EP1713430A1

EP1713430A1 - Medical transfer device

Info

Publication number: EP1713430A1
Application number: EP05701341A
Authority: EP
Inventors: Hans Dr. Haindl
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-02-04
Filing date: 2005-02-04
Publication date: 2006-10-25
Also published as: DE102004005435B3; WO2005074860A1; US7540863B2; JP2007525264A; US20070088315A1

Abstract

The invention relates to a medical transfer device which is used to conduct a fluid from a container to a bottle (58) which is provided with a neck, the neck thereof being provided with a closing element which can be pierced by means of a needle. The device comprises a first tubular-shaped part (2) which can be displaced in a telescopic manner in a second tubular-shaped part (4) between an inserted position and an extracted position. A holding part (14) which is connected thereto is arranged in the inside of the first tubular-shaped part (2), and from said holding part, a cannula (18) extends into the inside of the second tubular-shaped part (4) without axially overlapping into said extracted position. The cannula (18) comprises a lateral opening which is arranged on the distal end thereof. A conical-shaped receiving element (26), which is used to connect means for the detachable and sealed connection of conical-shaped receiving elements with the container comprising the liquid, is connected to the inside of the cannula (18) in the holding part (14). The tubular-shaped parts (2, 4) can be detachably locked by means of locking tongues (62) which can be indented in the extracted position in such a manner that the tip of the cannula (18) is located inside the tubular-shaped part (2, 4), such that there is no risk of injury. The penetration depth of the tip of the cannula (18) in the bottle (58) can be determined due to mutual rotation of the tubular-shaped parts (2, 4). The construction of the device is simple and, in practice, is easy to use.

Description

Medical transfer device

The invention relates to a medical transfer device of the type mentioned in the preamble of claim 1. Numerous medicaments cannot be stored in liquid form, but must be dissolved in sterile water or another solvent immediately before use. It has long been known for a long time to provide a drug as a dry substance on the one hand and a solvent on the other hand in separate injection bottles. These are closed with a closure that can be pierced with an injection needle. In use, the bottle containing the water was first closed by means of a syringe attached to it

Pierced steel cannula and drawn the water onto the syringe. After the steel cannula was withdrawn, it was inserted into the cap of a bottle containing the drug as a dry substance, and the water was conveyed from the syringe into this bottle.

This bottle was then shaken until the drug was dissolved, after which the dissolved drug was drawn onto the syringe using the same cannula. This process is relatively complex and dangerous because of the free-to-use steel cannula. A medical transfer device is known from US Pat. No. 6,558,365 B2, which essentially consists of two caps, from the bottom of which a puncture is made in each case. spine extends into the interior of the caps. Extending from the outer surface of the bottom of one cap is a peg with a conical outer surface which projects into a conical recess of a peg extending from the bottom of the other cap. A connection channel runs through the spikes and the pins. The cylindrical parts of the caps are split and thus radially expandable in such a way that the caps can be snapped onto the bulge of a neck of a bottle. The length of the piercing mandrels is such that the bottle is pierced during this snap-on operation. First, one of the caps is snapped onto the neck of a bottle containing water or another solvent, so that the associated piercing pin pierces the closure of the bottle and comes into contact with the inside of the bottle. Then the other cap is snapped onto the neck of a bottle containing a drug as a dry substance. Then the two caps are connected with their tenons.

The liquid is then brought into the bottle with the dry substance and this is dissolved in the liquid. The cap facing away from the bottle with the dissolved medicament is then removed, so that the complementary conical pin of a syringe is inserted into the conical receptacle of the remaining cap and the medicament can thus be suctioned off. However, this known construction has several disadvantages. A disadvantage is that the caps can be confused when placed on the necks of the bottles, and so there is a risk that the cap remains on the bottle with the dissolved medicament with a conical spigot that does not allow connection to the conical spigot of a syringe , so that the drug cannot be removed. Thereafter, a cannula must be placed on the syringe, which can lead to injuries from the tip of the cannula, especially if the patient is handling it himself, which is usually the case in practice. US Pat. No. 6,070,623 discloses a medical transfer device of the type mentioned in the preamble of claim 1, in which a first tubular part can be displaced in a piston-like manner in a second tubular part between an inserted and an extended position. A holding part is connected to the first tubular part and has a conical receptacle for connecting means for releasably and tightly connecting the conical receptacle to a container having the liquid or the solvent. This is formed by a syringe which, in a known manner, has a cylindrical wall and a piston which is displaceable therein and which can be advanced by means of a piston rod. A cannula extends from the second tubular part on the side facing away from the conical receptacle, through which a channel extends from the interior of the conical receptacle to its tip. When using this known device, sterile water or a sterile solution is first drawn onto the syringe, after which the syringe is inserted with its front conical pin into the conical receptacle in the first tubular part. The second tubular part is then placed on the neck of a bottle provided with a pierceable closure containing a dry, powdered medicament, and the cannula is passed through the pierceable closure by means of the tubular body of the syringe the bottle containing the drug. Then, by actuating the syringe, the liquid therein is injected into the container containing the medicament and the medicament is thus dissolved in the liquid. While in these operations the

Container with the medication at the bottom and the syringe at the top, this device is now turned upside down so that the liquid containing the medication is above the piercing spike, so that the liquid containing the medication can be drawn off with the syringe. Then the connecting pin of the syringe is separated from the tapered receptacle of the first tubular part and an injection needle is placed on the connecting pin of the syringe so that the medicament can be injected into the body of a patient. As with the known device mentioned above, the placement of an injection needle can lead to injuries from the tip of the injection needle, in particular when the handling is carried out by the patient himself, which is usually the case in practice. There is also the disadvantage that the penetration depth of the cannula depends on the handling when injecting and withdrawing the liquid. The invention is based on the object

To provide transfer device of the type mentioned in the preamble of claim 1, in which the disadvantages of the known construction are avoided, which is particularly easy to use and reduces or eliminates the risk of injury from pointed parts. The object on which the invention is based is achieved by the teaching specified in the characterizing part of claim 1. A basic idea of this teaching is to arrange the pointed cannula required for piercing the pierceable closure of the bottle with the medication within two tubular parts which can be telescopically displaced between an inserted and an extended position. In the interior of the first tubular part there is a holding part connected to it, from which the cannula extends into the interior of the second tubular part without projecting axially beyond it. The rear

The end of the cannula is connected to a conical receptacle on the side of the holding part facing away from the cannula. In the extended position, the two tubular parts are locked against mutual movements by a locking device, so that the tip of the cannula is located within the tubular parts, so that there is no risk of injury. An essential basic idea of the teaching of the invention is to ensure that, after the cannula has been inserted into the closure, the liquid emerges from the lateral opening at the tip of the cannula directed laterally against the inner side wall of the bottle if the cannula after piercing the closure protrudes into the bottle. This has the advantage that the liquid runs down the inner wall of the bottle and reaches the medicament over the entire inner circumference of the bottle, so that the liquid is effectively mixed with the medicament. In this position, since the side opening at the tip of the cannula does not protrude into the lower region of the liquid adjacent to the closure after the transfer device has been turned over, the disadvantage would arise that the liquid cannot subsequently be completely removed from the bottle. For this reason, the The invention further provides that the cannula can be withdrawn exactly up to a stop after the liquid has been injected, so that the lateral opening of the cannula is in the piercing direction immediately before the closure. According to a development of this basic embodiment of the invention, a pin is arranged on the inner wall of the second tubular part, while two grooves are arranged in the outer wall of the first tubular part in the sliding direction, which are connected to one another via a switch and in which the pin is guided, whereby the pin slides out of the inserted position into one of the two grooves as far as the extended position and, with subsequent movement in the direction of the extended position, slides through the switch into the other groove until it engages in a recess and thus in this Stop position is locked. In this stop position it is ensured that the lateral opening at the tip of the cannula is located just above the closure, so that all of the liquid can be withdrawn from the container. In this embodiment there are a total of three positions. In the first position, the two tubular parts are locked together by a locking device. After unlocking this locking device, the cannula can be advanced sufficiently deep into the inside of the bottle containing the medicament, while in the third position the side opening is at the tip of the

