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DK653688A - Stabiliserede laegemiddelaktive forbindelser, fremgangsmaade til deres frmstilling samt stabile laegemiddelpraeparater - Google Patents

Stabiliserede laegemiddelaktive forbindelser, fremgangsmaade til deres frmstilling samt stabile laegemiddelpraeparater

Info

Publication number
DK653688A
DK653688A DK653688A DK653688A DK653688A DK 653688 A DK653688 A DK 653688A DK 653688 A DK653688 A DK 653688A DK 653688 A DK653688 A DK 653688A DK 653688 A DK653688 A DK 653688A
Authority
DK
Denmark
Prior art keywords
preparation
procedures
active compounds
stabilized
pharmaceutical preparations
Prior art date
Application number
DK653688A
Other languages
English (en)
Other versions
DK168423B1 (da
DK653688D0 (da
Inventor
Werner Fuehlberth
Richard Leeb
Manfred Radau
Willi Stammberger
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK653688D0 publication Critical patent/DK653688D0/da
Publication of DK653688A publication Critical patent/DK653688A/da
Application granted granted Critical
Publication of DK168423B1 publication Critical patent/DK168423B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G59/00—Polycondensates containing more than one epoxy group per molecule; Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups
    • C08G59/18—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing
    • C08G59/40—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing characterised by the curing agents used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK653688A 1987-11-24 1988-11-23 Stabilt, presset farmaceutisk præparat og fremgangsmåde til fremstilling deraf. DK168423B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3739690 1987-11-24
DE19873739690 DE3739690A1 (de) 1987-11-24 1987-11-24 Stabilisierte arzneistoffe, verfahren zu ihrer herstellung sowie stabile arzneizubereitungen

Publications (3)

Publication Number Publication Date
DK653688D0 DK653688D0 (da) 1988-11-23
DK653688A true DK653688A (da) 1989-05-25
DK168423B1 DK168423B1 (da) 1994-03-28

Family

ID=6341084

Family Applications (1)

Application Number Title Priority Date Filing Date
DK653688A DK168423B1 (da) 1987-11-24 1988-11-23 Stabilt, presset farmaceutisk præparat og fremgangsmåde til fremstilling deraf.

Country Status (21)

Country Link
US (2) US5151433A (da)
EP (1) EP0317878B1 (da)
JP (1) JPH0768140B2 (da)
KR (1) KR970004908B1 (da)
CN (1) CN1028962C (da)
AT (1) ATE74513T1 (da)
AU (1) AU615495B2 (da)
CA (1) CA1338344C (da)
DE (2) DE3739690A1 (da)
DK (1) DK168423B1 (da)
ES (1) ES2033400T3 (da)
FI (1) FI93693C (da)
GR (1) GR3004925T3 (da)
HU (1) HU202100B (da)
IE (1) IE61173B1 (da)
IL (1) IL88460A0 (da)
NO (1) NO176550C (da)
NZ (1) NZ227032A (da)
PH (1) PH27416A (da)
PT (1) PT89061B (da)
ZA (1) ZA888734B (da)

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SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
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US6869963B2 (en) * 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
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KR100679166B1 (ko) 2005-10-04 2007-02-06 신풍제약주식회사 안정성이 증진된 약제학적 조성물 및 그의 제조방법
US20070098782A1 (en) * 2005-10-28 2007-05-03 Selamine Limited Ramipril Formulation
GB2431579A (en) * 2005-10-28 2007-05-02 Arrow Int Ltd Ramipril formulations
BRPI0708842A2 (pt) * 2006-03-28 2011-06-14 Gelesis Inc uso de materiais polimÉricos com outras substÂncias para aumento do desempenho
US20070232680A1 (en) * 2006-04-04 2007-10-04 Vijayabhaskar Bolugoddu Preparation of ramipril and stable pharmaceutical compositions
BRPI0710172A2 (pt) * 2006-04-19 2011-08-23 Teva Pharma composição farmacêutica estável de ácido carboxìlico derivado de 2-aza-biciclo[3,3,0]-octana-3
WO2007142628A1 (en) * 2006-06-02 2007-12-13 Teva Pharmaceutical Industries Ltd. Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
US20070281000A1 (en) * 2006-06-02 2007-12-06 Michael Fox Stable formulation comprising moisture sensitive drug/s and manufacturing procedure thereof
EP1917973A1 (en) * 2006-06-02 2008-05-07 Teva Pharmaceutical Industries Ltd Stable formulation comprising a moisture sensitive drug and manufacturing procedure thereof
AU2007264414A1 (en) * 2006-06-30 2008-01-03 Alphapharm Pty Ltd A stabilised composition comprising ACE inhibitors
MX2009002091A (es) * 2006-08-28 2009-03-09 Sanofi Aventis Deutschland Metodos para reducir las concentraciones de glucosa.
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
PL382311A1 (pl) * 2007-04-27 2008-11-10 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Kompozycja farmaceutyczna o polepszonej stabilności zawierająca inhibitor acetylocholinoesterazy lub farmaceutycznie dopuszczalną jego sól oraz sposób jej wytwarzania
HUE028919T2 (en) 2008-03-28 2017-01-30 Ferrer Int Capsules for preventing cardiovascular diseases
US20100062062A1 (en) * 2008-09-11 2010-03-11 Aethos Pharmaceuticals, Inc. Stabilized Coating for Pharmaceutical Formulations
TR200906322A2 (tr) 2009-08-17 2011-07-21 Bi̇lgi̇ç Mahmut Çözünürlük ve stabilite özellikleri geliştirilmiş granüller.
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
WO2013121233A1 (en) 2012-02-17 2013-08-22 Egis Gyógyszergyár Nyilvánosan Működö Részvénytársaság Pharmaceutical formulation having improved stability
PL227900B1 (pl) 2012-11-15 2018-01-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Kompozycja farmaceutyczna zawierająca inhibitor ACE i bloker kanałów wapniowych, sposób jej wytwarzania i jednostka dawkowania zawierająca tę kompozycję
HUP1300496A2 (hu) 2013-08-16 2015-03-02 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Stabil kombinációs gyógyszerkészítmény
TWI668285B (zh) * 2015-12-31 2019-08-11 長興材料工業股份有限公司 可熱聚合之組合物、由此形成之組成液及其用途
EP3275432A1 (en) 2016-07-25 2018-01-31 H e x a l Aktiengesellschaft Dosage form with ace inhibitor
RS66060B1 (sr) 2020-02-10 2024-11-29 Adamed Pharma S A Sastav koji sadrži ramipril i indapamid
CN115068434B (zh) * 2022-08-03 2023-05-09 昆山龙灯瑞迪制药有限公司 一种雷米普利片的制备方法

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Also Published As

Publication number Publication date
FI885398A0 (fi) 1988-11-22
CN1042917A (zh) 1990-06-13
US5151433A (en) 1992-09-29
ATE74513T1 (de) 1992-04-15
PT89061B (pt) 1993-03-31
JPH01165596A (ja) 1989-06-29
GR3004925T3 (da) 1993-04-28
HU202100B (en) 1991-02-28
PT89061A (pt) 1988-12-01
EP0317878B1 (de) 1992-04-08
DE3869919D1 (de) 1992-05-14
DK168423B1 (da) 1994-03-28
KR970004908B1 (ko) 1997-04-08
IE61173B1 (en) 1994-10-05
ES2033400T3 (es) 1993-03-16
PH27416A (en) 1993-06-21
KR890007739A (ko) 1989-07-05
NO885213D0 (no) 1988-11-23
HUT48455A (en) 1989-06-28
NZ227032A (en) 1991-05-28
NO885213L (no) 1989-05-25
IE883505L (en) 1989-05-24
CN1028962C (zh) 1995-06-21
FI93693B (fi) 1995-02-15
DE3739690A1 (de) 1989-06-08
FI885398A7 (fi) 1989-05-25
IL88460A0 (en) 1989-06-30
FI93693C (fi) 1995-05-26
JPH0768140B2 (ja) 1995-07-26
CA1338344C (en) 1996-05-21
NO176550B (no) 1995-01-16
NO176550C (no) 1995-04-26
AU2581888A (en) 1989-05-25
AU615495B2 (en) 1991-10-03
EP0317878A1 (de) 1989-05-31
DK653688D0 (da) 1988-11-23
US5442008A (en) 1995-08-15
ZA888734B (en) 1989-07-26

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired