DK3592742T3 - JAK inhibitorer med en 4-leddet heterocyclisk amid - Google Patents

JAK inhibitorer med en 4-leddet heterocyclisk amid Download PDF

Info

Publication number: DK3592742T3
Authority: DK; Denmark
Prior art keywords: membered heterocyclic; jak inhibitors; heterocyclic amide; amide; jak
Prior art date: 2017-03-09

Application number

DK18711796.5T

Other languages

English (en)

Inventor

Paul R Fatheree

Gary E L Brandt

Cameron Smith

Steven D E Sullivan

Orden Lori Jean Van

Melanie A Kleinschek

Glenn D Crater

Original Assignee

Theravance Biopharma R&D Ip Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-03-09

Filing date

2018-03-08

Publication date

2021-08-09

2018-03-08 Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc

2021-08-09 Application granted granted Critical

2021-08-09 Publication of DK3592742T3 publication Critical patent/DK3592742T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pulmonology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Peptides Or Proteins (AREA)

DK18711796.5T 2017-03-09 2018-03-08 JAK inhibitorer med en 4-leddet heterocyclisk amid DK3592742T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201762469073P	2017-03-09	2017-03-09
PCT/US2018/021489 WO2018165392A1 (en)	2017-03-09	2018-03-08	Jak inhibitors containing a 4-membered heterocyclic amide

Publications (1)

Publication Number	Publication Date
DK3592742T3 true DK3592742T3 (da)	2021-08-09

Family

ID=61683956

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK18711796.5T DK3592742T3 (da)	2017-03-09	2018-03-08	JAK inhibitorer med en 4-leddet heterocyclisk amid

Country Status (20)

Country	Link
US (10)	US10208040B2 (da)
EP (2)	EP3592743A1 (da)
JP (2)	JP7134990B2 (da)
KR (2)	KR102526764B1 (da)
CN (2)	CN110382498B (da)
AR (2)	AR111242A1 (da)
AU (2)	AU2018231032B2 (da)
BR (2)	BR112019018648A2 (da)
CA (1)	CA2997772A1 (da)
DK (1)	DK3592742T3 (da)
EA (2)	EA037748B1 (da)
ES (1)	ES2882186T3 (da)
IL (2)	IL268679B (da)
MX (2)	MX2019010539A (da)
PH (2)	PH12019501941A1 (da)
PT (1)	PT3592742T (da)
SG (2)	SG11201907544VA (da)
TW (2)	TWI779016B (da)
WO (2)	WO2018165392A1 (da)
ZA (2)	ZA201905585B (da)

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SG11201907544VA (en)	2017-03-09	2019-09-27	Theravance Biopharma R&D Ip Llc	Jak inhibitors containing a 4-membered heterocyclic amide
MY199353A (en)	2017-05-01	2023-10-24	Theravance Biopharma R&D Ip Llc	Methods of treatment using a jak inhibitor compound
AR111495A1 (es)	2017-05-01	2019-07-17	Theravance Biopharma R&D Ip Llc	Compuestos de imidazo-piperidina fusionada como inhibidores de jak
AU2019335200A1 (en) *	2018-09-04	2021-03-11	Theravance Biopharma R&D Ip, Llc	5 to 7 membered heterocyclic amides as JAK inhibitors
TWI808250B (zh)	2018-09-04	2023-07-11	美商施萬生物製藥研發 Ip有限責任公司	用於製備jak抑制劑之方法及其中間體
HUE068058T2 (hu)	2018-09-04	2024-12-28	Theravance Biopharma R&D Ip Llc	Dimetil-amino-azetidin-amidok mint JAK-gátlók
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TW202144343A (zh)	2020-03-02	2021-12-01	美商施萬生物製藥研發 Ip有限責任公司	Jak抑制劑化合物之結晶水合物
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JP2024524214A (ja) *	2021-06-25	2024-07-05	セラヴァンスバイオファーマアール＆ディーアイピー，エルエルシー	Ｊａｋ阻害剤としてのイミダゾロインダゾール化合物
US20250066319A1 (en)	2021-12-17	2025-02-27	Daewoong Pharmaceutical Co., Ltd.	NOVEL ACID ADDITION SALT AND CRYSTALLINE FORM OF (2R, 3S)-2-(3-(4,5-DICHLORO-1H-BENZO[d]IMIDAZOL-1-YL)PROPYL)PIPERIDIN-3-OL
CN118903009B (zh) *	2024-10-11	2025-01-21	江苏长泰药业股份有限公司	一种调节呼吸道微生态的丙酮酸钠气雾剂及其制备方法和应用

