KR900700495A - 치료제로서 유용한 치환된 아데닌 유도체 - Google Patents

치료제로서 유용한 치환된 아데닌 유도체

Info

Publication number: KR900700495A
Authority: KR; South Korea
Prior art keywords: therapeutic agents; adenine derivatives; derivatives useful; substituted adenine; formula
Prior art date: 1988-03-16

Application number

KR1019890702130A

Other languages

English (en)

Other versions

KR0138996B1 (ko

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-16

Filing date

1989-11-16

Publication date

1990-08-13

1989-03-16 Application filed filed Critical

1990-08-13 Publication of KR900700495A publication Critical patent/KR900700495A/ko

1998-04-30 Application granted granted Critical

1998-04-30 Publication of KR0138996B1 publication Critical patent/KR0138996B1/ko

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/19—Purine radicals with arabinosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Table Equipment (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Orthopedics, Nursing, And Contraception (AREA)

KR1019890702130A 1988-03-16 1989-03-16 치환된 아데닌 유도체 및 이를 함유하는 약제학적 조성물 KR0138996B1 (ko)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US16961888A	1988-03-16	1988-03-16
US?169,618?		1988-03-16
US32335089A	1989-03-14	1989-03-14
US?323,350?		1989-03-14
PCT/US1989/001088 WO1989008658A1 (en)	1988-03-16	1989-03-16	Substituted adenine derivatives useful as therapeutic agents

Publications (2)

Publication Number	Publication Date
KR900700495A true KR900700495A (ko)	1990-08-13
KR0138996B1 KR0138996B1 (ko)	1998-04-30

Family

ID=26865224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1019890702130A KR0138996B1 (ko)	1988-03-16	1989-03-16	치환된 아데닌 유도체 및 이를 함유하는 약제학적 조성물

Country Status (9)

Country	Link
EP (1)	EP0364559B1 (ko)
JP (1)	JP3090456B2 (ko)
KR (1)	KR0138996B1 (ko)
AT (1)	ATE128141T1 (ko)
AU (1)	AU626296B2 (ko)
CA (1)	CA1339964C (ko)
DE (1)	DE68924319T2 (ko)
FI (1)	FI895447A0 (ko)
WO (1)	WO1989008658A1 (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5384310A (en) *	1989-05-23	1995-01-24	Southern Research Institute	2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions
US5034518A (en) *	1989-05-23	1991-07-23	Southern Research Institute	2-fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine nucleosides
US5420115A (en) *	1990-09-10	1995-05-30	Burroughs Wellcome Co.	Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides
WO1992011276A1 (en) *	1990-12-18	1992-07-09	Sloan-Kettering Institute For Cancer Research	Novel synthesis of 2'-'up' fluorinated 2''-deoxy-arabinofuranosylpurines
GB9301000D0 (en) *	1993-01-20	1993-03-10	Glaxo Group Ltd	Chemical compounds
IL108524A0 (en) *	1993-02-03	1994-05-30	Gensia Inc	Imidazodiazepine analogs
AU735319B2 (en) *	1994-05-26	2001-07-05	Scripps Research Institute, The	2-halo-2'-deoxyadenosine treatment for inflammatory bowel disease
AU7470794A (en) *	1994-05-26	1995-12-21	Scripps Research Institute, The	2-halo-2'-deoxyadenosine treatement for inflammatory bowel disease
US5559114A (en) *	1994-12-16	1996-09-24	Exley; Ray W.	Treatment of autoimmune disease using 2-amino purine derivatives
DE19832519A1 (de) *	1998-07-20	2000-01-27	Hartmut Oswald	Arzneimittelzubereitungen zur topischen Behandlung mukokutaner Herpesinfektionen sowie der Keratitis herpetica des Auges
WO2001060383A1 (en)	2000-02-18	2001-08-23	Southern Research Institute	METHODS FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO-β-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE
US7528247B2 (en)	2001-08-02	2009-05-05	Genzyme Corporation	Process for preparing purine nucleosides
CA2500360A1 (en) *	2002-09-27	2004-04-08	Bioenvision, Inc.	Methods and compositions for the treatment of autoimmune disorders using clofarabine
EP1551386A4 (en) *	2002-09-27	2009-03-25	Bioenvision Inc	METHOD AND COMPOSITIONS FOR TREATING LUPUS WITH CLOFARABIN
EP1768662A2 (en)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Small molecule immunopotentiators and assays for their detection
JP6510621B2 (ja) *	2017-11-29	2019-05-08	華安醫學股分有限公司ＥｎｅｒｇｅｎｅｓｉｓＢｉｏｍｅｄｉｃａｌＣｏ．，Ｌｔｄ．	活性化ａｍｐｋの化合物及びその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3539550A (en) *	1967-01-23	1970-11-10	Syntex Corp	Process for the preparation of 2'-halo-2'-deoxy pyrimidine nucleosides
US3472838A (en) *	1967-12-01	1969-10-14	Parke Davis & Co	9 - (beta - d - arabinofuranosyl) - 6 - (amidino) purine compounds and methods for their production
BE759011A (fr) *	1969-11-17	1971-05-17	Wellcome Found	Aminopurines
GB1386585A (en) *	1970-11-16	1975-03-12	Wellcome Found	Purine sugar derivatives
US4081534A (en) *	1973-09-11	1978-03-28	Burroughs Wellcome Co.	Amino purine nucleosides as autoimmune suppressant agents
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
US4751221A (en) *	1985-10-18	1988-06-14	Sloan-Kettering Institute For Cancer Research	2-fluoro-arabinofuranosyl purine nucleosides
GB8708050D0 (en) *	1987-04-03	1987-05-07	Wellcome Found	Therapeutic nucleosides
CA1340645C (en) *	1987-04-17	1999-07-13	Victor E. Marquez	Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
EP0314011A3 (de) *	1987-10-30	1990-04-11	F. Hoffmann-La Roche Ag	Purinderivate

