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DK3459965T3 - Fremgangsmåder til forudsigelse af forfædrevirussekvenser og anvendelser deraf - Google Patents

Fremgangsmåder til forudsigelse af forfædrevirussekvenser og anvendelser deraf Download PDF

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Publication number
DK3459965T3
DK3459965T3 DK18190809.6T DK18190809T DK3459965T3 DK 3459965 T3 DK3459965 T3 DK 3459965T3 DK 18190809 T DK18190809 T DK 18190809T DK 3459965 T3 DK3459965 T3 DK 3459965T3
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anniversary
consequences
predicting
virus
procedures
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DK18190809.6T
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English (en)
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Luk H Vandenberghe
Eric Zinn
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Massachusetts Eye & Ear Infirmary
Schepens Eye Res Inst
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DK18190809.6T 2013-10-11 2014-10-10 Fremgangsmåder til forudsigelse af forfædrevirussekvenser og anvendelser deraf DK3459965T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361889827P 2013-10-11 2013-10-11
EP14789476.0A EP3060575B1 (en) 2013-10-11 2014-10-10 Methods of predicting ancestral virus sequences and uses thereof

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DK3459965T3 true DK3459965T3 (da) 2021-02-22

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US (8) US9695220B2 (da)
EP (3) EP3060575B1 (da)
JP (6) JP6552511B2 (da)
CN (6) CN115141259A (da)
AU (7) AU2014331708B2 (da)
CA (2) CA3182790A1 (da)
DK (1) DK3459965T3 (da)
ES (2) ES2857751T3 (da)
HU (1) HUE052676T2 (da)
LT (1) LT3459965T (da)
NZ (5) NZ758025A (da)
PL (1) PL3459965T3 (da)
PT (1) PT3459965T (da)
WO (1) WO2015054653A2 (da)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2383346T3 (da) * 2005-04-07 2015-01-05 Univ Pennsylvania Modificerede AAVrh.64-capsider, sammensætninger indeholdende disse samt deres anvendelser
US8663624B2 (en) 2010-10-06 2014-03-04 The Regents Of The University Of California Adeno-associated virus virions with variant capsid and methods of use thereof
HUE049629T2 (hu) 2011-04-22 2020-09-28 Univ California Adeno-asszociált vírus virionok kapszid variánssal és eljárások alkalmazásukra
EP2986635B1 (en) 2013-04-18 2018-10-03 Fondazione Telethon Effective delivery of large genes by dual aav vectors
ES2897508T3 (es) 2013-05-31 2022-03-01 Univ California Variantes de virus adenoasociados y métodos de uso de las mismas
CN115141259A (zh) 2013-10-11 2022-10-04 马萨诸塞眼科耳科诊所 预测祖先病毒序列的方法及其用途
CN112626125A (zh) 2014-03-17 2021-04-09 阿德夫拉姆生物技术股份有限公司 用于视锥细胞中增强的基因表达的组合物和方法
US10577627B2 (en) 2014-06-09 2020-03-03 Voyager Therapeutics, Inc. Chimeric capsids
BR112017009497A2 (pt) 2014-11-05 2018-02-06 Voyager Therapeutics, Inc. polinucleotídeos de aadc para o tratamento da doença de parkinson
RU2020108189A (ru) 2014-11-14 2020-03-11 Вояджер Терапьютикс, Инк. Композиции и способы лечения бокового амиотрофического склероза (als)
SG10202001102XA (en) 2014-11-14 2020-03-30 Voyager Therapeutics Inc Modulatory polynucleotides
US11697825B2 (en) 2014-12-12 2023-07-11 Voyager Therapeutics, Inc. Compositions and methods for the production of scAAV
SG11201707063TA (en) 2015-03-02 2017-09-28 Adverum Biotechnologies Inc Compositions and methods for intravitreal delivery of polynucleotides to retinal cones
