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ES2124196B1 - Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion. - Google Patents

Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.

Info

Publication number
ES2124196B1
ES2124196B1 ES009701213A ES9701213A ES2124196B1 ES 2124196 B1 ES2124196 B1 ES 2124196B1 ES 009701213 A ES009701213 A ES 009701213A ES 9701213 A ES9701213 A ES 9701213A ES 2124196 B1 ES2124196 B1 ES 2124196B1
Authority
ES
Spain
Prior art keywords
semi
topical treatment
solid pharmaceutical
pharmaceutical form
inflammation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES009701213A
Other languages
English (en)
Other versions
ES2124196A1 (es
Inventor
Casellas David Mauleon
Perez M Luisa Garcia
Benet Albert Palomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES009701213A priority Critical patent/ES2124196B1/es
Priority to UA99116289A priority patent/UA57075C2/uk
Priority to DK98937444T priority patent/DK0996437T3/da
Priority to NZ501487A priority patent/NZ501487A/en
Priority to EEP199900556A priority patent/EE03905B1/xx
Priority to TR1999/03018T priority patent/TR199903018T2/xx
Priority to EP98937444A priority patent/EP0996437B1/en
Priority to AT98937444T priority patent/ATE201137T1/de
Priority to SK1649-99A priority patent/SK284317B6/sk
Priority to PL337156A priority patent/PL190779B1/pl
Priority to IDW991478A priority patent/ID26240A/id
Priority to EA199900998A priority patent/EA002026B1/ru
Priority to KR1019997011315A priority patent/KR100543558B1/ko
Priority to HU0002734A priority patent/HU226686B1/hu
Priority to CA002293589A priority patent/CA2293589C/en
Priority to CNB988057417A priority patent/CN1195510C/zh
Priority to CZ19994313A priority patent/CZ290118B6/cs
Priority to JP50151599A priority patent/JP2002502407A/ja
Priority to DE69800804T priority patent/DE69800804T2/de
Priority to PCT/EP1998/003333 priority patent/WO1998055113A1/en
Priority to AU86244/98A priority patent/AU728442B2/en
Priority to BRPI9810072-6A priority patent/BR9810072B1/pt
Priority to PT98937444T priority patent/PT996437E/pt
Priority to ES98937444T priority patent/ES2156446T3/es
Publication of ES2124196A1 publication Critical patent/ES2124196A1/es
Priority to BG103926A priority patent/BG64299B1/bg
Priority to CU1999212A priority patent/CU22866A3/es
Application granted granted Critical
Publication of ES2124196B1 publication Critical patent/ES2124196B1/es
Priority to HK00106945A priority patent/HK1027753A1/xx
Priority to HN2001000137A priority patent/HN2001000137A/es
Priority to EC2001004108A priority patent/ECSP014108A/es
Priority to GR20010401170T priority patent/GR3036319T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la fabricación de una forma farmacéutica semisólida conteniendo dexketoprofeno trometamol y su utilización en el tratamiento tópico de la inflamación. La presente invención se refiere a un procedimiento para la obtención de una forma farmacéutica semisólida (gel o crema) conteniendo dexketoprofeno trometamol y diversas aminas como agentes neutralizantes, aplicable al tratamiento tópico en humanos de los síndromes inflamatorios. Las formulaciones farmacéuticas objeto de la presente invención presentan ventajas derivadas de su elevada estabilidad al almacenado sin observarse variaciones con el tiempo en el aspecto del producto, así como de su menor actividad alergénica y fotoalergénica.
ES009701213A 1997-06-04 1997-06-04 Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion. Expired - Lifetime ES2124196B1 (es)

Priority Applications (30)

