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EA201791480A1 - Новые производные бензимидазола в качестве антигистаминных агентов - Google Patents

Новые производные бензимидазола в качестве антигистаминных агентов

Info

Publication number
EA201791480A1
EA201791480A1 EA201791480A EA201791480A EA201791480A1 EA 201791480 A1 EA201791480 A1 EA 201791480A1 EA 201791480 A EA201791480 A EA 201791480A EA 201791480 A EA201791480 A EA 201791480A EA 201791480 A1 EA201791480 A1 EA 201791480A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antiharmonal
agents
benzimidazole derivatives
new benzimidazole
compounds
Prior art date
Application number
EA201791480A
Other languages
English (en)
Other versions
EA033827B1 (ru
Inventor
Роса Родес Соланес
Роберто Оливера Тисне
Гонсало Эрнандес Эрреро
Виктор Рубио Ройо
Франсиско Ледо Гомес
Original Assignee
Фаэс Фарма, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фаэс Фарма, С.А. filed Critical Фаэс Фарма, С.А.
Publication of EA201791480A1 publication Critical patent/EA201791480A1/ru
Publication of EA033827B1 publication Critical patent/EA033827B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к соединениям формулы (I)или их фармацевтически приемлемым солям или сольватам, способу синтеза указанных соединений, содержащим их фармацевтическим композициям и их применению в лечении и/или профилактике состояний, опосредованных H-гистаминовым рецептором, таких как аллергические расстройства или заболевания.
EA201791480A 2014-12-29 2015-12-28 Производные бензимидазола в качестве антигистаминных агентов EA033827B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14382576.8A EP3040334A1 (en) 2014-12-29 2014-12-29 New benzimidazole derivatives as antihistamine agents
PCT/EP2015/081292 WO2016107848A1 (en) 2014-12-29 2015-12-28 New benzimidazole derivatives as antihistamine agents

Publications (2)

Publication Number Publication Date
EA201791480A1 true EA201791480A1 (ru) 2017-11-30
EA033827B1 EA033827B1 (ru) 2019-11-29

Family

ID=52302107

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791480A EA033827B1 (ru) 2014-12-29 2015-12-28 Производные бензимидазола в качестве антигистаминных агентов

Country Status (17)

Country Link
US (1) US10106522B2 (ru)
EP (2) EP3040334A1 (ru)
JP (1) JP6585718B2 (ru)
KR (1) KR20170097669A (ru)
CN (1) CN107108575B (ru)
AU (1) AU2015373457B2 (ru)
BR (1) BR112017013998A2 (ru)
CA (1) CA2970854A1 (ru)
CL (1) CL2017001720A1 (ru)
CO (1) CO2017005806A2 (ru)
EA (1) EA033827B1 (ru)
ES (1) ES2706475T3 (ru)
MX (1) MX371102B (ru)
PE (1) PE20171089A1 (ru)
PT (1) PT3240783T (ru)
WO (1) WO2016107848A1 (ru)
ZA (1) ZA201704462B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
LT3681475T (lt) * 2017-10-16 2021-02-25 Faes Farma, S.A. Vandeninės kompozicijos, apimančios bilastiną ir mometazoną
CA3088740A1 (en) 2018-01-18 2019-07-25 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
DE102019211434B3 (de) 2019-07-31 2020-11-05 Premium Aerotec Gmbh Spantkomponente und verfahren zur herstellung einer spantkomponente, spant und rumpfstruktur für ein luftfahrzeug
AU2023221541A1 (en) 2022-02-17 2024-08-08 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ238863A (en) * 1990-07-19 1993-03-26 Janssen Pharmaceutica Nv Substituted thiazolyl and pyridinyl derivatives
ES2048109B1 (es) 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
ES2124167B1 (es) 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
WO2002034719A1 (fr) * 2000-04-21 2002-05-02 Sankyo Company, Limited Composes heterocycliques azotes satures
JP2001011050A (ja) * 1999-04-30 2001-01-16 Sankyo Co Ltd 含窒素飽和複素環化合物
ES2165274B1 (es) * 1999-06-04 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
AU2002212683A1 (en) * 2000-10-30 2002-05-15 Sankyo Company, Limited Preventive or therapeutic medicines for hepatitis and/or hepatopathy
JP2002322059A (ja) * 2001-04-25 2002-11-08 Sankyo Co Ltd 炎症性腸疾患の予防又は治療剤
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents

Also Published As

Publication number Publication date
US10106522B2 (en) 2018-10-23
MX2017008495A (es) 2017-09-19
KR20170097669A (ko) 2017-08-28
CL2017001720A1 (es) 2018-03-16
CN107108575B (zh) 2019-07-26
WO2016107848A1 (en) 2016-07-07
CA2970854A1 (en) 2016-07-07
ES2706475T3 (es) 2019-03-29
JP6585718B2 (ja) 2019-10-02
BR112017013998A2 (pt) 2018-03-06
EP3240783B1 (en) 2018-11-21
ZA201704462B (en) 2019-09-25
JP2018502075A (ja) 2018-01-25
PT3240783T (pt) 2019-01-28
US20180016251A1 (en) 2018-01-18
MX371102B (es) 2020-01-16
CO2017005806A2 (es) 2017-09-20
PE20171089A1 (es) 2017-08-03
EA033827B1 (ru) 2019-11-29
EP3040334A1 (en) 2016-07-06
CN107108575A (zh) 2017-08-29
AU2015373457B2 (en) 2019-09-19
EP3240783A1 (en) 2017-11-08
AU2015373457A1 (en) 2017-07-27

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