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DK554789A - Insulinderivater og deres anvendelse - Google Patents

Insulinderivater og deres anvendelse

Info

Publication number
DK554789A
DK554789A DK554789A DK554789A DK554789A DK 554789 A DK554789 A DK 554789A DK 554789 A DK554789 A DK 554789A DK 554789 A DK554789 A DK 554789A DK 554789 A DK554789 A DK 554789A
Authority
DK
Denmark
Prior art keywords
amino acid
insulin derivatives
genetically encodable
formula
amide
Prior art date
Application number
DK554789A
Other languages
English (en)
Other versions
DK554789D0 (da
DK173196B1 (da
Inventor
Michael Doerschug
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6366698&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK554789(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK554789D0 publication Critical patent/DK554789D0/da
Publication of DK554789A publication Critical patent/DK554789A/da
Application granted granted Critical
Publication of DK173196B1 publication Critical patent/DK173196B1/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198905547A 1988-11-08 1989-11-07 Insulinderivater, deres anvendelse og farmaceutisk præparat indeholdende mindst ét sådant insulinderivat DK173196B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3837825 1988-11-08
DE3837825A DE3837825A1 (de) 1988-11-08 1988-11-08 Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (3)

Publication Number Publication Date
DK554789D0 DK554789D0 (da) 1989-11-07
DK554789A true DK554789A (da) 1990-05-09
DK173196B1 DK173196B1 (da) 2000-03-13

Family

ID=6366698

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905547A DK173196B1 (da) 1988-11-08 1989-11-07 Insulinderivater, deres anvendelse og farmaceutisk præparat indeholdende mindst ét sådant insulinderivat

Country Status (21)

Country Link
US (2) US5656722A (da)
EP (1) EP0368187B1 (da)
JP (1) JP2680145B2 (da)
KR (1) KR0158197B1 (da)
AT (1) ATE93868T1 (da)
AU (1) AU621680B2 (da)
CA (1) CA1339044C (da)
DE (3) DE3837825A1 (da)
DK (1) DK173196B1 (da)
ES (1) ES2059676T4 (da)
FI (1) FI100185B (da)
HU (2) HU213018B (da)
IE (1) IE63338B1 (da)
IL (1) IL92222A (da)
LU (1) LU90614I2 (da)
NL (1) NL300019I2 (da)
NO (2) NO177963C (da)
NZ (1) NZ231272A (da)
PH (1) PH30695A (da)
PT (1) PT92220B (da)
ZA (1) ZA898456B (da)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
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TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患治療
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FR3052072A1 (fr) 2016-06-07 2017-12-08 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
EP3329930A1 (en) 2016-12-05 2018-06-06 Nuritas Limited Pharmaceuctical compositions
EP4129321A1 (en) 2016-12-05 2023-02-08 Nuritas Limited Compositions comprising peptide wkdeagkplvk
KR20190122706A (ko) 2017-03-09 2019-10-30 다이어메디카 인코포레이티드 조직 칼리크레인 1의 투약 형태
FR3070264A1 (fr) 2017-08-24 2019-03-01 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris de 5,8 a 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
WO2019110625A1 (fr) 2017-12-06 2019-06-13 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
FR3083088B1 (fr) 2018-06-29 2020-10-02 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
FR3083089A1 (fr) 2018-06-29 2020-01-03 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
EP3740229B1 (fr) 2017-12-07 2025-04-09 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
KR20240171196A (ko) 2017-12-07 2024-12-06 아도시아 pI가 5.8 내지 8.5인 적어도 1종의 기저 인슐린, 및 카복실산염 전하 및 소수성 라디칼을 보유하는 코-폴리아미노산을 포함하는 pH 7의 주사용 용액
KR20200106892A (ko) 2017-12-07 2020-09-15 아도시아 pI가 5.8 내지 8.5인 적어도 1종의 기저 인슐린, 및 카복실산염 전하 및 소수성 라디칼을 보유하는 코-폴리아미노산을 포함하는 pH 7의 주사용 용액
US20210214412A1 (en) * 2018-04-16 2021-07-15 University Of Utah Research Foundation Glucose-responsive insulin
WO2019243628A1 (fr) 2018-06-22 2019-12-26 Adocia Composition injectable a ph 7 comprenant un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes et au moins une insuline basale presentant au moins un effet prandial et un effet basal
FR3084585B1 (fr) 2018-08-03 2020-11-06 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un compose amphiphile porteur de radicaux hydrophobes
KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
WO2020115334A1 (fr) 2018-12-07 2020-06-11 Adocia Procede de preparation d'une composition stable sous forme d'une solution aqueuse injectable
US20200179489A1 (en) 2018-12-07 2020-06-11 Adocia Injectable solution at ph 7 comprising at least one basal insulin which pi is from 5.8 to 8.5 and a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals and a limited amount of m-cresol
KR20200080748A (ko) 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법
KR20200080747A (ko) 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
KR20200082618A (ko) 2018-12-31 2020-07-08 주식회사 폴루스 인슐린 과발현용 램프 태그 및 이를 이용한 인슐린의 제조방법
WO2020245470A1 (fr) 2019-06-07 2020-12-10 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5, du liraglutide et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
TW202434620A (zh) 2019-07-31 2024-09-01 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
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CN114805610B (zh) * 2022-06-23 2022-10-04 北京惠之衡生物科技有限公司 一种高表达甘精胰岛素前体的重组基因工程菌及其构建方法

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NL300019I1 (nl) 2000-12-01
EP0368187B1 (de) 1993-09-01
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HK1006171A1 (en) 1999-02-12
NO894424D0 (no) 1989-11-07
PH30695A (en) 1997-09-16
DE10075022I1 (de) 2000-10-05
EP0368187A2 (de) 1990-05-16
IE893576L (en) 1990-05-08
KR0158197B1 (ko) 1998-12-01
JP2680145B2 (ja) 1997-11-19
CA1339044C (en) 1997-04-01
DE3837825A1 (de) 1990-05-10
LU90614I2 (fr) 2000-09-26
US5656722A (en) 1997-08-12
ES2059676T4 (es) 2012-03-13
HU210800A9 (en) 1995-07-28
FI100185B (fi) 1997-10-15
IL92222A0 (en) 1990-07-26
ATE93868T1 (de) 1993-09-15
HU895678D0 (en) 1990-01-28
AU4441289A (en) 1990-05-17
US6100376A (en) 2000-08-08
PT92220A (pt) 1990-05-31
FI895259A0 (fi) 1989-11-06
IL92222A (en) 1999-09-22
NO177963B (no) 1995-09-18
KR900007435A (ko) 1990-06-01
NO2001023I1 (no) 2001-12-17
IE63338B1 (en) 1995-04-19
HU213018B (en) 1997-01-28
NO177963C (no) 1995-12-27
EP0368187A3 (de) 1991-07-03
HUT52549A (en) 1990-07-28
ZA898456B (en) 1990-06-27
DK554789D0 (da) 1989-11-07
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NZ231272A (en) 1992-11-25
AU621680B2 (en) 1992-03-19
DE58905456D1 (de) 1993-10-07
PT92220B (pt) 1995-07-06
NL300019I2 (nl) 2001-02-01
JPH02218696A (ja) 1990-08-31
DK173196B1 (da) 2000-03-13
NO894424L (no) 1990-05-09

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