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EA201000885A1 - Новые соединения диазениумдиолата, способ их изготовления и лекарственные препараты, содержащие их - Google Patents

Новые соединения диазениумдиолата, способ их изготовления и лекарственные препараты, содержащие их

Info

Publication number
EA201000885A1
EA201000885A1 EA201000885A EA201000885A EA201000885A1 EA 201000885 A1 EA201000885 A1 EA 201000885A1 EA 201000885 A EA201000885 A EA 201000885A EA 201000885 A EA201000885 A EA 201000885A EA 201000885 A1 EA201000885 A1 EA 201000885A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
manufacture
new connections
medicines containing
diazenium diolate
Prior art date
Application number
EA201000885A
Other languages
English (en)
Inventor
Алексис Корди
Лора Эберкорн
Тони Вербёрен
Кристине Куршай
Серж Симоне
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA201000885A1 publication Critical patent/EA201000885A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединения формулы (I)где Rпредставляет собой атом водорода или группу -COOR, Rпредставляет собой группу G или неразветвленную или разветвленную (С1-С6)алкильную группу, замещенную G группой, где G представляет собой группу -(CH)-A-(CH)-B-(CRR)-(CH)-R, как определено в описании, Rпредставляет собой атом водорода, алкильную группу или группу NO,применимые в области заболеваний артериальной гипертензией и заболеваний сердечно-сосудистой системы.
EA201000885A 2007-12-11 2008-12-10 Новые соединения диазениумдиолата, способ их изготовления и лекарственные препараты, содержащие их EA201000885A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0708604A FR2924713B1 (fr) 2007-12-11 2007-12-11 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2008/001716 WO2009103875A1 (fr) 2007-12-11 2008-12-10 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
EA201000885A1 true EA201000885A1 (ru) 2011-02-28

Family

ID=39158541

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000885A EA201000885A1 (ru) 2007-12-11 2008-12-10 Новые соединения диазениумдиолата, способ их изготовления и лекарственные препараты, содержащие их

Country Status (26)

Country Link
US (1) US8288433B2 (ru)
EP (1) EP2231598B1 (ru)
JP (1) JP5247814B2 (ru)
KR (1) KR20100083195A (ru)
CN (1) CN101910128B (ru)
AR (1) AR069643A1 (ru)
AT (1) ATE520658T1 (ru)
AU (1) AU2008351147B2 (ru)
BR (1) BRPI0822066A2 (ru)
CA (1) CA2707853C (ru)
DK (1) DK2231598T3 (ru)
EA (1) EA201000885A1 (ru)
ES (1) ES2371699T3 (ru)
FR (1) FR2924713B1 (ru)
GE (1) GEP20135733B (ru)
HR (1) HRP20110755T1 (ru)
MA (1) MA31901B1 (ru)
MX (1) MX2010006446A (ru)
MY (1) MY147973A (ru)
NZ (1) NZ586070A (ru)
PL (1) PL2231598T3 (ru)
PT (1) PT2231598E (ru)
RS (1) RS52001B (ru)
SI (1) SI2231598T1 (ru)
UA (1) UA97035C2 (ru)
WO (1) WO2009103875A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354394B2 (en) * 2009-10-29 2013-01-15 Merck Sharp & Dohme Corp. Diuretics
CN102883610A (zh) 2010-02-12 2013-01-16 默沙东公司 二醇二氮烯*环戊基衍生物
WO2011146371A1 (en) 2010-05-21 2011-11-24 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives
RU2013124814A (ru) 2010-10-29 2014-12-10 Мерк Шарп Энд Домэ Корп. Гетероциклические производные диазенийдиолата
JO3350B1 (ar) * 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
EP2704568B1 (en) 2011-05-02 2018-01-24 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives
CN109608371B (zh) * 2019-01-16 2020-12-29 泰州学院 O2-4-(3-(4-胺磺酰基苯基)脲)苯基偶氮鎓二醇盐衍生物、制备方法及用途
CN114805183B (zh) * 2022-05-07 2022-12-27 武汉科技大学 一类no供体型荜茇酰胺衍生物、制备方法及用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203691A (en) * 1968-03-06 1970-09-03 Science Union & Cie New disubstituted n-amino indoline derivatives and process for preparing them
JPH0233030B2 (ja) * 1982-01-18 1990-07-25 Mitsui Toatsu Chemicals Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu
JPH07118231A (ja) * 1993-10-22 1995-05-09 Nippon Oil & Fats Co Ltd スルファモイル安息香酸誘導体
US5958427A (en) * 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
AUPS236902A0 (en) * 2002-05-16 2002-06-13 Northern Sydney Area Health Service Composition and method for treating hypertension
CA2574535A1 (en) * 2004-11-15 2006-05-26 Nitromed, Inc. Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use
CA2597460A1 (en) * 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
AU2009206635A1 (en) * 2008-01-24 2009-07-30 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists
US8106034B2 (en) * 2008-02-08 2012-01-31 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists

Also Published As

Publication number Publication date
US20100286225A1 (en) 2010-11-11
EP2231598A1 (fr) 2010-09-29
AR069643A1 (es) 2010-02-10
MA31901B1 (fr) 2010-12-01
NZ586070A (en) 2012-06-29
AU2008351147A1 (en) 2009-08-27
UA97035C2 (ru) 2011-12-26
MX2010006446A (es) 2010-07-05
HRP20110755T1 (hr) 2011-11-30
ES2371699T3 (es) 2012-01-09
US8288433B2 (en) 2012-10-16
SI2231598T1 (sl) 2011-11-30
GEP20135733B (en) 2013-01-25
BRPI0822066A2 (pt) 2015-09-22
CN101910128A (zh) 2010-12-08
CA2707853A1 (fr) 2009-08-27
JP5247814B2 (ja) 2013-07-24
AU2008351147B2 (en) 2012-04-12
JP2011506408A (ja) 2011-03-03
ATE520658T1 (de) 2011-09-15
EP2231598B1 (fr) 2011-08-17
KR20100083195A (ko) 2010-07-21
MY147973A (en) 2013-02-28
PL2231598T3 (pl) 2011-12-30
CA2707853C (fr) 2013-02-05
CN101910128B (zh) 2013-01-16
RS52001B (en) 2012-04-30
DK2231598T3 (da) 2011-12-05
FR2924713A1 (fr) 2009-06-12
PT2231598E (pt) 2011-10-11
FR2924713B1 (fr) 2010-01-29
WO2009103875A1 (fr) 2009-08-27

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