[go: up one dir, main page]

EA201892625A1 - КОМБИНИРОВАННАЯ ТЕРАПИЯ С ПРИМЕНЕНИЕМ ИНГИБИТОРА АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) ДЛЯ ЛЕЧЕНИЯ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ - Google Patents

КОМБИНИРОВАННАЯ ТЕРАПИЯ С ПРИМЕНЕНИЕМ ИНГИБИТОРА АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) ДЛЯ ЛЕЧЕНИЯ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ

Info

Publication number
EA201892625A1
EA201892625A1 EA201892625A EA201892625A EA201892625A1 EA 201892625 A1 EA201892625 A1 EA 201892625A1 EA 201892625 A EA201892625 A EA 201892625A EA 201892625 A EA201892625 A EA 201892625A EA 201892625 A1 EA201892625 A1 EA 201892625A1
Authority
EA
Eurasian Patent Office
Prior art keywords
disease
acc
alcoholic
carboxylase
coa
Prior art date
Application number
EA201892625A
Other languages
English (en)
Inventor
Джеральдин С. Харриман
Розана Капеллер-Либерманн
Вильям Ф. Вестлин
Х. Джеймс Харвуд
Original Assignee
Джилид Аполло, Ллс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Аполло, Ллс filed Critical Джилид Аполло, Ллс
Publication of EA201892625A1 publication Critical patent/EA201892625A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В настоящем изобретении предложены способы лечения, стабилизации, или снижения тяжести, или замедления прогрессирования неалкогольной жировой болезни печени с применением ингибитора ACC отдельно или с одним или более дополнительными терапевтическими агентами.
EA201892625A 2015-01-09 2016-01-08 КОМБИНИРОВАННАЯ ТЕРАПИЯ С ПРИМЕНЕНИЕМ ИНГИБИТОРА АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) ДЛЯ ЛЕЧЕНИЯ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ EA201892625A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562101726P 2015-01-09 2015-01-09

Publications (1)

Publication Number Publication Date
EA201892625A1 true EA201892625A1 (ru) 2019-07-31

Family

ID=56356482

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201791258A EA201791258A1 (ru) 2015-01-09 2016-01-08 Комбинированная терапия с применением ингибитора ацетил-коа-карбоксилазы (acc) для лечения неалкогольной жировой болезни печени
EA201892625A EA201892625A1 (ru) 2015-01-09 2016-01-08 КОМБИНИРОВАННАЯ ТЕРАПИЯ С ПРИМЕНЕНИЕМ ИНГИБИТОРА АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) ДЛЯ ЛЕЧЕНИЯ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201791258A EA201791258A1 (ru) 2015-01-09 2016-01-08 Комбинированная терапия с применением ингибитора ацетил-коа-карбоксилазы (acc) для лечения неалкогольной жировой болезни печени

Country Status (13)

