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ES2072881T3 - Procedimiento de preparacion de glicoconjugados de fosforamida mostaza e isofosforamida mostaza. - Google Patents

Procedimiento de preparacion de glicoconjugados de fosforamida mostaza e isofosforamida mostaza.

Info

Publication number
ES2072881T3
ES2072881T3 ES89119408T ES89119408T ES2072881T3 ES 2072881 T3 ES2072881 T3 ES 2072881T3 ES 89119408 T ES89119408 T ES 89119408T ES 89119408 T ES89119408 T ES 89119408T ES 2072881 T3 ES2072881 T3 ES 2072881T3
Authority
ES
Spain
Prior art keywords
mustard
glycoconjugates
procedure
sugar
phosphoramide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89119408T
Other languages
English (en)
Inventor
Manfred Prof Dr Wiessler
Michael Dickes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Application granted granted Critical
Publication of ES2072881T3 publication Critical patent/ES2072881T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

EL INVENTO SE REFIERE A UN PROCEDIMIENTO PARA LA PRODUCCION DE GLICOCONJUGADOS DE FOSFOROAMIDAS DE FORMULA I O II QUE CONSISTE EN CONJUGAR AZUCAR BROMADO PROTEGIDO EN FORMA CONOCIDA CON COMPUESTOS FOSFORADOS Y ELIMINAR GRUPOS PROTECTORES DEL COMPUESTO DE CONJUGACION; TRATA DEL D-GLUCOPIRAMOSILO (2-CLOROETILO) FOSFORO ACIDODIAMIDA Y DESCRIBE SU APLICACION COMO ANTITUMORAL. LA LIGAZON DE LOS AZUCARES CON LA FUNCION IPERITA-FOSFORAMIDA SE REALIZA EN LA POSICION 1. SIENDO R1 Y R2 IGUALES O DIFERENTES HIDROGENO, ALQUILO DE 1 A 4 O HALOGENOALQUILO DE C 1 A 6 Y SE UTILIZA COMO MONO, DI O PLISACARIDO EN FORMA ISOMERA O ENANTIOMERA COMO AZUCAR.
ES89119408T 1988-10-20 1989-10-19 Procedimiento de preparacion de glicoconjugados de fosforamida mostaza e isofosforamida mostaza. Expired - Lifetime ES2072881T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3835772A DE3835772A1 (de) 1988-10-20 1988-10-20 Tumorhemmende saccharid-konjugate

Publications (1)

Publication Number Publication Date
ES2072881T3 true ES2072881T3 (es) 1995-08-01

Family

ID=6365559

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89119408T Expired - Lifetime ES2072881T3 (es) 1988-10-20 1989-10-19 Procedimiento de preparacion de glicoconjugados de fosforamida mostaza e isofosforamida mostaza.

Country Status (16)

