FI893405A0 - Menetelmä kinoloniyhdisteiden valmistamiseksi - Google Patents

Menetelmä kinoloniyhdisteiden valmistamiseksi

Info

Publication number: FI893405A0
Authority: FI; Finland
Prior art keywords: preparation; compounds; formula; quinolone compounds; cyclisation
Prior art date: 1987-11-18

Application number

FI893405A

Other languages

English (en)

Swedish (sv)

Other versions

FI91063B (fi

FI893405L (fi

FI91063C (fi

Inventor

Lachlan Maclean

David Lloyd Roberts

Kenneth Barron

Kenneth John Nichol

Original Assignee

Boots Co Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-18

Filing date

1989-07-13

Publication date

1989-07-13

1989-07-13 Application filed by Boots Co Plc filed Critical Boots Co Plc

1989-07-13 Publication of FI893405A0 publication Critical patent/FI893405A0/fi

1989-07-13 Publication of FI893405L publication Critical patent/FI893405L/fi

1994-01-31 Publication of FI91063B publication Critical patent/FI91063B/fi

1994-05-10 Application granted granted Critical

1994-05-10 Publication of FI91063C publication Critical patent/FI91063C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Physical Or Chemical Processes And Apparatus (AREA)

FI893405A 1987-11-18 1989-07-13 Menetelmä kinoloniyhdisteiden valmistamiseksi FI91063C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB8726950		1987-11-18
GB878726950A GB8726950D0 (en)	1987-11-18	1987-11-18	Chemical process
PCT/GB1988/000952 WO1989004827A1 (en)	1987-11-18	1988-11-07	Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments
GB8800952		1988-11-07

Publications (4)

Publication Number	Publication Date
FI893405A0 true FI893405A0 (fi)	1989-07-13
FI893405L FI893405L (fi)	1989-07-13
FI91063B FI91063B (fi)	1994-01-31
FI91063C FI91063C (fi)	1994-05-10

Family

ID=10627131

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI893405A FI91063C (fi)	1987-11-18	1989-07-13	Menetelmä kinoloniyhdisteiden valmistamiseksi

Country Status (28)

Country	Link
US (2)	US5011931A (fi)
EP (2)	EP0343206A1 (fi)
JP (1)	JPH02502013A (fi)
KR (1)	KR890701563A (fi)
AT (1)	ATE69221T1 (fi)
AU (1)	AU628305B2 (fi)
BG (1)	BG50157A3 (fi)
CS (1)	CS274487B2 (fi)
DD (1)	DD290188A5 (fi)
DE (1)	DE3866086D1 (fi)
ES (1)	ES2038310T3 (fi)
FI (1)	FI91063C (fi)
GB (1)	GB8726950D0 (fi)
GR (1)	GR3003378T3 (fi)
HU (1)	HU204511B (fi)
IE (1)	IE883366L (fi)
IL (1)	IL88358A (fi)
MX (1)	MX168918B (fi)
NZ (1)	NZ227008A (fi)
PH (1)	PH27439A (fi)
PL (1)	PL157191B1 (fi)
PT (1)	PT89024B (fi)
RO (1)	RO104615B1 (fi)
SU (1)	SU1766255A3 (fi)
TW (1)	TW204344B (fi)
WO (1)	WO1989004827A1 (fi)
YU (1)	YU46989B (fi)
ZA (1)	ZA888241B (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8726950D0 (en) *	1987-11-18	1987-12-23	Boots Co Plc	Chemical process
GB8804016D0 (en) *	1988-02-22	1988-03-23	Boots Co Plc	Therapeutic agents
US6110489A (en) *	1998-05-01	2000-08-29	Cutler; Neal R.	Use of quinolines and quinolones to treat male erectile dysfunction
US6132757A (en) *	1998-05-01	2000-10-17	Neal R. Cutler	Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) *	2000-06-19	2002-07-30	Neal R. Cutler	Treatment of sexual dysfunction in certain patient groups
US6132753A (en) *	1998-05-01	2000-10-17	Neal R. Cutler	Treatment of sexual dysfunction in certain patient groups
US6194433B1 (en)	1998-10-05	2001-02-27	Neal R. Cutler	Sexual dysfunction in females
US6303135B1 (en)	1999-07-08	2001-10-16	Neal R. Cutler	Use of quinolines and quinolones to treat male erectile dysfunction
US6307050B1 (en) *	2000-08-29	2001-10-23	R. T. Alamo Venture I Llc	Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6458804B1 (en)	2001-01-26	2002-10-01	R.T. Alamo Venturesi, Llc	Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en)	2001-01-26	2003-05-13	R. T. Alamo Ventures I, L.L.C.	Treatment of cardiovascular disease with quinolinone enantiomers
US6451813B1 (en)	2001-01-26	2002-09-17	R. T. Alamo Ventures I, Llc	Treatment of gastroparesis in certain patient groups
US6573382B2 (en)	2001-06-29	2003-06-03	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en)	2001-06-29	2002-05-14	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en)	2001-06-29	2003-07-22	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en)	2001-06-29	2003-12-02	Grayson Walker Stowell	Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en)	2001-06-29	2003-03-11	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en)	2001-06-29	2003-12-09	Grayson Walker Stowell	Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
US6649764B2 (en)	2001-10-25	2003-11-18	R. T. Alamo Ventures I, Llc	Stereospecific enrichment of heterocyclic enantiomers
US7041677B2 (en) *	2002-03-01	2006-05-09	R.T. Alamo Ventures I, Llc	Use of monochloroflosequinan in the treatment of sexual dysfunction
US6730790B2 (en) *	2002-03-01	2004-05-04	R.T. Alamo Ventures I. Llc	Chlorinated heterocyclic compounds and methods of synthesis
CN103259027A (zh)	2005-04-28	2013-08-21	普罗透斯数字保健公司	药物信息系统
EP2063905B1 (en)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
CN102316902B (zh)	2009-02-20	2014-09-24	to-BBB控股股份有限公司	基于谷胱甘肽的药物递送系统
CN110075069A (zh)	2009-05-06	2019-08-02	实验室护肤股份有限公司	包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3920699A (en) *	1974-04-26	1975-11-18	Warner Lambert Co	Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby
US4192873A (en) *	1976-11-25	1980-03-11	Ciba-Geigy Corporation	Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones
NZ193167A (en) *	1979-03-27	1984-08-24	Boots Co Plc	Quinoline derivatives and pharmaceutical compositions
IE51542B1 (en) *	1980-09-26	1987-01-07	Boots Co Ltd	Therapeutic agents
FR2532939A1 (fr) *	1982-09-13	1984-03-16	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0149519B1 (en) *	1984-01-13	1990-06-27	The Boots Company PLC	Use of quinolones for the manufacture of a composition for the treatment of heart failure.
FR2566405B1 (fr) *	1984-06-25	1986-09-26	Roussel Uclaf	Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
GB8515209D0 (en) *	1985-06-15	1985-07-17	Boots Co Plc	Therapeutic agents
GB8627698D0 (en) *	1986-11-20	1986-12-17	Boots Co Plc	Therapeutic agents
GB8726950D0 (en) *	1987-11-18	1987-12-23	Boots Co Plc	Chemical process

1987
- 1987-11-18 GB GB878726950A patent/GB8726950D0/en active Pending
1988
- 1988-11-03 ZA ZA888241A patent/ZA888241B/xx unknown
- 1988-11-07 JP JP63508842A patent/JPH02502013A/ja active Pending
- 1988-11-07 ES ES198888310463T patent/ES2038310T3/es not_active Expired - Lifetime
- 1988-11-07 EP EP88909581A patent/EP0343206A1/en active Pending
- 1988-11-07 KR KR1019890701326A patent/KR890701563A/ko not_active Ceased
- 1988-11-07 EP EP88310463A patent/EP0317149B1/en not_active Expired - Lifetime
- 1988-11-07 HU HU886294A patent/HU204511B/hu not_active IP Right Cessation
- 1988-11-07 WO PCT/GB1988/000952 patent/WO1989004827A1/en active IP Right Grant
- 1988-11-07 DE DE8888310463T patent/DE3866086D1/de not_active Expired - Fee Related
- 1988-11-07 US US07/378,216 patent/US5011931A/en not_active Expired - Fee Related
- 1988-11-07 AU AU26163/88A patent/AU628305B2/en not_active Ceased
- 1988-11-07 AT AT88310463T patent/ATE69221T1/de not_active IP Right Cessation
- 1988-11-07 RO RO140740A patent/RO104615B1/ro unknown
- 1988-11-09 IE IE883366A patent/IE883366L/xx unknown
- 1988-11-09 PH PH37784A patent/PH27439A/en unknown
- 1988-11-10 IL IL88358A patent/IL88358A/xx unknown
- 1988-11-10 MX MX013748A patent/MX168918B/es unknown
- 1988-11-11 YU YU209788A patent/YU46989B/sh unknown
- 1988-11-11 TW TW077107879A patent/TW204344B/zh active
- 1988-11-15 CS CS748988A patent/CS274487B2/cs unknown
- 1988-11-16 DD DD88321853A patent/DD290188A5/de not_active IP Right Cessation
- 1988-11-17 PT PT89024A patent/PT89024B/pt not_active IP Right Cessation
- 1988-11-18 NZ NZ227008A patent/NZ227008A/en unknown
- 1988-11-18 PL PL1988275880A patent/PL157191B1/pl unknown
1989
- 1989-05-17 SU SU894614311A patent/SU1766255A3/ru active
- 1989-07-13 FI FI893405A patent/FI91063C/fi not_active IP Right Cessation
- 1989-07-17 BG BG089219A patent/BG50157A3/xx unknown
1991
- 1991-03-01 US US07/663,085 patent/US5079264A/en not_active Expired - Fee Related
- 1991-12-18 GR GR91402063T patent/GR3003378T3/el unknown

