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YU47063B - Postupak sinteze amikacina - Google Patents

Postupak sinteze amikacina

Info

Publication number
YU47063B
YU47063B YU218888A YU218888A YU47063B YU 47063 B YU47063 B YU 47063B YU 218888 A YU218888 A YU 218888A YU 218888 A YU218888 A YU 218888A YU 47063 B YU47063 B YU 47063B
Authority
YU
Yugoslavia
Prior art keywords
sinteze
amikacina
postupak
acylation
reaction
Prior art date
Application number
YU218888A
Other languages
English (en)
Other versions
YU218888A (en
Inventor
A. Maniga
Original Assignee
Pierrel S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel S.P.A. filed Critical Pierrel S.P.A.
Publication of YU218888A publication Critical patent/YU218888A/xx
Publication of YU47063B publication Critical patent/YU47063B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Insulating Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymerisation Methods In General (AREA)
  • Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

POSTUPAK SINTEZE AMIKACINA, formule acilira, pri čemu se to aciliranje vrši jednim derivativom L-(-)-4-amino-2-hidroksibutiračne kiseline (L-HABA), s tim što se zaštitne početne grupe zatim uklanjaju iz proizvoda reakcije pomoću poznatih postupaka, naznačen time, što se to aciliranje vrši korišćenjem kao reakcionog rastvarača samo vode i regulisanjem pH na vrednost izmedju 3 i 10, pri čemu je temperatura reakcije izmedju 0 i 60В°C. Prijava sadrži još 6 zavisnih zahteva.
YU218888A 1987-11-27 1988-11-28 Postupak sinteze amikacina YU47063B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8722783A IT1225484B (it) 1987-11-27 1987-11-27 Procedimento di sintesi dell'amikacina

Publications (2)

Publication Number Publication Date
YU218888A YU218888A (en) 1989-12-31
YU47063B true YU47063B (sh) 1994-12-28

Family

ID=11200418

Family Applications (1)

Application Number Title Priority Date Filing Date
YU218888A YU47063B (sh) 1987-11-27 1988-11-28 Postupak sinteze amikacina

Country Status (23)

Country Link
US (1) US5763587A (sh)
EP (1) EP0317970B1 (sh)
JP (1) JPH0637512B2 (sh)
AT (1) ATE125544T1 (sh)
AU (1) AU608665B2 (sh)
BG (1) BG49048A3 (sh)
CA (1) CA1324375C (sh)
CS (1) CS277017B6 (sh)
DD (1) DD283564A5 (sh)
DE (1) DE3854225T2 (sh)
DK (1) DK170050B1 (sh)
ES (1) ES2074431T3 (sh)
FI (1) FI90243C (sh)
HU (1) HU201771B (sh)
IT (1) IT1225484B (sh)
NO (1) NO171505C (sh)
NZ (1) NZ227113A (sh)
PH (1) PH25818A (sh)
PL (1) PL161416B1 (sh)
RO (1) RO102339B1 (sh)
RU (1) RU1776262C (sh)
YU (1) YU47063B (sh)
ZA (1) ZA888855B (sh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW465235B (en) 1998-09-17 2001-11-21 United Video Properties Inc Electronic program guide with digital storage
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
BRPI0616642A2 (pt) 2005-09-29 2011-06-28 Nektar Therapeutics formulações de antibióticos, doses unitárias, kits e métodos
ES2707787T3 (es) 2005-12-02 2019-04-05 Ionis Pharmaceuticals Inc Análogos antibacterianos de aminoglucósido 4,5-sustituidos que tienen sustituyentes múltiples
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US20080300199A1 (en) * 2007-04-10 2008-12-04 Achaogen Inc. Antibacterial 1,4,5-substituted aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
AU2009299118B2 (en) 2008-10-03 2015-12-17 Glycan Biosciences Llc Anionic conjugates of glycosylated bacterial metabolite
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
CA2777107A1 (en) 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
EP2640735A1 (en) 2010-11-17 2013-09-25 Achaogen, Inc. Antibacterial amiinoglycoside analogs
CN103113429B (zh) * 2013-03-05 2015-02-18 齐鲁天和惠世制药有限公司 一种由阿米卡星制备硫酸阿米卡星的方法
CN105440090B (zh) * 2014-08-27 2018-03-09 北大医药重庆大新药业股份有限公司 一种阿米卡星的合成方法
CN111233952A (zh) * 2020-04-02 2020-06-05 管炫棣 一种阿卡米星的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL157910B (nl) * 1973-11-14 1978-09-15 Bristol Myers Co Werkwijze voor het bereiden van 1-(l-(-)-gamma-amino-alfa-hydroxybutyryl)kanamycine a.
JPS51127045A (en) * 1975-04-24 1976-11-05 Microbial Chem Res Found A process for preparing 3'- deoxykanamycin a derivatives.
GB1530201A (en) * 1976-04-14 1978-10-25 Pfizer Ltd Process for the preparation of aminoglycoside antibiotics and intermediates therefor
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
IE54288B1 (en) * 1982-03-05 1989-08-16 Fujisawa Pharmaceutical Co New 1,4-diaminocyclitol derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS6041692A (ja) * 1983-08-15 1985-03-05 Microbial Chem Res Found ２′，３′−ジデオキシカナマイシンａ誘導体
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina

Also Published As

Publication number Publication date
JPH0637512B2 (ja) 1994-05-18
HUT49144A (en) 1989-08-28
BG49048A3 (en) 1991-07-15
CS277017B6 (en) 1992-11-18
DK661588A (da) 1989-05-28
FI885489A (fi) 1989-05-28
DK170050B1 (da) 1995-05-08
HU201771B (en) 1990-12-28
AU608665B2 (en) 1991-04-11
FI90243B (fi) 1993-09-30
ATE125544T1 (de) 1995-08-15
ZA888855B (en) 1990-02-28
RU1776262C (ru) 1992-11-15
PL276047A1 (en) 1989-07-10
US5763587A (en) 1998-06-09
EP0317970A3 (en) 1991-08-28
FI885489A0 (fi) 1988-11-25
NO885270D0 (no) 1988-11-25
YU218888A (en) 1989-12-31
ES2074431T3 (es) 1995-09-16
DK661588D0 (da) 1988-11-25
PL161416B1 (pl) 1993-06-30
DE3854225T2 (de) 1996-01-04
NZ227113A (en) 1991-01-29
NO171505B (no) 1992-12-14
RO102339B1 (ro) 1992-08-01
NO885270L (no) 1989-05-29
AU2596388A (en) 1989-06-01
DD283564A5 (de) 1990-10-17
EP0317970A2 (en) 1989-05-31
DE3854225D1 (de) 1995-08-31
CA1324375C (en) 1993-11-16
EP0317970B1 (en) 1995-07-26
IT8722783A0 (it) 1987-11-27
PH25818A (en) 1991-11-05
CS777988A3 (en) 1992-06-17
JPH01186900A (ja) 1989-07-26
IT1225484B (it) 1990-11-14
FI90243C (fi) 1994-01-10
NO171505C (no) 1993-03-24

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