JP3491727B2 - Drug container with communication means - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drug container, more specifically, a drug used by mixing with another drug, or
A drug container containing a drug to be dissolved in a solution just before use, for example, an anticancer drug, an antibiotic, a powdered or freeze-dried drug such as a blood product, which is mixed with another drug or a solution. The present invention relates to a drug container provided with a convenient communication means.

[0002]

2. Description of the Related Art Anticancer drugs, antibiotics, blood products, or freeze-dried products contained in vials or the like are liable to change the blending ratio when used as a mixture with an infusion solution, and are also stored as liquid drugs. If it is left, there is a problem that the medicinal effect decreases. Therefore, conventionally, in medical institutions such as hospitals, this is dissolved just before use and used as an infusion solution for drip treatment, and the communication operation of a drug is performed by a drug container and a container containing a solution that dissolves the drug. Is connected by using a connecting tool such as a double-ended needle or a connecting pipe, and the solution is transferred to a drug container. However, this operation is complicated and time-consuming. Therefore, a drug container provided with a communication means has been proposed so that the communication operation can be performed easily in such a case (Japanese Patent Publication No. 6-69474 and Japanese Patent Laid-Open No. 6-74).
09 publication).

The bottle disclosed in Japanese Examined Patent Publication No. 6-69474 is mounted in a bottle body, a capsule slidably mounted in an opening neck of the bottle body, and an annular flow passage in a cylindrical portion of the capsule. Annular gasket,
The container comprises a closure member attached to the bottom of the tubular portion of the capsule, and the capsule is slid to move the closure member downward so that the outside communicates with the inside of the bottle. It is possible to communicate with each other and can be manufactured at low cost. However,
This bottle cannot use existing drug vials and requires major changes in the production line.

The drug container disclosed in Japanese Patent Laid-Open No. 6-7409 has a container body, a main stopper having an airtight fitting portion with an opening of the container and having a piercing needle in the central portion, It is composed of a sub stopper that airtightly seals the needle hole provided at the tip of the piercing needle, and a cap that air-tightly wraps this sub stopper and main stopper to prevent bacterial contamination and contamination of foreign substances during preparation. It is intended to prevent the danger and reduce the work load on the medical staff. However, this drug container has a problem in airtightness because the mouth of the container is sealed with a plastic main stopper.

[0005]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances and is a conventional drug container in which a direct communication means is incorporated into a drug vial, which is easy to manufacture and has a drug dissolving operation. It is an object of the present invention to provide an inexpensive drug container which is easy and free from malfunction.

[0006]

Therefore, the present inventors have
As a result of intensive studies to solve the problems described above, the present invention
Was conceived. That is, the present invention is (1) A vial, an inner cylinder part and an outer cylinder part
A bottomed container that holds and holds the vial with the mouth exposed.
A heavy cylindrical vial holder and the vial holder
Airtight and slidably held between the inner and outer cylinders
A double-ended needle having a hub with a cylindrical skirt,
Between the inner tube of the vial holder and the cylindrical skirt of the double-ended needle
To protect the packing that seals the needle and the needle above the double-ended needle
To a drug container having a communication means including a cap and
At the outer cylinder of the vial holder,
In addition to providing an inverted L-shaped slit consisting of
A protrusion is provided on the outer wall of the lower end of the cylindrical skirt of the double-ended needle.
When the protrusion is in the lateral part of the slit, the double-ended needle
It becomes impossible to slide on theBelow the vertical section
Close to the end of the double-ended needle punctured in the rubber stopper of the vial.
The cylindrical shape is provided with a protrusion to prevent kickback.
Two vertical ribs provided from the lower end of the upper end of the skirt down
Gutter-shaped groove for air bleedingDrug content
vessel, (2) A cylinder that is airtightly fitted to the cap on the hub of the double-ended needle
-Shaped fitting part is provided, and a bridge is provided under the cap.
A cylindrical fixing means that can be easily broken by
The drug container according to claim 1, wherein the drug is fixed to the hub of the double-ended needle.
vessel, (3) A rubber cap is attached to the lower needle of the double-ended needle.
The pharmaceutical container according to claim 1 or 2, and the like.

Here, an inverted L-shaped slit consisting of a laterally running portion and a vertically running portion is provided in the outer cylindrical portion of the vial holder, and a protrusion is provided on the outer wall of the lower end portion of the cylindrical skirt of the double-ended needle. It is preferable that the double-ended needle cannot slide downward when it is in the lateral running portion of the slit. In addition, in order to confirm the removal of the cap, the hub of the double-ended needle is provided with a cylindrical fitting portion that air-tightly fits with the cap, and a cylindrical fixing means that can be easily broken by a bridge is provided under the cap, The fixing means may be fixed to the hub of the double-ended needle. A rubber cap is preferably capped on the lower needle of the double-ended needle, and air bleeding means is preferably provided on the inner wall of the cylindrical skirt portion of the double-ended needle. A vertical rib may be provided on the inner wall of the inner tube portion of the vial holder.

[0008]

Embodiments of the present invention will now be described with reference to the drawings. 1 is a front view showing a drug container according to an embodiment of the present invention, FIG. 2 is a sectional view taken along the line AA of the drug container shown in FIG. 1, FIG. 3 is a front view of a vial holder shown in FIG. 4 is a sectional view taken along line BB of FIG. 3, FIG. 5 is a plan view of the double-ended needle shown in FIG. 1, FIG. 6 is a sectional view taken along line CC of FIG. 5, and FIG. 7 is a bottom view of the cap shown in FIG. , FIG. 8 is DD of FIG.
It is a line sectional view. 9 and 10 are explanatory views showing the usage status of the drug container of the present invention. As shown in FIGS. 1 and 2, the drug container of the present invention has a vial 1, an inner tubular portion 21 and an outer tubular portion 22, and holds and holds the vial 1 so that a mouth 11 is exposed. A heavy-cylinder-shaped vial holder 2, and a double-ended needle 3 having a hub 33 having a cylindrical skirt 35 that is hermetically and slidably held between an inner cylindrical portion 21 and an outer cylindrical portion 22 of the vial holder 2. A packing 6 that seals between the inner cylindrical portion 21 of the vial holder 2 and the cylindrical skirt 35 of the double-ended needle 3, and a cap 4 that protects the upper needle (upper puncture needle 31) of the double-ended needle 3 are included. . Here, the vial 1 does not need to be specifically designed for the present invention, and a commercially available vial can be adopted.

As shown in FIGS. 3 and 4, the vial holder 2 is formed in a bottomed double cylindrical shape having an inner tubular portion 21 and an outer tubular portion 22, and the inner wall of the inner tubular portion 21 is The vial 1 is accommodated and held so that its mouth portion 11 is exposed to the outside of the inner tubular portion 21, and the annular groove 2 between the inner tubular portion 21 and the outer tubular portion 22 is held.
A cylindrical skirt 35 of the double-ended needle 3 is airtightly and slidably inserted and held at 4. The inner tubular portion 21 is formed longer than the outer tubular portion 22, and the inner wall thereof is preferably provided with a vertical rib 212 for holding the vial 1.
An upper end portion thereof has an annular notch 211 for attaching the packing 6. Further, the outer cylinder portion 22 is preferably provided with a protrusion 35 of a cylindrical skirt 35 of the double-ended needle 3 described later.
A slit 23 for slidably fitting 1 is formed. The slit 23 is an inverted L-shaped slit composed of a laterally running portion 231 running in the horizontal direction at the upper end and a vertical running portion 232 running in the vertical direction from one end of the horizontal running portion 231, and is adjacent to the lower end of the vertical running portion 232. And preferably vial 1
The rubber plug 12 is provided with a protrusion 233 for preventing kickback of the double-ended needle 3 punctured. In the double-ended needle 3, the protrusion 351 of the cylindrical skirt 35 is formed into the slit 2
When it is in the lateral running portion 231 of No. 3, it cannot slide downward. In addition, the slit 2 is formed in the outer cylinder portion 22.
Instead of 3, a reverse L-shaped groove (not shown) may be provided on the inner wall of the double-ended needle 3 as in the case of the slit.
The protrusion 351 of the cylindrical skirt 35 can be slid along the groove.

