DK3363805T3 - Fremgangsmåder til syntese af sphingomyeliner og dihydrosphingomyeliner - Google Patents
Fremgangsmåder til syntese af sphingomyeliner og dihydrosphingomyeliner Download PDFInfo
- Publication number
- DK3363805T3 DK3363805T3 DK18160532.0T DK18160532T DK3363805T3 DK 3363805 T3 DK3363805 T3 DK 3363805T3 DK 18160532 T DK18160532 T DK 18160532T DK 3363805 T3 DK3363805 T3 DK 3363805T3
- Authority
- DK
- Denmark
- Prior art keywords
- dihydrosphingomyelins
- sphingomyelins
- synthesis
- methods
- Prior art date
Links
- LRYZPFWEZHSTHD-HEFFAWAOSA-O 2-[[(e,2s,3r)-2-formamido-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium Chemical class CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](NC=O)COP(O)(=O)OCC[N+](C)(C)C LRYZPFWEZHSTHD-HEFFAWAOSA-O 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/141—Esters of phosphorous acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/24—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361801641P | 2013-03-15 | 2013-03-15 | |
| EP13306056 | 2013-07-23 | ||
| EP14729036.5A EP2970344A2 (en) | 2013-03-15 | 2014-03-14 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3363805T3 true DK3363805T3 (da) | 2021-03-08 |
Family
ID=51538203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18160532.0T DK3363805T3 (da) | 2013-03-15 | 2014-03-14 | Fremgangsmåder til syntese af sphingomyeliner og dihydrosphingomyeliner |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20140316154A1 (da) |
| EP (3) | EP3842443B1 (da) |
| JP (2) | JP6438417B2 (da) |
| KR (1) | KR20150132188A (da) |
| CN (1) | CN105051051B (da) |
| AU (2) | AU2014229638B2 (da) |
| BR (1) | BR112015023558A2 (da) |
| CA (1) | CA2900902C (da) |
| DK (1) | DK3363805T3 (da) |
| HK (2) | HK1212705A1 (da) |
| MX (1) | MX2015012877A (da) |
| PH (1) | PH12015501835A1 (da) |
| SG (2) | SG11201506456VA (da) |
| WO (1) | WO2014140787A2 (da) |
| ZA (1) | ZA201505860B (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2396017B1 (en) | 2009-02-16 | 2015-07-01 | Cerenis Therapeutics Holding SA | Apolipoprotein a-i mimics |
| LT2629776T (lt) | 2010-10-18 | 2017-11-10 | Cerenis Therapeutics Holding Sa | Junginiai, kompozicijos ir būdai, tinkami cholesterolio mobilizavimui |
| EP3842443B1 (en) | 2013-03-15 | 2025-02-19 | Cerenis Therapeutics Holding SA | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| WO2019030575A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding | APOMÈRES |
| TW201919712A (zh) | 2017-08-10 | 2019-06-01 | 法商塞勒尼斯醫療控股公司 | 運送子(cargomers) |
| JPWO2019189133A1 (ja) * | 2018-03-27 | 2021-03-18 | 日油株式会社 | スフィンゴミエリン誘導脂質およびその製造方法 |
| JP7303618B2 (ja) * | 2018-10-05 | 2023-07-05 | 日本精化株式会社 | スフィンゴリン脂質前駆体及びその製造方法、並びに、スフィンゴリン脂質の製造方法 |
| US11752163B2 (en) | 2020-04-16 | 2023-09-12 | Abionyx Pharma Sa | CER-001 therapy for treating kidney disease |
| AU2021256086A1 (en) | 2020-04-16 | 2022-12-15 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein- based complexes |
| WO2021209808A1 (en) | 2020-04-16 | 2021-10-21 | Abionyx Pharma Sa | Cer-001 therapy for treating kidney disease |
| MX2023003877A (es) | 2020-10-01 | 2023-04-18 | Abionyx Pharma Sa | Composiciones que comprenden complejos basados en proteina de union a lipidos para usarse en el tratamiento de enfermedades oculares. |
| KR20240018430A (ko) | 2021-04-15 | 2024-02-13 | 아비오닉스 파마 에스에이 | 기관 보존 용액에서의 지질 결합 단백질-기반 복합체의 사용 |
| IL316100A (en) | 2022-04-06 | 2024-12-01 | Abionyx Pharma Sa | Methods for treating leukocytosis, endothelial dysfunction, and carditis using lipid-binding protein-based complexes |
| WO2023194797A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| IL317448A (en) | 2022-06-10 | 2025-02-01 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using complexes based on lipid-binding proteins |
| WO2023237935A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
| IL317896A (en) | 2022-06-28 | 2025-02-01 | Abionyx Pharma Sa | Compounds and processes for the synthesis of sphingomyelins |
| WO2024150064A1 (en) | 2023-01-13 | 2024-07-18 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0146810A3 (de) | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| US5220043A (en) * | 1991-03-21 | 1993-06-15 | Ohio University | Synthesis of D-erythro-sphingomyelins |
| HUT75162A (en) | 1993-11-16 | 1997-04-28 | Depotech Corp | Vesicles with controlled release of actives |
| US5766627A (en) | 1993-11-16 | 1998-06-16 | Depotech | Multivescular liposomes with controlled release of encapsulated biologically active substances |
| AU765809B2 (en) | 1998-02-12 | 2003-10-02 | Emory University | Sphingolipid derivatives and their methods of use |
| JP2004002215A (ja) * | 2002-05-23 | 2004-01-08 | National Institute Of Advanced Industrial & Technology | スフィンゴ脂質誘導体の製造方法 |
| EP1704155A1 (en) | 2004-01-15 | 2006-09-27 | Biolab Ltd. | Sphingomyelin, intermediates thereof and methods for preparation of same |
| US7811602B2 (en) | 2004-05-17 | 2010-10-12 | Tekmira Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
| EP2065040A3 (en) * | 2004-06-29 | 2009-09-09 | Jado Technologies GmbH | Sphingolipids against pathological processes in lipid rafts |
| JP4825947B2 (ja) | 2004-08-04 | 2011-11-30 | 学校法人関西学院 | 不飽和アミノジオール類の製造方法 |
| JP2006045113A (ja) | 2004-08-04 | 2006-02-16 | Kemikurea:Kk | リン酸エステル類 |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| US7470664B2 (en) | 2005-07-20 | 2008-12-30 | Merck & Co., Inc. | HCV NS3 protease inhibitors |
| JP2007204384A (ja) | 2006-01-31 | 2007-08-16 | Kemikurea:Kk | 光学活性リン酸誘導体およびこれを用いた光学活性スフィンゴシン１−リン酸誘導体の製造方法 |
| WO2008096880A1 (ja) * | 2007-02-09 | 2008-08-14 | Gifu University | スフィンゴ糖脂質の合成法 |
| WO2008111450A1 (ja) * | 2007-03-09 | 2008-09-18 | Otsuka Chemical Co., Ltd. | スフィンゴシン化合物、その製造方法及びスフィンゴミエリナーゼ阻害剤 |
| US9713591B2 (en) | 2008-10-07 | 2017-07-25 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same |
| EP4400511A3 (en) | 2011-02-07 | 2024-09-04 | Abionyx Pharma SA | Lipoprotein complexes and manufacturing and uses thereof |
| FR3000959B1 (fr) * | 2013-01-14 | 2015-08-21 | Holis Technologies | Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines |
| US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| EP3842443B1 (en) * | 2013-03-15 | 2025-02-19 | Cerenis Therapeutics Holding SA | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
-
2014
- 2014-03-14 EP EP20214357.4A patent/EP3842443B1/en active Active
- 2014-03-14 BR BR112015023558A patent/BR112015023558A2/pt not_active Application Discontinuation
- 2014-03-14 KR KR1020157025911A patent/KR20150132188A/ko not_active Application Discontinuation
- 2014-03-14 WO PCT/IB2014/000494 patent/WO2014140787A2/en active Application Filing
- 2014-03-14 SG SG11201506456VA patent/SG11201506456VA/en unknown
- 2014-03-14 SG SG10201804887YA patent/SG10201804887YA/en unknown
- 2014-03-14 JP JP2015562366A patent/JP6438417B2/ja active Active
- 2014-03-14 CN CN201480015700.6A patent/CN105051051B/zh active Active
- 2014-03-14 US US14/213,269 patent/US20140316154A1/en not_active Abandoned
- 2014-03-14 EP EP14729036.5A patent/EP2970344A2/en not_active Withdrawn
- 2014-03-14 DK DK18160532.0T patent/DK3363805T3/da active
- 2014-03-14 MX MX2015012877A patent/MX2015012877A/es unknown
- 2014-03-14 AU AU2014229638A patent/AU2014229638B2/en active Active
- 2014-03-14 EP EP18160532.0A patent/EP3363805B1/en active Active
- 2014-03-14 CA CA2900902A patent/CA2900902C/en active Active
-
2015
- 2015-04-22 US US14/693,520 patent/US9643915B2/en active Active
- 2015-08-14 ZA ZA2015/05860A patent/ZA201505860B/en unknown
- 2015-08-19 PH PH12015501835A patent/PH12015501835A1/en unknown
-
2016
- 2016-01-19 HK HK16100549.8A patent/HK1212705A1/zh unknown
- 2016-02-24 HK HK16102047.1A patent/HK1214266A1/zh unknown
-
2017
- 2017-04-04 US US15/478,532 patent/US20170204122A1/en not_active Abandoned
-
2018
- 2018-06-21 JP JP2018117808A patent/JP2018168171A/ja active Pending
- 2018-11-21 AU AU2018267598A patent/AU2018267598A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20160075634A1 (en) | 2016-03-17 |
| US9643915B2 (en) | 2017-05-09 |
| CN105051051A (zh) | 2015-11-11 |
| EP3363805A1 (en) | 2018-08-22 |
| EP3842443A1 (en) | 2021-06-30 |
| ZA201505860B (en) | 2017-11-29 |
| US20170204122A1 (en) | 2017-07-20 |
| SG11201506456VA (en) | 2015-09-29 |
| CN105051051B (zh) | 2021-07-16 |
| KR20150132188A (ko) | 2015-11-25 |
| AU2014229638A1 (en) | 2015-08-20 |
| BR112015023558A2 (pt) | 2017-07-18 |
| CA2900902A1 (en) | 2014-09-18 |
| EP3842443B1 (en) | 2025-02-19 |
| HK1212705A1 (zh) | 2016-06-17 |
| AU2014229638B2 (en) | 2018-09-06 |
| PH12015501835B1 (en) | 2015-11-09 |
| JP6438417B2 (ja) | 2018-12-12 |
| SG10201804887YA (en) | 2018-07-30 |
| WO2014140787A2 (en) | 2014-09-18 |
| WO2014140787A3 (en) | 2015-03-26 |
| EP2970344A2 (en) | 2016-01-20 |
| CA2900902C (en) | 2022-08-02 |
| HK1214266A1 (zh) | 2016-07-22 |
| PH12015501835A1 (en) | 2015-11-09 |
| JP2018168171A (ja) | 2018-11-01 |
| EP3363805B1 (en) | 2020-12-16 |
| MX2015012877A (es) | 2016-02-03 |
| JP2016511281A (ja) | 2016-04-14 |
| US20140316154A1 (en) | 2014-10-23 |
| AU2018267598A1 (en) | 2018-12-06 |
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