Country Link
US (2) US20180021341A1 (ru)
EP (2) EP3242722A4 (ru)
JP (2) JP2018501276A (ru)
KR (1) KR20170102299A (ru)
CN (1) CN107106873A (ru)
AU (1) AU2016205138A1 (ru)
BR (1) BR112017014341A2 (ru)
CA (1) CA2972919A1 (ru)
EA (2) EA201791258A1 (ru)
HK (2) HK1243369A1 (ru)
MX (1) MX2017008844A (ru)
SG (1) SG11201705361PA (ru)
WO (1) WO2016112305A1 (ru)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1993360T (pt) 2005-12-28 2017-05-25 Vertex Pharma Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida
TWI625121B (zh) 2009-07-13 2018-06-01 基利科學股份有限公司 調節細胞凋亡信號之激酶的抑制劑
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
US11571431B2 (en) 2013-12-04 2023-02-07 Galmed Research And Development Ltd Aramchol salts
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
HUE043310T2 (hu) 2015-07-06 2019-08-28 Gilead Sciences Inc COT modulátorok és eljárások alkalmazásukra
PT3380480T (pt) * 2015-11-25 2023-03-14 Gilead Apollo Llc Inibidores de pirazol acc e seus usos
WO2017091602A1 (en) 2015-11-25 2017-06-01 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
IL243707A0 (en) 2016-01-20 2016-05-01 Galmed Res And Dev Ltd Treatment to regulate the microbiota in the intestine
EP3423456B1 (en) 2016-03-02 2023-12-27 Gilead Apollo, LLC Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
US11066650B2 (en) 2016-05-05 2021-07-20 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
CA2968836A1 (en) 2016-06-13 2017-12-13 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
EP3468962A1 (en) 2016-06-13 2019-04-17 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
US20190298775A1 (en) 2016-11-04 2019-10-03 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
US11197870B2 (en) 2016-11-10 2021-12-14 Galmed Research And Development Ltd Treatment for hepatic fibrosis
CA3152584C (en) * 2016-11-10 2024-02-13 Galmed Research And Development Ltd. Treatment for fibrosis
MX2019005531A (es) * 2016-11-10 2019-09-16 Galmed Res And Development Ltd Inhibicion de la fibrosis en pacientes con enfermedad de higado graso no alcoholico.
NZ753873A (en) 2016-12-05 2023-01-27 Children’S Hospital Medical Center Colonic organoids and methods of making and using same
JP7300394B2 (ja) 2017-01-17 2023-06-29 ヘパリジェニックス ゲーエムベーハー 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
WO2018133858A1 (en) * 2017-01-22 2018-07-26 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivative and use thereof in medicine
WO2018171699A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途
PT4122464T (pt) * 2017-03-28 2024-06-27 Gilead Sciences Inc Combinações terapêuticas para o tratamento de doenças do fígado
WO2018183342A1 (en) * 2017-03-28 2018-10-04 Gilead Sciences, Inc. Methods of treating liver disease
CA3059883A1 (en) * 2017-04-12 2018-10-18 Gilead Sciences, Inc. Methods of treating liver disease
KR102699958B1 (ko) * 2017-04-18 2024-08-29 장피트 엘라피브라노르와 같은 ppar 작용제 및 아세틸-coa 카르복실라아제 (acc) 저해제를 포함하는 조합
CN110545837B (zh) * 2017-04-24 2022-09-27 清华大学 与自体诱导物相关的通路在诱导凋亡和抗感染治疗中的应用
JP2020524181A (ja) * 2017-06-19 2020-08-13 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｎａｆｌｄおよびｎａｓｈの治療のための化合物および方法
WO2019015583A1 (en) 2017-07-17 2019-01-24 Nanjing Ruijie Pharmatech Co., Ltd. NOVEL COMPOUNDS AND THEIR USES AS ACC INHIBITORS
WO2019020041A1 (zh) * 2017-07-26 2019-01-31 南京圣和药业股份有限公司 作为acc抑制剂的化合物及其应用
CN109316601B (zh) * 2017-07-31 2021-11-09 武汉朗来科技发展有限公司 药物组合物及其用途
EP3676262A4 (en) 2017-09-03 2021-03-31 Angion Biomedica Corp. VINYLHETEROCYCLENE AS RHO-ASSOCIATED COILED COIL KINASE (ROCK) INHIBITORS
US11033601B2 (en) * 2017-09-14 2021-06-15 The Regents Of The University Of Colorado, A Body Corporate Selective inhibition of V1b for treating fatty liver
WO2019071216A1 (en) * 2017-10-06 2019-04-11 Gilead Sciences, Inc. POLYTHERAPY COMPRISING AN ACC INHIBITOR
CN111278853B (zh) * 2017-11-06 2022-06-21 深圳市图微安创科技开发有限公司 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗胆汁性肝硬化
CN107693514A (zh) * 2017-12-04 2018-02-16 威海贯标信息科技有限公司 一种鲁格列净组合物
KR20200138166A (ko) 2018-01-31 2020-12-09 헤파레게닉스 게엠베하 간 재생을 촉진하거나 또는 간세포 사멸을 감소 또는 예방하기 위한 단백질 키나제 mkk4 저해제
