ATE193880T1 - Synthese von taxol und seinen derivaten - Google Patents

Synthese von taxol und seinen derivaten

Info

Publication number: ATE193880T1
Authority: AT; Austria
Prior art keywords: taxol; synthesis; derivatives; tricyclic; intermediates
Prior art date: 1993-07-20

Application number

AT94923998T

Other languages

English (en)

Inventor

Robert A Holton

Carmen Somoza

Hyeong B Kim

Mitsuru Shindo

Ronald J Biediger

P Douglas Boatman

Chase Smith

Feng Liang

Krishna Murthi

Original Assignee

Univ Florida State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-20

Filing date

1994-07-20

Publication date

2000-06-15

1994-07-20 Application filed by Univ Florida State filed Critical Univ Florida State

2000-06-15 Application granted granted Critical

2000-06-15 Publication of ATE193880T1 publication Critical patent/ATE193880T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Furan Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT94923998T 1993-07-20 1994-07-20 Synthese von taxol und seinen derivaten ATE193880T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US9516193A	1993-07-20	1993-07-20
US13822993A	1993-10-15	1993-10-15
US08/189,058 US5405972A (en)	1993-07-20	1994-01-27	Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
PCT/US1994/008350 WO1995003265A1 (en)	1993-07-20	1994-07-20	Synthesis of taxol and its derivatives

Publications (1)

Publication Number	Publication Date
ATE193880T1 true ATE193880T1 (de)	2000-06-15

Family

ID=27377903

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT99116028T ATE238289T1 (de)	1993-07-20	1994-07-20	Synthese von taxol und deren derivate
AT94923998T ATE193880T1 (de)	1993-07-20	1994-07-20	Synthese von taxol und seinen derivaten

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT99116028T ATE238289T1 (de)	1993-07-20	1994-07-20	Synthese von taxol und deren derivate

Country Status (15)

Country	Link
US (4)	US5405972A (de)
EP (2)	EP0710223B1 (de)
JP (2)	JP3564135B2 (de)
KR (3)	KR100323273B1 (de)
CN (1)	CN1046261C (de)
AT (2)	ATE238289T1 (de)
AU (1)	AU687428B2 (de)
CA (1)	CA2167718C (de)
DE (2)	DE69424939T2 (de)
DK (2)	DK0960881T3 (de)
ES (2)	ES2198827T3 (de)
GR (1)	GR3034343T3 (de)
PT (2)	PT960881E (de)
SG (2)	SG97813A1 (de)
WO (1)	WO1995003265A1 (de)

Families Citing this family (53)

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Publication number	Priority date	Publication date	Assignee	Title
US6011056A (en)	1991-09-23	2000-01-04	Florida State University	C9 taxane derivatives and pharmaceutical compositions containing them
US6495704B1 (en)	1991-09-23	2002-12-17	Florida State University	9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5728725A (en) *	1991-09-23	1998-03-17	Florida State University	C2 taxane derivaties and pharmaceutical compositions containing them
US5739362A (en) *	1991-09-23	1998-04-14	Florida State University	Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5728850A (en) *	1991-09-23	1998-03-17	Florida State University	Taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en)	1991-09-23	2002-01-01	Florida State University	Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US6005138A (en)	1991-09-23	1999-12-21	Florida State University	Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) *	1991-09-23	1998-02-03	Florida State University	C10 taxane derivatives and pharmaceutical compositions
US5721268A (en) *	1991-09-23	1998-02-24	Florida State University	C7 taxane derivatives and pharmaceutical compositions containing them
US5654447A (en) *	1991-09-23	1997-08-05	Florida State University	Process for the preparation of 10-desacetoxybaccatin III
US5489601A (en) *	1991-09-23	1996-02-06	Florida State University	Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5998656A (en) *	1991-09-23	1999-12-07	Florida State University	C10 tricyclic taxanes
US6794523B2 (en)	1991-09-23	2004-09-21	Florida State University	Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US6018073A (en) *	1991-09-23	2000-01-25	Florida State University	Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6028205A (en) *	1991-09-23	2000-02-22	Florida State University	C2 tricyclic taxanes
FR2698871B1 (fr)	1992-12-09	1995-02-24	Rhone Poulenc Rorer Sa	Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5973160A (en)	1992-12-23	1999-10-26	Poss; Michael A.	Methods for the preparation of novel sidechain-bearing taxanes
US6339164B1 (en)	1993-01-29	2002-01-15	Florida State University	C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them
US6710191B2 (en)	1993-03-05	2004-03-23	Florida State University	9β-hydroxytetracyclic taxanes
ATE232854T1 (de) *	1993-03-05	2003-03-15	Univ Florida State	Verfahren zur herstellung von 9-desoxotaxanen
US6005120A (en)	1993-07-20	1999-12-21	Florida State University	Tricyclic and tetracyclic taxanes
FR2718137B1 (fr) *	1994-04-05	1996-04-26	Rhone Poulenc Rorer Sa	Procédé de préparation de trialcoylsilyl-7 baccatine III.
DE4416374A1 (de) *	1994-05-05	1995-11-09	Schering Ag	Neue Borneolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5508447A (en) *	1994-05-24	1996-04-16	Board Of Regents, The University Of Texas System	Short synthetic route to taxol and taxol derivatives
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
JP2000510470A (ja) *	1996-05-06	2000-08-15	フロリダ・ステイト・ユニバーシティ	１―デオキシバッカチンｉｉｉ、１―デオキシタキソールおよび１―デオキシタキソール類似体、ならびにこれらの製造方法
CA2188190A1 (en)	1996-10-18	1998-04-18	Sarala Balachandran	The semi-synthesis of a protected bacatin iii compound
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
DE69812395T2 (de)	1997-08-21	2004-02-05	Florida State University, Tallahassee	Verfahren zur synthese von taxanen
US6150537A (en) *	1997-12-12	2000-11-21	Emory University	Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
US6156789A (en) *	1998-03-17	2000-12-05	Rhone-Poulenc Rorer S.A.	Method for treating abnormal cell proliferation in the brain
EP1229934B1 (de)	1999-10-01	2014-03-05	Immunogen, Inc.	Zusammensetzungen und verfahren zur behandlung von krebs mittels immunkonjugaten und chemotherapeutischen agenzien
US6452024B1 (en)	2000-02-22	2002-09-17	Chaichem Pharmaceuticals International	Process for extraction and purification of paclitaxel from natural sources
PL366100A1 (en)	2000-09-22	2005-01-24	Bristol-Myers Squibb Company	Method for reducing toxicity of combined chemotherapies
JP2004512381A (ja)	2000-11-02	2004-04-22	スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ	Ｈｓｐ９０インヒビターの使用により細胞毒性剤の効力を増強させる方法
JP2006513152A (ja) *	2002-10-09	2006-04-20	ファイトジェンライフサイエンシズインコーポレイテッド	新規タキサンならびにその使用および調製に関する方法
US6759539B1 (en)	2003-02-27	2004-07-06	Chaichem Pharmaceuticals International	Process for isolation and purification of paclitaxel from natural sources
EP1613269B1 (de)	2003-04-04	2015-02-25	Incyte Corporation	Zusammensetzungen, verfahren und kits in zusammenhang mit her-2 spaltung
US7202370B2 (en) *	2003-10-27	2007-04-10	Conor Medsystems, Inc.	Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
WO2006102758A1 (en) *	2005-03-31	2006-10-05	Bioxel Pharma Inc.	Preparation of taxanes from 9-dihydro-13-acetylbaccatin iii
DK1948669T3 (da) *	2005-11-04	2013-10-07	Accord Healthcare Inc	Nye fremgangsmåder til fremstiling af taxaner under anvendelse af chirale hjælpestoffer
WO2008082487A2 (en)	2006-12-20	2008-07-10	Schering Corporation	Novel jnk inhibitors
US8658651B2 (en)	2009-09-30	2014-02-25	Merck Sharp & Dohme Corp.	Compounds that are ERK inhibitors
CA2811990C (en)	2010-08-23	2023-03-21	Dean Y. Maeda	Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators
CN104744315A (zh)	2011-06-07	2015-07-01	株式会社吴羽	氧杂环丁烷化合物的制造方法、唑甲基环戊醇化合物的制造方法、以及中间体化合物
US10561676B2 (en)	2013-08-02	2020-02-18	Syntrix Biosystems Inc.	Method for treating cancer using dual antagonists of CXCR1 and CXCR2
US8969365B2 (en)	2013-08-02	2015-03-03	Syntrix Biosystems, Inc.	Thiopyrimidinecarboxamides as CXCR1/2 modulators
JP6509851B2 (ja)	2013-08-02	2019-05-08	シントリックス・バイオシステムズ・インコーポレイテッドＳｙｎｔｒｉｘＢｉｏｓｙｓｔｅｍｓ，Ｉｎｃ．	２−［５−［ｎ−（４−フルオロフェニル）カルバモイル］ピリミジン−２−イルスルファニルメチル］−４−（トリフルオロメトキシ）フェニル」ボロン酸
US10046002B2 (en)	2013-08-02	2018-08-14	Syntrix Biosystems Inc.	Method for treating cancer using chemokine antagonists
CN110201717B (zh) *	2019-05-21	2021-11-23	南京工业大学	一种铜基金属有机多面体复合材料的制备方法与应用
AU2020348457A1 (en)	2019-09-19	2022-04-07	Leap Therapeutics, Inc.	Use of DKK-1 inhibitors for treating cancer
WO2021102403A1 (en)	2019-11-22	2021-05-27	Leap Therapeutics, Inc.	Methods of treating cancer using dkk-1-inhibitors

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601676B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) *	1987-11-02	1989-10-24	Research Corporation Technologies, Inc.	Taxols, their preparation and intermediates thereof
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
USRE34277E (en) *	1988-04-06	1993-06-08	Centre National De La Recherche Scientifique	Process for preparing taxol
FR2629819B1 (fr) *	1988-04-06	1990-11-16	Rhone Poulenc Sante	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
US5015744A (en) *	1989-11-14	1991-05-14	Florida State University	Method for preparation of taxol using an oxazinone
FR2662440B1 (fr) *	1990-05-22	1992-07-31	Rhone Poulenc Sante	Procede de preparation stereoselective de derives de la phenylisoserine.
FR2662441B1 (fr) *	1990-05-22	1992-10-23	Rhone Poulenc Sante	Procede de preparation enantioselective de derives de la phenylisoserine.
US5380916A (en) *	1990-11-02	1995-01-10	University Of Florida	Method for the isolation and purification of taxane derivatives
WO1993002064A1 (fr) *	1991-07-16	1993-02-04	Centre National De La Recherche Scientifique (Cnrs)	Nouveau derive de la 7-desacetoxy baccatine iv, sa preparation et son emploi
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides
US5416225A (en) *	1992-03-30	1995-05-16	Sloan-Kettering Institute For Cancer Research	Total synthesis of taxol
US5488116A (en) *	1992-03-30	1996-01-30	Sloan-Kettering Institute For Cancer Research	Total synthesis of taxol and analogues thereof
US5597931A (en) *	1992-03-30	1997-01-28	Sloan-Kettering Institute For Cancer Research	Total synthesis of taxol and analogues thereof
US5254703A (en) *	1992-04-06	1993-10-19	Florida State University	Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
US5248796A (en) *	1992-06-18	1993-09-28	Bristol-Myers Squibb Company	Taxol derivatives
US5461169A (en) *	1992-06-23	1995-10-24	The Scripps Research Institute	Total synthesis of taxol and taxol analogs
US5481007A (en) *	1992-06-23	1996-01-02	The Scripps Research Institute	Taxoid synthesis
US5274137A (en) *	1992-06-23	1993-12-28	Nicolaou K C	Intermediates for preparation of taxols
EP0668762B1 (de) *	1992-11-13	2003-09-17	Florida State University	Isobutenyl-substituierte taxane und deren pharmazeutische zusammensetzungen
US5508447A (en) *	1994-05-24	1996-04-16	Board Of Regents, The University Of Texas System	Short synthetic route to taxol and taxol derivatives