Application Number Priority Date Filing Date Title
ES009701213A ES2124196B1 (es) 1997-06-04 1997-06-04 Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.
UA99116289A UA57075C2 (uk) 1997-06-04 1998-04-06 Напівтверда фармацевтична композиція, що містить декскетопрофен-трометамол, та спосіб її одержання
DE69800804T DE69800804T2 (de) 1997-06-04 1998-06-04 Halbfeste pharmazeutische zubereitungen enthaltend dexketoprofen-trometamol
EEP199900556A EE03905B1 (et) 1997-06-04 1998-06-04 Deksketoprofeentrometamooli sisaldavad pooltahkedfarmatseutilised preparaadid
TR1999/03018T TR199903018T2 (xx) 1997-06-04 1998-06-04 Deksketopforen trometamol i�eren yar� kat� farmas�tik form�lasyon.
EP98937444A EP0996437B1 (en) 1997-06-04 1998-06-04 Semisolid pharmaceutical formulation containing dexketoprofen trometamol
AT98937444T ATE201137T1 (de) 1997-06-04 1998-06-04 Halbfeste pharmazeutische zubereitungen enthaltend dexketoprofen-trometamol
SK1649-99A SK284317B6 (sk) 1997-06-04 1998-06-04 Spôsob prípravy polotuhého farmaceutického prípravku
PL337156A PL190779B1 (pl) 1997-06-04 1998-06-04 Sposób wytwarzania półstałego preparatu farmaceutycznego zawierającego jako środek terapeutyczny sól kwasu (+)-(S)-2-(3-benzoilofenylo)propionowego z trometaminą i półstały preparat farmaceutyczny zawierajacy deksketoprofen trometamolu
IDW991478A ID26240A (id) 1997-06-04 1998-06-04 Formulasi obat setengah padat yang mengandung dekstoprofen trometamol
EA199900998A EA002026B1 (ru) 1997-06-04 1998-06-04 Полутвердый фармацевтический препарат, содержащий декскетопрофентрометамол
KR1019997011315A KR100543558B1 (ko) 1997-06-04 1998-06-04 덱스케토프로펜 트로메타몰을 함유하는 반고형 약제
HU0002734A HU226686B1 (en) 1997-06-04 1998-06-04 Semisolid pharmaceutical formulation containing dexketoprofen trometamol
CA002293589A CA2293589C (en) 1997-06-04 1998-06-04 Semisolid pharmaceutical formulation containing dexketoprofen trometamol
CNB988057417A CN1195510C (zh) 1997-06-04 1998-06-04 含有右酮洛芬氨基丁三醇的半固体药物制剂
CZ19994313A CZ290118B6 (cs) 1997-06-04 1998-06-04 Způsob výroby farmaceutického prostředku
DK98937444T DK0996437T3 (da) 1997-06-04 1998-06-04 Semifast farmaceutisk formulering indeholdende dexketoprofentrometamol
AU86244/98A AU728442B2 (en) 1997-06-04 1998-06-04 Semisolid pharmaceutical formulation containing dexketoprofen trometamol
NZ501487A NZ501487A (en) 1997-06-04 1998-06-04 Semisolid pharmaceutical formulation containing dexketoprofen trometamol
PCT/EP1998/003333 WO1998055113A1 (en) 1997-06-04 1998-06-04 Semisolid pharmaceutical formulation containing dexketoprofen trometamol
BRPI9810072-6A BR9810072B1 (pt) 1997-06-04 1998-06-04 formulação farmacêutica semi-sólida contendo dexcetoprofen trometamol e processo de preparação da mesma.
PT98937444T PT996437E (pt) 1997-06-04 1998-06-04 Formulacoes farmaceuticas semi-solida que contem dexcetoprofeno trometamol
ES98937444T ES2156446T3 (es) 1997-06-04 1998-06-04 Formulacion farmaceutica semisolida que contiene dexketoprofeno trometanol.
JP50151599A JP2002502407A (ja) 1997-06-04 1998-06-04 デクスケトプロフェントロメタモル含有半固体薬剤配合物
BG103926A BG64299B1 (bg) 1997-06-04 1999-11-25 Полутвърда фармацевтична форма, съдържаща декскетопрофен трометамол
CU1999212A CU22866A3 (es) 1997-06-04 1999-11-30 Formulación farmacéutica semisólida que contiene dexcetoprofentrometamol y procedimiento de obtención
HK00106945A HK1027753A1 (en) 1997-06-04 2000-11-01 Semisolid pharmaceutical formulation containing dexketoprofen trometamol
HN2001000137A HN2001000137A (es) 1997-06-04 2001-06-27 Procedimiento para la fabricacion de una forma farmaceutica semi solida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion
EC2001004108A ECSP014108A (es) 1997-06-04 2001-06-29 Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion
GR20010401170T GR3036319T3 (en) 1997-06-04 2001-08-03 Semisolid pharmaceutical formulation containing dexketoprofen trometamol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701213A ES2124196B1 (es) 1997-06-04 1997-06-04 Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.

Publications (2)

Publication Number Publication Date
ES2124196A1 ES2124196A1 (es) 1999-01-16
ES2124196B1 true ES2124196B1 (es) 1999-12-01

Family

ID=8299560

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009701213A Expired - Lifetime ES2124196B1 (es) 1997-06-04 1997-06-04 Procedimiento para la fabricacion de una forma farmaceutica semisolida conteniendo dexketoprofeno trometamol y su utilizacion en el tratamiento topico de la inflamacion.
ES98937444T Expired - Lifetime ES2156446T3 (es) 1997-06-04 1998-06-04 Formulacion farmaceutica semisolida que contiene dexketoprofeno trometanol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98937444T Expired - Lifetime ES2156446T3 (es) 1997-06-04 1998-06-04 Formulacion farmaceutica semisolida que contiene dexketoprofeno trometanol.

