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ES2137931T3 - Proteinas gdf-1 y uog-1. - Google Patents

Proteinas gdf-1 y uog-1.

Info

Publication number
ES2137931T3
ES2137931T3 ES91915864T ES91915864T ES2137931T3 ES 2137931 T3 ES2137931 T3 ES 2137931T3 ES 91915864 T ES91915864 T ES 91915864T ES 91915864 T ES91915864 T ES 91915864T ES 2137931 T3 ES2137931 T3 ES 2137931T3
Authority
ES
Spain
Prior art keywords
protein
gdf
uog
mammalian
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91915864T
Other languages
English (en)
Inventor
Se-Jin Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carnegie Institution of Washington
Original Assignee
Carnegie Institution of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carnegie Institution of Washington filed Critical Carnegie Institution of Washington
Application granted granted Critical
Publication of ES2137931T3 publication Critical patent/ES2137931T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN SEGMENTO DE ADN QUE CODIFICA UNA PROTEINA DE GDF-1 DE UN MAMIFERO Y A LA PROTEINA POR EL CODIFICADA. LA INVENCION TAMBIEN SE REFIERE A UNA MOLECULA DE ADN RECOMBINANTE QUE CONTIENE UNA SECUENCIA DE NUCLEOTIDOS QUE CODIFICA LA PROTEINA DE GDF-1 DE MAMIFEROS Y A CELULAS HUESPEDES TRASFORMADAS CON LA MISMA. LA INVENCION TAMBIEN SE REFIERE A UNA PROTEINA DE UOG-1 DE UN MAMIFERO Y A UN SEGMENTO DE ADN QUE LA CODIFICA.
ES91915864T 1990-06-15 1991-06-14 Proteinas gdf-1 y uog-1. Expired - Lifetime ES2137931T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53837290A 1990-06-15 1990-06-15
US61445290A 1990-11-16 1990-11-16

Publications (1)

Publication Number Publication Date
ES2137931T3 true ES2137931T3 (es) 2000-01-01

Family

ID=27065793

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91915864T Expired - Lifetime ES2137931T3 (es) 1990-06-15 1991-06-14 Proteinas gdf-1 y uog-1.

Country Status (10)

Country Link
US (2) US20040039162A1 (es)
EP (1) EP0652951B1 (es)
JP (1) JPH06500466A (es)
AT (1) ATE184052T1 (es)
AU (1) AU666291B2 (es)
CA (1) CA2085134C (es)
DE (1) DE69131580T2 (es)
ES (1) ES2137931T3 (es)
HK (1) HK1013847A1 (es)
WO (1) WO1992000382A1 (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
EP0601135B1 (en) * 1991-08-30 2005-11-02 Curis, Inc. Osteogenic proteins in the treatment of metabolic bone diseases
DK0653942T3 (da) * 1992-07-31 2003-10-20 Curis Inc Morphogen-induceret nerve-regenerering og -reparation
EP1439190A1 (en) * 1993-01-12 2004-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
US5821056A (en) 1993-01-12 1998-10-13 The Johns Hopkins University School Of Medicine Growth differentiation factor-9
CA2165776A1 (en) * 1993-07-09 1995-01-19 Se-Jin Lee Growth differentiation factor-6
CA2165778A1 (en) 1993-07-09 1995-01-19 Se-Jin Lee Growth differentiation factor-7
US20030167492A1 (en) 1994-07-08 2003-09-04 Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
JPH10502811A (ja) * 1994-07-08 1998-03-17 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−１１
US5831054A (en) * 1994-07-13 1998-11-03 The Johns Hopkins University School Of Medicine Polynucleotide encoding growth differentiation factor-12
JP4847634B2 (ja) 1996-03-22 2011-12-28 ストライカー・コーポレーション 中枢神経系の虚血または外傷の機能的回復を増大させる方法
US6524802B1 (en) * 1996-03-29 2003-02-25 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-14
WO1998034655A1 (en) 1997-02-07 1998-08-13 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
WO1998054572A1 (en) 1997-05-30 1998-12-03 Creative Biomolecules, Inc. Methods for evaluating tissue morphogenesis and activity
WO1999058671A2 (en) * 1998-05-08 1999-11-18 Research Corporation Technologies, Inc. Human and nematode homologues of the yeast longevity assurance gene lag1
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6872698B2 (en) * 1998-07-06 2005-03-29 Scion Pharmaceuticals, Inc. Methods for treating neurological injuries and disorders
AU771437B2 (en) * 1998-07-06 2004-03-25 Scion Pharmaceuticals, Inc. Methods for treating neurological injuries and disorders
CA2558395C (en) 2004-03-10 2011-11-29 Scil Technology Gmbh Coated implants, their manufacturing and use thereof
EP1740609A2 (en) 2004-04-27 2007-01-10 Research Development Foundation Antagonism of tgf-beta superfamily receptor signaling
JP5201987B2 (ja) 2004-05-25 2013-06-05 ストライカー コーポレイション 軟骨欠損を処置するための、形態形成タンパク質の使用
CA2652549A1 (en) 2006-05-17 2007-12-13 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
AU2007339280B2 (en) 2006-12-21 2013-12-05 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
WO2009020744A1 (en) 2007-08-07 2009-02-12 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations comprising gdf-5 in aqueous acidic solution
AU2009214629A1 (en) 2008-02-13 2009-08-20 Eric T. Choi BMP-7 for use in treating vascular sclerosis
US7947649B2 (en) 2008-04-14 2011-05-24 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
CN102369016A (zh) 2009-02-12 2012-03-07 史赛克公司 用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
CA2774024A1 (en) 2009-09-17 2011-03-24 Stryker Corporation Buffers for controlling the ph of bone morphogenetic proteins
WO2011087768A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
EP3124039B1 (en) 2010-08-20 2018-01-31 Wyeth LLC Designer osteogenic proteins
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses

Also Published As

Publication number Publication date
US20030040611A1 (en) 2003-02-27
US20040039162A1 (en) 2004-02-26
HK1013847A1 (en) 1999-12-10
EP0652951B1 (en) 1999-09-01
AU8496491A (en) 1992-01-23
EP0652951A1 (en) 1995-05-17
JPH06500466A (ja) 1994-01-20
AU666291B2 (en) 1996-02-08
DE69131580D1 (de) 1999-10-07
WO1992000382A1 (en) 1992-01-09
EP0652951A4 (en) 1993-08-16
CA2085134A1 (en) 1991-12-16
DE69131580T2 (de) 2000-01-13
ATE184052T1 (de) 1999-09-15
CA2085134C (en) 2003-03-18

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