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EP3831830A1 (en)	2015-11-03	2021-06-09	Topivert Pharma Limited	4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
US10100049B2 (en)	2015-11-03	2018-10-16	Theravance Biopharma R&D Ip, Llc	JAK kinase inhibitor compounds for treatment of respiratory disease
SG11201907544VA (en)	2017-03-09	2019-09-27	Theravance Biopharma R&D Ip Llc	Jak inhibitors containing a 4-membered heterocyclic amide
MY199353A (en)	2017-05-01	2023-10-24	Theravance Biopharma R&D Ip Llc	Methods of treatment using a jak inhibitor compound
KR20200003121A (ko)	2017-05-01	2020-01-08	세라밴스 바이오파마 알앤디 아이피, 엘엘씨	Jak 저해제 화합물의 결정형
AR111495A1 (es)	2017-05-01	2019-07-17	Theravance Biopharma R&D Ip Llc	Compuestos de imidazo-piperidina fusionada como inhibidores de jak
KR102032418B1 (ko)	2017-06-15	2019-10-16	한국화학연구원	접합 피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 브루톤티로신 키나제 활성 관련 질환의 예방 또는 치료용 약학적 조성물
AU2019335200A1 (en)	2018-09-04	2021-03-11	Theravance Biopharma R&D Ip, Llc	5 to 7 membered heterocyclic amides as JAK inhibitors
TWI808250B (zh)	2018-09-04	2023-07-11	美商施萬生物製藥研發 Ip有限責任公司	用於製備jak抑制劑之方法及其中間體
HUE068058T2 (hu)	2018-09-04	2024-12-28	Theravance Biopharma R&D Ip Llc	Dimetil-amino-azetidin-amidok mint JAK-gátlók

