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ES2055176T3 - Composicion de gemfibrozil con liberacion prolongada. - Google Patents

Composicion de gemfibrozil con liberacion prolongada.

Info

Publication number
ES2055176T3
ES2055176T3 ES90102021T ES90102021T ES2055176T3 ES 2055176 T3 ES2055176 T3 ES 2055176T3 ES 90102021 T ES90102021 T ES 90102021T ES 90102021 T ES90102021 T ES 90102021T ES 2055176 T3 ES2055176 T3 ES 2055176T3
Authority
ES
Spain
Prior art keywords
gemfibrozil
prolonged release
granulation
disintegratable
alkali
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90102021T
Other languages
English (en)
Inventor
Isaac Ghebre-Sellassie
Mahdi Fawzi
Uma Iyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2055176T3 publication Critical patent/ES2055176T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

UNA TABLETA DE GEMFIBROCIL DESINTEGRABLE PROVEE UNA REALIZACION INMEDIATA Y ENTERICA, Y ESTA COMPUESTA EN UNA MEZCLA DE GRANULACION DE GEMFIBROCIL CON AL MENOS UN RECUBRIMIENTO DE ACIDO DESINTEGRABLE Y UNA SEGUNDA GRANULACION FORMADA DE LA PRIMERA, PERO REGRANULADA O REVESTIDA CON UNA FORMULA ALCALI DESINTEGRABLE DE AL MENOS UN ALCALI - SOLUBLE SUSTANCIALMENTE Y UN POLIMERO ACIDO INSOLUBLE SUSTANCIALMENTE.
ES90102021T 1989-02-02 1990-02-01 Composicion de gemfibrozil con liberacion prolongada. Expired - Lifetime ES2055176T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/305,083 US4925676A (en) 1989-02-02 1989-02-02 Extended release gemfibrozil composition

Publications (1)

Publication Number Publication Date
ES2055176T3 true ES2055176T3 (es) 1994-08-16

Family

ID=23179257

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90102021T Expired - Lifetime ES2055176T3 (es) 1989-02-02 1990-02-01 Composicion de gemfibrozil con liberacion prolongada.

Country Status (20)