Cannula is located close to the closure. An expedient embodiment is characterized in claim 2, in which the different positions are achieved by rotating the two tubular parts. the. In this embodiment of the transfer device according to the invention, a pin is arranged on the outer wall of the first tubular part, while two grooves are arranged in the inner direction of the second tubular part in the sliding direction, which are connected to one another via a switch and in which the pin is guided, the pin slides out of the extended position in one of the two grooves to the inserted position and, when subsequently moved in the direction of the extended position, slides through the switch into the other groove until it stops so that the cannula is in the desired position It still protrudes from the second tubular part and thus protrudes into the bottle immediately near the pierceable closure. Of course, in this embodiment it is also possible for the pin to be located on the inner wall of the second tubular part and for the grooves to be in the outer wall of the first tubular part. According to a development of the invention, a piercing spike detachably and tightly engages with its end facing away from its tip in the conical receptacle and thus connects it to a container containing the liquid when the piercing spike is inserted into the pierceable closure of the container containing the liquid. The end of the piercing mandrel facing away from its tip is expediently designed to be complementary conical to the conical receptacle in the holding part, so that a secure connection is possible. According to another development of the invention, the end of the piercing mandrel facing away from its tip is cylindrical or conical with a cone angle that is smaller than the cone angle of the conical receptacle in the holding part. This prevents the pin of the piercing mandrel from being clamped too much in the conical receptacle, so that the piercing mandrel can be pulled off without a great deal of force and the usual conical stud of a syringe can be attached to the conical receptacle. Advantageously, clips extend from the end of the second tubular part facing away from the first tubular part for releasably engaging behind a bead at the end of the neck of a bottle. These clamps enable a central attachment to the bead of a bottle and thus also a central insertion of the piercing mandrel into the pierceable closure of a bottle. In the same way, it is expedient that clamps extend from the end of the first tubular part facing away from the second tubular part for preferably releasably engaging behind a bead at the end of the neck of a bottle. This ensures a central attachment of the transfer device according to the invention and a central insertion into the pierceable closure through the cannula. Since there are clamps on both tubular parts in these embodiments, the bottles with the solvent and the drug are hooked together as a dry substance. According to an expedient embodiment, the piercing mandrel is held in the center of a plate which is supported on the first tubular part against the piercing direction, which makes it easier to remove the piercing mandrel. An expedient development of this embodiment consists in that the plate clamps for engaging behind a bead at the end of the neck of a bottle has, wherein these clamps extend in the circumferential direction between the clamps of the first tubular part, and so that they engage behind the same bead of a bottle. The first tubular part and the plate with the piercing pin are thus held on the bottle independently of one another. A particularly expedient development of this embodiment consists in that the clamps of the plate have a greater holding force than the clamps of the first tubular part, such that when a bottle is pulled off the first tubular part, the plate is carried along with the piercing mandrel and remains on the bottle , In this way, the tapered receptacle is released, which is connected to the cannula, so that the tapered pin of a syringe can be attached and the dissolved medicament can be suctioned off. The spike is expediently made of plastic. Advantageously, the cannula is provided with a side opening which reduces or eliminates clogging by punched-out parts of the pierceable closure and in particular offers the advantage that the water jet emerges laterally and wets the wall of the bottle, which leads to better and foam-free dissolution of the dry substance , The cannula is expediently made of steel, and a filter can be arranged in the conical receptacle or in the end facing away from the tip of the piercing mandrel. The piercing mandrel and / or the cannula can expediently also be designed as a double mandrel or double cannula, in each of which one channel is designed as a ventilation channel. Based on the drawing, the invention is intended to to be refined.

1 shows an axially exploded view of an embodiment of a transfer device according to the invention in connection with two bottles in axial section,

2 to 15 illustrate the use of the transfer device according to FIG. 1.

Fig. 1 shows a first tubular part 2 which is telescopically displaceable in a second tubular part 4 between an inserted position in which an edge 6 of the first tubular part abuts a wall 8 of the second tubular part and an extended position, in which abuts an edge 10 of the first tubular part 2 against a pin 12 on the inner wall of the tubular part 4. A holding part 14 is arranged in the interior of the first tubular part 2 and is connected to the first tubular part 2 via a disk-shaped web 16. The web 16 has predetermined breaking points, not shown, so that the holding part 14 can be broken out of the interior of the first tubular part 2. The holding part 14 holds the rear end of a cannula 18, the tip 20 of which is directed towards an opening 24 in the wall 8 in the direction of an axis 22. The inner channel of the cannula 18 is connected to a conical receptacle 26 into which, in the assembled state, a rear cylindrical end 28 of a spike engages tightly, which is held in the center of a plate 32 which, in the assembled state, has its edge 34 on the edge 10 against the Plunge direction supported. From the edge 10 of the tubular part 2 extend from clips 36 which engage behind a bead 38 of a bottle 40 when the bottle 40 is pressed with its pierceable closure 42 against the piercing pin 30, so that its inner channel 44 with the interior of the container 40 is connected. The interior of the container 40 is thus also connected to the tip 20 of the cannula 18. Between the clamps 36 are arranged in the circumferential direction, spaces not visible in the drawing, into which, in the assembled state, clamps 46 protrude which, when the container 40 is seated, engage behind the bead 38 in the same way as the clamps 36. The brackets 46 have slopes 48 which are steeper than the slopes 50 of the brackets 36, so that the pulling force of the brackets 46 with their slopes 48 is greater than that of the clips 36 with the slopes 50 with the result that the clips 46 with the plate 32 and the piercing mandrel 30 get caught on the bead 38 and be taken away from the container 40 when it is pulled off. On the second tubular part 4 there are guide clips 52 on the side facing away from the tubular part 2, which with their slopes 54 form one

Reach behind the bead 56 on the neck of a bottle 58 and thus ensure a central position of the second tubular part 4 in relation to the bottle 58, so that when the first tubular part 2 moves, the cannula 18 sticks centrally into a closure 60 of the bottle 58 with the As a result, the inside of the bottle 58 is ultimately connected to the inside of the container 40 via the cannula 18, the conical receptacle 26 and the inner channel 44 of the piercing mandrel 30. Located in practice There is a drug in the bottle 58 as a dry substance, while in the container 40 there is a solvent, usually water. The tubular parts 2 and 4 and the piercing mandrel 30 with the parts connected to them form in assembled

Condition of a medical transfer device according to the invention. The handling of the transfer device is explained in more detail below with reference to FIGS. 2 to 15. For reasons of clarity, only the essential parts in FIGS. 2 to 15 are provided with the reference numbers from FIG. 1. Fig. 2 shows the transfer device in the assembled state, the tubular parts 2 and 4 being in the pushed-out state, in which they are locked against axial movements with respect to one another by push-in locking tabs, which are explained below in connection with FIGS. 6 and 7. In this position, the tips of the cannula 18 and the piercing mandrel 30 are located inside the tubular parts 2 and 4, so that none

There is a risk of injury. The transfer device is then pressed against the container 40 from above, so that the piercing mandrel 30 pierces the closure 42 and the clamps 36 and 46 engage behind the bead 38. This situation is shown in Fig. 3. 4, the bottle 58, in which a medicament is in the dry state, is moved downward against the guide clips 52 until they snap behind the bead 56 of the bottle 58 and hold them in a central position. This situation is in

Fig. 5 shown, which differs from Fig. 4, however, by a rotation about the axis, so that push-in locking tabs 62 can be seen. The entire arrangement according to FIG. 6 is then opened turned upside down, after which the locking tabs 62 are pressed in the direction of arrows 64, so that the first tubular part 2 can be moved down into the second tubular part 4, with the result that the tip 20 of the cannula 18 through the closure 60 stings and thus comes into contact with the inside of the bottle 58. The process is illustrated in Fig. 7. At the end of this movement, the tip 20 of the cannula 18 has the position according to FIG. 8. In this position, liquid flows out of the lateral opening in the cannula 18, which is not visible in the drawing because of its small size, against and against the inner side wall of the bottle 58 down to the dry medication lying in the region of the bottom of the bottle 58 and dissolves it. Since, in this position of the opening at the tip 20, the medication cannot be drawn onto a syringe, the cannula 18 must be able to be moved back to a position which is shown in FIG. 10, in which the opening at the tip 20 just protrudes through the closure 60 into the interior of the bottle 58. In order to safely achieve this position, there are two axially extending grooves 66 in the outer wall of the first tubular part 2, in which the pin 12 engages, in such a way that it firstly when the first tubular part 2 is inserted 8 and 9 slides in one of the grooves 66, as shown in FIGS. 8 and 9, but slides in the opposite direction through a switch, not shown, from one of the grooves 66 into the other of the grooves 66 and engages there in a recess 13 and so on as

Stop acts against a movement in the direction of an arrow 68 and thus ensures that the opening at the tip 20 of the cannula 18 remains just in connection with the interior of the bottle 58. In this position the pin 12 is locked against further movements. Fig. Li shows this position after a rotation of the transfer device by 90 ° around the axis. 12, the container 40 is then pulled up together with the piercing mandrel 30 in the direction of an arrow 70, so that the conical receptacle 26 is released and, according to FIG. 13, a conical pin 72 of a syringe 74 can be plugged on, as shown in FIG. 14 is shown. The entire arrangement is then turned over so that, in the position shown in FIG. 15, the medicament can be sucked out of the bottle 58 and drawn onto the syringe 74. After the syringe has been removed, an injection needle can be attached to the pin 72 in a known manner. Instead of the container 40, the conical receptacle of a syringe filled with the liquid can be plugged directly into the conical receptacle 26 and the liquid can be sprayed through the lateral opening at the tip 20 of the cannula 18 against the inner wall of the bottle 58. Then the operations shown in FIGS. 13 to 15 are carried out.

