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EA202091693A1 - Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения - Google Patents

Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения

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Publication number
EA202091693A1
EA202091693A1 EA202091693A EA202091693A EA202091693A1 EA 202091693 A1 EA202091693 A1 EA 202091693A1 EA 202091693 A EA202091693 A EA 202091693A EA 202091693 A EA202091693 A EA 202091693A EA 202091693 A1 EA202091693 A1 EA 202091693A1
Authority
EA
Eurasian Patent Office
Prior art keywords
targetingly
synucleine
applications
sense oligonucleotides
affecting
Prior art date
Application number
EA202091693A
Other languages
English (en)
Inventor
Ричард Е. Олсон
Анджела М. Какасе
Джери Е. мл. Мередит
Нино Девидзе
Джеймс К. Лой
Карл Дж. Болдик
Аннапурна Пендри
Айвар М. МакДональд
Питер Хагедорн
Марианне Лербех Дженсен
Original Assignee
Бристол-Маерс Сквибб Компани
Роше Инновейшн Сентер Копенгаген А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Маерс Сквибб Компани, Роше Инновейшн Сентер Копенгаген А/С filed Critical Бристол-Маерс Сквибб Компани
Publication of EA202091693A1 publication Critical patent/EA202091693A1/ru

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Abstract

Настоящее изобретение относится к антисмысловым олигонуклеотидам, которые оказывают целенаправленное воздействие на мРНК SNCA (например, в месте соединения интрона и экзона) в клетке, что приводит к пониженной экспрессии белка SNCA. Снижение экспрессии белка SNCA является благоприятным для лечения определенных медицинских нарушений, например неврологического нарушения.
EA202091693A 2018-01-12 2019-01-11 Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения EA202091693A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862616994P 2018-01-12 2018-01-12
PCT/US2019/013255 WO2019140236A1 (en) 2018-01-12 2019-01-11 Antisense oligonucleotides targeting alpha-synuclein and uses thereof

Publications (1)

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EA202091693A1 true EA202091693A1 (ru) 2021-04-14

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EA202091693A EA202091693A1 (ru) 2018-01-12 2019-01-11 Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения

Country Status (15)

Country Link
US (1) US12241065B2 (ru)
EP (1) EP3737761A1 (ru)
JP (2) JP7547201B2 (ru)
KR (1) KR20200140240A (ru)
CN (1) CN111819283A (ru)
AU (1) AU2019208011A1 (ru)
BR (1) BR112020014011A2 (ru)
CA (1) CA3087966A1 (ru)
CO (1) CO2020009715A2 (ru)
EA (1) EA202091693A1 (ru)
IL (1) IL275903A (ru)
MX (1) MX2020007439A (ru)
PE (1) PE20211749A1 (ru)
SG (1) SG11202006528XA (ru)
WO (1) WO2019140236A1 (ru)

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SG11201906947SA (en) 2017-02-17 2019-08-27 Bristol Myers Squibb Co Antibodies to alpha-synuclein and uses thereof
TWI809004B (zh) 2017-11-09 2023-07-21 美商Ionis製藥公司 用於降低snca表現之化合物及方法
EA202091693A1 (ru) 2018-01-12 2021-04-14 Бристол-Маерс Сквибб Компани Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения
SG11202006526YA (en) 2018-01-12 2020-08-28 Bristol Myers Squibb Co Antisense oligonucleotides targeting alpha-synuclein and uses thereof
CA3090901A1 (en) 2018-02-12 2019-08-15 Ionis Pharmaceuticals, Inc. Modified compounds and uses thereof
WO2021141917A1 (en) * 2020-01-06 2021-07-15 AUM LifeTech, Inc. Antisense oligonucleotides for treatment of neurological disorders
WO2024173759A2 (en) * 2023-02-17 2024-08-22 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating alpha-synuclein expression
WO2024196752A2 (en) * 2023-03-17 2024-09-26 Duke University Compositions for cell specific snca-targeted gene therapy and methods of making and using same

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