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EE03873B1 - Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine - Google Patents

Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine

Info

Publication number
EE03873B1
EE03873B1 EEP200000024A EEP200000024A EE03873B1 EE 03873 B1 EE03873 B1 EE 03873B1 EE P200000024 A EEP200000024 A EE P200000024A EE P200000024 A EEP200000024 A EE P200000024A EE 03873 B1 EE03873 B1 EE 03873B1
Authority
EE
Estonia
Prior art keywords
alkyloxfuranone
preparation
compounds obtained
amine derivatives
amine
Prior art date
Application number
EEP200000024A
Other languages
English (en)
Estonian (et)
Inventor
Bouchet Rapha�l
Brion Francis
Colladant Colette
Lagouardat Jacques
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Publication of EE200000024A publication Critical patent/EE200000024A/xx
Publication of EE03873B1 publication Critical patent/EE03873B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EEP200000024A 1997-07-15 1998-07-09 Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine EE03873B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9708932A FR2766188B1 (fr) 1997-07-15 1997-07-15 Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
PCT/FR1998/001480 WO1999003852A1 (fr) 1997-07-15 1998-07-09 Procede de preparation de derives amines d'alkyloxyfuranone, composes issus de ce procede et utilisation de ces composes

Publications (2)

Publication Number Publication Date
EE200000024A EE200000024A (et) 2000-10-16
EE03873B1 true EE03873B1 (et) 2002-10-15

Family

ID=9509210

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000024A EE03873B1 (et) 1997-07-15 1998-07-09 Meetod alküüloksüfuranooni amiinderivaatide valmistamiseks, sel meetodil saadud ühendid ja nende kasutamine

Country Status (34)

Country Link
US (1) US6235899B1 (id)
EP (1) EP0998470B1 (id)
JP (1) JP4450987B2 (id)
KR (1) KR100519691B1 (id)
CN (1) CN100363355C (id)
AP (1) AP1071A (id)
AR (1) AR015924A1 (id)
AT (1) ATE239713T1 (id)
AU (1) AU744272B2 (id)
BG (1) BG64050B1 (id)
BR (1) BR9810896A (id)
CA (1) CA2296742C (id)
CZ (1) CZ295312B6 (id)
DE (1) DE69814395T2 (id)
DK (1) DK0998470T3 (id)
EA (1) EA002883B1 (id)
EE (1) EE03873B1 (id)
ES (1) ES2197489T3 (id)
FR (1) FR2766188B1 (id)
HR (1) HRP20000027B1 (id)
HU (1) HU230148B1 (id)
ID (1) ID23784A (id)
IL (1) IL134031A (id)
ME (1) ME01708B (id)
NO (1) NO324508B1 (id)
NZ (1) NZ502338A (id)
PL (1) PL200820B1 (id)
PT (1) PT998470E (id)
RS (1) RS49832B (id)
SK (1) SK284168B6 (id)
TR (1) TR200000117T2 (id)
UA (1) UA66364C2 (id)
WO (1) WO1999003852A1 (id)
ZA (1) ZA986203B (id)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053056B2 (en) * 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
EP1278737B1 (en) * 2000-04-24 2010-06-30 Vertex Pharmaceuticals Incorporated Process and intermediates for making substituted aspartic acid acetals
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) * 2000-09-20 2003-11-19 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸誘導体の製造方法
JPWO2002055478A1 (ja) * 2001-01-16 2004-05-13 鐘淵化学工業株式会社 光学活性アミノラクトン誘導体の製造法およびその中間体
JP2007525503A (ja) 2004-02-27 2007-09-06 バーテックス　ファーマシューティカルズ　インコーポレイテッド カスパーゼインヒビターおよびそれらの使用
DK2399916T3 (en) 2004-03-12 2015-03-02 Vertex Pharma A process and intermediates for the preparation of asparaginacetal-caspase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme

Also Published As

Publication number Publication date
PT998470E (pt) 2003-09-30
BG64050B1 (bg) 2003-11-28
ATE239713T1 (de) 2003-05-15
DE69814395D1 (de) 2003-06-12
AU8633398A (en) 1999-02-10
UA66364C2 (uk) 2004-05-17
CZ200065A3 (cs) 2000-07-12
JP4450987B2 (ja) 2010-04-14
AP2000001732A0 (en) 2000-03-31
NO20000182L (no) 2000-03-07
CN100363355C (zh) 2008-01-23
EA002883B1 (ru) 2002-10-31
EP0998470A1 (fr) 2000-05-10
IL134031A (en) 2004-06-01
BG104073A (en) 2001-05-31
KR100519691B1 (ko) 2005-10-13
YU1500A (sh) 2002-10-18
DE69814395T2 (de) 2003-12-11
ZA986203B (en) 1999-08-18
EA200000127A1 (ru) 2000-08-28
AR015924A1 (es) 2001-05-30
NZ502338A (en) 2001-09-28
HUP0003857A2 (hu) 2001-04-28
HRP20000027B1 (en) 2006-07-31
DK0998470T3 (da) 2003-09-01
FR2766188B1 (fr) 2000-02-11
TR200000117T2 (tr) 2000-07-21
EE200000024A (et) 2000-10-16
JP2001510191A (ja) 2001-07-31
CN1269795A (zh) 2000-10-11
HUP0003857A3 (en) 2002-08-28
AU744272B2 (en) 2002-02-21
US6235899B1 (en) 2001-05-22
PL338035A1 (en) 2000-09-25
ES2197489T3 (es) 2004-01-01
SK302000A3 (en) 2000-11-07
BR9810896A (pt) 2000-09-26
HU230148B1 (hu) 2015-09-28
CA2296742C (fr) 2009-12-08
CA2296742A1 (fr) 1999-01-28
FR2766188A1 (fr) 1999-01-22
WO1999003852A1 (fr) 1999-01-28
SK284168B6 (sk) 2004-10-05
CZ295312B6 (cs) 2005-07-13
KR20010021834A (ko) 2001-03-15
EP0998470B1 (fr) 2003-05-07
AP1071A (en) 2002-05-20
IL134031A0 (en) 2001-04-30
NO20000182D0 (no) 2000-01-14
NO324508B1 (no) 2007-11-05
ME01708B (me) 2008-08-07
RS49832B (sr) 2008-08-07
HRP20000027A2 (en) 2000-10-31
PL200820B1 (pl) 2009-02-27
ID23784A (id) 2000-05-11

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231