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BG50157A3 - Метод за получаване на производни на хинолина - Google Patents

Метод за получаване на производни на хинолина

Info

Publication number
BG50157A3
BG50157A3 BG089219A BG8921989A BG50157A3 BG 50157 A3 BG50157 A3 BG 50157A3 BG 089219 A BG089219 A BG 089219A BG 8921989 A BG8921989 A BG 8921989A BG 50157 A3 BG50157 A3 BG 50157A3
Authority
BG
Bulgaria
Prior art keywords
quinoline derivatives
formula
value
obtaining
obtaining quinoline
Prior art date
Application number
BG089219A
Other languages
English (en)
Inventor
Lachlan Maclean
David Roberts
Kenneth Barron
Kenneth Nichol
Original Assignee
The Boots Company Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Boots Company Plc filed Critical The Boots Company Plc
Publication of BG50157A3 publication Critical patent/BG50157A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Производните на хинолина намират приложение в медицината за третиране на сърдечни заболявания и имат ценни терапевтични свойства. По метода се получаватсъединения с формулав която n има стойност 0, 1 или 2, и се състои в това, че се циклизират съединения с формула в която n има стойност 0, 1 или 2. Циклизацията се осъществява или в присъствието на органична или неорганична база, или термично при температура от 40 до 1600с. 11 претенции
BG089219A 1987-11-18 1989-07-17 Метод за получаване на производни на хинолина BG50157A3 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878726950A GB8726950D0 (en) 1987-11-18 1987-11-18 Chemical process
PCT/GB1988/000952 WO1989004827A1 (en) 1987-11-18 1988-11-07 Process for the synthesis of 3-thio-4-quinolone derivatives and intermediate compounds for use therein, and their use as medicaments

Publications (1)

Publication Number Publication Date
BG50157A3 true BG50157A3 (bg) 1992-05-15

Family

ID=10627131

Family Applications (1)

Application Number Title Priority Date Filing Date
BG089219A BG50157A3 (bg) 1987-11-18 1989-07-17 Метод за получаване на производни на хинолина

Country Status (28)

Country Link
US (2) US5011931A (bg)
EP (2) EP0343206A1 (bg)
JP (1) JPH02502013A (bg)
KR (1) KR890701563A (bg)
AT (1) ATE69221T1 (bg)
AU (1) AU628305B2 (bg)
BG (1) BG50157A3 (bg)
CS (1) CS274487B2 (bg)
DD (1) DD290188A5 (bg)
DE (1) DE3866086D1 (bg)
ES (1) ES2038310T3 (bg)
FI (1) FI91063C (bg)
GB (1) GB8726950D0 (bg)
GR (1) GR3003378T3 (bg)
HU (1) HU204511B (bg)
IE (1) IE883366L (bg)
IL (1) IL88358A (bg)
MX (1) MX168918B (bg)
NZ (1) NZ227008A (bg)
PH (1) PH27439A (bg)
PL (1) PL157191B1 (bg)
PT (1) PT89024B (bg)
RO (1) RO104615B1 (bg)
SU (1) SU1766255A3 (bg)
TW (1) TW204344B (bg)
WO (1) WO1989004827A1 (bg)
YU (1) YU46989B (bg)
ZA (1) ZA888241B (bg)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process
GB8804016D0 (en) * 1988-02-22 1988-03-23 Boots Co Plc Therapeutic agents
US6110489A (en) * 1998-05-01 2000-08-29 Cutler; Neal R. Use of quinolines and quinolones to treat male erectile dysfunction
US6132757A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132753A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6194433B1 (en) 1998-10-05 2001-02-27 Neal R. Cutler Sexual dysfunction in females
US6303135B1 (en) 1999-07-08 2001-10-16 Neal R. Cutler Use of quinolines and quinolones to treat male erectile dysfunction
US6307050B1 (en) * 2000-08-29 2001-10-23 R. T. Alamo Venture I Llc Method of synthesizing flosequinan from 4-fluoroanthranilic acid
US6458804B1 (en) 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6573382B2 (en) 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6657061B2 (en) 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6660864B2 (en) 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6649764B2 (en) 2001-10-25 2003-11-18 R. T. Alamo Ventures I, Llc Stereospecific enrichment of heterocyclic enantiomers
US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US6730790B2 (en) * 2002-03-01 2004-05-04 R.T. Alamo Ventures I. Llc Chlorinated heterocyclic compounds and methods of synthesis
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
CN102316902B (zh) 2009-02-20 2014-09-24 to-BBB控股股份有限公司 基于谷胱甘肽的药物递送系统
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920699A (en) * 1974-04-26 1975-11-18 Warner Lambert Co Process for the cyclization of aryl(methylsulfinyl)-methyl ketones and compounds produced thereby
US4192873A (en) * 1976-11-25 1980-03-11 Ciba-Geigy Corporation Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones
NZ193167A (en) * 1979-03-27 1984-08-24 Boots Co Plc Quinoline derivatives and pharmaceutical compositions
IE51542B1 (en) * 1980-09-26 1987-01-07 Boots Co Ltd Therapeutic agents
FR2532939A1 (fr) * 1982-09-13 1984-03-16 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur preparation, leur application comme medicament, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0149519B1 (en) * 1984-01-13 1990-06-27 The Boots Company PLC Use of quinolones for the manufacture of a composition for the treatment of heart failure.
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
GB8515209D0 (en) * 1985-06-15 1985-07-17 Boots Co Plc Therapeutic agents
GB8627698D0 (en) * 1986-11-20 1986-12-17 Boots Co Plc Therapeutic agents
GB8726950D0 (en) * 1987-11-18 1987-12-23 Boots Co Plc Chemical process

Also Published As

Publication number Publication date
CS748988A2 (en) 1990-09-12
GR3003378T3 (en) 1993-02-17
EP0317149A1 (en) 1989-05-24
DD290188A5 (de) 1991-05-23
FI91063B (fi) 1994-01-31
YU209788A (en) 1990-08-31
WO1989004827A1 (en) 1989-06-01
NZ227008A (en) 1991-10-25
PT89024B (pt) 1993-02-26
CS274487B2 (en) 1991-04-11
GB8726950D0 (en) 1987-12-23
YU46989B (sh) 1994-09-09
IE883366L (en) 1989-05-18
FI893405A0 (fi) 1989-07-13
PT89024A (pt) 1988-12-01
PL275880A1 (en) 1989-06-12
EP0343206A1 (en) 1989-11-29
JPH02502013A (ja) 1990-07-05
HU204511B (en) 1992-01-28
KR890701563A (ko) 1989-12-21
RO104615B1 (en) 1992-11-03
AU2616388A (en) 1989-06-14
ZA888241B (en) 1989-10-25
FI893405L (fi) 1989-07-13
DE3866086D1 (de) 1991-12-12
US5011931A (en) 1991-04-30
ES2038310T3 (es) 1993-07-16
SU1766255A3 (ru) 1992-09-30
HUT53085A (en) 1990-09-28
TW204344B (bg) 1993-04-21
PH27439A (en) 1993-07-02
IL88358A0 (en) 1989-06-30
US5079264A (en) 1992-01-07
EP0317149B1 (en) 1991-11-06
FI91063C (fi) 1994-05-10
MX168918B (es) 1993-06-14
IL88358A (en) 1993-02-21
AU628305B2 (en) 1992-09-17
ATE69221T1 (de) 1991-11-15
PL157191B1 (pl) 1992-05-29

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