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ES2038310T3 - Procedimiento para la sintesis de derivados de 3-tio-4-quinolona y sus compuestos intermedios. - Google Patents

Procedimiento para la sintesis de derivados de 3-tio-4-quinolona y sus compuestos intermedios.

Info

Publication number
ES2038310T3
ES2038310T3 ES198888310463T ES88310463T ES2038310T3 ES 2038310 T3 ES2038310 T3 ES 2038310T3 ES 198888310463 T ES198888310463 T ES 198888310463T ES 88310463 T ES88310463 T ES 88310463T ES 2038310 T3 ES2038310 T3 ES 2038310T3
Authority
ES
Spain
Prior art keywords
quinolone
tio
synthesis
derivatives
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888310463T
Other languages
English (en)
Inventor
Lachlan Maclean
David Lloyd Roberts
Kenneth Barron
Kenneth John Nichol
Albert Ernest Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co PLC filed Critical Boots Co PLC
Application granted granted Critical
Publication of ES2038310T3 publication Critical patent/ES2038310T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

UN PROCESO PARA PREPARAR COMPUESTOS DE FORMULA(I), EN DONDE N ES 0, 1 O 2 COMPRENDIENDO LA CICLACION DE COMPUESTOS DE FORMULA(II), EN DONDE N ES 0, 1 O 2. LA CICLACION PUEDE SER ORGANICA O INORGANICA O TERMICAMENTE A UNA TEMPERATURA EN EL INTERVALO DE 40 A 160 (GRADOS) C. COMPUESTOS DE FORMULA(II) Y CIERTOS ANALOGOS DE ESTO SE PRESENTAN COMO AGENTES CARDIOVASCULARES.
ES198888310463T 1987-11-18 1988-11-07 Procedimiento para la sintesis de derivados de 3-tio-4-quinolona y sus compuestos intermedios. Expired - Lifetime ES2038310T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878726950A GB8726950D0 (en) 1987-11-18 1987-11-18 Chemical process

Publications (1)

Publication Number Publication Date
ES2038310T3 true ES2038310T3 (es) 1993-07-16

Family

ID=10627131

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888310463T Expired - Lifetime ES2038310T3 (es) 1987-11-18 1988-11-07 Procedimiento para la sintesis de derivados de 3-tio-4-quinolona y sus compuestos intermedios.

Country Status (28)

Country Link
US (2) US5011931A (es)
EP (2) EP0343206A1 (es)
JP (1) JPH02502013A (es)
KR (1) KR890701563A (es)
AT (1) ATE69221T1 (es)
AU (1) AU628305B2 (es)
BG (1) BG50157A3 (es)
CS (1) CS274487B2 (es)
DD (1) DD290188A5 (es)
DE (1) DE3866086D1 (es)
ES (1) ES2038310T3 (es)
FI (1) FI91063C (es)
GB (1) GB8726950D0 (es)
GR (1) GR3003378T3 (es)
HU (1) HU204511B (es)
IE (1) IE883366L (es)
IL (1) IL88358A (es)
MX (1) MX168918B (es)
NZ (1) NZ227008A (es)
PH (1) PH27439A (es)
PL (1) PL157191B1 (es)
PT (1) PT89024B (es)
RO (1) RO104615B1 (es)
SU (1) SU1766255A3 (es)
TW (1) TW204344B (es)
WO (1) WO1989004827A1 (es)
YU (1) YU46989B (es)
ZA (1) ZA888241B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
US6110489A (en) * 1998-05-01 2000-08-29 Cutler; Neal R. Use of quinolines and quinolones to treat male erectile dysfunction
US6132757A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132753A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6194433B1 (en) 1998-10-05 2001-02-27 Neal R. Cutler Sexual dysfunction in females
US6303135B1 (en) 1999-07-08 2001-10-16 Neal R. Cutler Use of quinolines and quinolones to treat male erectile dysfunction
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6649764B2 (en) 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
CN102316902B (zh) 2009-02-20 2014-09-24 to-BBB控股股份有限公司 基于谷胱甘肽的药物递送系统
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920699A (en) * 1974-04-26 1975-11-18 Warner Lambert Co Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby
US4192873A (en) * 1976-11-25 1980-03-11 Ciba-Geigy Corporation Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
FR2532939A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0149519B1 (en) * 1984-01-13 1990-06-27 The Boots Company PLC Use of quinolones for the manufacture of a composition for the treatment of heart failure.
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process

Also Published As

Publication number Publication date
CS748988A2 (en) 1990-09-12
GR3003378T3 (en) 1993-02-17
EP0317149A1 (en) 1989-05-24
DD290188A5 (de) 1991-05-23
FI91063B (fi) 1994-01-31
YU209788A (en) 1990-08-31
WO1989004827A1 (en) 1989-06-01
NZ227008A (en) 1991-10-25
PT89024B (pt) 1993-02-26
CS274487B2 (en) 1991-04-11
GB8726950D0 (en) 1987-12-23
YU46989B (sh) 1994-09-09
IE883366L (en) 1989-05-18
FI893405A0 (fi) 1989-07-13
PT89024A (pt) 1988-12-01
PL275880A1 (en) 1989-06-12
EP0343206A1 (en) 1989-11-29
BG50157A3 (bg) 1992-05-15
JPH02502013A (ja) 1990-07-05
HU204511B (en) 1992-01-28
KR890701563A (ko) 1989-12-21
RO104615B1 (en) 1992-11-03
AU2616388A (en) 1989-06-14
ZA888241B (en) 1989-10-25
FI893405L (fi) 1989-07-13
DE3866086D1 (de) 1991-12-12
US5011931A (en) 1991-04-30
SU1766255A3 (ru) 1992-09-30
HUT53085A (en) 1990-09-28
TW204344B (es) 1993-04-21
PH27439A (en) 1993-07-02
IL88358A0 (en) 1989-06-30
US5079264A (en) 1992-01-07
EP0317149B1 (en) 1991-11-06
FI91063C (fi) 1994-05-10
MX168918B (es) 1993-06-14
IL88358A (en) 1993-02-21
AU628305B2 (en) 1992-09-17
ATE69221T1 (de) 1991-11-15
PL157191B1 (pl) 1992-05-29

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