Also Published As

Publication number	Publication date
CS748988A2 (en)	1990-09-12
GR3003378T3 (en)	1993-02-17
EP0317149A1 (en)	1989-05-24
DD290188A5 (de)	1991-05-23
FI91063B (fi)	1994-01-31
YU209788A (en)	1990-08-31
WO1989004827A1 (en)	1989-06-01
NZ227008A (en)	1991-10-25
PT89024B (pt)	1993-02-26
CS274487B2 (en)	1991-04-11
GB8726950D0 (en)	1987-12-23
YU46989B (sh)	1994-09-09
IE883366L (en)	1989-05-18
PT89024A (pt)	1988-12-01
PL275880A1 (en)	1989-06-12
EP0343206A1 (en)	1989-11-29
BG50157A3 (bg)	1992-05-15
JPH02502013A (ja)	1990-07-05
HU204511B (en)	1992-01-28
KR890701563A (ko)	1989-12-21
RO104615B1 (en)	1992-11-03
AU2616388A (en)	1989-06-14
ZA888241B (en)	1989-10-25
FI893405L (fi)	1989-07-13
DE3866086D1 (de)	1991-12-12
US5011931A (en)	1991-04-30
ES2038310T3 (es)	1993-07-16
SU1766255A3 (ru)	1992-09-30
HUT53085A (en)	1990-09-28
TW204344B (fi)	1993-04-21
PH27439A (en)	1993-07-02
IL88358A0 (en)	1989-06-30
US5079264A (en)	1992-01-07
EP0317149B1 (en)	1991-11-06
FI91063C (fi)	1994-05-10
MX168918B (es)	1993-06-14
IL88358A (en)	1993-02-21
AU628305B2 (en)	1992-09-17
ATE69221T1 (de)	1991-11-15
PL157191B1 (pl)	1992-05-29

Publication	Publication Date	Title
FI893405A0 (fi)	1989-07-13	Menetelmä kinoloniyhdisteiden valmistamiseksi
DK506587A (da)	1988-03-27	Imidderivater
ES2093013T3 (es)	1996-12-16	Derivados de alcoxiiminoacetamida y su aplicacion como fungicidas.
NO902301D0 (no)	1990-05-23	Fremgangsmaate for fremstilling av diarylstyrylkinolin-disyrer.
NO902394D0 (no)	1990-05-30	Fremgangsmaate for fremstilling av pyranyl-cyanoguanidin-derivater.
NO842014L (no)	1984-11-28	Fremgangsmaate til fremstilling av beta-karbolin-3-karboksylsyrederivater
FI842533A (fi)	1984-12-24	Hexahydropyrrolo/2,1-a/isokinolin- derivat.
NO892973L (no)	1990-01-22	Fremgangsmaate for fremstilling av substituerte guanyltiourinstoff-forbindelser.
MA21366A1 (fr)	1989-04-01	Herbicides a base de diphenylether.
DK46884D0 (da)	1984-02-02	5-aminomethyl-imidazol-1-yl-1,3-dialkyl-1h-pyrazol-4-yl-aroyl-methanoner,fremgangsmaade til deres fremstilling samt deres anvendelse
DE69213049D1 (de)	1996-10-02	Isoquinolinderivate
DK669388D0 (da)	1988-11-30	Azolderivater
DK277787D0 (da)	1987-05-29	Azaphospholener og deres anvendelse
GR3002699T3 (en)	1993-01-25	Process for stabilising procaterol
DK305182A (da)	1982-07-07	Biologisk aktive heterobicycliske hydroximidater og thiolhydroximidater samt carbamatesterderivater deraf

Legal Events

Date	Code	Title	Description
1994-01-03	BB	Publication of examined application
1995-06-12	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: THE BOOTS COMPANY PLC