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ES2036183T3 - Procedimiento para preparar un derivado de oxabicicloheptano. - Google Patents

Procedimiento para preparar un derivado de oxabicicloheptano.

Info

Publication number
ES2036183T3
ES2036183T3 ES198787102795T ES87102795T ES2036183T3 ES 2036183 T3 ES2036183 T3 ES 2036183T3 ES 198787102795 T ES198787102795 T ES 198787102795T ES 87102795 T ES87102795 T ES 87102795T ES 2036183 T3 ES2036183 T3 ES 2036183T3
Authority
ES
Spain
Prior art keywords
group
sup
defined above
pharmaceutically acceptable
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787102795T
Other languages
English (en)
Inventor
Toshio Tatsuoka
Kenji Suzuki
Kayoko Imao
Fumio Satoh
Seiji Miyano
Kunihiro Sumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2036183T3 publication Critical patent/ES2036183T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO DERIVADO DE OXABICICLOHEPTANO DE FORMULA (I), Y DE UNA SAL FARMACEUTICAMENTE ACEPTABLE DE EL, SIENDO D UN ATOMO DE H, HALOGENO, UN GRUPO OH, ALCOXI, ARILALCOXI, ACILOXI, DIALQUILCARBAMOILOXI; O AMIDOALQUILOXI; B ES UN GRUPO FENILO, TIENILO O FURILO; A ES EL GRUPO (II) EN EL QUE L ES CERO O 1; M Y N SON 1 O MAYOR TENIENDO M+N UN VALOR ENTRE 2 Y 8; R1 ES UN GRUPO ALQUILAMINO, DIALQUILAMINO, MORFOLINO, TIOMORFOLINO, L-PIRROLIDINILO, PIPERIDINO, N-ALQUILPIPERAZINILO; N-HIDROXIALQUILPIPERAZINILO O PIRROLIZIDINILO; Y R2 ES UN GRUPO ALQUILO O HIDROXILO O EL GRUPO (III) DEL QUE SE DEFINEN LOS DIFERENTES VALORES DE LOS RADICALES. LOS DERIVADOS DE LA INVENCION Y SUS SALES FARMACEUTICAMENTE ACEPTABLES PUEDEN EMPLEARSE EN LA PREPARACION DE MEDICAMENTOS EFECTIVOS PARA MEJORAR O ELIMINAR LOS SINTOMAS QUE APARECEN COMO RESULTADO DE DESORDENES ORGANICOS EN EL CEREBRO O A CAUSA DE PATERGASIA. TIENEN TAMBIEN EFECTOS ANTIDEPRESIVOS Y SON UTILES COMO PSICOFARMACOS.EN ESTA INVEMCION SE INCLUYE TAMBIEN UNA COMPOSICION FARMACEUTICA CON EL COMPUESTO INDICADO COMO INGREDIENTE ACTIVO Y UN VEHICULO FARMACEUTICAMENTE ACEPTABLE.
ES198787102795T 1986-02-27 1987-02-27 Procedimiento para preparar un derivado de oxabicicloheptano. Expired - Lifetime ES2036183T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61042732A JPH0723367B2 (ja) 1986-02-27 1986-02-27 オキサビシクロヘプタン誘導体

Publications (1)

Publication Number Publication Date
ES2036183T3 true ES2036183T3 (es) 1993-05-16

Family

ID=12644212

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787102795T Expired - Lifetime ES2036183T3 (es) 1986-02-27 1987-02-27 Procedimiento para preparar un derivado de oxabicicloheptano.

Country Status (8)

Country Link
US (1) US4713453A (es)
EP (1) EP0238883B1 (es)
JP (1) JPH0723367B2 (es)
AT (1) ATE52506T1 (es)
CA (1) CA1300138C (es)
DE (1) DE3762621D1 (es)
ES (1) ES2036183T3 (es)
GR (2) GR3000693T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401850A (en) * 1990-06-06 1995-03-28 Suntory Limited Cyclopropachromen derivatives
CA2037187A1 (en) * 1990-06-06 1991-12-07 Toshio Tatsuoka Cyclopropachromen derivatives
JP3089040B2 (ja) * 1990-06-06 2000-09-18 サントリー株式会社 脳神経変性性疾患治療剤
JP3993651B2 (ja) * 1994-10-21 2007-10-17 アスビオファーマ株式会社 シクロプロパクロメンカルボン酸誘導体
AU2005320585A1 (en) * 2004-12-28 2006-07-06 Asubio Pharma Co., Ltd. Process for producing carbon-diminished aldose compound
IT1400964B1 (it) * 2010-06-15 2013-07-05 Dipharma Francis Srl Procedimento per la preparazione di derivati pteridinici
WO2016134257A1 (en) 2015-02-19 2016-08-25 Lixter Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468897A (en) * 1966-10-05 1969-09-23 Pierre Fournari Certain 6-amino-2-(aryl or heteroaryl)-4-chromanone-hydrazones and derivatives
JPS5829782A (ja) * 1981-08-12 1983-02-22 Nippon Zoki Pharmaceut Co Ltd 新規複素環化合物、その製法及び該化合物を含有する医薬組成物

Also Published As

Publication number Publication date
GR3000693T3 (en) 1991-09-27
JPH0723367B2 (ja) 1995-03-15
JPS62198676A (ja) 1987-09-02
EP0238883A1 (en) 1987-09-30
CA1300138C (en) 1992-05-05
DE3762621D1 (de) 1990-06-13
EP0238883B1 (en) 1990-05-09
GR900300046T1 (en) 1991-07-31
US4713453A (en) 1987-12-15
ATE52506T1 (de) 1990-05-15

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