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FR2924713B1 - Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2924713B1
FR2924713B1 FR0708604A FR0708604A FR2924713B1 FR 2924713 B1 FR2924713 B1 FR 2924713B1 FR 0708604 A FR0708604 A FR 0708604A FR 0708604 A FR0708604 A FR 0708604A FR 2924713 B1 FR2924713 B1 FR 2924713B1
Authority
FR
France
Prior art keywords
preparing
pharmaceutical compositions
compositions containing
containing same
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0708604A
Other languages
English (en)
French (fr)
Other versions
FR2924713A1 (fr
Inventor
Alexis Cordi
Laure Haberkorn
Tony Verbeuren
Christine Courchay
Serge Simonet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0708604A priority Critical patent/FR2924713B1/fr
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to MYPI2010002633A priority patent/MY147973A/en
Priority to PL08872697T priority patent/PL2231598T3/pl
Priority to JP2010537487A priority patent/JP5247814B2/ja
Priority to MX2010006446A priority patent/MX2010006446A/es
Priority to PCT/FR2008/001716 priority patent/WO2009103875A1/fr
Priority to CN2008801229307A priority patent/CN101910128B/zh
Priority to UAA201008615A priority patent/UA97035C2/ru
Priority to KR1020107012930A priority patent/KR20100083195A/ko
Priority to BRPI0822066A priority patent/BRPI0822066A2/pt
Priority to DK08872697.1T priority patent/DK2231598T3/da
Priority to SI200830404T priority patent/SI2231598T1/sl
Priority to RS20110438A priority patent/RS52001B/en
Priority to CA2707853A priority patent/CA2707853C/fr
Priority to ES08872697T priority patent/ES2371699T3/es
Priority to AU2008351147A priority patent/AU2008351147B2/en
Priority to GEAP200811874A priority patent/GEP20135733B/en
Priority to US12/735,048 priority patent/US8288433B2/en
Priority to NZ586070A priority patent/NZ586070A/en
Priority to EP08872697A priority patent/EP2231598B1/fr
Priority to EA201000885A priority patent/EA201000885A1/ru
Priority to PT08872697T priority patent/PT2231598E/pt
Priority to AT08872697T priority patent/ATE520658T1/de
Priority to ARP080105371A priority patent/AR069643A1/es
Publication of FR2924713A1 publication Critical patent/FR2924713A1/fr
Application granted granted Critical
Publication of FR2924713B1 publication Critical patent/FR2924713B1/fr
Priority to MA32894A priority patent/MA31901B1/fr
Priority to HR20110755T priority patent/HRP20110755T1/hr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR0708604A 2007-12-11 2007-12-11 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2924713B1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR0708604A FR2924713B1 (fr) 2007-12-11 2007-12-11 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2008351147A AU2008351147B2 (en) 2007-12-11 2008-12-10 Novel diazeniumdiolate derivatives, method for the preparation thereof and pharmaceutical compositions containing the same
JP2010537487A JP5247814B2 (ja) 2007-12-11 2008-12-10 新規ジアゼニウムジオラート誘導体、それを製造する方法、およびそれを含有する薬学的組成物
MX2010006446A MX2010006446A (es) 2007-12-11 2008-12-10 Nuevos derivados de diazeniodiolato, procedimiento para la preparacion de los mismos y composiciones farmaceuticas que los contienen.
PCT/FR2008/001716 WO2009103875A1 (fr) 2007-12-11 2008-12-10 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN2008801229307A CN101910128B (zh) 2007-12-11 2008-12-10 二醇二氮烯*化合物、其制备方法以及含有它们的药用组合物
UAA201008615A UA97035C2 (ru) 2007-12-11 2008-12-10 Соединения диазенийдиолата, способ их получения и фармацевтическая композиция, которая их содержит
KR1020107012930A KR20100083195A (ko) 2007-12-11 2008-12-10 신규한 디아제니움디올레이트 유도체, 이들의 제조 방법 및 상기 화합물을 포함하는 약제 조성물
BRPI0822066A BRPI0822066A2 (pt) 2007-12-11 2008-12-10 derivados diolatos daizênio, o respectivo processo de preparo e as composições farmacêuticas que os contêm
DK08872697.1T DK2231598T3 (da) 2007-12-11 2008-12-10 Nye diazeniumdiolatderivater, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse
SI200830404T SI2231598T1 (sl) 2007-12-11 2008-12-10 Novi derivati diazeniumdiolata postopek pripravele teh in njihovi farmacevtski sestavki
RS20110438A RS52001B (en) 2007-12-11 2008-12-10 NEW DIAZENIUM DIIOLATE DERIVATIVES, PROCEDURE OF THEIR PRODUCTION AND THE PHARMACEUTICAL MIXTURES CONTAINING THEM
CA2707853A CA2707853C (fr) 2007-12-11 2008-12-10 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES08872697T ES2371699T3 (es) 2007-12-11 2008-12-10 nuevos derivados diolato de diazenio, su procedimiento de preparación y composiciones farmacéuticas que los contienen.
MYPI2010002633A MY147973A (en) 2007-12-11 2008-12-10 New diazeniumdiolate compounds, a process for their preparation and pharmaceutical compositions containing them
PT08872697T PT2231598E (pt) 2007-12-11 2008-12-10 Novos derivados diazéniodiolato, processo para a sua preparação e as composições farmacêuticas que os contenham
GEAP200811874A GEP20135733B (en) 2007-12-11 2008-12-10 Novel diazeniumdiolate derivatives, their preparation method and pharmaceutical compositions containing them
NZ586070A NZ586070A (en) 2007-12-11 2008-12-10 Novel diazeniumdiolate derivatives, method for the preparation thereof and pharmaceutical compositions containing the same
EP08872697A EP2231598B1 (fr) 2007-12-11 2008-12-10 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA201000885A EA201000885A1 (ru) 2007-12-11 2008-12-10 Новые соединения диазениумдиолата, способ их изготовления и лекарственные препараты, содержащие их
PL08872697T PL2231598T3 (pl) 2007-12-11 2008-12-10 Nowe pochodne diazeniodiolanów, sposób ich wytwarzania i kompozycje farmaceutyczne je zawierające
AT08872697T ATE520658T1 (de) 2007-12-11 2008-12-10 Neue diazeniumdiolat-derivate, ihr herstellungsverfahren und sie enthaltende pharmazeutische zusammensetzungen
US12/735,048 US8288433B2 (en) 2007-12-11 2008-12-10 Diazeniumdiolate compounds, a process for their preparation and pharmaceutical compositions containing them
ARP080105371A AR069643A1 (es) 2007-12-11 2008-12-11 Derivados diazenidiolatos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
MA32894A MA31901B1 (fr) 2007-12-11 2010-06-07 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HR20110755T HRP20110755T1 (hr) 2007-12-11 2011-10-17 Novi derivati diazenij-diolata, postupak za njegovu pripravu i farmaceutski pripravci koji ga sadržavaju

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0708604A FR2924713B1 (fr) 2007-12-11 2007-12-11 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2924713A1 FR2924713A1 (fr) 2009-06-12
FR2924713B1 true FR2924713B1 (fr) 2010-01-29

Family

ID=39158541

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0708604A Expired - Fee Related FR2924713B1 (fr) 2007-12-11 2007-12-11 Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (26)

Country Link
US (1) US8288433B2 (ru)
EP (1) EP2231598B1 (ru)
JP (1) JP5247814B2 (ru)
KR (1) KR20100083195A (ru)
CN (1) CN101910128B (ru)
AR (1) AR069643A1 (ru)
AT (1) ATE520658T1 (ru)
AU (1) AU2008351147B2 (ru)
BR (1) BRPI0822066A2 (ru)
CA (1) CA2707853C (ru)
DK (1) DK2231598T3 (ru)
EA (1) EA201000885A1 (ru)
ES (1) ES2371699T3 (ru)
FR (1) FR2924713B1 (ru)
GE (1) GEP20135733B (ru)
HR (1) HRP20110755T1 (ru)
MA (1) MA31901B1 (ru)
MX (1) MX2010006446A (ru)
MY (1) MY147973A (ru)
NZ (1) NZ586070A (ru)
PL (1) PL2231598T3 (ru)
PT (1) PT2231598E (ru)
RS (1) RS52001B (ru)
SI (1) SI2231598T1 (ru)
UA (1) UA97035C2 (ru)
WO (1) WO2009103875A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354394B2 (en) * 2009-10-29 2013-01-15 Merck Sharp & Dohme Corp. Diuretics
CN102883610A (zh) 2010-02-12 2013-01-16 默沙东公司 二醇二氮烯*环戊基衍生物
WO2011146371A1 (en) 2010-05-21 2011-11-24 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives
RU2013124814A (ru) 2010-10-29 2014-12-10 Мерк Шарп Энд Домэ Корп. Гетероциклические производные диазенийдиолата
JO3350B1 (ar) * 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
EP2704568B1 (en) 2011-05-02 2018-01-24 Merck Sharp & Dohme Corp. Diazeniumdiolate cyclohexyl derivatives
CN109608371B (zh) * 2019-01-16 2020-12-29 泰州学院 O2-4-(3-(4-胺磺酰基苯基)脲)苯基偶氮鎓二醇盐衍生物、制备方法及用途
CN114805183B (zh) * 2022-05-07 2022-12-27 武汉科技大学 一类no供体型荜茇酰胺衍生物、制备方法及用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1203691A (en) * 1968-03-06 1970-09-03 Science Union & Cie New disubstituted n-amino indoline derivatives and process for preparing them
JPH0233030B2 (ja) * 1982-01-18 1990-07-25 Mitsui Toatsu Chemicals Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu
JPH07118231A (ja) * 1993-10-22 1995-05-09 Nippon Oil & Fats Co Ltd スルファモイル安息香酸誘導体
US5958427A (en) * 1996-11-08 1999-09-28 Salzman; Andrew L. Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
AUPS236902A0 (en) * 2002-05-16 2002-06-13 Northern Sydney Area Health Service Composition and method for treating hypertension
CA2574535A1 (en) * 2004-11-15 2006-05-26 Nitromed, Inc. Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use
CA2597460A1 (en) * 2005-02-24 2006-08-31 Nitromed, Inc. Nitric oxide enhancing diuretic compounds, compositions and methods of use
AU2009206635A1 (en) * 2008-01-24 2009-07-30 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists
US8106034B2 (en) * 2008-02-08 2012-01-31 Merck Sharp & Dohme Corp. Angiotensin II receptor antagonists

Also Published As

Publication number Publication date
US20100286225A1 (en) 2010-11-11
EP2231598A1 (fr) 2010-09-29
AR069643A1 (es) 2010-02-10
MA31901B1 (fr) 2010-12-01
NZ586070A (en) 2012-06-29
AU2008351147A1 (en) 2009-08-27
UA97035C2 (ru) 2011-12-26
MX2010006446A (es) 2010-07-05
HRP20110755T1 (hr) 2011-11-30
ES2371699T3 (es) 2012-01-09
US8288433B2 (en) 2012-10-16
SI2231598T1 (sl) 2011-11-30
GEP20135733B (en) 2013-01-25
BRPI0822066A2 (pt) 2015-09-22
CN101910128A (zh) 2010-12-08
CA2707853A1 (fr) 2009-08-27
JP5247814B2 (ja) 2013-07-24
AU2008351147B2 (en) 2012-04-12
JP2011506408A (ja) 2011-03-03
ATE520658T1 (de) 2011-09-15
EP2231598B1 (fr) 2011-08-17
KR20100083195A (ko) 2010-07-21
MY147973A (en) 2013-02-28
PL2231598T3 (pl) 2011-12-30
CA2707853C (fr) 2013-02-05
CN101910128B (zh) 2013-01-16
EA201000885A1 (ru) 2011-02-28
RS52001B (en) 2012-04-30
DK2231598T3 (da) 2011-12-05
FR2924713A1 (fr) 2009-06-12
PT2231598E (pt) 2011-10-11
WO2009103875A1 (fr) 2009-08-27

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