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EA201791747A1 - 3-алкил-4-амидобициклические [4,5,0] гидроксамовые кислоты в качестве ингибиторов hdac - Google Patents

3-алкил-4-амидобициклические [4,5,0] гидроксамовые кислоты в качестве ингибиторов hdac

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Publication number
EA201791747A1
EA201791747A1 EA201791747A EA201791747A EA201791747A1 EA 201791747 A1 EA201791747 A1 EA 201791747A1 EA 201791747 A EA201791747 A EA 201791747A EA 201791747 A EA201791747 A EA 201791747A EA 201791747 A1 EA201791747 A1 EA 201791747A1
Authority
EA
Eurasian Patent Office
Prior art keywords
amidobicyclic
alkyl
hdac inhibitors
hydroxamic acids
hdac
Prior art date
Application number
EA201791747A
Other languages
English (en)
Other versions
EA036711B1 (ru
Inventor
Сяочжан ЧЖЭН
Пуи Йи Нг
Бинсун ХАН
Дженнифер Р. Томасон
Мэри-Маргарет Заблоцки
Цуйсянь Лю
Хитер ДЭВИС
Александра Рудницкая
Мл. Дэвид Р. Лансия
Кеннет В. БЭЙР
Дэвид С. МИЛЛАН
Мэттью В. Мартин
Original Assignee
Форма Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Форма Терапьютикс, Инк. filed Critical Форма Терапьютикс, Инк.
Publication of EA201791747A1 publication Critical patent/EA201791747A1/ru
Publication of EA036711B1 publication Critical patent/EA036711B1/ru

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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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Abstract

Изобретение относится к ингибиторам цинкзависимых гистондеацетилаз (HDAC), подходящим для применения для лечения заболеваний или нарушений, связанных с HDAC, например, HDAC6, имеющим формулу Iгде R, L, X, X, X, X, Y, Y, Yи Yописаны в настоящем документе.
EA201791747A 2015-02-02 2016-02-02 3-алкил-4-амидобициклические [4,5,0] гидроксамовые кислоты в качестве ингибиторов hdac EA036711B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562110716P 2015-02-02 2015-02-02
US201562205438P 2015-08-14 2015-08-14
PCT/US2016/016201 WO2016126725A1 (en) 2015-02-02 2016-02-02 3-alkyl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors

Publications (2)

Publication Number Publication Date
EA201791747A1 true EA201791747A1 (ru) 2018-01-31
EA036711B1 EA036711B1 (ru) 2020-12-10

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