JP6812368B2 (ja) 2015-03-06 2021-01-13 マサチューセッツ アイ アンド イヤー インファーマリー Prpf31遺伝子における変異により引き起こされる遺伝性網膜変性に対する遺伝子増強療法
MX388331B (es) * 2015-03-24 2025-03-19 Univ California Variantes de virus adenoasociado y métodos de uso de estas
US10881548B2 (en) 2015-05-07 2021-01-05 Massachusetts Eye And Ear Infirmary Methods of delivering an agent to the eye
GB201508026D0 (en) * 2015-05-11 2015-06-24 Ucl Business Plc Capsid
WO2016190780A1 (en) 2015-05-22 2016-12-01 Dmitry Dmitrievich Genkin Extracellular dna as a therapeutic target in neurodegeneration
AU2016298394C1 (en) * 2015-07-30 2024-02-15 Massachusetts Eye And Ear Infirmary Ancestral virus sequences and uses thereof
WO2017058892A2 (en) * 2015-09-28 2017-04-06 The University Of North Carolina At Chapel Hill Methods and compositions for antibody-evading virus vectors
AU2016347887B2 (en) 2015-11-05 2019-11-14 Bamboo Therapeutics, Inc. Modified friedreich ataxia genes and vectors for gene therapy
EP3384035A4 (en) * 2015-12-02 2019-08-07 Voyager Therapeutics, Inc. ASSAYS FOR DETECTION OF NEUTRALIZING ANTIBODIES OF VAA
CN109310745B (zh) 2015-12-11 2022-12-06 马萨诸塞眼科耳科诊所 用于将核酸递送至耳蜗和前庭细胞的材料和方法
SG11201808426XA (en) 2016-04-15 2018-10-30 Univ Pennsylvania Compositions for treatment of wet age-related macular degeneration
US20190142969A1 (en) * 2016-04-26 2019-05-16 Massachusetts Eye And Ear Infirmary ISL1-Based Gene Therapy to Treat Hearing Loss
US11951121B2 (en) 2016-05-18 2024-04-09 Voyager Therapeutics, Inc. Compositions and methods for treating Huntington's disease
IL302748A (en) 2016-05-18 2023-07-01 Voyager Therapeutics Inc Modulatory polynucleotides
IL305149A (en) 2016-07-26 2023-10-01 Biomarin Pharm Inc Novel adeno-associated virus capsid proteins
KR102508820B1 (ko) 2016-07-29 2023-03-13 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 변이체 캡시드를 갖는 아데노-관련된 바이러스 비리온 및 이의 사용 방법
EP4219724A3 (en) 2016-08-23 2023-09-27 Akouos, Inc. Compositions and methods for treating non-age-associated hearing impairment in a human subject
US11192925B2 (en) 2016-10-19 2021-12-07 Adverum Biotechnologies, Inc. Modified AAV capsids and uses thereof
US11730827B2 (en) 2017-02-06 2023-08-22 Children's Medical Center Corporation Materials and methods for delivering nucleic acids to cochlear and vestibular cells
ES2982270T3 (es) 2017-03-17 2024-10-15 Rescue Hearing Inc Constructos y procedimientos de terapia génica para el tratamiento de la pérdida de audición
KR20240093919A (ko) 2017-04-14 2024-06-24 리젠엑스바이오 인크. 인간 뉴런 또는 신경교 세포에 의해 생성된 재조합 인간 이두로네이트-2 설파타제(ids)를 이용한 뮤코다당증 ii형의 치료
WO2018204786A1 (en) 2017-05-05 2018-11-08 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (als)
CN119491003A (zh) 2017-05-05 2025-02-21 沃雅戈治疗公司 治疗亨廷顿病的组合物和方法
JP7330899B2 (ja) * 2017-05-10 2023-08-22 マサチューセッツ アイ アンド イヤー インファーマリー ウイルスのアセンブリ活性化タンパク質(aap)依存性を改変する方法および組成物
CN110831611A (zh) * 2017-05-10 2020-02-21 马萨诸塞眼科耳科诊所 用于修饰病毒的组装活化蛋白(aap)依赖性的方法和组合物
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
US11168322B2 (en) 2017-06-30 2021-11-09 Arbor Biotechnologies, Inc. CRISPR RNA targeting enzymes and systems and uses thereof
KR20200039617A (ko) 2017-08-28 2020-04-16 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 아데노-연관 바이러스 캡시드 변이체 및 이의 사용 방법
MX2020003042A (es) 2017-09-29 2020-11-18 Voyager Therapeutics Inc Rescate del fenotipo neurológico central y periférico de la ataxia de friedreich mediante administración intravenosa.
EP3697449A1 (en) 2017-10-18 2020-08-26 REGENXBIO Inc. Treatment of ocular diseases and metastatic colon cancer with human post-translationally modified vegf-trap
EP4509527A2 (en) 2017-10-18 2025-02-19 REGENXBIO Inc. Fully-human post-translationally modified antibody therapeutics
US20210071149A1 (en) 2017-12-19 2021-03-11 Akouos, Inc. Aav-mediated delivery of therapeutic antibodies to the inner ear
AU2019209770A1 (en) 2018-01-16 2020-09-03 Cls Therapeutics Limited Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (DNase) activity
HUE063005T2 (hu) 2018-03-14 2023-12-28 Arbor Biotechnologies Inc Új CRISPR DNS-célzó enzimek és rendszerek
WO2019178428A1 (en) 2018-03-14 2019-09-19 Arbor Biotechnologies, Inc. Novel crispr dna and rna targeting enzymes and systems
JP7425738B2 (ja) 2018-04-03 2024-01-31 ギンコ バイオワークス インコーポレイテッド 眼組織を標的とするウイルスベクター
JP2021519581A (ja) 2018-04-03 2021-08-12 ストライドバイオ,インコーポレイテッド 抗体を回避するウイルスベクター
MX2020010464A (es) 2018-04-03 2021-01-29 Vectores de virus que evitan anticuerpos.
US12037707B2 (en) 2018-04-05 2024-07-16 Massachusetts Eye And Ear Infirmary Methods of making and using combinatorial barcoded nucleic acid libraries having defined variation
US20210231560A1 (en) 2018-04-29 2021-07-29 Regenxbio Inc. Systems and methods of spectrophotometry for the determination of genome content, capsid content and full/empty ratios of adeno-associated virus particles
WO2019212921A1 (en) 2018-04-29 2019-11-07 Regenxbio Inc. Scalable clarification process for recombinant aav production
CA3099704A1 (en) 2018-05-09 2019-11-14 Biomarin Pharmaceutical Inc. Methods of treating phenylketonuria
WO2019217911A1 (en) 2018-05-11 2019-11-14 Massachusetts Eye And Ear Infirmary Liver-specific tropism of adeno-associated viruses
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
US20210180084A1 (en) 2018-05-14 2021-06-17 Vivet Therapeutics Gene therapy vectors comprising s/mar sequences
IL279193B1 (en) 2018-06-14 2025-03-01 Regenxbio Inc Anion exchange chromatography for recombinant AAV production
US20210244827A1 (en) 2018-06-29 2021-08-12 Icahn School Of Medicine At Mount Sinai Anc80 encoding sphingolipid-metabolizing proteins
WO2020018142A1 (en) 2018-07-16 2020-01-23 Arbor Biotechnologies, Inc. Novel crispr dna targeting enzymes and systems
US20210163991A1 (en) 2018-08-10 2021-06-03 Regenxbio Inc. Scalable method for recombinant aav production
UY38407A (es) 2018-10-15 2020-05-29 Novartis Ag Anticuerpos estabilizadores de trem2
AU2019362833A1 (en) 2018-10-15 2021-04-29 Regenxbio Inc. Method for measuring the infectivity of replication defective viral vectors and viruses
CN114144518A (zh) 2019-02-15 2022-03-04 爱科霍拉有限公司 用于基因疗法的双亮氨酸拉链激酶抑制剂
US11718834B2 (en) 2019-02-15 2023-08-08 Sangamo Therapeutics, Inc. Compositions and methods for producing recombinant AAV
BR112021018776A2 (pt) 2019-03-21 2021-11-30 Stridebio Inc Vetores de vírus adenoassociado recombinante
MX2021011889A (es) 2019-04-03 2021-10-26 Regenxbio Inc Tratamiento genico para patologias oculares.
