ATE520658T1 - Neue diazeniumdiolat-derivate, ihr herstellungsverfahren und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Neue diazeniumdiolat-derivate, ihr herstellungsverfahren und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number: ATE520658T1
Authority: AT; Austria
Prior art keywords: derivatives; new; pharmaceutical compositions; production process; compositions containing
Prior art date: 2007-12-11

Application number

AT08872697T

Other languages

English (en)

Inventor

Alexis Cordi

Laure Haberkorn

Tony Verbeuren

Christine Courchay

Serge Simonet

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-11

Filing date

2008-12-10

Publication date

2011-09-15

2008-12-10 Application filed by Servier Lab filed Critical Servier Lab

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE520658T1 publication Critical patent/ATE520658T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT08872697T 2007-12-11 2008-12-10 Neue diazeniumdiolat-derivate, ihr herstellungsverfahren und sie enthaltende pharmazeutische zusammensetzungen ATE520658T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0708604A FR2924713B1 (fr)	2007-12-11	2007-12-11	Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2008/001716 WO2009103875A1 (fr)	2007-12-11	2008-12-10	Nouveaux derives diazeniumdiolates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE520658T1 true ATE520658T1 (de)	2011-09-15

Family

ID=39158541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08872697T ATE520658T1 (de)	2007-12-11	2008-12-10	Neue diazeniumdiolat-derivate, ihr herstellungsverfahren und sie enthaltende pharmazeutische zusammensetzungen

Country Status (26)

Country	Link
US (1)	US8288433B2 (de)
EP (1)	EP2231598B1 (de)
JP (1)	JP5247814B2 (de)
KR (1)	KR20100083195A (de)
CN (1)	CN101910128B (de)
AR (1)	AR069643A1 (de)
AT (1)	ATE520658T1 (de)
AU (1)	AU2008351147B2 (de)
BR (1)	BRPI0822066A2 (de)
CA (1)	CA2707853C (de)
DK (1)	DK2231598T3 (de)
EA (1)	EA201000885A1 (de)
ES (1)	ES2371699T3 (de)
FR (1)	FR2924713B1 (de)
GE (1)	GEP20135733B (de)
HR (1)	HRP20110755T1 (de)
MA (1)	MA31901B1 (de)
MX (1)	MX2010006446A (de)
MY (1)	MY147973A (de)
NZ (1)	NZ586070A (de)
PL (1)	PL2231598T3 (de)
PT (1)	PT2231598E (de)
RS (1)	RS52001B (de)
SI (1)	SI2231598T1 (de)
UA (1)	UA97035C2 (de)
WO (1)	WO2009103875A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8354394B2 (en) *	2009-10-29	2013-01-15	Merck Sharp & Dohme Corp.	Diuretics
CN102883610A (zh)	2010-02-12	2013-01-16	默沙东公司	二醇二氮烯*环戊基衍生物
WO2011146371A1 (en)	2010-05-21	2011-11-24	Merck Sharp & Dohme Corp.	Diazeniumdiolate cyclohexyl derivatives
RU2013124814A (ru)	2010-10-29	2014-12-10	Мерк Шарп Энд Домэ Корп.	Гетероциклические производные диазенийдиолата
JO3350B1 (ar) *	2011-03-07	2019-03-13	Merck Sharp & Dohme	مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
EP2704568B1 (de)	2011-05-02	2018-01-24	Merck Sharp & Dohme Corp.	Diazeniumdiolat-cyclohexyl-derivate
CN109608371B (zh) *	2019-01-16	2020-12-29	泰州学院	O2-4-(3-(4-胺磺酰基苯基)脲)苯基偶氮鎓二醇盐衍生物、制备方法及用途
CN114805183B (zh) *	2022-05-07	2022-12-27	武汉科技大学	一类no供体型荜茇酰胺衍生物、制备方法及用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1203691A (en) *	1968-03-06	1970-09-03	Science Union & Cie	New disubstituted n-amino indoline derivatives and process for preparing them
JPH0233030B2 (ja) *	1982-01-18	1990-07-25	Mitsui Toatsu Chemicals	Surufuamoiruansokukosanjudotaioyobisoreojukoseibuntoshitefukumuchiryoyososeibutsu
JPH07118231A (ja) *	1993-10-22	1995-05-09	Nippon Oil & Fats Co Ltd	スルファモイル安息香酸誘導体
US5958427A (en) *	1996-11-08	1999-09-28	Salzman; Andrew L.	Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications
AUPS236902A0 (en) *	2002-05-16	2002-06-13	Northern Sydney Area Health Service	Composition and method for treating hypertension
CA2574535A1 (en) *	2004-11-15	2006-05-26	Nitromed, Inc.	Diuretic compounds comprising heterocyclic nitric oxide donor groups, compositions and methods of use
CA2597460A1 (en) *	2005-02-24	2006-08-31	Nitromed, Inc.	Nitric oxide enhancing diuretic compounds, compositions and methods of use
AU2009206635A1 (en) *	2008-01-24	2009-07-30	Merck Sharp & Dohme Corp.	Angiotensin II receptor antagonists
US8106034B2 (en) *	2008-02-08	2012-01-31	Merck Sharp & Dohme Corp.	Angiotensin II receptor antagonists

