclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94923998T
Other languages
English (en)
Inventor
Robert A Holton
Carmen Somoza
Hyeong B Kim
Mitsuru Shindo
Ronald J Biediger
P Douglas Boatman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University filed Critical Florida State University
Application granted granted Critical
Publication of ES2149883T3 publication Critical patent/ES2149883T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESO PARA LA SINTESIS DE TAXOL Y OTROS TAXANOS TRICICLICOS Y TETRACICLICOS.
ES94923998T 1993-07-20 1994-07-20 Sintesis quimica de taxol y de derivados de taxol. Expired - Lifetime ES2149883T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9516193A 1993-07-20 1993-07-20
US13822993A 1993-10-15 1993-10-15
US08/189,058 US5405972A (en) 1993-07-20 1994-01-27 Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes

Publications (1)

Publication Number Publication Date
ES2149883T3 true ES2149883T3 (es) 2000-11-16

Family

ID=27377903

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99116028T Expired - Lifetime ES2198827T3 (es) 1993-07-20 1994-07-20 Sintesis de taxol y sus derivados.
ES94923998T Expired - Lifetime ES2149883T3 (es) 1993-07-20 1994-07-20 Sintesis quimica de taxol y de derivados de taxol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES99116028T Expired - Lifetime ES2198827T3 (es) 1993-07-20 1994-07-20 Sintesis de taxol y sus derivados.

Country Status (15)

Country Link
US (4) US5405972A (es)
EP (2) EP0710223B1 (es)
JP (2) JP3564135B2 (es)
KR (3) KR100323273B1 (es)
CN (1) CN1046261C (es)
AT (2) ATE238289T1 (es)
AU (1) AU687428B2 (es)
CA (1) CA2167718C (es)
DE (2) DE69424939T2 (es)
DK (2) DK0960881T3 (es)
ES (2) ES2198827T3 (es)
GR (1) GR3034343T3 (es)
PT (2) PT960881E (es)
SG (2) SG97813A1 (es)
WO (1) WO1995003265A1 (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5728725A (en) * 1991-09-23 1998-03-17 Florida State University C2 taxane derivaties and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5728850A (en) * 1991-09-23 1998-03-17 Florida State University Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5721268A (en) * 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6028205A (en) * 1991-09-23 2000-02-22 Florida State University C2 tricyclic taxanes
FR2698871B1 (fr) 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US6339164B1 (en) 1993-01-29 2002-01-15 Florida State University C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
US6710191B2 (en) 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
ATE232854T1 (de) * 1993-03-05 2003-03-15 Univ Florida State Verfahren zur herstellung von 9-desoxotaxanen
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
FR2718137B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation de trialcoylsilyl-7 baccatine III.
DE4416374A1 (de) * 1994-05-05 1995-11-09 Schering Ag Neue Borneolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
JP2000510470A (ja) * 1996-05-06 2000-08-15 フロリダ・ステイト・ユニバーシティ １―デオキシバッカチンｉｉｉ、１―デオキシタキソールおよび１―デオキシタキソール類似体、ならびにこれらの製造方法
CA2188190A1 (en) 1996-10-18 1998-04-18 Sarala Balachandran The semi-synthesis of a protected bacatin iii compound
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
DE69812395T2 (de) 1997-08-21 2004-02-05 Florida State University, Tallahassee Verfahren zur synthese von taxanen
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
PL366100A1 (en) 2000-09-22 2005-01-24 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
JP2004512381A (ja) 2000-11-02 2004-04-22 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ Ｈｓｐ９０インヒビターの使用により細胞毒性剤の効力を増強させる方法
JP2006513152A (ja) * 2002-10-09 2006-04-20 ファイトジェン ライフ サイエンシズ インコーポレイテッド 新規タキサンならびにその使用および調製に関する方法
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
EP1613269B1 (en) 2003-04-04 2015-02-25 Incyte Corporation Compositions, methods and kits relating to her-2 cleavage
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
WO2006102758A1 (en) * 2005-03-31 2006-10-05 Bioxel Pharma Inc. Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
DK1948669T3 (da) * 2005-11-04 2013-10-07 Accord Healthcare Inc Nye fremgangsmåder til fremstiling af taxaner under anvendelse af chirale hjælpestoffer
WO2008082487A2 (en) 2006-12-20 2008-07-10 Schering Corporation Novel jnk inhibitors
US8658651B2 (en) 2009-09-30 2014-02-25 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
CA2811990C (en) 2010-08-23 2023-03-21 Dean Y. Maeda Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators
CN104744315A (zh) 2011-06-07 2015-07-01 株式会社吴羽 氧杂环丁烷化合物的制造方法、唑甲基环戊醇化合物的制造方法、以及中间体化合物
US10561676B2 (en) 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
JP6509851B2 (ja) 2013-08-02 2019-05-08 シントリックス・バイオシステムズ・インコーポレイテッドＳｙｎｔｒｉｘ Ｂｉｏｓｙｓｔｅｍｓ， Ｉｎｃ． ２−［５−［ｎ−（４−フルオロフェニル）カルバモイル］ピリミジン−２−イルスルファニルメチル］−４−（トリフルオロメトキシ）フェニル」ボロン酸
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
CN110201717B (zh) * 2019-05-21 2021-11-23 南京工业大学 一种铜基金属有机多面体复合材料的制备方法与应用
AU2020348457A1 (en) 2019-09-19 2022-04-07 Leap Therapeutics, Inc. Use of DKK-1 inhibitors for treating cancer
WO2021102403A1 (en) 2019-11-22 2021-05-27 Leap Therapeutics, Inc. Methods of treating cancer using dkk-1-inhibitors

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) * 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
USRE34277E (en) * 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
FR2629819B1 (fr) * 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
FR2662440B1 (fr) * 1990-05-22 1992-07-31 Rhone Poulenc Sante Procede de preparation stereoselective de derives de la phenylisoserine.
FR2662441B1 (fr) * 1990-05-22 1992-10-23 Rhone Poulenc Sante Procede de preparation enantioselective de derives de la phenylisoserine.
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
WO1993002064A1 (fr) * 1991-07-16 1993-02-04 Centre National De La Recherche Scientifique (Cnrs) Nouveau derive de la 7-desacetoxy baccatine iv, sa preparation et son emploi
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5416225A (en) * 1992-03-30 1995-05-16 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol
US5488116A (en) * 1992-03-30 1996-01-30 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol and analogues thereof
US5597931A (en) * 1992-03-30 1997-01-28 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol and analogues thereof
US5254703A (en) * 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
US5248796A (en) * 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
US5461169A (en) * 1992-06-23 1995-10-24 The Scripps Research Institute Total synthesis of taxol and taxol analogs
US5481007A (en) * 1992-06-23 1996-01-02 The Scripps Research Institute Taxoid synthesis
US5274137A (en) * 1992-06-23 1993-12-28 Nicolaou K C Intermediates for preparation of taxols
EP0668762B1 (en) * 1992-11-13 2003-09-17 Florida State University Isobutenyl-substituted taxanes and their pharmaceutical compositions
US5508447A (en) * 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives

Also Published As

Publication number Publication date
ATE238289T1 (de) 2003-05-15
EP0710223A4 (en) 1996-08-21
EP0710223A1 (en) 1996-05-08
CN1046261C (zh) 1999-11-10
EP0710223B1 (en) 2000-06-14
PT710223E (pt) 2000-12-29
AU687428B2 (en) 1998-02-26
ATE193880T1 (de) 2000-06-15
KR100353666B1 (ko) 2002-09-23
KR100325791B1 (ko) 2002-10-11
CN1137789A (zh) 1996-12-11
DE69424939T2 (de) 2000-11-02
DK0960881T3 (da) 2003-08-11
US5405972A (en) 1995-04-11
EP0960881B1 (en) 2003-04-23
ES2198827T3 (es) 2004-02-01
CA2167718C (en) 2006-10-03
US5618952A (en) 1997-04-08
JP3564135B2 (ja) 2004-09-08
GR3034343T3 (en) 2000-12-29
JP2004115526A (ja) 2004-04-15
EP0960881A1 (en) 1999-12-01
US5760252A (en) 1998-06-02
DK0710223T3 (da) 2000-09-11
KR960703837A (ko) 1996-08-31
CA2167718A1 (en) 1995-02-02
SG44727A1 (en) 1997-12-19
DE69424939D1 (de) 2000-07-20
DE69432569T2 (de) 2003-11-27
PT960881E (pt) 2003-09-30
SG97813A1 (en) 2003-08-20
AU7404294A (en) 1995-02-20
KR100323273B1 (ko) 2002-03-15
US5637732A (en) 1997-06-10
DE69432569D1 (de) 2003-05-28
JPH09501153A (ja) 1997-02-04
WO1995003265A1 (en) 1995-02-02

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