[go: up one dir, main page]

EA201070779A1 - Триазолсодержащие производные оксадиазола - Google Patents

Триазолсодержащие производные оксадиазола

Info

Publication number
EA201070779A1
EA201070779A1 EA201070779A EA201070779A EA201070779A1 EA 201070779 A1 EA201070779 A1 EA 201070779A1 EA 201070779 A EA201070779 A EA 201070779A EA 201070779 A EA201070779 A EA 201070779A EA 201070779 A1 EA201070779 A1 EA 201070779A1
Authority
EA
Eurasian Patent Office
Prior art keywords
triazole
oxadiazole derivatives
containing oxadiazole
compounds
useful
Prior art date
Application number
EA201070779A
Other languages
English (en)
Other versions
EA020887B1 (ru
Inventor
Анна Кваттропани
Кристоф Клева
Эрик Себий
Маттиас Шварц
Дельфин Марэн
Аньес Бомбрэн
Уэсли Блэкеби
Чарльз Бейкер-Гленн
Крис Найт
Крейг Рауз
Original Assignee
Мерк Сероно С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Сероно С.А. filed Critical Мерк Сероно С.А.
Publication of EA201070779A1 publication Critical patent/EA201070779A1/ru
Publication of EA020887B1 publication Critical patent/EA020887B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к соединениям формулы Iгде R, R, R, R, Х имеют значения, данные в п.1 формулы изобретения. Соединения являются пригодными, например, в лечении аутоиммунных нарушений, таких как рассеянный склероз.
EA201070779A 2007-12-21 2008-12-17 Триазолсодержащие производные оксадиазола EA020887B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07150311 2007-12-21
US6638508P 2008-02-20 2008-02-20
PCT/EP2008/067776 WO2009080663A1 (en) 2007-12-21 2008-12-17 Triazole oxadiazoles derivatives

Publications (2)

Publication Number Publication Date
EA201070779A1 true EA201070779A1 (ru) 2011-02-28
EA020887B1 EA020887B1 (ru) 2015-02-27

Family

ID=39367513

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070779A EA020887B1 (ru) 2007-12-21 2008-12-17 Триазолсодержащие производные оксадиазола

Country Status (13)

Country Link
US (1) US8202856B2 (ru)
EP (1) EP2250165B1 (ru)
JP (1) JP5451633B2 (ru)
KR (1) KR20100110834A (ru)
CN (1) CN101918395B (ru)
AR (1) AR070043A1 (ru)
AU (1) AU2008340113B2 (ru)
BR (1) BRPI0821357A2 (ru)
CA (1) CA2710345C (ru)
EA (1) EA020887B1 (ru)
IL (1) IL206514A (ru)
MX (1) MX2010007026A (ru)
WO (1) WO2009080663A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009054794A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Amino 1,2,4-triazole derivatives as modulators of mglur5
WO2009054791A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Fused pyrrolidine 1,2,4-triazole derivatives as modulators of mglur5
CN102361868A (zh) * 2009-01-23 2012-02-22 百时美施贵宝公司 作为1-磷酸-鞘氨醇激动剂的吡唑-1，2，4-噁二唑衍生物
US8399451B2 (en) * 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2014127141A1 (en) * 2013-02-15 2014-08-21 Allergan, Inc. Substituted 1h-pyrazol-1,2,4-oxadiazole derivatives as sphingosine receptor modulators
US20140235587A1 (en) * 2013-02-15 2014-08-21 Allergan, Inc. Substituted pyrazoles as sphingosine receptor modulators
WO2015126912A1 (en) * 2014-02-18 2015-08-27 H. Lee Moffitt Cancer Center And Research Institute, Inc. Marinopyrrole derivatives and methods of making and using same
WO2016141258A1 (en) * 2015-03-04 2016-09-09 Medivation Technologies, Inc. Sterol regulatory element-binding proteins (srebps) inhibitors
EP3265088A1 (en) 2015-03-04 2018-01-10 Medivation Technologies LLC Srebp blockers for use in treating liver fibrosis, elevated cholesterol and insulin resistance
TW202417417A (zh) * 2017-04-06 2024-05-01 美商富曼西公司 殺真菌之噁二唑

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062252A1 (en) * 2002-01-18 2003-07-31 Merck & Co., Inc. Edg receptor agonists
CA2472713C (en) * 2002-01-18 2011-07-19 Merck & Co., Inc. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists
CN104056278B (zh) * 2003-04-11 2017-01-18 Ptc 治疗公司 1,2,4‑噁二唑苯甲酸化合物
EP1697333A4 (en) * 2003-12-17 2009-07-08 Merck & Co Inc 3,4-DISUSBSTITUTED PROPANOIC CARBOXYLATES AS S1P RECEPTOR AGONISTS (EDG)
MX2007015422A (es) * 2005-06-08 2008-02-21 Novartis Ag Oxadiazoles o isoxazoles policiclicos y su uso como ligandos del receptor de s1p.
WO2007132307A1 (en) * 2006-05-09 2007-11-22 Pfizer Products Inc. Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
AU2008306885B2 (en) 2007-10-04 2013-12-05 Merck Serono S.A. Oxadiazole derivatives
US8404676B2 (en) 2007-10-04 2013-03-26 Merck Serono Sa Oxadiazole diaryl compounds

Also Published As

Publication number Publication date
EA020887B1 (ru) 2015-02-27
JP2011506559A (ja) 2011-03-03
WO2009080663A1 (en) 2009-07-02
CA2710345C (en) 2016-11-15
EP2250165A1 (en) 2010-11-17
IL206514A0 (en) 2010-12-30
AU2008340113A1 (en) 2009-07-02
AU2008340113B2 (en) 2014-01-09
US8202856B2 (en) 2012-06-19
JP5451633B2 (ja) 2014-03-26
EP2250165B1 (en) 2018-07-25
BRPI0821357A2 (pt) 2017-05-23
IL206514A (en) 2013-09-30
KR20100110834A (ko) 2010-10-13
CA2710345A1 (en) 2009-07-02
CN101918395A (zh) 2010-12-15
AR070043A1 (es) 2010-03-10
US20100305092A1 (en) 2010-12-02
CN101918395B (zh) 2014-04-16
MX2010007026A (es) 2010-10-05

Similar Documents

Publication Publication Date Title
EA201070779A1 (ru) Триазолсодержащие производные оксадиазола
EA201070423A1 (ru) Диарильные соединения оксадиазолов
MX2010003612A (es) Derivados de oxadiazol.
EA201070238A1 (ru) Соединения пиримидина
EA201171211A1 (ru) Производные оксадиазола
TN2011000279A1 (en) Novel pyrazole -4-n-alkoxycarboxamides as microbiocides
MX2010003366A (es) Derivados de piperidina y piperazina para el tratamiento de tumores.
EA201000395A1 (ru) Фунгицидные производные 2-алкилтио-2-хинолинилоксиацетамида
EA200901609A1 (ru) Амиды пиразолкарбоновой кислоты, применимые в качестве микробиоцидов
EA201100880A1 (ru) Бензонафтиридиновые соединения в качестве ингибиторов аутотаксина
WO2010033701A3 (en) Inhibitors of sphingosine kinase 1
EA201390877A1 (ru) Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение
MX2012008049A (es) Compuestos heterociclicos triciclicos, composiciones y metodos de uso de los mismos,.
EA201070912A1 (ru) Производные оксима в качестве ингибиторов hsp90
MA32811B1 (fr) Nouveaux composés
MX2007011847A (es) Derivados de pirimidindiona como antagonistas del receptor de procineticina 2.
WO2009024342A3 (en) Novel microbiocides
EA201000550A1 (ru) Производные тиазола
EA201101099A1 (ru) Гербициды, полученные из циклопентадиона
MA32505B1 (fr) 5-alcynyl-pyrimidines
MX2010001364A (es) Derivados de ciclopentandiona puenteados triciclicos como herbicidas.
MX2010007392A (es) Antagonistas de trpa1.
EA200901124A1 (ru) Соединения формулы (i) в качестве ингибиторов серинпротеазы
MX2012002641A (es) Inhibidores de cinasa janus (jak).
WO2008151828A8 (en) Novel microbiocides

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU