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DE69814395D1 - Verfahren zur herstellung von alkoxyfuranon-amin-derivaten, durch dieses verfahren erhaltene verbindungen und verwendung dieser verbindungen - Google Patents

Verfahren zur herstellung von alkoxyfuranon-amin-derivaten, durch dieses verfahren erhaltene verbindungen und verwendung dieser verbindungen

Info

Publication number
DE69814395D1
DE69814395D1 DE69814395T DE69814395T DE69814395D1 DE 69814395 D1 DE69814395 D1 DE 69814395D1 DE 69814395 T DE69814395 T DE 69814395T DE 69814395 T DE69814395 T DE 69814395T DE 69814395 D1 DE69814395 D1 DE 69814395D1
Authority
DE
Germany
Prior art keywords
compounds
alkoxyfuranone
producing
amine derivatives
compounds obtained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69814395T
Other languages
English (en)
Other versions
DE69814395T2 (de
Inventor
Raphael Bouchet
Francis Brion
Colette Colladant
Jacques Lagouardat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE69814395D1 publication Critical patent/DE69814395D1/de
Application granted granted Critical
Publication of DE69814395T2 publication Critical patent/DE69814395T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69814395T 1997-07-15 1998-07-09 Verfahren zur herstellung von alkoxyfuranon-amin-derivaten, durch dieses verfahren erhaltene verbindungen und verwendung dieser verbindungen Expired - Lifetime DE69814395T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9708932A FR2766188B1 (fr) 1997-07-15 1997-07-15 Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
PCT/FR1998/001480 WO1999003852A1 (fr) 1997-07-15 1998-07-09 Procede de preparation de derives amines d'alkyloxyfuranone, composes issus de ce procede et utilisation de ces composes

Publications (2)

Publication Number Publication Date
DE69814395D1 true DE69814395D1 (de) 2003-06-12
DE69814395T2 DE69814395T2 (de) 2003-12-11

Family

ID=9509210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69814395T Expired - Lifetime DE69814395T2 (de) 1997-07-15 1998-07-09 Verfahren zur herstellung von alkoxyfuranon-amin-derivaten, durch dieses verfahren erhaltene verbindungen und verwendung dieser verbindungen

Country Status (34)

Country Link
US (1) US6235899B1 (de)
EP (1) EP0998470B1 (de)
JP (1) JP4450987B2 (de)
KR (1) KR100519691B1 (de)
CN (1) CN100363355C (de)
AP (1) AP1071A (de)
AR (1) AR015924A1 (de)
AT (1) ATE239713T1 (de)
AU (1) AU744272B2 (de)
BG (1) BG64050B1 (de)
BR (1) BR9810896A (de)
CA (1) CA2296742C (de)
CZ (1) CZ295312B6 (de)
DE (1) DE69814395T2 (de)
DK (1) DK0998470T3 (de)
EA (1) EA002883B1 (de)
EE (1) EE03873B1 (de)
ES (1) ES2197489T3 (de)
FR (1) FR2766188B1 (de)
HR (1) HRP20000027B1 (de)
HU (1) HU230148B1 (de)
ID (1) ID23784A (de)
IL (1) IL134031A (de)
ME (1) ME01708B (de)
NO (1) NO324508B1 (de)
NZ (1) NZ502338A (de)
PL (1) PL200820B1 (de)
PT (1) PT998470E (de)
RS (1) RS49832B (de)
SK (1) SK284168B6 (de)
TR (1) TR200000117T2 (de)
UA (1) UA66364C2 (de)
WO (1) WO1999003852A1 (de)
ZA (1) ZA986203B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053056B2 (en) * 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
ES2347133T3 (es) * 2000-04-24 2010-10-26 Vertex Pharmaceuticals Incorporated Procedimiento e intermedios para preparar acetales de acido aspartico sustituidos.
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) * 2000-09-20 2003-11-19 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸誘導体の製造方法
WO2002055478A1 (fr) * 2001-01-16 2002-07-18 Kaneka Corporation Procede de preparation de derives d'aminolactone optiquement actifs et intermediaires de ces derives
CN102161656B (zh) 2004-02-27 2013-02-20 沃泰克斯药物股份有限公司 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
DK1725548T3 (en) * 2004-03-12 2015-03-23 Vertex Pharma Process and intermediates for the preparation of asparagine acetal caspase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme

Also Published As

Publication number Publication date
FR2766188A1 (fr) 1999-01-22
RS49832B (sr) 2008-08-07
SK302000A3 (en) 2000-11-07
IL134031A0 (en) 2001-04-30
AR015924A1 (es) 2001-05-30
ID23784A (id) 2000-05-11
ES2197489T3 (es) 2004-01-01
EA002883B1 (ru) 2002-10-31
SK284168B6 (sk) 2004-10-05
AP2000001732A0 (en) 2000-03-31
PL338035A1 (en) 2000-09-25
HUP0003857A2 (hu) 2001-04-28
CZ200065A3 (cs) 2000-07-12
UA66364C2 (uk) 2004-05-17
ZA986203B (en) 1999-08-18
HRP20000027A2 (en) 2000-10-31
AU8633398A (en) 1999-02-10
TR200000117T2 (tr) 2000-07-21
ATE239713T1 (de) 2003-05-15
CN1269795A (zh) 2000-10-11
CA2296742C (fr) 2009-12-08
JP2001510191A (ja) 2001-07-31
AP1071A (en) 2002-05-20
AU744272B2 (en) 2002-02-21
KR20010021834A (ko) 2001-03-15
NZ502338A (en) 2001-09-28
FR2766188B1 (fr) 2000-02-11
IL134031A (en) 2004-06-01
EP0998470A1 (de) 2000-05-10
BG104073A (en) 2001-05-31
BG64050B1 (bg) 2003-11-28
HU230148B1 (hu) 2015-09-28
EA200000127A1 (ru) 2000-08-28
HRP20000027B1 (en) 2006-07-31
NO20000182L (no) 2000-03-07
ME01708B (me) 2008-08-07
CA2296742A1 (fr) 1999-01-28
KR100519691B1 (ko) 2005-10-13
BR9810896A (pt) 2000-09-26
JP4450987B2 (ja) 2010-04-14
YU1500A (sh) 2002-10-18
US6235899B1 (en) 2001-05-22
CN100363355C (zh) 2008-01-23
HUP0003857A3 (en) 2002-08-28
NO20000182D0 (no) 2000-01-14
NO324508B1 (no) 2007-11-05
DE69814395T2 (de) 2003-12-11
WO1999003852A1 (fr) 1999-01-28
PT998470E (pt) 2003-09-30
EP0998470B1 (de) 2003-05-07
EE200000024A (et) 2000-10-16
CZ295312B6 (cs) 2005-07-13
PL200820B1 (pl) 2009-02-27
DK0998470T3 (da) 2003-09-01
EE03873B1 (et) 2002-10-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC