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EP0380647A4 - Compositions and in situ methods for forming films on body tissue - Google Patents

Compositions and in situ methods for forming films on body tissue

Info

Publication number
EP0380647A4
EP0380647A4 EP19890909293 EP89909293A EP0380647A4 EP 0380647 A4 EP0380647 A4 EP 0380647A4 EP 19890909293 EP19890909293 EP 19890909293 EP 89909293 A EP89909293 A EP 89909293A EP 0380647 A4 EP0380647 A4 EP 0380647A4
Authority
EP
European Patent Office
Prior art keywords
composition
hydroxypropyl cellulose
film
compositions
body tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19890909293
Other languages
English (en)
French (fr)
Other versions
EP0380647A1 (en
Inventor
Edwin Pomerantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zila Pharmaceuticals Inc
Original Assignee
Zila Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Pharmaceuticals Inc filed Critical Zila Pharmaceuticals Inc
Publication of EP0380647A1 publication Critical patent/EP0380647A1/en
Publication of EP0380647A4 publication Critical patent/EP0380647A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D101/00—Coating compositions based on cellulose, modified cellulose, or cellulose derivatives
    • C09D101/08—Cellulose derivatives
    • C09D101/26—Cellulose ethers
    • C09D101/28—Alkyl ethers
    • C09D101/284—Alkyl ethers with hydroxylated hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on