US20210113561A1 (en) * 2018-04-17 2021-04-22 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US10806735B2 (en) * 2018-04-24 2020-10-20 Ph Pharma Co., Ltd. Use of neutrophil elastase inhibitors in liver disease
EP3810139A1 (en) 2018-06-21 2021-04-28 HepaRegeniX GmbH Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
CN112424201B (zh) 2018-07-16 2024-04-02 海帕瑞吉尼克斯股份有限公司 促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂
JP2022514731A (ja) * 2018-08-14 2022-02-15 アヴォリント 原発性硬化性胆管炎の処置方法
MA53496A (fr) 2018-08-31 2021-12-08 Pfizer Combinaisons pour le traitement de la stéatohépatite non alcoolique (nash)/maladie du foie gras non alcoolique (nafld) et de maladies associées
EP3846821B1 (en) * 2018-09-06 2023-10-04 Galmed Research and Development Ltd. Combination therapy for the treatment of liver disease
CN110950884B (zh) * 2018-09-27 2024-03-26 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
EP3904357A4 (en) * 2018-11-20 2022-08-03 The National Institutes of Pharmaceutical R&D Co., Ltd SPYRO COMPOUND AND ITS MEDICAL APPLICATIONS
IL284591B1 (en) 2019-01-15 2024-12-01 Gilead Sciences Inc Fxr (nr1h4) modulating compounds
CN118388473A (zh) 2019-02-19 2024-07-26 吉利德科学公司 Fxr激动剂的固体形式
MA55592A (fr) * 2019-04-10 2022-02-16 Genfit Polythérapie comprenant des composés de formule (i) et des agonistes du récepteur glp-1
EP4523692A2 (en) 2019-05-08 2025-03-19 Aligos Therapeutics, Inc. Modulators of thr-ss and methods of use thereof
TWI770527B (zh) 2019-06-14 2022-07-11 美商基利科學股份有限公司 Cot 調節劑及其使用方法
AU2019452636A1 (en) 2019-07-02 2022-01-20 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivatives having stereo configurations and use thereof in medicine
CN114269745A (zh) 2019-07-29 2022-04-01 海帕瑞吉尼克斯股份有限公司 用于促进肝再生或减少或预防肝细胞死亡的杂芳基取代的吡唑并吡啶蛋白激酶抑制剂
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
CN110628810B (zh) * 2019-08-13 2022-06-28 浙江大学 一种提高植物光合效率的方法
WO2021040440A1 (ko) * 2019-08-30 2021-03-04 (주)셀트리온 비알콜성 지방간염(nash, nonalcoholic steatohepatitis) 치료 또는 예방을 위한 약학 조성물
US20230105984A1 (en) 2019-12-23 2023-04-06 Svetlana Marukian Compositions and methods for the treatment of liver diseases and disorders
JP7639008B2 (ja) 2020-01-15 2025-03-04 ヘパリジェニックス ゲーエムベーハー 肝再生促進又は肝細胞死の抑制もしくは防止のためのプロテインキナーゼ阻害剤
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
JP2021134211A (ja) 2020-02-24 2021-09-13 ファイザー・インク Ｎａｆｌｄ／ｎａｓｈおよび関連疾患の処置のための組合せ
MX2022011128A (es) * 2020-03-11 2022-10-13 Dong A St Co Ltd Composicion farmaceutica para la prevencion o el tratamiento de la esteatohepatitis no alcoholica.
EP4126231A1 (en) 2020-03-30 2023-02-08 Gilead Sciences, Inc. Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
US11845737B2 (en) 2020-04-02 2023-12-19 Gilead Sciences, Inc. Process for preparing a Cot inhibitor compound
CN111407892A (zh) * 2020-04-08 2020-07-14 中国药科大学 Acsl4及其在nash中的应用
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
KR20230013126A (ko) 2020-05-21 2023-01-26 시오노기 앤드 컴파니, 리미티드 지방성 간질환의 치료용 의약
EP4000616A1 (en) * 2020-11-17 2022-05-25 Inventiva Combination therapy for the treatment of a liver disease
US12091404B2 (en) 2021-03-11 2024-09-17 Gilead Sciences, Inc. GLP-1R modulating compounds
AU2022252182B2 (en) 2021-03-29 2025-02-20 Gilead Sciences, Inc. Khk inhibitors
TW202345826A (zh) 2021-06-04 2023-12-01 美商基利科學股份有限公司 治療nash之方法
TW202311256A (zh) 2021-06-18 2023-03-16 美商基利科學股份有限公司 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑
US20250006331A1 (en) * 2021-08-31 2025-01-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Quantitative systems pharmacology methods for identifying therapeutics for disease states
WO2023047203A1 (en) * 2021-09-25 2023-03-30 Torrent Pharmaceuticals Ltd Combination of omzotirome and antidiabetic agent, antihypertensive agent or anti-dyslipidemic agent
US20250041279A1 (en) 2021-11-19 2025-02-06 Shionogi & Co., Ltd. Therapeutic medicine for heart disease or skeletal muscle disease
WO2024263785A1 (en) * 2023-06-20 2024-12-26 Sagimet Biosciences Inc. Combination therapies of fasn inhibitors with thyroid hormone receptor agonists