2018
- 2018-03-08 SG SG11201907544VA patent/SG11201907544VA/en unknown
- 2018-03-08 PT PT187117965T patent/PT3592742T/pt unknown
- 2018-03-08 EA EA201992128A patent/EA037748B1/ru unknown
- 2018-03-08 AR ARP180100543A patent/AR111242A1/es unknown
- 2018-03-08 AR ARP180100542A patent/AR111241A1/es not_active Application Discontinuation
- 2018-03-08 JP JP2019548369A patent/JP7134990B2/ja active Active
- 2018-03-08 JP JP2019548449A patent/JP6974487B2/ja active Active
- 2018-03-08 EP EP18712398.9A patent/EP3592743A1/en not_active Withdrawn
- 2018-03-08 EP EP18711796.5A patent/EP3592742B1/en active Active
- 2018-03-08 AU AU2018231032A patent/AU2018231032B2/en not_active Ceased
- 2018-03-08 MX MX2019010539A patent/MX2019010539A/es unknown
- 2018-03-08 US US15/915,434 patent/US10208040B2/en active Active
- 2018-03-08 TW TW107107936A patent/TWI779016B/zh active
- 2018-03-08 WO PCT/US2018/021489 patent/WO2018165392A1/en unknown
- 2018-03-08 EA EA201992126A patent/EA037261B1/ru not_active IP Right Cessation
- 2018-03-08 WO PCT/US2018/021492 patent/WO2018165395A1/en unknown
- 2018-03-08 MX MX2019010541A patent/MX2019010541A/es unknown
- 2018-03-08 CN CN201880016693.XA patent/CN110382498B/zh not_active Expired - Fee Related
- 2018-03-08 SG SG11201907840RA patent/SG11201907840RA/en unknown
- 2018-03-08 TW TW107107939A patent/TWI754019B/zh not_active IP Right Cessation
- 2018-03-08 DK DK18711796.5T patent/DK3592742T3/da active
- 2018-03-08 BR BR112019018648-4A patent/BR112019018648A2/pt unknown
- 2018-03-08 KR KR1020197029560A patent/KR102526764B1/ko active Active
- 2018-03-08 US US15/915,418 patent/US10196393B2/en active Active
- 2018-03-08 BR BR112019018649A patent/BR112019018649A2/pt active Search and Examination
- 2018-03-08 AU AU2018231035A patent/AU2018231035B2/en not_active Ceased
- 2018-03-08 CA CA2997772A patent/CA2997772A1/en active Pending
- 2018-03-08 ES ES18711796T patent/ES2882186T3/es active Active
- 2018-03-08 CN CN201880017046.0A patent/CN110461839B/zh active Active
- 2018-03-08 KR KR1020197029543A patent/KR102533646B1/ko active Active
- 2018-12-17 US US16/222,647 patent/US10392386B2/en active Active
- 2018-12-19 US US16/225,473 patent/US10519153B2/en active Active
2019
- 2019-07-15 US US16/511,410 patent/US10550118B2/en active Active
- 2019-08-13 IL IL268679A patent/IL268679B/en unknown
- 2019-08-13 IL IL268689A patent/IL268689B2/en unknown
- 2019-08-22 PH PH12019501941A patent/PH12019501941A1/en unknown
- 2019-08-23 ZA ZA2019/05585A patent/ZA201905585B/en unknown
- 2019-08-26 ZA ZA2019/05618A patent/ZA201905618B/en unknown
- 2019-08-29 PH PH12019501985A patent/PH12019501985A1/en unknown
- 2019-11-11 US US16/679,676 patent/US11254669B2/en active Active
- 2019-12-03 US US16/701,426 patent/US10954237B2/en active Active
2021
- 2021-02-12 US US17/248,907 patent/US11453668B2/en active Active
2022
- 2022-01-14 US US17/576,089 patent/US11667637B2/en active Active
- 2022-08-10 US US17/885,475 patent/US11878977B2/en active Active

