ECSP10010337A - Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica - Google Patents
Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéuticaInfo
- Publication number
- ECSP10010337A ECSP10010337A EC2010010337A ECSP10010337A ECSP10010337A EC SP10010337 A ECSP10010337 A EC SP10010337A EC 2010010337 A EC2010010337 A EC 2010010337A EC SP10010337 A ECSP10010337 A EC SP10010337A EC SP10010337 A ECSP10010337 A EC SP10010337A
- Authority
- EC
- Ecuador
- Prior art keywords
- therapeutics
- preparation
- application
- nitrogen atom
- cycle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se refiere a los compuestos de fórmula general (I) en la que X1, X2, X3, y X4 representan, independientemente el uno del otro, un átomo de nitrógeno o un grupo C-R1 ; Z1, Z2, Z3 y Z4 representan, independientemente el uno del otro, un átomo de nitrógeno o un grupo C-R2 ; Ra y Rb forman junto con los átomos de carbono a los que están unidos un ciclo de cinco eslabones, conteniendo este ciclo un átomo de nitrógeno y átomos de carbono, estando este ciclo parcialmente saturado o insaturado y estando sustituido opcionalmente con uno o varios sustituyentes R3 ; W representa un átomo de oxígeno o de azufre ; n es igual a 0, 1, 2 ó 3 ; Y representa un arilo o un heteroarilo sustituido opcionalmente ; en el estado de base o de sal de adición a un ácido, así como en el estado de hidrato o de solvato. Procedimiento de preparación y aplicación en terapéutica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800308A FR2926554B1 (fr) | 2008-01-22 | 2008-01-22 | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| PCT/FR2009/000052 WO2009112678A2 (fr) | 2008-01-22 | 2009-01-20 | Derives de carboxam i d es azabicycliques, leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP10010337A true ECSP10010337A (es) | 2010-08-31 |
Family
ID=39843820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2010010337A ECSP10010337A (es) | 2008-01-22 | 2010-07-12 | Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8354425B2 (es) |
| EP (1) | EP2235015B1 (es) |
| JP (1) | JP5478512B2 (es) |
| KR (1) | KR101593711B1 (es) |
| CN (1) | CN101977911A (es) |
| AR (1) | AR070206A1 (es) |
| AU (1) | AU2009224533B2 (es) |
| BR (1) | BRPI0907381A2 (es) |
| CA (1) | CA2712609C (es) |
| CO (1) | CO6280509A2 (es) |
| CR (1) | CR11546A (es) |
| DO (1) | DOP2010000213A (es) |
| EA (1) | EA201070872A1 (es) |
| EC (1) | ECSP10010337A (es) |
| FR (1) | FR2926554B1 (es) |
| HN (1) | HN2010001459A (es) |
| IL (1) | IL207078A (es) |
| MA (1) | MA32089B1 (es) |
| MX (1) | MX2010007977A (es) |
| MY (1) | MY150576A (es) |
| NI (1) | NI201000124A (es) |
| NZ (1) | NZ586938A (es) |
| PA (1) | PA8812801A1 (es) |
| PE (1) | PE20091320A1 (es) |
| TW (1) | TWI428339B (es) |
| UA (1) | UA102837C2 (es) |
| UY (1) | UY31606A1 (es) |
| WO (1) | WO2009112678A2 (es) |
| ZA (1) | ZA201005202B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926555B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| NZ587215A (en) * | 2008-01-22 | 2012-08-31 | Takeda Pharmaceutical | Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them |
| AR090044A1 (es) | 2011-12-21 | 2014-10-15 | Novira Therapeutics Inc | Agentes antivirales para la hepatitis b |
| SG10201605291WA (en) | 2012-08-28 | 2016-08-30 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| JP6466348B2 (ja) | 2013-02-28 | 2019-02-06 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | スルファモイル−アリールアミドおよびｂ型肝炎を処置するための医薬品としてのその使用 |
| DK2981536T3 (en) | 2013-04-03 | 2017-09-25 | Janssen Sciences Ireland Uc | N-PHENYLC CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICINES FOR THE TREATMENT OF HEPATITIS B |
| PT2997019T (pt) | 2013-05-17 | 2018-11-21 | Janssen Sciences Ireland Uc | Derivados de sulfamoíltiofenamida e o seu uso como medicamentos para o tratamento da hepatite b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| NO3024819T3 (es) | 2013-07-25 | 2018-07-21 | ||
| EA034448B1 (ru) | 2013-10-23 | 2020-02-10 | Янссен Сайенсиз Айрлэнд Юси | Производные карбоксамида и их применение в качестве медикаментов для лечения гепатита b |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| JP6466461B2 (ja) | 2014-02-03 | 2019-02-06 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Ｒｏｒガンマのジヒドロピロロピリジン阻害剤 |
| EP3102225B1 (en) | 2014-02-05 | 2020-03-25 | Novira Therapeutics Inc. | Combination therapy for treatment of hbv infections |
| PL3102572T3 (pl) | 2014-02-06 | 2019-04-30 | Janssen Sciences Ireland Uc | Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B |
| JP6564029B2 (ja) | 2014-10-14 | 2019-08-21 | ヴァイティー ファーマシューティカルズ，エルエルシー | Ｒｏｒ−ガンマのジヒドロピロロピリジン阻害剤 |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| EA201792069A1 (ru) | 2015-03-19 | 2018-04-30 | Новира Терапьютикс, Инк. | Производные азокана и азонана и способы лечения инфекций гепатита в |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| EP3331876B1 (en) | 2015-08-05 | 2020-10-07 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
| WO2017059059A1 (en) | 2015-09-29 | 2017-04-06 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis b antiviral agent |
| MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| JP2019511542A (ja) | 2016-04-15 | 2019-04-25 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | カプシド集合阻害剤を含む組み合わせ及び方法 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| SG11202000621VA (en) | 2017-07-24 | 2020-02-27 | Vitae Pharmaceuticals Llc | Inhibitors of ror? |
| EP3765011A1 (en) | 2018-03-14 | 2021-01-20 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| BR112021015618A2 (pt) | 2019-02-22 | 2021-10-05 | Janssen Sciences Ireland Unlimited Company | Derivados de amida úteis no tratamento da infecção pelo hbv ou doenças induzidas pelo hbv |
| MA55879A (fr) | 2019-05-06 | 2022-03-16 | Janssen Sciences Ireland Unlimited Co | Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2677358B1 (fr) | 1991-06-05 | 1994-09-30 | Rhone Poulenc Chimie | Composes organosilyles et leur procede de synthese. |
| JP2001151771A (ja) | 1999-09-10 | 2001-06-05 | Kyowa Hakko Kogyo Co Ltd | 含窒素芳香族複素環誘導体 |
| EP2033953A1 (en) | 2002-02-15 | 2009-03-11 | Glaxo Group Limited | Vanilloid receptor modulators |
| US7338950B2 (en) | 2003-10-07 | 2008-03-04 | Renovis, Inc. | Amide compounds as ion channel ligands and uses thereof |
| JP2007518816A (ja) | 2004-01-23 | 2007-07-12 | アムジエン・インコーポレーテツド | バニロイド受容体リガンド及び炎症性及び神経因性疼痛の治療におけるこれらの使用 |
| GB0403780D0 (en) | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Therapeutic agents |
| CA2566332A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| FR2874015B1 (fr) * | 2004-08-05 | 2006-09-15 | Sanofi Synthelabo | Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| CA2581516C (en) | 2004-10-12 | 2013-06-11 | Astrazeneca Ab | Quinazoline derivatives |
| FR2880625B1 (fr) * | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2888848B1 (fr) * | 2005-07-22 | 2007-09-28 | Sanofi Aventis Sa | Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2888847B1 (fr) * | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| FR2897061B1 (fr) | 2006-02-03 | 2010-09-03 | Sanofi Aventis | Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique. |
| FR2904316B1 (fr) * | 2006-07-31 | 2008-09-05 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique. |
| FR2910473B1 (fr) * | 2006-12-26 | 2009-02-13 | Sanofi Aventis Sa | Derives de n-(amino-heteroaryl)-1h-pyrrolopyridine-2- carboxamides, leur preparation et leur application en therapeutique. |
| FR2911605B1 (fr) * | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique |
| FR2911604B1 (fr) * | 2007-01-19 | 2009-04-17 | Sanofi Aventis Sa | Derives de n-(heteroaryl-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| FR2926555B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives bicycliques de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| FR2926553B1 (fr) * | 2008-01-23 | 2010-02-19 | Sanofi Aventis | Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique |
-
2008
- 2008-01-22 FR FR0800308A patent/FR2926554B1/fr not_active Expired - Fee Related
-
2009
- 2009-01-20 PE PE2009000064A patent/PE20091320A1/es not_active Application Discontinuation
- 2009-01-20 EP EP09719730.5A patent/EP2235015B1/fr not_active Not-in-force
- 2009-01-20 WO PCT/FR2009/000052 patent/WO2009112678A2/fr active Application Filing
- 2009-01-20 MX MX2010007977A patent/MX2010007977A/es active IP Right Grant
- 2009-01-20 CN CN2009801100023A patent/CN101977911A/zh active Pending
