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EA199900906A1 - Новый способ получения (+/-)3-(3,4-дихлорфенил)-2-диметиламино-2-метилпропан-1-ола или церикламина (inn) - Google Patents

Новый способ получения (+/-)3-(3,4-дихлорфенил)-2-диметиламино-2-метилпропан-1-ола или церикламина (inn)

Info

Publication number
EA199900906A1
EA199900906A1 EA199900906A EA199900906A EA199900906A1 EA 199900906 A1 EA199900906 A1 EA 199900906A1 EA 199900906 A EA199900906 A EA 199900906A EA 199900906 A EA199900906 A EA 199900906A EA 199900906 A1 EA199900906 A1 EA 199900906A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dichlorophenyl
cericlamine
ola
methylpropan
dimethylamine
Prior art date
Application number
EA199900906A
Other languages
English (en)
Other versions
EA004399B1 (ru
Inventor
Марк Никола
Бландин Лабу
Доминик Депернэ
Original Assignee
Парк-Давиз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Парк-Давиз filed Critical Парк-Давиз
Publication of EA199900906A1 publication Critical patent/EA199900906A1/ru
Publication of EA004399B1 publication Critical patent/EA004399B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Способ изготовления церикламина, включающий: i) арилирование метакриловой кислоты хлоридом диазония 3,4-дихлоранилина, с получением (+/-)2-хлор-3-(3,4-дихлорфенил)-2-метилпропионовой кислоты, ii) аминирование кислоты диметиламином с получением (+/-)3-(3,4-дихлорфенил)-2-диметиламин-2-метилпропионовой кислоты или ее соли щелочного металла, iii) этерификацию аминокислоты или ее соли, затем iv) восстановление эфира металлогидридом или органометаллогидридом с получением (+/-)3-(3,4-дихлорфенил)-2- диметиламин-2 метилпропан-1-ола.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900906A 1997-04-07 1998-04-06 Способ получения (+/-)3-(3,4-дихлорфенил)-2-диметиламино-2-метилпропан-1-ола или церикламина (inn) EA004399B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9704311A FR2761686B1 (fr) 1997-04-07 1997-04-07 Nouveau procede de preparation du (+/-)3-(3,4- dichlorophenyl)-2-dimethylamino-2-methyl-propan-1-ol ou cericlamine (inn)
PCT/EP1998/002213 WO1998045248A1 (en) 1997-04-07 1998-04-06 Novel process for the preparation of (+/-)3- (3,4-dichlorophenyl)-2- dimethylamino-2-methylpropan-1-ol or cericlamine (inn)

Publications (2)

Publication Number Publication Date
EA199900906A1 true EA199900906A1 (ru) 2000-08-28
EA004399B1 EA004399B1 (ru) 2004-04-29

Family

ID=9505666

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900906A EA004399B1 (ru) 1997-04-07 1998-04-06 Способ получения (+/-)3-(3,4-дихлорфенил)-2-диметиламино-2-метилпропан-1-ола или церикламина (inn)

Country Status (21)

Country Link
US (1) US6121491A (ru)
EP (1) EP0973724B1 (ru)
JP (1) JP2001519799A (ru)
KR (1) KR20010006073A (ru)
AT (1) ATE251116T1 (ru)
AU (1) AU728636B2 (ru)
BR (1) BR9811459A (ru)
CA (1) CA2277874A1 (ru)
DE (1) DE69818653T2 (ru)
DK (1) DK0973724T3 (ru)
EA (1) EA004399B1 (ru)
ES (1) ES2209137T3 (ru)
FR (1) FR2761686B1 (ru)
HU (1) HUP0001753A3 (ru)
IL (1) IL130813A (ru)
NZ (1) NZ337588A (ru)
PL (1) PL336041A1 (ru)
PT (1) PT973724E (ru)
SK (1) SK284184B6 (ru)
WO (1) WO1998045248A1 (ru)
ZA (1) ZA982927B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2378746A1 (fr) * 1977-01-28 1978-08-25 Synthelabo Derives d'acides a-amines
JPS6078921A (ja) * 1983-10-05 1985-05-04 Toyo Soda Mfg Co Ltd ハロゲン含有エチルベンゼン誘導体の製造方法
JPS61204150A (ja) * 1985-03-08 1986-09-10 Sagami Chem Res Center α―ハロ―α―トリフルオロメチル―β―アリールプロピオン酸
FR2593499B1 (fr) * 1986-01-30 1988-08-12 Jouveinal Sa Aminoalcools, leur procede de preparation et leurs applications, notamment en therapeutique
FR2690916B1 (fr) * 1992-05-05 1994-06-17 Jouveinal Inst Rech Nouveaux enantiomeres derives du (s)-amino-2-(dichloro-3,4-benzyl)-2-propanol-1.
US5472970A (en) * 1992-05-05 1995-12-05 Institut De Recherche Jouveinal S.A. Allylaminoesters and their application in therapeutics

Also Published As

Publication number Publication date
KR20010006073A (ko) 2001-01-15
EA004399B1 (ru) 2004-04-29
AU728636B2 (en) 2001-01-11
DK0973724T3 (da) 2004-02-02
IL130813A0 (en) 2001-01-28
ZA982927B (en) 1999-07-15
JP2001519799A (ja) 2001-10-23
DE69818653T2 (de) 2004-08-19
SK136099A3 (en) 2000-05-16
US6121491A (en) 2000-09-19
PT973724E (pt) 2004-02-27
ES2209137T3 (es) 2004-06-16
EP0973724B1 (en) 2003-10-01
BR9811459A (pt) 2000-09-19
FR2761686A1 (fr) 1998-10-09
DE69818653D1 (de) 2003-11-06
HUP0001753A2 (hu) 2000-11-28
PL336041A1 (en) 2000-06-05
ATE251116T1 (de) 2003-10-15
AU7525998A (en) 1998-10-30
SK284184B6 (sk) 2004-10-05
FR2761686B1 (fr) 1999-05-14
IL130813A (en) 2003-07-06
EP0973724A1 (en) 2000-01-26
HUP0001753A3 (en) 2000-12-28
WO1998045248A1 (en) 1998-10-15
CA2277874A1 (en) 1998-10-15
NZ337588A (en) 2000-05-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU