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ES2019243A6 - Procedimiento para preparar nuevos derivados de tieno-triazolo-diazepina. - Google Patents

Procedimiento para preparar nuevos derivados de tieno-triazolo-diazepina.

Info

Publication number
ES2019243A6
ES2019243A6 ES9000912A ES9000912A ES2019243A6 ES 2019243 A6 ES2019243 A6 ES 2019243A6 ES 9000912 A ES9000912 A ES 9000912A ES 9000912 A ES9000912 A ES 9000912A ES 2019243 A6 ES2019243 A6 ES 2019243A6
Authority
ES
Spain
Prior art keywords
tieno
triazolo
procedure
new derivatives
diazepina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9000912A
Other languages
English (en)
Inventor
Pierre Braquet
Andre Esanu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES2019243A6 publication Critical patent/ES2019243A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS DE TIENO-TRIAZOLO-DIZEPINA DE FORMULA FORMULA EN DONDE <Y> REPRESENTA OXIGENO O AZUFRE Y <R> REPRESENTA DIVERSOS SUSTITUYENTES, QUE CONSISTE EN HACER REACCIONAR BAJO CIRCULACION DE NITROGENO, UN EXCESO DE UN COMPUESTO DE TIENO-TRIAZONOLO-DIAZEPINA DE FORMULA II DADA EN LA MEMORIA DESCRIPTIVA, CON EL APROPIADO DERIVADO DE R - N = C = Y EN DONDE <R> E <Y> SON COMO ANTES SE DEFINEN, EN EL SENO DE UN DISOLVENTE APROTICO Y A UNA TEMPERATURA COMPRENDIDA ENTRE LA TEMPERATURA Y APROXIMADAMENTE 70GC.
ES9000912A 1989-03-31 1990-03-30 Procedimiento para preparar nuevos derivados de tieno-triazolo-diazepina. Expired - Lifetime ES2019243A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898907256A GB8907256D0 (en) 1989-03-31 1989-03-31 New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors

Publications (1)

Publication Number Publication Date
ES2019243A6 true ES2019243A6 (es) 1991-06-01

Family

ID=10654231

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9000912A Expired - Lifetime ES2019243A6 (es) 1989-03-31 1990-03-30 Procedimiento para preparar nuevos derivados de tieno-triazolo-diazepina.

Country Status (30)

Country Link
US (1) US5492906A (es)
JP (1) JPH07103127B2 (es)
KR (1) KR900014396A (es)
AT (1) AT394561B (es)
AU (1) AU622007B2 (es)
BE (1) BE1003699A3 (es)
CA (1) CA2013518C (es)
CH (1) CH680365A5 (es)
DE (1) DE4010316C2 (es)
DK (1) DK80890A (es)
ES (1) ES2019243A6 (es)
FI (1) FI95036C (es)
FR (2) FR2645022B1 (es)
GB (2) GB8907256D0 (es)
GR (1) GR1000394B (es)
HK (1) HK95192A (es)
IE (1) IE64564B1 (es)
IN (1) IN174015B (es)
IT (1) IT1240350B (es)
LU (1) LU87710A1 (es)
MA (1) MA21790A1 (es)
MY (1) MY105538A (es)
NL (1) NL194827C (es)
NO (1) NO173784C (es)
NZ (1) NZ233011A (es)
OA (1) OA09442A (es)
PT (1) PT93629B (es)
SE (1) SE505417C2 (es)
TN (1) TNSN90042A1 (es)
ZA (1) ZA901765B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
US5221671A (en) * 1988-10-31 1993-06-22 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5304553A (en) * 1988-10-31 1994-04-19 Eisai Co., Ltd. 1,4-diazepine derivative and its pharmaceutical use
US5382579A (en) * 1988-10-31 1995-01-17 Eisai Co., Ltd. Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
ES2061406B1 (es) * 1993-05-07 1995-06-01 Uriach & Cia Sa J Nuevos derivados de la 2-(quinolina) con actividad farmacologica.
FI101989B1 (fi) * 1996-11-22 1998-09-30 Enso Oy Menetelmät neste- ja kaasutiiviin pakkauskartongin sekä pakkauksen valmistamiseksi sekä menetelmien mukaisesti valmistetut tuotteet
CA2294139A1 (en) 1997-06-25 1998-12-30 Nikken Chemicals Co., Ltd. Triazolo-1,4-diazepine compounds and medicinal composition containing the same
FR2779652B1 (fr) * 1998-06-15 2001-06-08 Sod Conseils Rech Applic Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique
US6987105B2 (en) * 2000-04-28 2006-01-17 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Synthesis and use of thienotriazolodiazepines
MXPA05012900A (es) * 2003-05-30 2006-02-22 Ranbaxy Lab Ltd Derivados de pirrol sustituidos.
CA2627599A1 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
CL2007000667A1 (es) * 2006-03-14 2008-03-14 Ranbaxi Lab Ltd Composicion farmaceutica que comprende al acido 7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]pirrol-1-il]-3,5-dihidroxi-heptanoico o una sal y al menos un agente estabilizante; procedimiento de preparacion, util en e
AR063469A1 (es) * 2006-07-14 2009-01-28 Ranbaxy Lab Ltd Formas polimorficas de ácido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3, 5-dihidroxi-heptanoico, sal hemicalcio, metodos de preparacion de las mismas, una composicion farmaceutica que las comprende y su uso en el tratamiento de enfermedades
KR101675984B1 (ko) * 2015-02-23 2016-11-14 한양대학교 에리카산학협력단 티에노디아제핀 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
EP0316456A4 (en) * 1987-06-08 1990-05-14 Yoshitomi Pharmaceutical Ester-substituted thienotriazolodiazepine compounds and their medicinal use.
FI95708C (fi) * 1988-10-31 1996-03-11 Eisai Co Ltd Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
NL9000627A (nl) * 1990-03-29 1991-10-16 Scras Werkwijze ter bereiding van nieuwe thienotriazolo-diazepines.