- 2009-01-20 AU AU2009224533A patent/AU2009224533B2/en not_active Ceased
- 2009-01-20 MY MYPI20103439 patent/MY150576A/en unknown
- 2009-01-20 EA EA201070872A patent/EA201070872A1/ru unknown
- 2009-01-20 NZ NZ586938A patent/NZ586938A/en not_active IP Right Cessation
- 2009-01-20 BR BRPI0907381-7A patent/BRPI0907381A2/pt not_active IP Right Cessation
- 2009-01-20 AR ARP090100166A patent/AR070206A1/es unknown
- 2009-01-20 CA CA2712609A patent/CA2712609C/fr not_active Expired - Fee Related
- 2009-01-20 KR KR1020107018566A patent/KR101593711B1/ko active Active
- 2009-01-20 JP JP2010543539A patent/JP5478512B2/ja not_active Expired - Fee Related
- 2009-01-20 UA UAA201010237A patent/UA102837C2/ru unknown
- 2009-01-21 TW TW098102268A patent/TWI428339B/zh not_active IP Right Cessation
- 2009-01-21 PA PA20098812801A patent/PA8812801A1/es unknown
- 2009-01-22 UY UY031606A patent/UY31606A1/es not_active Application Discontinuation
-
2010
- 2010-06-29 CR CR11546A patent/CR11546A/es not_active Application Discontinuation
- 2010-07-09 DO DO2010000213A patent/DOP2010000213A/es unknown
- 2010-07-12 EC EC2010010337A patent/ECSP10010337A/es unknown
- 2010-07-19 IL IL207078A patent/IL207078A/en not_active IP Right Cessation
- 2010-07-21 US US12/840,659 patent/US8354425B2/en not_active Expired - Fee Related
- 2010-07-21 NI NI201000124A patent/NI201000124A/es unknown
- 2010-07-21 ZA ZA2010/05202A patent/ZA201005202B/en unknown
- 2010-07-21 HN HN2010001459A patent/HN2010001459A/es unknown
- 2010-07-22 CO CO10089487A patent/CO6280509A2/es not_active Application Discontinuation
- 2010-08-17 MA MA33097A patent/MA32089B1/fr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP10010337A (es) | Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica | |
| DOP2010000227A (es) | Derivados biciclicos de carboxamidas aza-biciclicas, su preparacion y su aplicacion terapeutica | |
| ES2624795T3 (es) | Derivados de N-(heteroaril)-1-heteroaril-1H-indol-2-carboxamidas, su preparación y su aplicación en terapéutica | |
| DOP2010000215A (es) | Derivados de carboxamidas azabiciclicas, su preparacion y su aplicacion en terapeutica | |
| NI200900037A (es) | Derivados de 2-aril-6-fenil-imidazo[1,2-alfa] piridinas, su preparación y su aplicación en terapéutica. | |
| PA8786101A1 (es) | "DERIVADOS DE 6-CICLOAMINO-3-(PIRIDIN-4-IL) IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA" | |
| AR066107A1 (es) | Derivados de triazolopiridin - carboxamidas y triazolopirimidin-carboxamidas, su preparacion y su aplicacion en terapeutica como inhibidores de la enzimamonoacil glicerol lipasa y composiciones qu los contienen. | |
| PE20170303A1 (es) | Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas | |
| AR075243A1 (es) | Derivados del 1-fenil-2-piridinil alquil alcohol como inhibidores de fosfodiesterasa | |
| MY150289A (en) | Derivatives of indole-2-carboxamides and of azaindole-2-carboxamides substituted with a silanyl group, preparation thereof and therapeutic use thereof | |
| AR079077A1 (es) | Derivados de piridino-piridinonas, su preparacion y su aplicacion en terapeutica de enfermedades mediadas por la tirosina quinasa | |
| NI201000134A (es) | Nuevos derivados dihidroindolonas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
| ECSP11011384A (es) | Sales de adición de trometamina con derivados de ácido azabifenilaminobenzoico como inhibidores de dhodh. | |
| DOP2012000296A (es) | Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparación y su uso terapéutico | |
| AR072880A1 (es) | Derivados nitrogenados de la pancratistatina | |
| ECSP066810A (es) | Derivados de carbamato de 2h- ó 3h-benzo[e]indazol-1-ilo, su preparación y su aplicación en terapéutica | |
| CU20120041A7 (es) | Nuevos derivados dihidro-oxazolobenzodiazepinonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| CO6331311A2 (es) | Derivados de n-heterociclico-6-heterociclico-imidazo[1,2-alfa]piriidina-2-carboxamidas su preparacion y su aplicacion en terapeutica | |
| UY32895A (es) | Derivados acetilénicos de 5-fenilpirazolopiridina, su preparación y su aplicación terapéutica | |
| TN2010000333A1 (en) | Bicyclic derivativesof azabicyclic carboxamides, preparation thereof and therapeutic use thereof |