2007
- 2007-12-11 FR FR0708604A patent/FR2924713B1/fr not_active Expired - Fee Related
2008
- 2008-12-10 ES ES08872697T patent/ES2371699T3/es active Active
- 2008-12-10 MX MX2010006446A patent/MX2010006446A/es active IP Right Grant
- 2008-12-10 AT AT08872697T patent/ATE520658T1/de active
- 2008-12-10 UA UAA201008615A patent/UA97035C2/ru unknown
- 2008-12-10 JP JP2010537487A patent/JP5247814B2/ja not_active Expired - Fee Related
- 2008-12-10 MY MYPI2010002633A patent/MY147973A/en unknown
- 2008-12-10 CA CA2707853A patent/CA2707853C/fr not_active Expired - Fee Related
- 2008-12-10 KR KR1020107012930A patent/KR20100083195A/ko active IP Right Grant
- 2008-12-10 PL PL08872697T patent/PL2231598T3/pl unknown
- 2008-12-10 DK DK08872697.1T patent/DK2231598T3/da active
- 2008-12-10 RS RS20110438A patent/RS52001B/en unknown
- 2008-12-10 EP EP08872697A patent/EP2231598B1/de active Active
- 2008-12-10 NZ NZ586070A patent/NZ586070A/en not_active IP Right Cessation
- 2008-12-10 WO PCT/FR2008/001716 patent/WO2009103875A1/fr active Application Filing
- 2008-12-10 SI SI200830404T patent/SI2231598T1/sl unknown
- 2008-12-10 AU AU2008351147A patent/AU2008351147B2/en not_active Ceased
- 2008-12-10 CN CN2008801229307A patent/CN101910128B/zh not_active Expired - Fee Related
- 2008-12-10 EA EA201000885A patent/EA201000885A1/ru unknown
- 2008-12-10 BR BRPI0822066A patent/BRPI0822066A2/pt not_active IP Right Cessation
- 2008-12-10 US US12/735,048 patent/US8288433B2/en not_active Expired - Fee Related
- 2008-12-10 GE GEAP200811874A patent/GEP20135733B/en unknown
- 2008-12-10 PT PT08872697T patent/PT2231598E/pt unknown
- 2008-12-11 AR ARP080105371A patent/AR069643A1/es not_active Application Discontinuation
2010
- 2010-06-07 MA MA32894A patent/MA31901B1/fr unknown
2011
- 2011-10-17 HR HR20110755T patent/HRP20110755T1/hr unknown

Also Published As

Publication number	Publication date
US20100286225A1 (en)	2010-11-11
EP2231598A1 (de)	2010-09-29
AR069643A1 (es)	2010-02-10
MA31901B1 (fr)	2010-12-01
NZ586070A (en)	2012-06-29
AU2008351147A1 (en)	2009-08-27
UA97035C2 (ru)	2011-12-26
MX2010006446A (es)	2010-07-05
HRP20110755T1 (hr)	2011-11-30
ES2371699T3 (es)	2012-01-09
US8288433B2 (en)	2012-10-16
SI2231598T1 (sl)	2011-11-30
GEP20135733B (en)	2013-01-25
BRPI0822066A2 (pt)	2015-09-22
CN101910128A (zh)	2010-12-08
CA2707853A1 (fr)	2009-08-27
JP5247814B2 (ja)	2013-07-24
AU2008351147B2 (en)	2012-04-12
JP2011506408A (ja)	2011-03-03
EP2231598B1 (de)	2011-08-17
KR20100083195A (ko)	2010-07-21
MY147973A (en)	2013-02-28
PL2231598T3 (pl)	2011-12-30
CA2707853C (fr)	2013-02-05
CN101910128B (zh)	2013-01-16
EA201000885A1 (ru)	2011-02-28
RS52001B (en)	2012-04-30
DK2231598T3 (da)	2011-12-05
FR2924713A1 (fr)	2009-06-12
PT2231598E (pt)	2011-10-11
FR2924713B1 (fr)	2010-01-29
WO2009103875A1 (fr)	2009-08-27

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