Definitions

  • This invention relates to compositions and methods for in situ treatment of body tissues.
  • the invention pertains to the use of hydroxypropyl cellulose (HPC) in the manufacture of such compositions and the use of such compositions, manufactured from HPC.
  • HPC hydroxypropyl cellulose
  • the invention relates to methods of treating skin, mucosal tissue and other moist tissue, by forming an adherent film thereon.
  • the invention in another respect, relates to compositions and methods for forming films in situ on body tissues, which films are effective sustained release carriers for medicinal and cosmetic components, to maintain such medicaments at and on a treatment site on body tissue.
  • topical anesthetics for reducing pain
  • commercially-available preparations containing benzocaine are widely used.
  • these do not form coherent films in the mouth and are easily displaced from the ulcer site by saliva and physical movement of the surrounding tissues.
  • An intra-oral ointment base for use in the oral cavity has been proposed which consists essentially of sodium carboxy ethyl cellulose and pectin.
  • such ointments are not considered sufficiently persistent to solve the basic problem of maintaining a topical analgesic agent in contact with an ulcer for up to several hours.
  • Topical adhesive dosages for mucosal ulcers have also been proposed in the form of a two-phase tablet having an adhesive peripheral layer of hydroxypropyl cellulose with the medication carried in an oleaginous core of cocoa butter. This device adheres to the ucosa of dogs for thirty minutes to six hours.
  • HPC hydroxypropyl cellulose
  • polyvinylacetate hydroxypropyl cellulose
  • Precast films of hydroxypropyl cellulose containing analgesics and antibiotics has been reported anecdotally fur the treatment of pain of leukoplakia.
  • Alkyl cellulose and/or cellulose ether compounds have been used as thickeners or ointment bases for a wide variety of medicaments.
  • an alkyl cellulose believed to be methyl cellulose, was used as a carrier and ointment base for the topical medicinal composition described in U.S. Patent No. 4,381,296 to Tinnell.
  • Hydroxyethyl cellulose and/or hydroxypropyl cellulose was used to form .a gel for application of the topical acne medications of U.S. Patent No. 4,244,948 to Boghosian et al.
  • a water-soluble film formed of hydroxypropyl cellulose was used as the carrier for a bactericide in a teat-dip composition in U.S. Patent No. 4,434,181 to Marks et al.
  • the cellulosic component of the commercially available gels containing the Tinnell , 296 medicaments is, in fact, hydroxypropyl cellulose, rather than methylcellulose as previously understood
  • the mechanism of film formation is specific to hydroxypropyl cellulose.
  • Closely related alkyl or hydroxyalkyl-substituted cellulose, such as methylcellulose, hydroxyethyl cellulose and hydroxybutyl cellulose are not suitable substitutes for HPC.
  • the barrier effect of the film derived from HPC provides practically instantaneous and long-lasting substantial reduction of the pain associated with aphthous and other ulcers and trauma. This pain relief and prevention activity by the barrier action of the film is very surprising in view of the previous belief that is was necessary to provide an analgesic, e.g., benzocaine, at the ulcer site.
  • compositions for forming the HPC-derived films in situ on body tissues can also function as stable carriers for a wide variety of medicinal components.
  • the medicinal components are incorporated in the resulting in situ formed films, from which they are released to provide a sustained supply of the medicine at the treatment site.
  • HPC in the manufacture of a film-forming composition for topical treatment of human tissue.
  • the composition comprises hydroxypropyl cellulose, an esterification agent, and a suitable volatile solvent which functions as a medium for reaction of the HPC and the acid and also to maintain the esterification reaction product in the form of a gel or lotion for convenient application.
  • Such compositions are especially adapted to treatment of trauma of skin and mucosal tissue from external causes, e.g. cuts, abrasions, incisions and burns, as well as bacterial and fungal infections and ulcers of unknown etiology.
  • the solvent is alcoholic, e.g. ethyl, isopropyl or methyl alcohol.
  • the specific solvent is chosen for its ability to dissolve the HPC and esterificaticn agent and to maintain the esterification reaction product in solution or suspension until application of the composition to the treatment site. Obviously, the solvent should not be toxic to the body in the quantities employed.
  • the esterification agent can, advantageously, be a weak carboxylic acid which is substantially non-toxic.
  • the specific acid or acids are selected for their ability to react with the HPC to form an esterification reaction product (see below) which is soluble in the reaction mixture at storage temperatures, e.g. 40-80 degrees Fahrenheit, but which is insoluble in body fluids at or near body temperatures and above.
  • Suitable weak organic acids include salicylic acid and tannic acid and mixtures thereof.
  • Other suitable esterification agents can be identified by those skilled in the art, having regard for this disclosure.
  • compositions which comprise the film-forming compositions described above and a biologically active topical treatment component, cosmetics, or medication.
  • the biologically active component is physically incorporated in the film-forming components and in the films formed therefrom, to provide medically effective quantities of the topical agent at the treatment site on body tissue.
  • the incorporated biologically active components are thus maintained in contact with the tissue for a time effective to treat the medical condition for which they are intended, rather than being displaced by physical movement of the tissue, abrasion or by irrigation by body fluids.
  • the films provide a sustained release mechanism which increases the efficacy of the treatment.
  • the HPC derived films are inert and do not interfere with the normal action of the topical treatment agent.
  • the esterification component of the compositions esterifies at least a portion of the HPC.
  • This esterification reaction apparently takes place primarily upon drying of the solvent carrier.
  • the HPC and acid components of my composition, as well as any ester derivative which may form in solution prior to application of the composition to the body tissue are soluble in the solvent carrier at room temperature under normal pre-application and storage conditions.
  • a film is formed in situ which is insoluble in body fluids at and above normal body temperature of about 37 degrees centigrade.
  • I also incorporate a non-toxic weak cross-linking agent in the compositions of the invention.
  • the resultant in situ formed film is somewhat tougher and more resilient and has better adhesion to body tissue than such films which are formed from compositions without such cross-linking agent.
  • the agents for cellulosic compounds, the specific agent being chosen so as to avoid premature formation of an insoluble mass prior to application of the composition.
  • boric acid is an appropriately effective cross- linking agent for use in practicing the present invention. While I do not wish to be bound by this mechanism, it appears that the cross-linking agent effectively bonds some of the un- esterified hydroxyl groups into the film formed on drying of the composition after application to the body issue.
  • HPC-derived films are soluble in ethyl alcohol and similar non-toxic volatile solvents, e.g., isopropyl alcohol and the like, but are insoluble in water and water- containing body fluids, e.g., saliva at normal human body temperature. Films formed by evaporation of the solutions are tough, resilient and adhesive to body tissues and form a protective barrier against air, other body fluids and foreign substances.
  • the cellulosic compound which is reacted with weak carboxylic acids to form the film according to my invention, is selected for its ability to react with the carboxylic acid component to form a film which is insoluble in water and aqueous body fluids at a temperature equal to or greater than body temperature.
  • hydroxypropyl cellulose HPC
  • Such cellulosic compound is available commerically, for example, the product sold under the name "Klucel 1 *, a registered trademark of Aqualon Company.
  • the type ⁇ MF" Klucel product is particularly suitable.
  • the solvent for forming the solutions of the HPC is selected for its ability to dissolve the HPC and HPC esters and its non-toxic characteristics when the composition is applied in the amount necessary to from a protective film.
  • ethyl alcohol is preferred when the film is to be deposited in the oral cavity whereas isopropyl alcohol is suitable for use in depositing films on the skin.
  • suitable solvents will be readily identified by those skilled in the art having a regard for he disclosures herein, e.g.. volatile polar solvents which are medically compatible with body tissue.
  • the specific esterification agent component of the compositions is chosen for its ability to react with the HPC to form, upon air-drying of the composition, a tough resilient film which adheres to body tissue.
  • Strong carboxylic acids e.g., acetic acid, citric acid and the like do not provide this result.
  • weak carboxylic acids, especially salicylic acid, tannic acid and the like and mixture thereof function effectively.
  • the in situ film formation capability appears to be related to the solubility of the HPC derivative in water and aqueous body fluids at body temperature.
  • any such weak carboxylic acid which is non-toxic and has the capability to form such insoluble films can be effectively employed, the selection of such weak acid being within the capability of persons skilled in this art, having regard for this disclosure.
  • Salicylic acid and tannic acid have been identified as particularly effective in the practice of my invention.
  • a mixture of these two acids in the film forming compositions of the invention produce a superior film in terms of adhesion and mechanical integrity, although either of these acids alone provides an effective in situ deposited film.
  • the film of HPC which is formed by evaporation of the compositions is apparently a "physical film", i.e., the cellulosic compounds do not polymerize.
  • Evidence of the physical characteristics of these films is provided by the fact that such film, once formed, simply re-dissolves upon further application of the compositions to the same site.
  • the film forming composition can be applied to the body tissue by any convenient technique, e.g., spraying. dipping or simple direct application by a swab.
  • the HPC component is present in the solution in an amount from about 0.1 - 20% by weight of the final composition.
  • the proportion of the HPC in the composition affects the time required for the composition to air dry and form the tough adhesive film.
  • the composition dries more slowly, but he resultant film is more coherent and abrasion-resisitant.
  • the film forms more quickly by air drying, but the resultant film is less coherent and adhesive owing to the fact that the portion of the film at the surface of the applied composition and at the body tissue surface dries at different rates.
  • the carboxylic acid component of the composition can be a single acid, alone or in combination with other weak carboxylic acids. Whether present alone or in combination, however, the proportion of the carboxylic acid can vary from about 1 to about 10% by weight of the composition with the optimum concentration being closer to the upper portion of this range. Indeed, there are indications that higher proportions of the carboxylic acids do not appreciably interfere with the film formation. In the lower range, the film forms more slowly and is less coherent.
  • compositions are applied typically in localized areas, to the body tissue and air-dried to form the film in situ, adhesively secured to the tissue.
  • steps should be taken to remove as much of the water, moisture or other body fluids from the surface of the body tissue before applying the composition.
  • normal dental procedures for substantially drying the mucosal tissue are employed and air is drawn or blown over the surface of the applied composition to promote more rapid evaporation of the solvent and formation of the film.