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009259839A1 (en) * 2008-06-20 2009-12-23 Kinemed, Inc. Compositions for the treatment of fibrotic diseases or conditions
US20100113473A1 (en) * 2008-10-30 2010-05-06 Player Mark R Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor
WO2012090219A2 (en) * 2010-12-31 2012-07-05 Jubilant Biosys Ltd. Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors
TWI612050B (zh) * 2011-11-11 2018-01-21 基利阿波羅有限責任公司 Ａｃｃ抑制劑及彼等之用途
KR20160007598A (ko) 2013-05-10 2016-01-20 님버스 아폴로, 인코포레이티드 Acc 억제제 및 이의 용도
AU2014262547A1 (en) * 2013-05-10 2015-11-26 Gilead Apollo, Llc ACC inhibitors and uses thereof
EP2994128B1 (en) 2013-05-10 2019-01-30 Gilead Apollo, LLC Acc inhibitors and uses thereof
US10208063B2 (en) * 2013-05-10 2019-02-19 Gilead Apollo, Llc ACC inhibitors and uses thereof

Also Published As

Publication number Publication date
BR112017014341A2 (pt) 2018-03-27
CA2972919A1 (en) 2016-07-14
SG11201705361PA (en) 2017-08-30
EP3242722A4 (en) 2018-07-11
EP3242722A1 (en) 2017-11-15
KR20170102299A (ko) 2017-09-08
EA201791258A1 (ru) 2017-12-29
MX2017008844A (es) 2018-03-14
CN107106873A (zh) 2017-08-29
AU2016205138A1 (en) 2017-07-13
JP2020109130A (ja) 2020-07-16
US20180021341A1 (en) 2018-01-25
HK1246232A1 (zh) 2018-09-07
HK1243369A1 (zh) 2018-07-13
EP3597271A1 (en) 2020-01-22
WO2016112305A1 (en) 2016-07-14
US20190381045A1 (en) 2019-12-19
JP2018501276A (ja) 2018-01-18

Similar Documents

Publication Publication Date Title
EA201892625A1 (ru) КОМБИНИРОВАННАЯ ТЕРАПИЯ С ПРИМЕНЕНИЕМ ИНГИБИТОРА АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) ДЛЯ ЛЕЧЕНИЯ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ
CO2018012894A2 (es) Derivados de pirazol como inhibidores de calicreína plasmática
CY1120246T1 (el) Ενωσεις αναστολεων μεταλλοενζυμου
EA201591509A1 (ru) Ингибиторы cdc7
CO2017006230A2 (es) Compuestos de n-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de calicreína plasmática
EA201790998A1 (ru) Иммуннорегуляторные агенты
CL2017002567A1 (es) Composiciones para modular la expresión de c9orf72
CL2019002368A1 (es) Composiciones y métodos para el tratamiento de cáncer.
EA201891340A1 (ru) Лечение рака с использованием 2-дезокси-2-фтор-l-фукозы в комбинации с ингибитором контрольных точек
UY36357A (es) Composiciones y métodos para la inhibición de la expresión génica de hao1 (hidroxiácido oxidasa 1 (glicolato oxidasa))
MX2018008105A (es) Compuestos inhibidores de metaloenzima.
BR112018001853A2 (pt) métodos para tratamento de um distúrbio e para melhoria do tratamento de um distúrbio
SG10201808940WA (en) Nox inhibitor and nfкb inhibitor containing methoxyflavone
EA201791736A1 (ru) Комбинированная терапия для лечения рака
EA201792604A1 (ru) Ингибиторы аутотаксина и их применения
PH12017501879A1 (en) Methods for treating cancer
EA201990567A1 (ru) Комбинированная терапия с ингибиторами глутаминазы
LT3534885T (lt) Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui
MX2022012386A (es) Compuestos inhibidores de metaloenzimas.
MX2018003301A (es) Inhibidores de pcna.
EA201991360A1 (ru) Модифицированные олигонуклеотиды для лечения поликистозной болезни почек
CL2018002074A1 (es) Composiciones y métodos para tratar infecciones.
CO2018008249A2 (es) Composiciones terapéuticas y métodos para el tratamiento de la hepatitis b
EA201792288A1 (ru) Способы лечения рака
EA201691896A1 (ru) Соединения и способы их применения