1994
- 1994-01-27 US US08/189,058 patent/US5405972A/en not_active Expired - Fee Related
- 1994-07-20 PT PT99116028T patent/PT960881E/pt unknown
- 1994-07-20 EP EP94923998A patent/EP0710223B1/de not_active Expired - Lifetime
- 1994-07-20 EP EP99116028A patent/EP0960881B1/de not_active Expired - Lifetime
- 1994-07-20 WO PCT/US1994/008350 patent/WO1995003265A1/en active Application Filing
- 1994-07-20 DE DE69424939T patent/DE69424939T2/de not_active Expired - Fee Related
- 1994-07-20 SG SG9904909A patent/SG97813A1/en unknown
- 1994-07-20 AT AT99116028T patent/ATE238289T1/de not_active IP Right Cessation
- 1994-07-20 KR KR1020017011074A patent/KR100323273B1/ko not_active IP Right Cessation
- 1994-07-20 CA CA002167718A patent/CA2167718C/en not_active Expired - Fee Related
- 1994-07-20 KR KR1020017011073A patent/KR100353666B1/ko not_active IP Right Cessation
- 1994-07-20 AU AU74042/94A patent/AU687428B2/en not_active Ceased
- 1994-07-20 DE DE69432569T patent/DE69432569T2/de not_active Expired - Fee Related
- 1994-07-20 SG SG1996006396A patent/SG44727A1/en unknown
- 1994-07-20 ES ES99116028T patent/ES2198827T3/es not_active Expired - Lifetime
- 1994-07-20 DK DK99116028T patent/DK0960881T3/da active
- 1994-07-20 CN CN94192841A patent/CN1046261C/zh not_active Expired - Fee Related
- 1994-07-20 KR KR1019960700300A patent/KR100325791B1/ko not_active IP Right Cessation
- 1994-07-20 JP JP50536795A patent/JP3564135B2/ja not_active Expired - Fee Related
- 1994-07-20 DK DK94923998T patent/DK0710223T3/da active
- 1994-07-20 PT PT94923998T patent/PT710223E/pt unknown
- 1994-07-20 AT AT94923998T patent/ATE193880T1/de not_active IP Right Cessation
- 1994-07-20 ES ES94923998T patent/ES2149883T3/es not_active Expired - Lifetime
1995
- 1995-02-06 US US08/383,956 patent/US5618952A/en not_active Expired - Fee Related
- 1995-02-06 US US08/383,775 patent/US5637732A/en not_active Expired - Fee Related
1996
- 1996-12-19 US US08/769,935 patent/US5760252A/en not_active Expired - Fee Related
2000
- 2000-09-06 GR GR20000402031T patent/GR3034343T3/el not_active IP Right Cessation
2003
- 2003-10-08 JP JP2003349652A patent/JP2004115526A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
ATE238289T1 (de)	2003-05-15
EP0710223A4 (de)	1996-08-21
EP0710223A1 (de)	1996-05-08
ES2149883T3 (es)	2000-11-16
CN1046261C (zh)	1999-11-10
EP0710223B1 (de)	2000-06-14
PT710223E (pt)	2000-12-29
AU687428B2 (en)	1998-02-26
KR100353666B1 (ko)	2002-09-23
KR100325791B1 (ko)	2002-10-11
CN1137789A (zh)	1996-12-11
DE69424939T2 (de)	2000-11-02
DK0960881T3 (da)	2003-08-11
US5405972A (en)	1995-04-11
EP0960881B1 (de)	2003-04-23
ES2198827T3 (es)	2004-02-01
CA2167718C (en)	2006-10-03
US5618952A (en)	1997-04-08
JP3564135B2 (ja)	2004-09-08
GR3034343T3 (en)	2000-12-29
JP2004115526A (ja)	2004-04-15
EP0960881A1 (de)	1999-12-01
US5760252A (en)	1998-06-02
DK0710223T3 (da)	2000-09-11
KR960703837A (ko)	1996-08-31
CA2167718A1 (en)	1995-02-02
SG44727A1 (en)	1997-12-19
DE69424939D1 (de)	2000-07-20
DE69432569T2 (de)	2003-11-27
PT960881E (pt)	2003-09-30
SG97813A1 (en)	2003-08-20
AU7404294A (en)	1995-02-20
KR100323273B1 (ko)	2002-03-15
US5637732A (en)	1997-06-10
DE69432569D1 (de)	2003-05-28
JPH09501153A (ja)	1997-02-04
WO1995003265A1 (en)	1995-02-02