Also Published As

Publication number Publication date
NO901070D0 (no) 1990-03-07
DK80890D0 (da) 1990-03-30
GB9007000D0 (en) 1990-05-30
ZA901765B (en) 1990-12-28
SE505417C2 (sv) 1997-08-25
IE64564B1 (en) 1996-08-23
HK95192A (en) 1992-12-04
AU622007B2 (en) 1992-03-26
DK80890A (da) 1990-10-01
FR2645022B1 (fr) 1992-04-17
NO901070L (no) 1990-10-01
TNSN90042A1 (fr) 1991-03-05
GR900100165A (en) 1990-07-31
GB2229723B (en) 1992-07-01
GR1000394B (el) 1992-06-30
NO173784B (no) 1993-10-25
DE4010316A1 (de) 1990-10-04
IN174015B (es) 1994-08-27
IT1240350B (it) 1993-12-07
FI95036B (fi) 1995-08-31
LU87710A1 (fr) 1990-07-24
PT93629B (pt) 1996-07-31
MA21790A1 (fr) 1990-10-01
NL9000626A (nl) 1990-10-16
FR2645022A1 (fr) 1990-10-05
IE900806L (en) 1990-09-30
FR2645153B1 (fr) 1992-04-17
ATA56790A (de) 1991-10-15
JPH02289582A (ja) 1990-11-29
FR2645153A1 (fr) 1990-10-05
IT9019884A1 (it) 1991-09-30
MY105538A (en) 1994-10-31
CA2013518C (en) 2004-02-24
NO173784C (no) 1994-02-02
SE9000871L (sv) 1990-10-01
SE9000871D0 (sv) 1990-03-12
JPH07103127B2 (ja) 1995-11-08
US5492906A (en) 1996-02-20
NL194827C (nl) 2003-04-03
NZ233011A (en) 1991-02-26
PT93629A (pt) 1990-11-20
FI901605A0 (fi) 1990-03-30
GB8907256D0 (en) 1989-05-17
AU5242590A (en) 1990-11-01
IT9019884A0 (it) 1990-03-30
FI95036C (fi) 1995-12-11
DE4010316C2 (de) 2003-05-28
KR900014396A (ko) 1990-10-23
GB2229723A (en) 1990-10-03
AT394561B (de) 1992-05-11
CH680365A5 (es) 1992-08-14
BE1003699A3 (fr) 1992-05-26
CA2013518A1 (en) 1990-09-30
NL194827B (nl) 2002-12-02
OA09442A (fr) 1992-10-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050331