Country Link
US (1) US4925676A (es)
EP (1) EP0381218B1 (es)
JP (1) JPH02235810A (es)
CN (1) CN1044590A (es)
AT (1) ATE88888T1 (es)
AU (1) AU624217B2 (es)
CA (1) CA2009134A1 (es)
DE (1) DE69001487T2 (es)
DK (1) DK0381218T3 (es)
ES (1) ES2055176T3 (es)
FI (1) FI900492A0 (es)
HU (1) HU204194B (es)
IE (1) IE900372L (es)
IL (1) IL92995A0 (es)
MY (1) MY104899A (es)
NO (1) NO900483L (es)
NZ (1) NZ232322A (es)
PH (1) PH26308A (es)
PT (1) PT93028A (es)
ZA (1) ZA90778B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1246382B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
EP0462067A1 (en) * 1990-06-15 1991-12-18 Warner-Lambert Company Gemfibrozil formulations
EP0462066A1 (en) * 1990-06-15 1991-12-18 Warner-Lambert Company Amorphous gemfibrozil
EP0475894A1 (en) * 1990-08-27 1992-03-18 Warner-Lambert Company Gemfibrozil formulations
US5102668A (en) * 1990-10-05 1992-04-07 Kingaform Technology, Inc. Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
DE69207656T2 (de) * 1991-01-30 1996-10-17 The Wellcome Foundation Ltd., London Wasserlösliche tabletten
US5358723A (en) * 1991-11-26 1994-10-25 Warner-Lambert Company Process and composition for the development of controlled release gemfibrozil dosage form
US5492700A (en) * 1991-11-26 1996-02-20 Warner-Lambert Company Process and composition for the development of controlled release gemfibrozil dosage form
JPH07503236A (ja) * 1991-11-26 1995-04-06 ワーナー−ランバート・コンパニー 制御放出性ジェムフィブロジル剤形の開発のための方法および組成物
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
HU212428B (en) * 1994-05-13 1996-06-28 Egyt Gyogyszervegyeszeti Gyar Process to prepare pharmaceutical compositions containing gemfibrozyl
US6814977B1 (en) 1998-12-18 2004-11-09 Abbott Laboratories Formulations comprising lipid-regulating agents
US7014864B1 (en) 1998-12-18 2006-03-21 Abbott Laboratories Formulations comprising lipid-regulating agents
US6838091B2 (en) * 1998-12-18 2005-01-04 Abbott Laboratories Formulations comprising lipid-regulating agents
US6719999B2 (en) 1999-03-31 2004-04-13 Abbott Laboratories Formulations comprising lipid-regulating agents
US6372251B2 (en) 1999-06-11 2002-04-16 Abbott Laboratories Formulations comprising lipid-regulating agents
RU2356549C2 (ru) * 2002-12-17 2009-05-27 Эббетт ГмбХ унд Ко.КГ Композиция, включающая фенофибриновую кислоту, ее физиологически приемлемую соль или производное
CA2569968C (en) * 2004-06-10 2014-08-19 Glatt Air Techniques, Inc. Controlled release matrix pharmaceutical dosage formulation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
US4291016A (en) * 1976-07-27 1981-09-22 Sandoz Ltd. Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate
US4195084A (en) * 1977-01-07 1980-03-25 Eli Lilly And Company Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof
IT1101649B (it) * 1978-12-15 1985-10-07 Lehner Ag Composizione farmaceutica ad azione prolungata contenente acidi biliari
JPS57171428A (en) * 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
JPS59193831A (ja) * 1983-04-18 1984-11-02 Sankyo Co Ltd 腸溶性製剤の製造法
HU190619B (en) * 1983-11-11 1986-09-29 Bezzegh,Denes,Hu Process for producing tablets with controlled dissolution of active ingredients
JPS618A (ja) * 1984-06-09 1986-01-06 Sawai Seiyaku Kk ニフエジピン含有製剤
JPS6144811A (ja) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd 徐放性ジクロフエナクナトリウム製剤
DE3678644D1 (de) * 1985-08-16 1991-05-16 Procter & Gamble Wirkstoffpartikel mit sowohl kontinuierlicher als auch schneller freisetzung.
US4778676A (en) * 1985-12-20 1988-10-18 Warner-Lambert Company Confectionery delivery system for actives
IL81419A0 (en) * 1986-01-30 1987-08-31 Syntex Inc Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation
US4716033A (en) * 1986-03-27 1987-12-29 Warner-Lambert Company Medicament adsorbates with surfactant and their preparation
US4816264A (en) * 1986-06-06 1989-03-28 Warner-Lambert Company Sustained release formulations
US4814354A (en) * 1986-09-26 1989-03-21 Warner-Lambert Company Lipid regulating agents
AU1422388A (en) * 1987-01-27 1988-08-10 Warner-Lambert Company Lipid regulating compositions

Also Published As

Publication number Publication date
NZ232322A (en) 1991-02-26
AU624217B2 (en) 1992-06-04
JPH02235810A (ja) 1990-09-18
PH26308A (en) 1992-04-29
HU204194B (en) 1991-12-30
NO900483L (no) 1990-08-03
CA2009134A1 (en) 1990-08-02
EP0381218B1 (en) 1993-05-05
DE69001487D1 (de) 1993-06-09
NO900483D0 (no) 1990-02-01
US4925676A (en) 1990-05-15
EP0381218A3 (en) 1990-12-05
ATE88888T1 (de) 1993-05-15
IL92995A0 (en) 1990-09-17
AU4899090A (en) 1990-08-09
IE900372L (en) 1990-08-02
PT93028A (pt) 1990-08-31
DK0381218T3 (da) 1993-06-01
MY104899A (en) 1994-06-30
HU900640D0 (en) 1990-04-28
DE69001487T2 (de) 1993-08-26
HUT52952A (en) 1990-09-28
ZA90778B (en) 1991-10-30
FI900492A0 (fi) 1990-01-31
CN1044590A (zh) 1990-08-15
EP0381218A2 (en) 1990-08-08

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