Publication	Publication Date	Title
DE69424939D1 (de)	2000-07-20	Synthese von taxol und seinen derivaten
HU9402342D0 (en)	1994-10-28	Phosphono-oxymethyl-ethers of taxane derivatives
ITMI920528A1 (it)	1993-09-06	14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
DE69333062D1 (de)	2003-07-31	4-mercaptoacetylamino-[2]benzazepinon(3)- derivate, und verwendung als enkephalinase-inhibitoren
FI952680L (fi)	1995-06-01	Injektoitavia taksaanijohdannaisiin pohjautuvia koostumuksia
FI921345A0 (fi)	1992-03-27	Piperidinderivat.
DE69302508D1 (de)	1996-06-13	Taxanderivate, ihre Herstellung und ihre Anwendung in der Onkologie
DE68906345D1 (de)	1993-06-09	Antimalariazusammenstellungen, gebrauchmachend von quinidin, artemisinin und ihren derivaten.
FI945581L (fi)	1994-11-28	Substituoidut (aryylialkoksibentsyyli) aminopropaaniamidijohdannaiset, niiden valmistus ja käyttö antiepileptisinä, neuroprotektiivisina ja antidepressiivisinä aineina
FI960076L (fi)	1996-01-08	Uudet (1-heteroatsolyyli-1-heterosyklyyli) alkaanijohdannaiset ja niiden käyttö hermostoa suojaavina aineina
ATE319698T1 (de)	2006-03-15	Taxane mit alkyl substituierte seiten-kette und diese enthaltende pharmazeutische zusammenstellungen
ATE220393T1 (de)	2002-07-15	Eine heteroethynylen-brücke enthaltende bi- aromatische verbindungen und diese enthaltende pharmazeutische und kosmetische zusammensetzungen
ATE225656T1 (de)	2002-10-15	C10-taxanderivate und pharmazeutische zusammensetzungen
FI945582L (fi)	1994-11-28	Substituoidut (aryylialkyyliaminobentsyyli) aminopropioniamidijohdannaiset, niiden valmistus ja käyttö anti-epileptisinä, neuroprotektiivisina ja antidepressiivisina aineina
HUP0100375A3 (en)	2002-04-29	Baccatin and oxazol derivatives and their use as intermediates in the synthesis of paclitaxel and analogs
FI955225L (fi)	1995-11-01	Välituotteet ja menetelmät antrapyratsoloni-syöpälääkkeiden synteesiä varten
DE69434010D1 (de)	2004-10-21	C7-Taxan-Derivate und diese enthaltende pharmazeutische Zusammenstellungen
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ITMI931729A0 (it)	1993-07-30	Derivati benzossazinonici e benzotiazinonici e loro uso terapeutico

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