TW202102526A (zh) 2019-04-04 2021-01-16 美商銳進科斯生物股份有限公司 重組腺相關病毒及其用途
FI3953483T3 (fi) 2019-04-11 2023-11-30 Regenxbio Inc Kokoekskluusiokromatografiamenetelmiä rekombinanttien adenoassosioituneiden viruskoostumusten karakterisoimiseksi
JP7630443B2 (ja) 2019-04-19 2025-02-17 レジェンクスバイオ インコーポレーテッド アデノ随伴ウイルスベクター製剤及び方法
WO2020219868A1 (en) 2019-04-24 2020-10-29 Regenxbio Inc. Fully-human post-translationally modified antibody therapeutics
WO2021005223A1 (en) 2019-07-10 2021-01-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of epilepsy
CA3147034A1 (en) * 2019-07-12 2021-01-21 Cls Therapeutics Limited Treatment of diseases associated with protein misfolding by nervous system expression of an enzyme which has a deoxyribonuclease (dnase) activity
WO2021009805A1 (ja) * 2019-07-12 2021-01-21 株式会社遺伝子治療研究所 ヒト肝臓への遺伝子導入のためのアデノ随伴ウイルスビリオン
JP2022544004A (ja) 2019-07-26 2022-10-17 リジェネックスバイオ インコーポレイテッド 操作された核酸調節エレメントならびにその使用方法
CA3151021A1 (en) * 2019-08-14 2021-02-18 University Of Florida Research Foundation, Incorporated Aav capsid variants for gene therapy
CA3149401A1 (en) 2019-08-26 2021-03-04 Stephen Joseph Pakola Treatment of diabetic retinopathy with fully-human post-translationally modified anti-vegf fab
EP4021934A4 (en) 2019-08-30 2024-02-14 The Regents of the University of California Gene fragment overexpression screening methodologies, and uses thereof
US20220411820A1 (en) 2019-09-09 2022-12-29 Massachusetts Eye And Ear Infirmary Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav
WO2021071835A1 (en) 2019-10-07 2021-04-15 Regenxbio Inc. Adeno-associated virus vector pharmaceutical composition and methods
EP4041903A1 (en) 2019-10-08 2022-08-17 Exhaura, Ltd. Compositions and methods for ocular therapy
WO2021073568A1 (en) * 2019-10-16 2021-04-22 Wuxi Apptec (Shanghai) Co., Ltd. A novel aav variant
MX2022004352A (es) 2019-10-17 2022-07-19 Stridebio Inc Vectores virales adenoasociados para el tratamiento de la enfermedad de niemann-pick tipo c.