Country Status (29)

Country Link
EP (1) EP0996437B1 (es)
JP (1) JP2002502407A (es)
KR (1) KR100543558B1 (es)
CN (1) CN1195510C (es)
AT (1) ATE201137T1 (es)
AU (1) AU728442B2 (es)
BG (1) BG64299B1 (es)
BR (1) BR9810072B1 (es)
CA (1) CA2293589C (es)
CU (1) CU22866A3 (es)
CZ (1) CZ290118B6 (es)
DE (1) DE69800804T2 (es)
DK (1) DK0996437T3 (es)
EA (1) EA002026B1 (es)
EC (1) ECSP014108A (es)
EE (1) EE03905B1 (es)
ES (2) ES2124196B1 (es)
GR (1) GR3036319T3 (es)
HK (1) HK1027753A1 (es)
HN (1) HN2001000137A (es)
HU (1) HU226686B1 (es)
ID (1) ID26240A (es)
NZ (1) NZ501487A (es)
PL (1) PL190779B1 (es)
PT (1) PT996437E (es)
SK (1) SK284317B6 (es)
TR (1) TR199903018T2 (es)
UA (1) UA57075C2 (es)
WO (1) WO1998055113A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19935159A1 (de) * 1999-07-27 2001-02-22 Schuster Wolfgang Mittel zur Muskelentspannung
FR2797766B1 (fr) * 1999-08-27 2003-04-04 Menarini France Nouvelles formes topiques a consistance pateuse sous forme d'un gel distribue en doses
WO2013022410A2 (en) 2011-08-08 2013-02-14 Mahmut Bilgic Production method for effervescent formulations comprising dexketoprofen
EP2764875A1 (en) * 2013-02-06 2014-08-13 Galenicum Health S.L. Process for preparing a stable pharmaceutical composition comprising dexketoprofen trometamol
FR3024360A1 (fr) * 2014-07-30 2016-02-05 Pf Medicament Emulsions aux stearates
RU2667465C2 (ru) * 2015-10-28 2018-09-19 Закрытое Акционерное Общество "Фармфирма "Сотекс" Фармацевтическая композиция для наружного применения, содержащая соль декскетопрофена, и способ ее получения
CN109303762A (zh) * 2017-07-28 2019-02-05 韩美药品株式会社 含有酮洛芬的半固体制剂及其制备方法
KR101935830B1 (ko) * 2018-02-13 2019-01-07 주식회사 오스테오시스 외부역박동시스템과 그 제어방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319340A1 (fr) * 1975-07-28 1977-02-25 Roussel Uclaf Nouveau sel de l'acide a-methyl benzoyl-5 thiophene-2 acetique, procede de preparation et application a titre de medicament
IT1124398B (it) * 1979-12-05 1986-05-07 Menarini Sas Utilizzazione della forma farmaceutica gel contenente acido 23 benzoilfenil propionico impiegabile in terapia per uso topico
IT1207994B (it) * 1986-01-03 1989-06-01 Therapicon Srl Sali idrosulubili di composti adattivita' antiinfiammatoria ed analgesica, loro preparazione ed utilizzo in composizioni farmaceutiche.
US4960892A (en) * 1988-06-10 1990-10-02 American Home Products Corporation Naphthalenepropionic acid derivatives as anti-inflammatory/anti-allergic agents
US5091182A (en) * 1990-07-23 1992-02-25 Syntex (U.S.A.) Inc. Dispensing units for ketorolac topical gel formlations
ES2058024B1 (es) * 1992-11-10 1995-05-01 Menarini Lab Nuevo derivado arilpropionico, procedimiento de fabricacion del mismo y su utilizacion como analgesico.

Also Published As

Publication number Publication date
CN1195510C (zh) 2005-04-06
BR9810072A (pt) 2000-09-19
EE9900556A (et) 2000-06-15
EA199900998A1 (ru) 2000-06-26
DE69800804T2 (de) 2001-09-13
PT996437E (pt) 2001-09-28
AU8624498A (en) 1998-12-21
ES2124196A1 (es) 1999-01-16
EA002026B1 (ru) 2001-12-24
CZ290118B6 (cs) 2002-06-12
WO1998055113A1 (en) 1998-12-10
TR199903018T2 (xx) 2000-05-22
JP2002502407A (ja) 2002-01-22
HU226686B1 (en) 2009-06-29
CA2293589C (en) 2008-01-22
HK1027753A1 (en) 2001-01-23
ES2156446T3 (es) 2001-06-16
PL190779B1 (pl) 2006-01-31
BG103926A (en) 2000-09-29
ATE201137T1 (de) 2001-06-15
PL337156A1 (en) 2000-07-31
CA2293589A1 (en) 1998-12-10
HUP0002734A2 (hu) 2001-01-29
ECSP014108A (es) 2002-02-25
EP0996437B1 (en) 2001-05-16
CZ431399A3 (cs) 2000-05-17
SK164999A3 (en) 2000-09-12
NZ501487A (en) 2001-06-29
BG64299B1 (bg) 2004-09-30
AU728442B2 (en) 2001-01-11
KR100543558B1 (ko) 2006-01-20
UA57075C2 (uk) 2003-06-16
EE03905B1 (et) 2002-12-16
KR20010013320A (ko) 2001-02-26
GR3036319T3 (en) 2001-11-30
CN1259048A (zh) 2000-07-05
EP0996437A1 (en) 2000-05-03
ID26240A (id) 2000-12-07
BR9810072B1 (pt) 2010-07-13
CU22866A3 (es) 2003-08-13
HN2001000137A (es) 2001-10-29
DK0996437T3 (da) 2001-08-06
SK284317B6 (sk) 2005-01-03
DE69800804D1 (de) 2001-06-21
HUP0002734A3 (en) 2003-05-28

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