The double-ended needle 3, as shown in FIGS. 5 and 6, is preferably provided with two fluid passages 36,
It is composed of an upper puncture needle 31, a lower puncture needle 32, and a hub 33 provided at an intermediate portion between these puncture needles. The hub 33 includes a cylindrical skirt 35 extending downward (toward the lower puncture needle 32), and the cylindrical skirt 35 is slidably attached to the annular groove 24 of the vial holder 2.
The upper end portion 353 of the cylindrical skirt 35 may be reduced in diameter according to the mouth portion 11 of the vial 1, and the top surface 354 has an outer diameter equal to the inner diameter of the cap 4 so that the cap 4 can be easily attached. It is preferable to provide the cylindrical fitting portion 34 having. Further, a protrusion 351 is provided on the outer wall of the lower end portion of the cylindrical skirt 35, and the protrusion 351 is fitted into the slit 23 provided in the outer cylinder portion 22 of the vial holder 2 to form the protrusion 3
It is preferable that the double-ended needle 3 cannot slide downward when 51 is in the lateral running portion 231. The number of the protrusions 351 is the number of the slits 2 provided on the outer cylinder portion 22 of the vial holder 2.
It is the same as the number of 3 and is usually provided in 1 or 2. It should be noted that the lower puncture needle 32 has the upper puncture needle 31 connected to the dissolution liquid container (see FIG.
The rubber cap 5 is preferably attached so that the solution does not leak when the rubber plug of S) is penetrated.

When the double-ended needle 3 is slid downward, the air in the space between the double-ended needle 3, the vial holder 2 and the vial is compressed in the cylindrical skirt 35, and it becomes difficult for the air to escape downward. It is preferable to provide air bleeding means for this. As the air bleeding means, for example,
A trough-shaped groove 352 (air bleeding means) formed by two vertical ribs provided below the lower end of the upper end 353 of the cylindrical skirt 35 may be used. The groove 352 is formed to have a length that is located above the packing 6 when the protrusion 351 is in the laterally running portion 231 of the slit 23 of the vial holder 2, and when the double-ended needle 3 is slid downward. A gap is formed between the packing 6 and the inner wall of the cylindrical skirt 35 by passing over the packing 6, and the air in the space between the double-ended needle 3, the vial holder 2 and the vial is allowed to escape from this clearance.

A cap 4 is attached to the cylindrical fitting portion 34 of the hub 33 of the double-ended needle 3. The cap 4 has an inner diameter equal to the outer diameter of the cylindrical fitting portion 34.
And FIG. 8, are preferably readily cylindrical fixing means 41 connected by breakable bridges 42 are provided at its lower end. And this cylindrical fixing means 41
Is adhered and fixed to the top surface 354 of the hub 33 of the double-ended needle 3. A plurality of annular ribs 43 near the lower end of the cap 4
May be provided so as to be airtightly fitted to the cylindrical fitting portion 34 of the double-ended needle 3. The material for forming the vial holder 2, the double-ended needle 3, and the cap 4 is not limited, but a transparent flexible resin such as polyethylene or polypropylene is preferably used.

Next, the use of the drug container of the present invention will be described with reference to FIGS. 9 and 10. First, the cap 4 from the cylindrical fixing means 41 by twisting the cap 4 of the drug container V
Is removed, and this is pierced through the rubber stopper at the mouth of the solution container S (see FIG. 9). At this time, the cylindrical skirt 35 of the double-ended needle 3 is inserted into the annular groove 24 of the vial holder 2, and the protrusion 351 thereof is located at the lateral running portion 231 of the slit 23. Next, the vial holder 2 is rotated clockwise to remove the protrusion 351 from the laterally running portion 231 of the slit 23, and the vial holder 2 is pushed in the direction of the solution container S (even if the solution container S is pushed in the direction of the drug container V. Good.),
Since the protrusion 351 slides along the vertical running portion 232 of the slit 23, the vial holder 2 slides along the cylindrical skirt 35 of the double-ended needle 3. At this time, the rubber stopper 12 of the vial 1 that has moved together with the vial holder 2 is pierced by the lower puncture needle 32 of the double-ended needle 3, so that the dissolution liquid container S and the vial 1 are in liquid communication through the double-ended needle 3, It becomes the state of.