EP4061943A1 (en) 2019-11-19 2022-09-28 Institut National de la Santé et de la Recherche Médicale (INSERM) Antisense oligonucleotides and their use for the treatment of cancer
TW202134260A (zh) 2019-11-28 2021-09-16 美商銳進科斯生物股份有限公司 微小肌縮蛋白基因療法之構築體及其用途
IL294625A (en) 2020-01-22 2022-09-01 Regenxbio Inc Treatment of mucopolysaccharidosis i with human fully glycosylated human alpha-l-iduronidase (idua)
AU2021214174A1 (en) 2020-01-29 2022-08-18 Regenxbio Inc. Treatment of mucopolysaccharidosis II with recombinant human iduronate-2-sulfatase (IDS) produced by human neural or glial cells
KR20220133900A (ko) 2020-01-29 2022-10-05 리젠엑스바이오 인크. 점액다당류증 iva의 치료
JP2023519101A (ja) 2020-02-12 2023-05-10 マサチューセッツ アイ アンド イヤー インファーマリー Rp1関連網膜変性症のハプロタイプに基づく処置
KR20220157944A (ko) 2020-02-21 2022-11-29 아카우오스, 인크. 인간 대상체에서 비-연령-연관 청각 장애를 치료하기 위한 조성물 및 방법
BR112023000428A2 (pt) 2020-07-10 2023-03-14 Inst Nat Sante Rech Med Métodos e composições para tratar epilepsia
CA3189878A1 (en) 2020-08-19 2022-02-24 Colin O'BANION Adeno-associated virus vectors for treatment of rett syndrome
WO2022060916A1 (en) 2020-09-15 2022-03-24 Regenxbio Inc. Vectorized antibodies for anti-viral therapy
EP4213890A1 (en) 2020-09-15 2023-07-26 RegenxBio Inc. Vectorized lanadelumab and administration thereof
WO2022076549A1 (en) 2020-10-07 2022-04-14 Regenxbio Inc. Formulations for suprachoroidal administration such as high viscosity formulations
WO2022076750A2 (en) 2020-10-07 2022-04-14 Regenxbio Inc. Recombinant adeno-associated viruses for cns or muscle delivery
WO2022076711A2 (en) 2020-10-07 2022-04-14 Regenxbio Inc. Adeno-associated viruses for ocular delivery of gene therapy
KR20230106598A (ko) 2020-10-07 2023-07-13 리젠엑스바이오 인크. 겔 제형과 같은 맥락막위 투여용 제형
MX2023003988A (es) 2020-10-07 2023-06-22 Regenxbio Inc Formulaciones para administración supracoroidea tales como formulaciones con formación de agregados.
IL302279A (en) 2020-10-28 2023-06-01 Regenxbio Inc VECTORIZED ANTI-TNF-α ANTIBODIES FOR OCULAR INDICATIONS
WO2022094157A1 (en) 2020-10-28 2022-05-05 Regenxbio Inc. Vectorized anti-cgrp and anti-cgrpr antibodies and administration thereof
KR20230098176A (ko) 2020-10-29 2023-07-03 리젠엑스바이오 인크. 안구 적응증을 위한 벡터화된 tnf-알파 길항제
EP4236974A2 (en) 2020-10-29 2023-09-06 RegenxBio Inc. Vectorized factor xii antibodies and administration thereof
IL302608A (en) 2020-11-03 2023-07-01 Pfizer Methods for purification of aav vectors by anion exchange chromatography
CA3201533A1 (en) 2020-11-11 2022-05-19 European Molecular Biology Laboratory Modified viral particles for gene therapy
CR20230228A (es) * 2020-12-01 2023-07-18 Akouos Inc Construcciones de anticuerpos anti-vegf y métodos relacionados para el tratamiento de los síntomas asociados al schwannoma vestibular
US20240052322A1 (en) 2020-12-15 2024-02-15 Pfizer Inc. HILIC UPLC-MS Method For Separating and Analyzing Intact Adeno-Associated Virus Capsid Proteins
US20240167054A1 (en) 2020-12-16 2024-05-23 Regenxbio Inc. Method of producing a recombinant virus particle
JP2024503234A (ja) 2020-12-23 2024-01-25 ファイザー・インク 親和性クロマトグラフィーによるaavベクターの精製方法
WO2022147087A1 (en) 2020-12-29 2022-07-07 Regenxbio Inc. Tau-specific antibody gene therapy compositions, methods and uses thereof
WO2022150634A2 (en) 2021-01-08 2022-07-14 Massachusetts Eye And Ear Infirmary Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav
KR20230133314A (ko) 2021-01-21 2023-09-19 리젠엑스바이오 인크. 재조합 폴리펩티드 및 바이러스의 개선된 생산
EP4291249A2 (en) 2021-02-10 2023-12-20 RegenxBio Inc. Treatment of mucopolysaccharidosis ii with recombinant human iduronate-2-sulfatase (ids)
WO2022208342A1 (en) 2021-04-01 2022-10-06 Pfizer Inc. Pharmaceutical compositions containing adeno-associated viral vector
WO2023113806A1 (en) 2021-12-16 2023-06-22 Affinia Therapeutics, Inc. Recombinant aav for treatment of neural disease
WO2022221193A1 (en) 2021-04-12 2022-10-20 Affinia Therapeutics Inc. Recombinant aav for treatment of neural disease
US20240216543A1 (en) 2021-04-26 2024-07-04 Regenxbio Inc. Microdystrophin gene therapy administration for treatment of dystrophinopathies
EP4334454A2 (en) 2021-05-04 2024-03-13 RegenxBio Inc. Novel aav vectors and methods and uses thereof
WO2022241030A1 (en) 2021-05-11 2022-11-17 Regenxbio Inc. Treatment of duchenne muscular dystrophy and combinations thereof
BR112023023599A2 (pt) 2021-05-12 2024-03-12 Fond Telethon Sistema de vetor
CN117337326A (zh) 2021-05-27 2024-01-02 中国科学院动物研究所 工程化的Cas12i核酸酶、效应蛋白及其用途
EP4359547A1 (en) 2021-06-22 2024-05-01 Pfizer Inc. Production of adeno-associated virus vector in insect cells
CA3226452A1 (en) 2021-07-19 2023-01-26 New York University Auf1 combination therapies for treatment of muscle degenerative disease
WO2023060113A1 (en) 2021-10-05 2023-04-13 Regenxbio Inc. Compositions and methods for recombinant aav production
CN118202060A (zh) 2021-10-05 2024-06-14 再生生物股份有限公司 用于重组aav生产的组合物和方法
US20250001006A1 (en) 2021-10-07 2025-01-02 Regenxbio Inc. Recombinant adeno-associated viruses for targeted delivery
WO2023060272A2 (en) 2021-10-07 2023-04-13 Regenxbio Inc. Recombinant adeno-associated viruses for cns tropic delivery
US20250025574A1 (en) 2021-10-28 2025-01-23 Regenxbio Inc. Engineered nucleic acid regulatory elements and methods and uses thereof
WO2023114816A1 (en) 2021-12-14 2023-06-22 Neurogene, Inc. Recombinant optimized galc constructs and methods for treating galc-associated disorders
GB202201242D0 (en) 2022-01-31 2022-03-16 Univ Edinburgh Recombinant optimized mecp2 cassettes and methods for treating rett syndrome and related disorders
TW202346590A (zh) 2022-03-13 2023-12-01 美商銳進科斯生物股份有限公司 經修飾之肌肉特異性啟動子
EP4499154A1 (en) 2022-03-25 2025-02-05 REGENXBIO Inc. Dominant-negative tumor necrosis factor alpha adeno-associated virus gene therapy
TW202404651A (zh) 2022-04-06 2024-02-01 美商銳進科斯生物股份有限公司 用於脈絡膜上投與之調配物諸如形成聚集體之調配物
EP4504149A1 (en) 2022-04-06 2025-02-12 RegenxBio Inc. Pharmaceutical composition comprising a recombinant adeno-associated virus vector with an expression cassette encoding a transgene for suprachoidal administration
TW202345913A (zh) 2022-04-06 2023-12-01 美商銳進科斯生物股份有限公司 用於脈絡膜上投與之調配物諸如凝膠調配物
EP4507741A1 (en) 2022-04-14 2025-02-19 RegenxBio Inc. Gene therapy for treating an ocular disease
WO2023201277A1 (en) 2022-04-14 2023-10-19 Regenxbio Inc. Recombinant adeno-associated viruses for cns tropic delivery
GB202206336D0 (en) 2022-04-29 2022-06-15 Univ Edinburgh Recombinant therapeutic FMR1 constructs and methods of treating fragile X syndrome and related disorders
AR129215A1 (es) 2022-05-03 2024-07-31 Regenxbio Inc Anticuerpos anti-complemento y agentes del complemento vectorizados y administración de estos
TW202417633A (zh) 2022-05-03 2024-05-01 美商銳進科斯生物股份有限公司 用於眼適應症之載體化抗TNF-α抑制劑
CN118974284A (zh) 2022-05-06 2024-11-15 诺华股份有限公司 新型重组aav vp2融合多肽
WO2023239627A2 (en) 2022-06-08 2023-12-14 Regenxbio Inc. Methods for recombinant aav production
WO2024017990A1 (en) 2022-07-21 2024-01-25 Institut National de la Santé et de la Recherche Médicale Methods and compositions for treating chronic pain disorders
WO2024038365A1 (en) 2022-08-16 2024-02-22 Pfizer Inc. Methods for purification of aav vectors by anion exchange chromatography
WO2024044725A2 (en) 2022-08-24 2024-02-29 Regenxbio Inc. Recombinant adeno-associated viruses and uses thereof
WO2024073669A1 (en) 2022-09-30 2024-04-04 Regenxbio Inc. Treatment of ocular diseases with recombinant viral vectors encoding anti-vegf fab
WO2024081746A2 (en) 2022-10-11 2024-04-18 Regenxbio Inc. Engineered nucleic acid regulatory elements and methods and uses thereof
WO2024086747A1 (en) 2022-10-19 2024-04-25 Affinia Therapeutics Inc. Recombinant aavs with improved tropism and specificity
WO2024146935A1 (en) 2023-01-06 2024-07-11 Institut National de la Santé et de la Recherche Médicale Intravenous administration of antisense oligonucleotides for the treatment of pain
WO2024192281A2 (en) 2023-03-15 2024-09-19 Regenxbio Inc. Exon skipping gene therapy constructs, vectors and uses thereof
WO2024211780A1 (en) 2023-04-07 2024-10-10 Regenxbio Inc. Compositions and methods for recombinant aav production
WO2024216244A2 (en) 2023-04-13 2024-10-17 Regenxbio Inc. Targeting aav capsids, methods of manufacturing and using same
WO2024233529A2 (en) 2023-05-07 2024-11-14 Regenxbio Inc. Compositions and methods for recombinant aav production
WO2024238807A2 (en) 2023-05-16 2024-11-21 Affinia Therapeutics Inc. Recombinant aavs with improved tropism and specificity
WO2024238859A1 (en) 2023-05-16 2024-11-21 Regenxbio Inc. Vectorized c5 inhibitor agents and administration thereof
WO2024238853A1 (en) 2023-05-16 2024-11-21 Regenxbio Inc. Adeno-associated viruses for ocular delivery of gene therapy
WO2024238867A1 (en) 2023-05-16 2024-11-21 Regenxbio Inc. Vectorized anti-complement antibodies and administration thereof
WO2025008406A1 (en) 2023-07-04 2025-01-09 Institut National de la Santé et de la Recherche Médicale Antisense oligonucleotides and their use for the treatment of cancer
WO2025021771A1 (en) 2023-07-21 2025-01-30 Borea Therapeutics S.R.L. Methods of preparing surface modified viral capsids

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037384B2 (en) 1988-01-12 1995-12-26 Cornell Res Foundation Inc Method and apparatus for the treatment of complicated retinal detachments
US5817075A (en) 1989-08-14 1998-10-06 Photogenesis, Inc. Method for preparation and transplantation of planar implants and surgical instrument therefor
US6204059B1 (en) 1994-06-30 2001-03-20 University Of Pittsburgh AAV capsid vehicles for molecular transfer
US6024719A (en) 1998-07-06 2000-02-15 Morris; Robert E Method and apparatus for performing surgery inside the human retina using fluidic internal limiting membrane (ILM) seperation (FILMS)
US20040115621A1 (en) * 2000-02-18 2004-06-17 Allen Rodrigo Ancestral viruses and vaccines
US6692526B1 (en) 2000-03-15 2004-02-17 Michael E. Snyder Ophthalmological surgery colorant and delivery system
CA2413156C (en) * 2000-07-03 2009-08-18 Gala Design, Inc. Expression vectors
AU2003221733A1 (en) * 2002-04-17 2003-11-03 University Of Florida Research Foundation, Inc. Improved raav vectors
US9441244B2 (en) * 2003-06-30 2016-09-13 The Regents Of The University Of California Mutant adeno-associated virus virions and methods of use thereof
EP3211085B1 (en) 2003-09-30 2021-03-31 The Trustees of The University of Pennsylvania Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
US20070225727A1 (en) 2004-05-31 2007-09-27 Keiichi Matsuhisa Transparent Tissue-Visualizng Preparation
WO2006062233A1 (en) 2004-12-06 2006-06-15 National University Corporation Kyushu University A staining composition for staining an ophthalmic membrane
DK2383346T3 (da) * 2005-04-07 2015-01-05 Univ Pennsylvania Modificerede AAVrh.64-capsider, sammensætninger indeholdende disse samt deres anvendelser
US10022457B2 (en) 2005-08-05 2018-07-17 Gholam A. Peyman Methods to regulate polarization and enhance function of cells
US20150182756A1 (en) 2005-08-05 2015-07-02 Gholam A. Peyman Methods to regulate polarization and enhance function of cells
US8388668B2 (en) 2005-08-05 2013-03-05 Gholam A. Peyman Methods to regulate polarization of excitable cells
US20090226531A1 (en) 2008-03-07 2009-09-10 Allergan, Inc. Methods and composition for intraocular delivery of therapeutic sirna
AU2009274482A1 (en) 2008-05-20 2010-01-28 Eos Neuroscience, Inc. Vectors for delivery of light-sensitive proteins and methods of use
US20110098536A1 (en) 2008-11-05 2011-04-28 Corcosteugi Borja F ILM Spatula with Malleable Blade
US11890226B2 (en) 2009-02-25 2024-02-06 University Of Maryland, College Park Device and methods for directing agents into an eye
EP2772542B1 (en) * 2009-05-28 2016-12-28 Deutsches Krebsforschungszentrum Modified AAV capsid polypeptides
WO2011075838A1 (en) * 2009-12-21 2011-06-30 Audigen Inc. Method of treating or preventing hearing loss
WO2013170195A1 (en) 2012-05-11 2013-11-14 Medicus Biosciences, Llc Biocompatible hydrogel treatments for retinal detachment
EP2970946A4 (en) 2013-03-13 2016-09-07 Philadelphia Children Hospital ADENOASSOZED VIRUS VECTORS AND METHOD FOR USE THEREOF
US20160296221A1 (en) 2013-06-29 2016-10-13 Robert Edward Morris Safety cannula
CN115141259A (zh) 2013-10-11 2022-10-04 马萨诸塞眼科耳科诊所 预测祖先病毒序列的方法及其用途
AU2016298394C1 (en) 2015-07-30 2024-02-15 Massachusetts Eye And Ear Infirmary Ancestral virus sequences and uses thereof
US9782232B1 (en) 2016-04-25 2017-10-10 Novartis Ag Automated intraocular pressure tamponade
US20230048025A1 (en) * 2016-12-22 2023-02-16 Oregon Health & Science University Adeno associated viral vectors
JP7330899B2 (ja) 2017-05-10 2023-08-22 マサチューセッツ アイ アンド イヤー インファーマリー ウイルスのアセンブリ活性化タンパク質(aap)依存性を改変する方法および組成物
EP3723679B1 (en) 2018-02-22 2023-09-13 Alcon Inc. Systems and methods for gas mixing in ocular surgical equipment
JP2021519581A (ja) * 2018-04-03 2021-08-12 ストライドバイオ,インコーポレイテッド 抗体を回避するウイルスベクター
KR20210068068A (ko) 2018-09-28 2021-06-08 보이저 테라퓨틱스, 인크. 조작된 프로모터를 갖는 프라탁신 발현 구축물 및 그의 사용 방법
EP4097239A2 (en) 2020-01-29 2022-12-07 Voyager Therapeutics, Inc. Methods and systems for producing aav particles
WO2022150634A2 (en) 2021-01-08 2022-07-14 Massachusetts Eye And Ear Infirmary Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav

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