Country Link
US (1) US5622936A (es)
EP (1) EP0369182B1 (es)
JP (2) JP2518739B2 (es)
AT (1) ATE120465T1 (es)
CA (1) CA2001129C (es)
DE (2) DE3835772A1 (es)
DK (1) DK170422B1 (es)
ES (1) ES2072881T3 (es)
FI (1) FI95268C (es)
GR (1) GR3015566T3 (es)
HK (1) HK157495A (es)
HU (1) HU206124B (es)
IE (1) IE67529B1 (es)
NO (1) NO173548C (es)
PT (1) PT92034B (es)
WO (1) WO1990004597A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19524515A1 (de) * 1995-07-05 1997-01-09 Deutsches Krebsforsch Saccharid-Konjugate
US20040072889A1 (en) * 1997-04-21 2004-04-15 Pharmacia Corporation Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
US20050107310A1 (en) * 2002-03-19 2005-05-19 Holick Michael F. Carboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
AU2003230750A1 (en) * 2002-03-29 2003-10-13 Threshold Pharmaceuticals, Inc. Compositions and methods for treating cancer
US7560230B2 (en) * 2003-03-07 2009-07-14 Threshold Pharmaceuticals, Inc. Method for determining susceptibility of tumor to treatment with anti-neoplastic agent
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
WO2004110255A2 (en) * 2003-06-09 2004-12-23 Gang Zheng Antineoplastic agents targeted via glut transporters
CN1917885A (zh) 2004-02-06 2007-02-21 施瑞修德制药公司 抗癌疗法
WO2006122227A1 (en) * 2005-05-11 2006-11-16 Threshold Pharmaceuticals, Inc. Glufosfamide combination therapy
ES2389532T3 (es) 2005-06-29 2012-10-29 Threshold Pharmaceuticals, Inc. Profármacos alquilantes de fosforamidato
CN100358910C (zh) * 2006-02-14 2008-01-02 海南天源康泽医药科技有限公司 葡膦酰胺结晶及其制备方法与应用
WO2008011588A2 (en) * 2006-07-20 2008-01-24 Threshold Pharmaceuticals, Inc. Glycoconjugates of phosphoramidate alkylators for treatment of cancer
ES2884044T3 (es) * 2006-12-26 2021-12-10 Immunogenesis Inc Profármaco alquilante de fosforamidato para el tratamiento del cáncer
WO2008124691A1 (en) * 2007-04-05 2008-10-16 Threshold Pharmaceuticals, Inc. Glufosfamide combination therapy
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
CN101481394B (zh) * 2008-01-09 2013-01-30 苏州天人合生物技术有限公司 2,3,4,6-四-o-乙酰基-d-吡喃葡萄糖基-[n, n′-双(2-氯乙基)]-磷酸二酰胺的制备方法
US20110207680A1 (en) * 2008-08-13 2011-08-25 Curd John G Administration of Glufosfamide For The Treatment of Cancer
CN102115483B (zh) * 2009-12-30 2014-12-17 苏州天人合生物技术有限公司 卤代双去氧糖衍生物及其制备方法与应用
CN103142626B (zh) * 2010-07-21 2014-08-20 苏州天人合生物技术有限公司 三乙酰葡萄烯糖在制备抗肿瘤药物中的应用
CN105002235B (zh) * 2015-07-10 2019-02-22 江苏九旭药业有限公司 一种利用酶制备葡磷酰胺及其类似物的方法
CN105153251B (zh) * 2015-09-29 2018-03-20 浙江合糖科技有限公司 一种单糖甲苷的苄基化方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122386C (es) *
DD122386A1 (es) * 1975-06-24 1976-10-05
DE3225227A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5015733A (en) * 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
US5194428A (en) * 1986-05-23 1993-03-16 Worcester Foundation For Experimental Biology Inhibition of influenza virus replication by oligonucleotide phosphorothioates
US5055459A (en) * 1986-06-30 1991-10-08 Board Of Regents, The University Of Texas Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates

Also Published As

Publication number Publication date
NO173548C (no) 1993-12-29
NO173548B (no) 1993-09-20
ATE120465T1 (de) 1995-04-15
DK149290A (da) 1990-08-07
FI95268C (fi) 1996-01-10
CA2001129C (en) 2000-06-27
WO1990004597A1 (de) 1990-05-03
EP0369182B1 (de) 1995-03-29
EP0369182A1 (de) 1990-05-23
IE67529B1 (en) 1996-04-03
IE893360L (en) 1990-04-20
NO902717L (no) 1990-08-20
HK157495A (en) 1995-10-13
FI903123A0 (fi) 1990-06-20
DE58909141D1 (de) 1995-05-04
DK149290D0 (da) 1990-06-19
DK170422B1 (da) 1995-08-28
JPH08208680A (ja) 1996-08-13
HUT54702A (en) 1991-03-28
JP2518739B2 (ja) 1996-07-31
PT92034B (pt) 1995-05-31
JPH03502934A (ja) 1991-07-04
CA2001129A1 (en) 1990-04-20
US5622936A (en) 1997-04-22
HU896841D0 (en) 1990-12-28
HU206124B (en) 1992-08-28
FI95268B (fi) 1995-09-29
JP3056408B2 (ja) 2000-06-26
GR3015566T3 (en) 1995-06-30
DE3835772A1 (de) 1990-04-26
PT92034A (pt) 1990-04-30
NO902717D0 (no) 1990-06-19

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