EA201691252A1 - Соединения индазола в качестве агонистов 5-ht-рецептора - Google Patents
Соединения индазола в качестве агонистов 5-ht-рецептораInfo
- Publication number
- EA201691252A1 EA201691252A1 EA201691252A EA201691252A EA201691252A1 EA 201691252 A1 EA201691252 A1 EA 201691252A1 EA 201691252 A EA201691252 A EA 201691252A EA 201691252 A EA201691252 A EA 201691252A EA 201691252 A1 EA201691252 A1 EA 201691252A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- indasol
- receptor agonists
- relates
- agonists
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title abstract 2
- 102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 title abstract 2
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение относится к новым соединениям индазола формулы (I), в том числе к их стереоизомерам и их фармацевтически приемлемым солям. Это изобретение также относится к способам получения таких соединений и к фармацевтическим композициям, включающим такие соединения. Соединения этого изобретения применяют при лечении различных расстройств, которые связаны с агонистами 5-гидрокситриптаминовых рецепторов 4-го типа (5-НТ).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN5852CH2013 | 2013-12-16 | ||
| PCT/IN2014/000116 WO2015092804A1 (en) | 2013-12-16 | 2014-02-24 | Indazole compounds as 5-ht4 receptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201691252A1 true EA201691252A1 (ru) | 2016-12-30 |
| EA029951B1 EA029951B1 (ru) | 2018-06-29 |
Family
ID=50736125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201691252A EA029951B1 (ru) | 2013-12-16 | 2014-02-24 | Соединения индазола в качестве агонистов 5-ht-рецептора |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9951045B2 (ru) |
| EP (1) | EP3099675B1 (ru) |
| JP (1) | JP6161823B2 (ru) |
| KR (1) | KR101824154B1 (ru) |
| CN (1) | CN105873920B (ru) |
| AP (1) | AP2016009253A0 (ru) |
| AU (1) | AU2014369085B2 (ru) |
| BR (1) | BR112016013974B1 (ru) |
| CA (1) | CA2932428C (ru) |
| DK (1) | DK3099675T3 (ru) |
| EA (1) | EA029951B1 (ru) |
| ES (1) | ES2668873T3 (ru) |
| IL (1) | IL245948B (ru) |
| MX (1) | MX368017B (ru) |
| NZ (1) | NZ720879A (ru) |
| SG (1) | SG11201604849YA (ru) |
| WO (1) | WO2015092804A1 (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA030947B1 (ru) | 2014-08-16 | 2018-10-31 | Сувен Лайф Сайенсиз Лимитед | Способ крупномасштабного производства 1-изопропил-3-{5-[1-(3-метоксипропил)пиперидин-4-ил]-[1,3,4]оксадиазол-2-ил}-1h-индазола оксалата |
| JP6487564B2 (ja) * | 2015-02-13 | 2019-03-20 | スヴェン・ライフ・サイエンシズ・リミテッド | ５−ｈｔ４受容体アゴニストとしてのアミド化合物 |
| JP6900028B2 (ja) * | 2017-03-29 | 2021-07-07 | 国立大学法人帯広畜産大学 | パーキンソン病に併発した認知障害の治療剤 |
| EP3628660A1 (en) * | 2018-09-28 | 2020-04-01 | Université de Caen Normandie | Donecopride and flucopride as neuroprotective agents in the treatment of neurodegenerative diseases |
| EP4317141A1 (en) | 2022-08-04 | 2024-02-07 | Curia Spain S.A.U. | Process and intermediates for the preparation of viloxazine and other 2-substituted morpholine derivatives |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0664805A1 (en) | 1992-10-13 | 1995-08-02 | Smithkline Beecham Plc | Heterocyclic -esters or -amides used as 5-ht 4? receptor antagonists |
| NZ257545A (en) | 1992-11-05 | 1997-01-29 | Smithkline Beecham Plc | Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions |
| DE60206952T2 (de) | 2001-10-22 | 2006-06-22 | Pfizer Inc. | Imidazopyridinverbindungen als 5-ht4-rezeptormodulatoren |
| MXPA05011270A (es) | 2003-04-21 | 2006-01-24 | Pfizer | Compuestos de imidazopiridina que tienen actividad agonista del receptor 5-ht4 y actividad antagonista del receptor 5-ht3. |
| CA2545092C (en) | 2003-11-24 | 2010-08-17 | Pfizer Inc. | Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity |
| DK1701951T3 (da) * | 2003-12-23 | 2010-06-07 | Serodus As | Modulatorer af perifere 5-HT receptorer |
| DE602005021696D1 (de) * | 2004-12-22 | 2010-07-15 | Theravance Inc | Indazolcarbonsäureamidverbindungen |
| CA2598516C (en) | 2005-02-25 | 2010-05-11 | Pfizer Inc. | Benzisoxazole derivatives |
| WO2007010390A1 (en) | 2005-07-22 | 2007-01-25 | Pfizer Japan Inc. | Indazolecarboxamide derivatives as 5ht4 receptor agonists |
| MX343165B (es) * | 2010-02-12 | 2016-10-26 | Raqualia Pharma Inc | Agonistas del receptor 5-ht4 para el tratamiento de demencia. |
| KR20120123089A (ko) | 2010-02-16 | 2012-11-07 | 화이자 인코포레이티드 | 5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올 |
| ES2531885T3 (es) * | 2011-09-19 | 2015-03-20 | Suven Life Sciences Limited | Compuestos heteroarilo como ligandos del receptor de 5-HT4 |
-
2014
- 2014-02-24 DK DK14725246.4T patent/DK3099675T3/en active
- 2014-02-24 SG SG11201604849YA patent/SG11201604849YA/en unknown
- 2014-02-24 EP EP14725246.4A patent/EP3099675B1/en active Active
- 2014-02-24 NZ NZ720879A patent/NZ720879A/en not_active IP Right Cessation
- 2014-02-24 US US15/104,521 patent/US9951045B2/en active Active
- 2014-02-24 JP JP2016539987A patent/JP6161823B2/ja active Active
- 2014-02-24 WO PCT/IN2014/000116 patent/WO2015092804A1/en active Application Filing
- 2014-02-24 KR KR1020167015974A patent/KR101824154B1/ko active Active
- 2014-02-24 MX MX2016007857A patent/MX368017B/es active IP Right Grant
- 2014-02-24 CN CN201480068132.6A patent/CN105873920B/zh active Active
- 2014-02-24 AU AU2014369085A patent/AU2014369085B2/en not_active Ceased
- 2014-02-24 BR BR112016013974-7A patent/BR112016013974B1/pt active IP Right Grant
- 2014-02-24 ES ES14725246.4T patent/ES2668873T3/es active Active
- 2014-02-24 EA EA201691252A patent/EA029951B1/ru unknown
- 2014-02-24 AP AP2016009253A patent/AP2016009253A0/en unknown
- 2014-02-24 CA CA2932428A patent/CA2932428C/en active Active
-
2016
- 2016-05-31 IL IL245948A patent/IL245948B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN105873920A (zh) | 2016-08-17 |
| MX368017B (es) | 2019-09-13 |
| EP3099675A1 (en) | 2016-12-07 |
| AU2014369085B2 (en) | 2017-02-23 |
| US9951045B2 (en) | 2018-04-24 |
| SG11201604849YA (en) | 2016-07-28 |
| AP2016009253A0 (en) | 2016-06-30 |
| JP6161823B2 (ja) | 2017-07-12 |
| DK3099675T3 (en) | 2018-05-22 |
| CA2932428A1 (en) | 2015-06-25 |
| BR112016013974A8 (pt) | 2018-01-30 |
| BR112016013974B1 (pt) | 2022-11-22 |
| KR101824154B1 (ko) | 2018-03-14 |
| AU2014369085A1 (en) | 2016-06-30 |
| IL245948B (en) | 2019-08-29 |
| KR20160075832A (ko) | 2016-06-29 |
| CN105873920B (zh) | 2018-06-08 |
| JP2016540796A (ja) | 2016-12-28 |
| MX2016007857A (es) | 2016-09-07 |
| WO2015092804A1 (en) | 2015-06-25 |
| ES2668873T3 (es) | 2018-05-22 |
| BR112016013974A2 (pt) | 2017-08-08 |
| EA029951B1 (ru) | 2018-06-29 |
| EP3099675B1 (en) | 2018-02-14 |
| US20160311797A1 (en) | 2016-10-27 |
| IL245948A0 (en) | 2016-08-02 |
| NZ720879A (en) | 2017-05-26 |
| CA2932428C (en) | 2017-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SA518392101B1 (ar) | ROR-Gamma مشتقات البنزيميدازول في صورة مُعدلات لـ | |
| EA201791829A1 (ru) | Амидные соединения в качестве агонистов рецептора 5-ht | |
| SA518391624B1 (ar) | Ror- منظمات جاما | |
| EA201691302A1 (ru) | Новые гетероциклические соединения | |
| EA201990240A1 (ru) | Новые трициклические соединения в качестве противораковых средств | |
| UA108442C2 (ru) | Индазолы | |
| EA201492281A1 (ru) | Соединения n-арилтриазола в качестве антагонистов рецепторов лизофосфатидной кислоты (lpar) | |
| EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
| EA201700042A1 (ru) | Соединения имидазопиридазина | |
| EA201690888A1 (ru) | Новые гетероциклические соединения | |
| EA201600434A1 (ru) | Применение производных бензимидазолпролина | |
| PH12014502364A1 (en) | Substituted pyrazole compounds as lpar antagonists | |
| EA201790253A1 (ru) | Ингибиторы альдостеронсинтазы | |
| EA201790830A1 (ru) | Ингибиторы альдостеронсинтазы | |
| NZ737892A (en) | Muscarinic m1 receptor positive allosteric modulators | |
| MY176521A (en) | Pyrrole-substituted indolone derivative, preparation method therefor, composition comprising the same and use thereof | |
| MX2016009621A (es) | Derivados de fur0-3-carboxamida y metodos de uso. | |
| EA201691252A1 (ru) | Соединения индазола в качестве агонистов 5-ht-рецептора | |
| MX373162B (es) | Piridopirimidinonas y utilización de las mismas como moduladores de receptores de n-metil-d-aspartato (nmda). | |
| EA201890684A1 (ru) | Производные фториндола в качестве положительных аллостерических модуляторов мускаринового рецептора m1 | |
| EA201791480A1 (ru) | Новые производные бензимидазола в качестве антигистаминных агентов | |
| MY189372A (en) | Indole derivatives | |
| EA201390327A1 (ru) | Гетероциклильные соединения в качестве лигандов гистаминовых hрецепторов | |
| EA202090397A1 (ru) | Фторопиперидиновые соединения в качестве чистых антагонистов 5-ht-рецептора | |
| EA201791398A1 (ru) | Производные фумагиллола |