Also Published As

Publication number	Publication date
US10954237B2 (en)	2021-03-23
TWI754019B (zh)	2022-02-01
IL268679B (en)	2021-10-31
CN110461839B (zh)	2022-08-23
KR20190127796A (ko)	2019-11-13
AU2018231035B2 (en)	2021-09-09
US20200216447A1 (en)	2020-07-09
AU2018231032B2 (en)	2021-08-19
US11453668B2 (en)	2022-09-27
TWI779016B (zh)	2022-10-01
SG11201907544VA (en)	2019-09-27
US20200181141A1 (en)	2020-06-11
NZ756823A (en)	2021-04-30
PT3592742T (pt)	2021-07-30
AU2018231032A8 (en)	2019-10-17
AR111242A1 (es)	2019-06-19
MX2019010541A (es)	2019-10-21
EA201992126A1 (ru)	2020-02-05
CN110461839A (zh)	2019-11-15
KR102533646B1 (ko)	2023-05-17
CA2997772A1 (en)	2018-09-09
EP3592743A1 (en)	2020-01-15
IL268689A (en)	2019-10-31
US20180258088A1 (en)	2018-09-13
MX2019010539A (es)	2019-10-21
AU2018231035A1 (en)	2019-09-05
EP3592742B1 (en)	2021-05-19
JP6974487B2 (ja)	2021-12-01
US10550118B2 (en)	2020-02-04
US10208040B2 (en)	2019-02-19
IL268689B2 (en)	2023-02-01
US20210269436A1 (en)	2021-09-02
US11254669B2 (en)	2022-02-22
CN110382498B (zh)	2022-07-12
ES2882186T3 (es)	2021-12-01
US10519153B2 (en)	2019-12-31
TW201840560A (zh)	2018-11-16
EA037748B1 (ru)	2021-05-18
BR112019018648A2 (pt)	2020-06-16
JP2020510010A (ja)	2020-04-02
EA201992128A1 (ru)	2020-01-29
JP2020510015A (ja)	2020-04-02
AU2018231032A1 (en)	2019-09-05
US10196393B2 (en)	2019-02-05
US20180258087A1 (en)	2018-09-13
ZA201905618B (en)	2021-05-26
IL268679A (en)	2019-10-31
US11667637B2 (en)	2023-06-06
US20220289737A1 (en)	2022-09-15
US10392386B2 (en)	2019-08-27
PH12019501985A1 (en)	2020-10-05
EP3592742A1 (en)	2020-01-15
JP7134990B2 (ja)	2022-09-12
SG11201907840RA (en)	2019-09-27
US11878977B2 (en)	2024-01-23
KR20190127798A (ko)	2019-11-13
US20190119275A1 (en)	2019-04-25
US20190127371A1 (en)	2019-05-02
IL268689B (en)	2022-10-01
KR102526764B1 (ko)	2023-04-27
CN110382498A (zh)	2019-10-25
PH12019501941A1 (en)	2020-07-06
US20190337945A1 (en)	2019-11-07
WO2018165392A1 (en)	2018-09-13
AR111241A1 (es)	2019-06-19
EA037261B1 (ru)	2021-03-01
BR112019018649A2 (pt)	2020-04-07
US20230063643A1 (en)	2023-03-02
WO2018165395A1 (en)	2018-09-13
TW201837037A (zh)	2018-10-16
ZA201905585B (en)	2020-05-27

Publication	Publication Date	Title
DK3592742T3 (da)	2021-08-09	JAK inhibitorer med en 4-leddet heterocyclisk amid
HUE053564T2 (hu)	2021-07-28	Heterociklusos amidok kinázinhibitorként
HUE062913T2 (hu)	2023-12-28	Új heterociklusos vegyületek
DK3436444T3 (da)	2020-07-27	Heterocyklisk forbindelse
EP3463343A4 (en)	2019-10-23	HETEROCYCLIC INHIBITORS OF PTPN11
DK3233851T3 (da)	2020-08-31	Pesticidaktive heterocykliske derivater med svovlindeholdende substituenter
DK3498693T3 (da)	2025-01-20	Heterocyklisk forbindelse
BR112017003168A2 (pt)	2018-07-03	derivados de heterocíclicos ativos do ponto de vista pesticida com substituintes contendo enxofre
BR112017002598A2 (pt)	2018-07-17	derivados heterocíclicos ativos do ponto de vista pesticida com substituintes contendo enxofre
BR112017002407A2 (pt)	2018-06-26	derivados de heterocíclicos ativos do ponto de vista pesticida com substituintes contendo enxofre
BR112017000269A2 (pt)	2018-06-05	derivados de heterocíclicos ativos do ponto de vista pesticida com substituintes contendo enxofre
BR112017003366A2 (pt)	2018-07-03	derivados de heterocíclicos ativos do ponto de vista pesticida com substituintes contendo enxofre
HUE037763T2 (hu)	2018-09-28	Heterociklusos amidok kináz inhibitorokként
HK1251224A1 (zh)	2019-01-25	雙環雜環酰胺衍生物
DK3551625T3 (da)	2024-09-02	Heterocykliske inhibitorer af mct4
BR112016022217A2 (pt)	2018-04-10	derivados de heterocíclicos ativos do ponto de vista pesticida com substituintes contendo enxofre
EP3706747A4 (en)	2021-08-04	PRMT5 INHIBITORS
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