[0014]

As is clear from the above description, by employing the vial with a needle of the present invention, the drug dissolution operation can be easily and aseptically performed. Further, since the double-ended needle cannot slide downward unless the vial holder is rotated by a predetermined angle, there is no possibility that the double-ended needle inadvertently pierces the vial.

[Brief description of drawings]

FIG. 1 is a front view showing a drug container according to an embodiment of the present invention.

FIG. 2 is a sectional view taken along the line AA of the drug container shown in FIG.

FIG. 3 is a front view of the vial holder shown in FIG.

FIG. 4 is a sectional view taken along line BB of FIG.

5 is a plan view of the double-ended needle shown in FIG. 1. FIG.

6 is a cross-sectional view taken along the line CC of FIG.

FIG. 7 is a bottom view of the cap shown in FIG.

8 is a cross-sectional view taken along the line DD of FIG.

FIG. 9 is an explanatory view showing a usage state of the medicine container of the present invention.

FIG. 10 is an explanatory view showing a usage state of the medicine container of the present invention.

[Explanation of symbols]

1 vial 2 vial holder 21 Inner tube 212 vertical ribs 22 Outer cylinder 23 slits 231 Lateral running section 232 Vertical running unit 3 double-ended needle 31 upper puncture needle 32 Lower puncture needle 33 hubs 34 Cylindrical fitting part 35 Cylindrical skirt 352 gutter-shaped groove (air bleeding means) 4 cap 41 Cylindrical fixing means 42 bridge 5 rubber cap 6 packing

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Goo Akasaki 3-9-3 Honjo Nishi, Kita-ku, Osaka City Nissho Co., Ltd. (72) Inventor Katsuyuki Nagura 3-9-3 Honjo-nishi, Kita-ku, Osaka Stock company Nissho (56) Reference JP-A-6-142158 (JP, A) International publication 93/021891 (WO, A1) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61J 1/00 -3/10

Claims (3)

(57) [Claims] 1. A vial, a bottomed double cylindrical vial holder having an inner cylinder part and an outer cylinder part for accommodating and holding the vial so that the mouth part is exposed, and the inside of the vial holder. A double-ended needle having a hub having a cylindrical skirt that is held in an airtight and slidable manner between a cylindrical portion and an outer cylindrical portion, and a packing that seals between the inner cylinder of the vial holder and the cylindrical skirt of the double-ended needle. A cap for protecting an upper needle of the double-ended needle, and a drug container including a communication means including an inverted L-shaped slit including a laterally running portion and a vertically running portion in an outer cylinder portion of the vial holder. At the same time, a protrusion is provided on the outer wall of the lower end portion of the cylindrical skirt of the double-ended needle so that the double-ended needle cannot slide downward when the protrusion is in the lateral running portion of the slit . Near the bottom
Then, the kick bar of the double-ended needle punctured in the rubber stopper of the vial.
A protrusion for preventing the locking is provided, and the protrusion is provided downward from the lower end of the upper end of the cylindrical skirt.
Provide a gutter-shaped groove made of vertical ribs for the air vent
Become a drug container. 2. A hub of a double-ended needle is provided with a cylindrical fitting portion that is airtightly fitted with a cap, and a cylindrical fixing means that can be easily broken by a bridge is provided under the cap, and the fixing means is a double-ended needle. The drug container according to claim 1, wherein the drug container is fixed to the hub. 3. The drug container according to claim 1, wherein a rubber cap is capped on the lower needle of the double-ended needle.