  • compositions have been found especially useful in the treatment of aphthous ulcers of the mucosa, including recurrent aphthous stomatitis.
  • This treatment provides essentially immediate and long-lasting relief of the extraordinar pain associated with such ulcers in the formative and pre- localizing steps.
  • the particular composition which has been found most effective in alleviating such pain includes HPC, ethyl alcohol solvent, a mixture of tannic and salicylic acids as the weak carboxylic acid component and boric acid as the cross-linking agent.
  • HPC ethyl alcohol solvent
  • a mixture of tannic and salicylic acids as the weak carboxylic acid component
  • boric acid as the cross-linking agent.
  • the composition is applied directly to the surface of the ulcer and surrounding mucosa with a swab and is air dried by simply ensuring that the patient breathes normally through the mouth.
  • the film is adhesively retained on the ulcer site and surrounding mucosal tissue for extended periods of time, upwards of several hours. Furthermore, the initial pain relief, obtained by the exclusion of air, saliva, etc. , from the ulcer, continues during this extended retension period and even prevents recurrence of the pain despite repeated attempts to cause pain onset by deliberately insulting the ulcer with irritating foods such as orange juice.
  • EXAMPLE 1 EXAMPLE 1 ;
  • a composition is prepared by mixing the following components in the indicated proportions:
  • Example 1 The composition of Example 1 is tested for pain reduction capability in comparison with the commerically available medication sold under the name "Orabase", a composition containing benzocaine in a sodium carboxymethyl cellulose and pectin base.
  • Comparable test sites consisting of an aphthous ulcer and surrounding healthy mucosal tissue is selected in the mouths of each of the subjects. These sites are prepared by irrigating with distilled water and then carefully drying with cotton gauze pads.
  • composition prepared according to this example is applied as a thin coating to the prepared aphthous ulcer sites in the mouths of the test group and a similar thin coating of the Orbase control medication is applied to aphthous ulcer sites in the mouths of the control group.
  • Example 1 The patients of both the test group and the control group are required to breathe normally through the mouth for a period of two minutes, after which point it is noted that the composition of Example 1 has dried in the mouths of the test .”group patients to form a film over the aphthous ulcer site.
  • test and control patients Observation of the test and control patients demonstrates that the films of the test composition are still present in place in 80% of the test subjects*' mouths two hours after application, whereas the control medication completely disappears from the ulcer sites in all subjects in the control group.
  • Example 2 The procedure of Example 2 is repeated except that, just prior to the preparation of the ulcer sites, the aphthous ulcers in the mouths of both the test and control patients are insulted by application of orange juice. The incidence of pain is clinically observed for a period of one hour, at which time the treated ulcer sites are once again insulted with orange juice. Pain observation is continued for an additional three hours.
  • both the test and control groups all patients experience a large increase in pain after the first insult, followed by a mild to significant decrease in pain after the immediate application of both the test and control compositions.
  • the patients in the test group which are treated with the composition of the present invention experience no increase in pain and continue to experience mild to substantial pain reduction for the succeeding three hours.
  • the patients in the control group experience a large increase in pain at the second insult which decreases only slightly during the ensuing three hours.
  • compositions contain, respectively, 10% tannic acid, 10% salicylic acid and 7% boric acid. Both of these compositions yield comparable results to those set forth in Examples 2 and 3.
  • the boric acid cross-linking agent is omitted from the compositions of the preceeding Examples.
  • the in situ deposited films formed from these compositions actually comprise two layers which can be mechanically separated. Although these two-layer films are effective in pain treatment, they are less persistent.
  • compositions of Example 1 Therapeutically effective quantities of various topical medicines are incorporated into the compositions of Example 1.
  • the resulting mixtures are shelf-stable and are topically applied to body tissue and air-dried, forming resilient adherent films containing the medicaments, which migrate to the treatment site to effectively accomplish the desired treatment.
  • the flexural aspect of a subject's forearms are cleansed and approximately 10 mg of the test material is applied to a clearly marked 8 cm 2 area.
  • Four formulations are evaluated on four different 8 cm areas on each arm, totaling eight formulations per subject. The formulations are applied at 4 p.m. and allowed to remain in place overnight. At 8 a.m. the test sites are gently washed with soap and water and read two hours after washing. The intensity of blanching is determined on a four-point scale. Twenty subjects were used to evaluate a panel of eight formulations, with a ventilated guard placed over the test sites and ten subjects were used to evaluate the formulations with no guard placed over the test sites. The formulations tested were:
  • Example 1 The ability of the film forming compositions of Example 1 to carry and effectively release antibiotics was demonstrated by incorporating 1% neomycin therein. This formulation was compared to a commerical 1% neomycin cream by applying the formulations to hairless mouse skins (10 replications) and agar plates (4 replications) inoculated with staph. aureus. The radio of inhibitions (mm) of each replicate were summed to give a total score for each formulation. The results were: Mouse Skin A ⁇ ur Plate

