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DK3443979T3 - Il-2-doseringsplan til behandling af systemisk lupus erythematosus - Google Patents

Il-2-doseringsplan til behandling af systemisk lupus erythematosus Download PDF

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Publication number
DK3443979T3
DK3443979T3 DK18179669.9T DK18179669T DK3443979T3 DK 3443979 T3 DK3443979 T3 DK 3443979T3 DK 18179669 T DK18179669 T DK 18179669T DK 3443979 T3 DK3443979 T3 DK 3443979T3
Authority
DK
Denmark
Prior art keywords
treatment
lupus erythematosus
systemic lupus
dosage plan
dosage
Prior art date
Application number
DK18179669.9T
Other languages
English (en)
Inventor
David Klatzmann
David Saadoun
Patrice Cacoub
Michèle Rosenzwajg
Eliane Piaggio
Gilbert Bensimon
Claude Bernard
Original Assignee
Assist Publique - Hôpitaux De Paris
Univ Sorbonne
Inserm (Institut National De La Santé Et De La Rech Médicale)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44244599&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3443979(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Assist Publique - Hôpitaux De Paris, Univ Sorbonne, Inserm (Institut National De La Santé Et De La Rech Médicale) filed Critical Assist Publique - Hôpitaux De Paris
Application granted granted Critical
Publication of DK3443979T3 publication Critical patent/DK3443979T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK18179669.9T 2011-03-11 2012-03-09 Il-2-doseringsplan til behandling af systemisk lupus erythematosus DK3443979T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161451663P 2011-03-11 2011-03-11
EP11305269 2011-03-11
EP12708029.9A EP2683395B1 (en) 2011-03-11 2012-03-09 Use of low dose il-2 for treating type 1 diabetes

Publications (1)

Publication Number Publication Date
DK3443979T3 true DK3443979T3 (da) 2020-08-24

Family

ID=44244599

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12708029.9T DK2683395T3 (da) 2011-03-11 2012-03-09 Anvendelse af lav dosis il-2 til behandling af type 1-diabetes
DK18179669.9T DK3443979T3 (da) 2011-03-11 2012-03-09 Il-2-doseringsplan til behandling af systemisk lupus erythematosus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK12708029.9T DK2683395T3 (da) 2011-03-11 2012-03-09 Anvendelse af lav dosis il-2 til behandling af type 1-diabetes

Country Status (12)

Country Link
US (1) US20230149512A1 (da)
EP (3) EP3766513A1 (da)
JP (2) JP6054889B2 (da)
KR (1) KR102220006B1 (da)
CN (2) CN103732241A (da)
AU (4) AU2012228418B2 (da)
CA (1) CA2828657A1 (da)
DK (2) DK2683395T3 (da)
ES (1) ES2693645T3 (da)
MX (2) MX347324B (da)
PL (2) PL3443979T3 (da)
WO (1) WO2012123381A1 (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010206840B2 (en) 2009-01-21 2015-02-05 Amgen Inc. Compositions and methods of treating inflammatory and autoimmune diseases
US20140044675A1 (en) 2012-08-10 2014-02-13 Roche Glycart Ag Interleukin-2 fusion proteins and uses thereof
AU2014205366B2 (en) * 2013-01-09 2018-12-20 Eckhard R. Podack Compositions and methods for the regulation of T regulatory cells using Tl1a-Ig fusion protein
EP3013355B1 (en) 2013-06-25 2019-08-07 ICM - Institut du Cerveau et da la Moelle Epinière Il-2 for use in treating alzheimer disease and related disorders
EA201992609A1 (ru) 2014-02-06 2020-03-04 Ф.Хоффманн-Ля Рош Аг Слитые белки, содержащие интерлейкин-2, и их применения
EP2918285A1 (en) * 2014-03-11 2015-09-16 Université Pierre et Marie Curie (Paris 6) Interleukin-2 for treating food allergy
JP6612258B2 (ja) * 2014-04-22 2019-11-27 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 自己免疫疾患の診断のための方法
CN104189892A (zh) * 2014-08-22 2014-12-10 北京大学人民医院 低剂量白细胞介素2在免疫相关性疾病治疗中的应用
CA2963602A1 (en) * 2014-10-09 2016-04-14 Dana-Farber Cancer Institute, Inc. Multiple-variable il-2 dose regimen for treating immune disorders
CN104459129A (zh) * 2015-01-05 2015-03-25 复旦大学附属华山医院 一种鉴别活动性与潜伏性结核分枝杆菌感染的诊断试剂盒
TN2017000432A1 (en) 2015-04-10 2019-04-12 Amgen Inc Interleukin-2 muteins for the expansion of t-regulatory cells
WO2016205714A1 (en) 2015-06-19 2016-12-22 University Of Louisville Research Foundation, Inc. Immunomodulation for the long term prevention and treatment of autoimmune diseases and foreign tissue rejection
US20190060407A1 (en) * 2015-09-10 2019-02-28 Assistance Publique - Hôpitaux De Paris Use of interleukin 2 for treating spondyloarthritis
CA3042631A1 (en) * 2016-01-11 2017-07-20 Dignity Health Modulators of zinc activated cation channel
EP3431096B1 (en) * 2016-03-16 2024-12-18 Xie, Yanhui Glucocorticoid combined with polyethylene glycol-modified interleukin-2 for treating respiratory disease
WO2018170288A1 (en) 2017-03-15 2018-09-20 Pandion Therapeutics, Inc. Targeted immunotolerance
SG11201909949XA (en) 2017-05-24 2019-11-28 Pandion Therapeutics Inc Targeted immunotolerance
EP3710019A1 (en) * 2017-11-14 2020-09-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Regulatory t cells genetically modified for the lymphotoxin alpha gene and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
EP3752178A1 (en) 2018-02-16 2020-12-23 Iltoo Pharma Use of interleukin 2 for treating sjögren's syndrome
JP7235772B2 (ja) * 2018-05-21 2023-03-08 ネクター セラピューティクス 選択的Treg刺激因子RUR20kD-IL-2及び関連組成物
WO2020007937A1 (en) * 2018-07-03 2020-01-09 Iltoo Pharma Use of interleukin-2 for treating systemic sclerosis
US20200282013A1 (en) * 2019-03-08 2020-09-10 DrugCendR, Inc. Low-dose cytokine co-administered with irgd for treating cancer
CN109999179A (zh) * 2019-05-08 2019-07-12 山东省分析测试中心 低剂量白介素2用于制备治疗阿尔茨海默病药物中的应用
CA3141327A1 (en) 2019-05-20 2020-11-26 Pandion Operations, Inc. Madcam targeted immunotolerance
CN110251659A (zh) * 2019-07-03 2019-09-20 安徽省立医院 一种小剂量白细胞介素2在制备治疗慢性痛风药物中的应用
JP7483857B2 (ja) 2019-07-26 2024-05-15 ビステラ, インコーポレイテッド インターロイキン-2作用物質およびその使用
WO2021168079A1 (en) 2020-02-21 2021-08-26 Pandion Operations, Inc. Tissue targeted immunotolerance with a cd39 effector
TW202146041A (zh) 2020-03-06 2021-12-16 尼姆大學醫學中心 用於肌肉萎縮性脊髓側索硬化症之治療的低劑量人類介白素-2
AU2021391924A1 (en) 2020-12-04 2023-06-22 The General Hospital Corporation Methods of using interleukin-2 agents
AU2022235091A1 (en) * 2021-03-11 2023-09-21 Coya Therapeutics, Inc. Methods and compositions for treatment of disease
CN113304248B (zh) * 2021-07-01 2023-01-03 北京大学人民医院 Il-2在制备缓解糖皮质激素类药物副作用的药物中的应用
CN115607653B (zh) * 2022-07-09 2023-09-26 曹霞 低剂量白介素2在治疗孤独症中的应用
CN115487292B (zh) * 2022-09-28 2025-01-21 河北师范大学 一种治疗糖尿病的联合用药物及其应用
WO2024121173A1 (en) 2022-12-05 2024-06-13 Centre Hospitalier Universitaire De Nimes Low dose human interleukin-2 for the treatment of amyotrophic lateral sclerosis in a subgroup of patients
CN115779072B (zh) * 2023-02-06 2023-10-17 北京大学第三医院(北京大学第三临床医学院) 一种包含低浓度il-2的用于治疗干眼的药物组合物

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341562C (en) 1982-03-31 2007-11-27 Tadatsugu Taniguchi Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell
IE56026B1 (en) 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
WO1985000817A1 (en) 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
US4656132A (en) 1984-03-28 1987-04-07 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
US4530787A (en) 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4604377A (en) 1984-03-28 1986-08-05 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
US4752585A (en) 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
CA1340265C (en) 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
US4748234A (en) 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
EP0262802A3 (en) * 1986-09-01 1990-01-31 Takeda Chemical Industries, Ltd. Medicament for the treatment or improvement of rheumatoid arthritis or systemic lupus erythematosus
JPS63183538A (ja) * 1986-09-01 1988-07-28 Takeda Chem Ind Ltd 関節リウマチまたは全身性エリテマト−デスの改善,治療剤
US5466447A (en) 1988-06-29 1995-11-14 Amgen Inc. Method for treating psoriasis
WO1991014444A1 (en) 1990-03-19 1991-10-03 Brigham And Women's Hospital Treatment of cachexia with interleukin 2
FR2769505B1 (fr) 1997-10-10 2000-06-30 Michael Gerard Tovey Compositions de cytokines a administrer a la muqueuse buccale, et leurs utilisations
GB9724838D0 (en) 1997-11-26 1998-01-21 Franks Christopher R Compositions
WO2002078624A2 (en) * 2001-03-30 2002-10-10 Mayo Foundation For Medical Education And Research Aerosol administration of interleukin-2 liposomes
CN101072509A (zh) * 2002-03-08 2007-11-14 孟山都技术有限公司 炎症的治疗和预防
DE60233576D1 (de) * 2002-12-02 2009-10-15 Innate Pharma Interleukin-2 und Gamma Delta T Zellaktivator enthaltende Zusammensetzungen und deren Verwendungen
GB2401040A (en) * 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
US7569215B2 (en) 2003-07-18 2009-08-04 Massachusetts Institute Of Technology Mutant interleukin-2 (IL-2) polypeptides
US20070098685A1 (en) * 2005-01-19 2007-05-03 Brand Stephen J Methods and kits to treat chronic inflammatory immune diseases by administering a proteasome inhibitor and an interleukin 2 receptor agonist
KR20070102576A (ko) 2005-01-27 2007-10-18 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 신장 세포 암종의 치료 방법
CA2717812A1 (en) 2008-03-13 2009-09-17 Biotest Ag Agent for treating disease
DE102008023820A1 (de) 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
WO2010049438A2 (en) 2008-10-30 2010-05-06 Innate Pharma Improved methods of using phosphoantigens for the treatment of diseases
AU2010206840B2 (en) 2009-01-21 2015-02-05 Amgen Inc. Compositions and methods of treating inflammatory and autoimmune diseases
CN102462837B (zh) 2010-11-19 2016-08-03 生物林格斯Ip有限公司 抗炎组合物

Also Published As

Publication number Publication date
KR20140053869A (ko) 2014-05-08
PL3443979T3 (pl) 2020-11-16
AU2012228418B2 (en) 2016-09-29
CN103732241A (zh) 2014-04-16
AU2018206705A1 (en) 2018-08-02
MX2013010342A (es) 2014-03-05
AU2020204023A1 (en) 2020-07-09
JP6054889B2 (ja) 2016-12-27
JP7561893B2 (ja) 2024-10-04
CN109432407A (zh) 2019-03-08
DK2683395T3 (da) 2018-11-19
AU2016273847A1 (en) 2017-01-05
MX384095B (es) 2025-03-14
EP2683395A1 (en) 2014-01-15
US20230149512A1 (en) 2023-05-18
EP3443979A1 (en) 2019-02-20
MX347324B (es) 2017-04-19
AU2016273847B2 (en) 2018-04-19
PL2683395T3 (pl) 2019-04-30
WO2012123381A1 (en) 2012-09-20
JP2014510725A (ja) 2014-05-01
AU2016273847A2 (en) 2017-02-02
EP3443979B1 (en) 2020-05-27
AU2012228418A1 (en) 2013-09-05
CA2828657A1 (en) 2012-09-20
AU2018206705B2 (en) 2020-03-19
ES2693645T3 (es) 2018-12-13
EP3766513A1 (en) 2021-01-20
EP2683395B1 (en) 2018-08-01
KR102220006B1 (ko) 2021-02-24
AU2020204023B2 (en) 2022-06-02
JP2023029565A (ja) 2023-03-03

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