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FR3000959B1 - Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines - Google Patents

Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines

Info

Publication number
FR3000959B1
FR3000959B1 FR1300063A FR1300063A FR3000959B1 FR 3000959 B1 FR3000959 B1 FR 3000959B1 FR 1300063 A FR1300063 A FR 1300063A FR 1300063 A FR1300063 A FR 1300063A FR 3000959 B1 FR3000959 B1 FR 3000959B1
Authority
FR
France
Prior art keywords
acceding
sphingosine
ceramide
good yields
synthetic intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1300063A
Other languages
English (en)
Other versions
FR3000959A1 (fr
Inventor
Loic Guilloneau
Samuel Dufour
Olivier Guerret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
M2i Development Fr
Original Assignee
Holis Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Holis Technologies SA filed Critical Holis Technologies SA
Priority to FR1300063A priority Critical patent/FR3000959B1/fr
Priority to EP14700415.4A priority patent/EP2943466A1/fr
Priority to US14/760,561 priority patent/US9790171B2/en
Priority to PCT/EP2014/050618 priority patent/WO2014108564A1/fr
Publication of FR3000959A1 publication Critical patent/FR3000959A1/fr
Application granted granted Critical
Publication of FR3000959B1 publication Critical patent/FR3000959B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/31—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR1300063A 2013-01-14 2013-01-14 Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines Expired - Fee Related FR3000959B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR1300063A FR3000959B1 (fr) 2013-01-14 2013-01-14 Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines
EP14700415.4A EP2943466A1 (fr) 2013-01-14 2014-01-14 Nouveaux intermédiaires de synthèse permettant d'accéder avec de bons rendements à des dérivés de sphingosines, céramides et sphingomyelines
US14/760,561 US9790171B2 (en) 2013-01-14 2014-01-14 Synthesis intermediates for obtaining derivatives of sphingosines, ceramides and sphingomyelins with good yields
PCT/EP2014/050618 WO2014108564A1 (fr) 2013-01-14 2014-01-14 Nouveaux intermédiaires de synthèse permettant d'accéder avec de bons rendements à des dérivés de sphingosines, céramides et sphingomyelines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1300063A FR3000959B1 (fr) 2013-01-14 2013-01-14 Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines

Publications (2)

Publication Number Publication Date
FR3000959A1 FR3000959A1 (fr) 2014-07-18
FR3000959B1 true FR3000959B1 (fr) 2015-08-21

Family

ID=48468436

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1300063A Expired - Fee Related FR3000959B1 (fr) 2013-01-14 2013-01-14 Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines

Country Status (4)

Country Link
US (1) US9790171B2 (fr)
EP (1) EP2943466A1 (fr)
FR (1) FR3000959B1 (fr)
WO (1) WO2014108564A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201804887YA (en) * 2013-03-15 2018-07-30 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
US9708354B2 (en) 2013-03-15 2017-07-18 Cerenis Therapeutics Holding Sa Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
US10611347B1 (en) 2018-04-23 2020-04-07 Oshkosh Corporation Integrated ground pad

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5220043A (en) 1991-03-21 1993-06-15 Ohio University Synthesis of D-erythro-sphingomyelins
SE501697C2 (sv) 1993-02-11 1995-04-24 Svenska Mejeriernas Riksforeni Förfarande för utvinning av sfingomyelin
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
JP2006022019A (ja) 2004-07-06 2006-01-26 Daiso Co Ltd スフィンゴミエリン類縁体とその製法
EP2308954B1 (fr) 2008-06-20 2012-10-24 Umeda Jimusho Ltd. Procédé de production d'un phospholipide à pureté élevée et d'une sphingomyéline à pureté élevée et glycérophospholipide du type plasmalogène obtenu au moyen dudit procédé
KR101608108B1 (ko) 2008-07-23 2016-03-31 노파르티스 아게 스핑고신 1 포스페이트 수용체 조절제 및 근육 염증을 치료하기 위한 그의 용도

Also Published As

Publication number Publication date
EP2943466A1 (fr) 2015-11-18
WO2014108564A1 (fr) 2014-07-17
FR3000959A1 (fr) 2014-07-18
US20160083335A1 (en) 2016-03-24
US9790171B2 (en) 2017-10-17

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