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
EP19890909293 1988-05-02 1989-07-24 Compositions and in situ methods for forming films on body tissue Withdrawn EP0380647A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18903288A 1988-05-02 1988-05-02
WOPCT/US88/02515 1988-07-25

Publications (2)

Publication Number Publication Date
EP0380647A1 EP0380647A1 (en) 1990-08-08
EP0380647A4 true EP0380647A4 (en) 1991-07-24

Family

ID=22695630

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890909293 Withdrawn EP0380647A4 (en) 1988-05-02 1989-07-24 Compositions and in situ methods for forming films on body tissue

Country Status (14)

Country Link
EP (1) EP0380647A4 (no)
JP (1) JP3000104B2 (no)
KR (1) KR940011240B1 (no)
CN (1) CN1038227C (no)
AU (2) AU2252388A (no)
BR (1) BR9002342A (no)
CA (1) CA1337396C (no)
ES (1) ES2020655A6 (no)
FI (1) FI901443A0 (no)
IE (1) IE902096A1 (no)
MX (1) MX21686A (no)
NO (1) NO180618C (no)
NZ (1) NZ232625A (no)
WO (2) WO1989010745A1 (no)

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WO1989010745A1 (en) * 1988-05-02 1989-11-16 Pomerantz, Edwin Compositions and in situ methods for forming films on body tissue
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US7632517B2 (en) 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
US20030077227A1 (en) 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
FR2773068B1 (fr) * 1997-12-29 2000-09-01 Oreal Composition cosmetique filmogene a base d'un derive de cellulose contenant, en tant qu'agent epaississant, un tetraborate de metal alcalin
US6283933B1 (en) 1998-12-23 2001-09-04 Closure Medical Corporation Applicator for dispensable liquids
US6595940B1 (en) 1998-12-23 2003-07-22 Closure Medical Corporation Applicator for dispensable liquids
US20020064542A1 (en) * 1999-06-29 2002-05-30 George Endel Deckner Tissue products utilizing water soluble films as carriers for antiviral compositions and process for making
CN1891300B (zh) * 2005-07-06 2010-04-14 上海医药工业研究院 苯佐卡因成膜凝胶组合物及其用途
CN100446814C (zh) * 2005-07-22 2008-12-31 上海医药工业研究院 复方硝酸益康唑成膜凝胶组合物及其制药用途
CN101138543B (zh) * 2006-09-06 2012-01-04 上海医药工业研究院 积雪草总苷局部成膜凝胶组合物及其应用
CN101190178B (zh) * 2006-11-24 2010-05-12 上海医药工业研究院 抗病毒局部成膜凝胶组合物
FR2976808B1 (fr) * 2011-06-22 2013-06-28 Urgo Lab Composition filmogene et son utilisation pour le traitement de l'herpes
EP2742931A1 (de) * 2012-12-13 2014-06-18 LTS LOHMANN Therapie-Systeme AG Topisches Arzneimittel zur Behandlung von Aphten
CN104337939A (zh) * 2013-08-05 2015-02-11 天津司威林医疗器械科技有限公司 一种中药止血涂膜材料的制备方法
CN104997723A (zh) * 2014-04-16 2015-10-28 上海现代药物制剂工程研究中心有限公司 成膜凝胶组合物、其用途及药物成膜凝胶组合物
CN105012960A (zh) * 2014-04-16 2015-11-04 上海现代药物制剂工程研究中心有限公司 成膜凝胶组合物、其用途及护创材料
KR101874770B1 (ko) * 2018-01-02 2018-07-05 김진동 아파트형 공장
KR102072816B1 (ko) * 2018-05-28 2020-02-03 서석호 컨베이어 벨트를 이동하도록 지지하는 다수의 임팩트바를 구비한 컨베이어 벨트 스탠드 시스템
CN110201218A (zh) * 2018-12-23 2019-09-06 山东泰开制药有限公司 液体创可贴及其制备方法
WO2021033182A1 (en) * 2019-08-16 2021-02-25 Adel Penhasi Adhesive drug delivery film and a microparticle comprising thereof
WO2021132199A1 (ja) * 2019-12-26 2021-07-01 帝人ファーマ株式会社 医療用被覆材

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BR9002342A (pt) 1991-08-06
AU614179B2 (en) 1991-08-22
CA1337396C (en) 1995-10-24
ES2020655A6 (es) 1991-08-16
JPH03503052A (ja) 1991-07-11
NO180618B (no) 1997-02-10
CN1038227C (zh) 1998-05-06
JP3000104B2 (ja) 2000-01-17
NZ232625A (en) 1991-08-27
MX21686A (es) 1994-01-31
NO901346L (no) 1990-03-23
EP0380647A1 (en) 1990-08-08
WO1989010745A1 (en) 1989-11-16
KR900701251A (ko) 1990-12-01
CN1048979A (zh) 1991-02-06
AU2252388A (en) 1989-11-29
NO180618C (no) 1997-05-21
WO1990001046A1 (en) 1990-02-08
AU4053689A (en) 1990-02-19
IE902096A1 (en) 1991-06-19
NO901346D0 (no) 1990-03-23
KR940011240B1 (ko) 1994-12-03
FI901443A0 (fi) 1990-03-22

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