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EA201100942A1 - Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл - Google Patents

Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл

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Publication number
EA201100942A1
EA201100942A1 EA201100942A EA201100942A EA201100942A1 EA 201100942 A1 EA201100942 A1 EA 201100942A1 EA 201100942 A EA201100942 A EA 201100942A EA 201100942 A EA201100942 A EA 201100942A EA 201100942 A1 EA201100942 A1 EA 201100942A1
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EA
Eurasian Patent Office
Prior art keywords
copd
asthma
treatment
antagonists
carboxamides
Prior art date
Application number
EA201100942A
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English (en)
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EA020548B1 (ru
Inventor
Хайнер Эбель
Сара Фраттини
Риккардо Джованнини
Кристоф Хёнке
Томас Тризельманн
Патрик Тильманн
Штефан Шойерер
Зильке Хобби (Мари Катрин)
Франк Бюттнер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201100942A1 publication Critical patent/EA201100942A1/ru
Publication of EA020548B1 publication Critical patent/EA020548B1/ru

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Abstract

В заявке описаны новые антагонисты CCR2 (хемокинового рецептора СС 2) и их применение для разработки лекарственных средств, предназначенных для лечения патологических состояний и заболеваний, предпочтительно заболеваний легких, таких как астма и ХОЗЛ, формулы (I), в которой А выбран из группы, включающей ординарную связь, =СН-, -СН-, -О-, -S- и -NH-, где n равно 1, 2 или 3, Z обозначает С или N, другие переменные являются такими, как определено в формуле изобретения, а также в виде их солей присоединения с фармакологически приемлемыми кислотами
EA201100942A 2008-12-19 2009-12-17 Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл EA020548B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08172336 2008-12-19
EP09160416 2009-05-15
PCT/EP2009/067378 WO2010070032A1 (en) 2008-12-19 2009-12-17 Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd

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EA201100942A1 true EA201100942A1 (ru) 2012-01-30
EA020548B1 EA020548B1 (ru) 2014-12-30

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EA201100942A EA020548B1 (ru) 2008-12-19 2009-12-17 Циклические пиримидин-4-карбоксамиды в качестве антагонистов рецептора ccr2, предназначенные для лечения воспаления, астмы и хозл

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US20140336374A1 (en) 2014-11-13
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TW201026683A (en) 2010-07-16
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IL212605A0 (en) 2011-07-31
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