1989
- 1989-03-16 AT AT89904431T patent/ATE128141T1/de not_active IP Right Cessation
- 1989-03-16 EP EP89904431A patent/EP0364559B1/en not_active Expired - Lifetime
- 1989-03-16 DE DE68924319T patent/DE68924319T2/de not_active Expired - Lifetime
- 1989-03-16 KR KR1019890702130A patent/KR0138996B1/ko not_active IP Right Cessation
- 1989-03-16 WO PCT/US1989/001088 patent/WO1989008658A1/en active IP Right Grant
- 1989-03-16 JP JP01504299A patent/JP3090456B2/ja not_active Expired - Lifetime
- 1989-03-16 CA CA000593979A patent/CA1339964C/en not_active Expired - Lifetime
- 1989-03-16 AU AU34105/89A patent/AU626296B2/en not_active Expired
- 1989-11-15 FI FI895447A patent/FI895447A0/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0364559A4 (en)	1991-01-09
EP0364559A1 (en)	1990-04-25
AU626296B2 (en)	1992-07-30
JPH03501258A (ja)	1991-03-22
ATE128141T1 (de)	1995-10-15
FI895447A0 (fi)	1989-11-15
CA1339964C (en)	1998-07-21
EP0364559B1 (en)	1995-09-20
DE68924319T2 (de)	1996-05-15
AU3410589A (en)	1989-10-05
JP3090456B2 (ja)	2000-09-18
DE68924319D1 (de)	1995-10-26
WO1989008658A1 (en)	1989-09-21
KR0138996B1 (ko)	1998-04-30

Publication	Publication Date	Title
FI943805A0 (fi)	1994-08-18	Substituoituja adeniinijohdannaisten käyttö multippeliskleroosin hoitoon
KR900700495A (ko)	1990-08-13	치료제로서 유용한 치환된 아데닌 유도체
DE3774918D1 (de)	1992-01-16	Cancerostatisches mittel.
DE69324151D1 (de)	1999-04-29	Inhibitoren des arginin-ketoamid-enzyms
EA199900494A1 (ru)	2000-02-28	Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
DE69333109D1 (de)	2003-08-28	Therapeutische nukleoside
UA11192A (uk)	1996-12-25	Спосіб отримаhhя похідhих заміщеhого
EP0444196A4 (en)	1991-11-27	Agent for treatment and prophylaxis of ischemic disease of heart or brain
DK162883D0 (da)	1983-04-13	N-glucosylerede carboxylsyreamidderivater, fremgangsmade til fremstilling heraf samt deres anvendelse til pavirkning af organismens egen forsvarsmekanisme
ATE78465T1 (de)	1992-08-15	Kathartica.
ATE69953T1 (de)	1991-12-15	Verwendung von polysulfatierten heparinen.
FR2445834A1 (fr)	1980-08-01	Derives heterobicycliques de l'acide 7-acylamido-3-cephem-4-carboxylique insature, procedes de preparation de ceux-ci et utilisation en therapeutique
ES507807A0 (es)	1982-10-01	Procedimiento para la obtencion de derivados triciclicos de citosina.
ES2039408T3 (es)	1993-10-01	Un procedimiento para preparar un compuesto de tienotriazolodiazepina.
DK621487A (da)	1988-01-26	Fremgangsmaade til oegning af adenosinexkretion
ES2039196T3 (es)	1993-09-16	Procedimiento para preparar 4-(1,2,5,6-tetrahidro-1-alquil-3-piridinil)-2-tiazolaminas y 4-(hexahidro-1-alquil-3-piridinil)-2-tiazolaminas.
DE68927651D1 (de)	1997-02-27	Derivate von Fluorphosphonat-Nukleotiden
ES2016464A6 (es)	1990-11-01	Procedimiento para preparar derivados de 2', 5' -oligoadenilato.
EA200000448A1 (ru)	2000-10-30	Новые полиморфные формы ципамфиллина
FR2419291A1 (fr)	1979-10-05	2,3-dihydroimidazo(1,2-c)pyrimidines substituees et leur utilisation therapeutique
DK277387A (da)	1987-12-01	Terapeutisk topikal sammensaetning mod en hyperprolifererende epithelsygdom
ES2018807B3 (es)	1991-05-16	Procedimiento para curtir el cuero
ATE130194T1 (de)	1995-12-15	Subkutane verabreichung des humanen choriongonadotropins.
ES2055440T3 (es)	1994-08-16	Derivados del acido quinurenico, su preparacion y composiciones farmaceuticas que los contienen.
DK572189A (da)	1989-11-15	Substituerede adeninderivater og farmaceutisk praeparat indeholdende dem

Legal Events

Date	Code	Title	Description
1989-11-16	PA0109	Patent application	Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19891116
1990-08-13	PG1501	Laying open of application
1994-03-15	A201	Request for examination
1994-03-15	PA0201	Request for examination	Patent event code: PA02012R01D Patent event date: 19940315 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19891116 Comment text: Patent Application
1997-07-30	E902	Notification of reason for refusal
1997-07-30	PE0902	Notice of grounds for rejection	Comment text: Notification of reason for refusal Patent event date: 19970730 Patent event code: PE09021S01D
1997-12-16	E701	Decision to grant or registration of patent right
1997-12-16	PE0701	Decision of registration	Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 19971216
1998-02-24	GRNT	Written decision to grant
1998-02-24	PR0701	Registration of establishment	Comment text: Registration of Establishment Patent event date: 19980224 Patent event code: PR07011E01D
1998-02-24	PR1002	Payment of registration fee	Payment date: 19980224 End annual number: 3 Start annual number: 1
1998-04-30	PG1601	Publication of registration
2000-11-22	PR1001	Payment of annual fee	Payment date: 20001123 Start annual number: 4 End annual number: 4
2001-12-05	PR1001	Payment of annual fee	Payment date: 20011206 Start annual number: 5 End annual number: 5
2002-12-05	PR1001	Payment of annual fee	Payment date: 20021206 Start annual number: 6 End annual number: 6
2004-01-09	PR1001	Payment of annual fee	Payment date: 20040112 Start annual number: 7 End annual number: 7
2004-12-06	PR1001	Payment of annual fee	Payment date: 20041206 Start annual number: 8 End annual number: 8
2005-12-07	PR1001	Payment of annual fee	Payment date: 20051208 Start annual number: 9 End annual number: 9
2006-11-30	PR1001	Payment of annual fee	Payment date: 20061201 Start annual number: 10 End annual number: 10
2007-11-22	PR1001	Payment of annual fee	Payment date: 20071123 Start annual number: 11 End annual number: 11
2008-12-18	PR1001	Payment of annual fee	Payment date: 20081219 Start annual number: 12 End annual number: 12
2010-01-08	PR1001	Payment of annual fee	Payment date: 20100111 Start annual number: 13 End annual number: 13
2011-02-15	PR1001	Payment of annual fee	Payment date: 20110216 Start annual number: 14 End annual number: 14
2012-02-23	FPAY	Annual fee payment	Payment date: 20120224 Year of fee payment: 15
2012-02-23	PR1001	Payment of annual fee	Payment date: 20120224 Start annual number: 15 End annual number: 15
2013-02-25	EXPY	Expiration of term
2013-02-25	PC1801	Expiration of term	Termination date: 20131022 Termination category: Expiration of duration