Claims

claims

1. Medical transfer device for transferring a liquid from a container (40) into a bottle

(58), the neck of which is provided with a pierceable closure (60), and for removing the bottle

(58) transferred liquid, with a first tubular part (2) which is telescopically displaceable in a second tubular part (4) between an inserted and an extended position, with a holding part (14) which is connected to the first tubular part (2 ) is connected and in which a conical receptacle (26) for connecting means for the releasable and tight connection of the conical receptacle (26) to the liquid-containing container (40) is arranged, and

- With a cannula (18) which communicates with the interior of the tapered receptacle (26) and extends from the holding part (14) into the interior of the second tubular part (4) without axially projecting beyond it in the inserted position .

characterized in that a Riegella - Clear (62) locking device for releasably locking the two tubular parts (2, 4) is provided in the inserted position that the cannula (18) has a lateral opening at its distal end from which the liquid laterally against the lateral Inner wall of the bottle (58) emerges in a directed manner when the cannula (18) protrudes into the bottle (58) after the closure (60) has been pierced, and that the two tubular parts (2, 4) can be rotated relative to one another over a limited angle, such That in one rotational position the first tubular part (2) can be pushed into the extended position after releasing the lock, in which the cannula (18) from the second tubular part (4) through the closure (6) so far into that The inside of the bottle (58) clamped to the second tubular part (4) protrudes so that the lateral opening in the cannula is in the insertion direction away from the closure (60), while in the In another rotational position, the first tubular part (2) can be pulled back so far against a stop that the lateral opening of the cannula (18) is in the piercing direction immediately before the closure (60).

2. Medical transfer device according to claim 1, characterized in that on the inner wall of the second tubular part (4) a pin (12) is arranged that in the outer wall of the first tubular part (2) in the sliding direction two grooves (66) are arranged . which are connected to each other via a switch and in which the pin (12) is guided, the pin

(12) slides out of the inserted position in one of the two grooves up to the extended position and then slides in the direction of the extended position through the switch into the other groove (66) until it slides into a recess

(13) engages and is locked in this stop position.

3. Medical transfer device according to claim 1, characterized in that a spike (30) with its end facing away (28) releasably and tightly engages in the conical receptacle (26) and so the conical receptacle (26) with a Connects liquid-containing container (40) when the piercing mandrel (30) is inserted into the pierceable closure (42) of the container (40) containing the liquid,

4. Medical transfer device according to claim 3, characterized in that the end facing away from its tip (28) of the piercing mandrel (30) is complementary conical to the conical receptacle (26) in the holding part (14).

5. Medical transfer device according to claim 3, characterized in that the end of the piercing mandrel (30) facing away from its tip is cylindrical or conical with a cone angle which is smaller than the cone angle of the conical receptacle (26) in the holding part (14).

6. Medical transfer device according to claim 1, characterized in that from the first tubular part (2) facing away from the end of the second tubular Extend part (4) of clips (52) for releasable engagement behind a bead (56) at the end of the neck of the bottle (58).

7. Medical transfer device according to claim 1, characterized in that from the second tubular part (4) facing away from the end of the first tubular part (2) brackets (36) for preferably releasably engaging behind a bead (38) at the end of the neck of the Extend liquid-containing container (40).

8. Medical transfer device according to claim 3, characterized in that the piercing mandrel (30) is held in the center of a plate (32) which is supported on the first tubular part (2) against the piercing direction.

9. Medical transfer device according to claim 8, characterized in that the plate (32) brackets (46) for engaging behind a bead (38) at the end of the neck of the liquid-containing container (40), said brackets (46) in Extend gaps formed in the circumferential direction between the clamps (36) of the first tubular part (2) and as they engage behind the same bulge (38) of the container (40).

10. Medical transfer device according to claim 9, characterized in that the clips (46) of the plate (32) have a greater holding force than the clips

(36) of the first tubular part (2), such that when the container (40) is pulled off the first tubular part (2), the plate (32) with the piercing mandrel (30) is carried along and ver on the container (40) - remains .

11. Medical transfer device according to claim 1, characterized in that the piercing mandrel (30) consists of plastic.

12. A medical transfer device according to claim 1 or 2, characterized in that a filter is arranged in the conical receptacle (26) and / or in the end facing away from the tip of the piercing mandrel (30).

13. Medical transfer device according to claim 1, characterized in that the cannula (18) consists of steel.

14. Medical transfer device according to claim 1 or 3, characterized in that the piercing mandrel (30) and / or the cannula (18) are designed as a double mandrel or as a double cannula, in each of which a channel is designed as a ventilation channel.

15. Medical transfer device according to claim 1, characterized in that the container for holding a liquid (40) is a syringe (74) with a tapered connecting pin and that the tapered holder (26) is complementary to the tapered connecting pin of the syringe.