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DK3127551T3 - Pcv2-immunogen-sammensætning til at mindske kliniske symptomer i grise - Google Patents

Pcv2-immunogen-sammensætning til at mindske kliniske symptomer i grise Download PDF

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Publication number
DK3127551T3
DK3127551T3 DK16185663.8T DK16185663T DK3127551T3 DK 3127551 T3 DK3127551 T3 DK 3127551T3 DK 16185663 T DK16185663 T DK 16185663T DK 3127551 T3 DK3127551 T3 DK 3127551T3
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Denmark
Prior art keywords
pcv2
immunogene
pigs
composition
clinical symptoms
Prior art date
Application number
DK16185663.8T
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English (en)
Inventor
Michael B Roof
Phillip Wayne Hayes
Mark Eichmeyer
Greg Nitzel
Merrill Schaeffer
Original Assignee
Boehringer Ingelheim Animal Health Usa Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38371964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3127551(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Animal Health Usa Inc filed Critical Boehringer Ingelheim Animal Health Usa Inc
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Publication of DK3127551T3 publication Critical patent/DK3127551T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/125Picornaviridae, e.g. calicivirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02Immunomodulators
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    • A61K2039/525Virus
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    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DK16185663.8T 2005-12-29 2006-12-28 Pcv2-immunogen-sammensætning til at mindske kliniske symptomer i grise DK3127551T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75501605P 2005-12-29 2005-12-29
US82980906P 2006-10-17 2006-10-17
EP06850366.3A EP1976558B1 (en) 2005-12-29 2006-12-28 Pcv2 immunogenic composition for lessening clinical symptoms in pigs

Publications (1)

Publication Number Publication Date
DK3127551T3 true DK3127551T3 (da) 2020-10-12

Family

ID=38371964

Family Applications (5)

Application Number Title Priority Date Filing Date
DK11164849.9T DK2371382T3 (da) 2005-12-29 2006-12-28 Anvendelse af en PCV2-immunogen sammensætning til at mindske kliniske symptomer hos svin
DK11164854.9T DK2371385T3 (da) 2005-12-29 2006-12-28 Anvendelse af en PV2-immunogen sammensætning til mindskning af kliniske symptomer i grise
DK16185663.8T DK3127551T3 (da) 2005-12-29 2006-12-28 Pcv2-immunogen-sammensætning til at mindske kliniske symptomer i grise
DK11164850.7T DK2371383T3 (da) 2005-12-29 2006-12-28 Anvendelse af en PCV2-immunogen sammensætning til mindskning af kliniske symptomer i grise
DK06850366.3T DK1976558T3 (da) 2005-12-29 2006-12-28 Pcv2-immunogen sammensætning til at mindske kliniske symptomer i grise.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK11164849.9T DK2371382T3 (da) 2005-12-29 2006-12-28 Anvendelse af en PCV2-immunogen sammensætning til at mindske kliniske symptomer hos svin
DK11164854.9T DK2371385T3 (da) 2005-12-29 2006-12-28 Anvendelse af en PV2-immunogen sammensætning til mindskning af kliniske symptomer i grise

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK11164850.7T DK2371383T3 (da) 2005-12-29 2006-12-28 Anvendelse af en PCV2-immunogen sammensætning til mindskning af kliniske symptomer i grise
DK06850366.3T DK1976558T3 (da) 2005-12-29 2006-12-28 Pcv2-immunogen sammensætning til at mindske kliniske symptomer i grise.

Country Status (18)

Country Link
US (12) US20080181910A1 (da)
EP (11) EP2371384A1 (da)
JP (2) JP5739602B2 (da)
KR (2) KR20140019479A (da)
CN (4) CN104383526B (da)
AR (1) AR058871A1 (da)
AU (1) AU2006338182B2 (da)
BR (1) BRPI0620823B1 (da)
CA (1) CA2635430A1 (da)
DK (5) DK2371382T3 (da)
ES (5) ES2625903T3 (da)
HU (4) HUE026205T2 (da)
MX (4) MX2008008311A (da)
PL (4) PL2371383T3 (da)
PT (3) PT2371383E (da)
SG (1) SG170792A1 (da)
TW (1) TW200800256A (da)
WO (1) WO2007094893A2 (da)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2772047B1 (fr) * 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
PT2275132T (pt) 2005-12-29 2021-05-21 Boehringer Ingelheim Animal Health Usa Inc Composições imunogénicas de pcv2 multivalentes e métodos para produzir composições deste tipo
MX2008008311A (es) * 2005-12-29 2009-03-04 Boehringer Ingelheim Vetmed Uso de una composicion inmunogenica de pcv2 para reducir los sintomas clinicos en cerdos.
US20100136060A1 (en) * 2006-11-22 2010-06-03 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
EP2101815A4 (en) 2006-12-11 2010-10-06 Boehringer Ingelheim Vetmed EFFICIENT PROCESS FOR THE TREATMENT OF PORCINE CIRCOVIRUS AND LAWSONIA INTRACELLULARIS INFECTIONS
EP2094872B2 (en) * 2006-12-15 2020-02-19 Boehringer Ingelheim Animal Health USA Inc. Treatment of anti-PCV2 antibody seropositive pigs with PCV2 antigen
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US7829274B2 (en) * 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
CL2008003813A1 (es) * 2007-12-21 2009-03-20 Zoetis W Llc Circovirus porcino; molecula de acido nucleico que lo codifica; composicion inmunogenica que lo comprende; metodo para inmunizar un cerdo contra la infeccion virica o para prevenir el sindrome postdestete de desgaste multi-sistemico (pmsw);y metodo para determinar si un mamifero tiene o esta en riesgo de desarrollar pmsw.
EP2231182A4 (en) * 2007-12-31 2012-08-22 Boehringer Ingelheim Vetmed PCV2-ORF2-VIRUSELY PARTICLES WITH FREMDAMINO-ACID INSERTION
AU2009234345B2 (en) 2008-01-23 2013-08-22 Boehringer Ingelheim Vetmedica, Inc. PCV2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
US20110033495A1 (en) * 2008-02-15 2011-02-10 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
TWI449533B (zh) 2008-04-18 2014-08-21 Intervet Int Bv 防備胞內勞森菌(Lawsonia intracellularis)、豬肺炎黴漿菌(Mycoplasma hyopneumoniae)及豬環狀病毒(Porcine circo virus)用疫苗
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
AU2010357208A1 (en) 2010-07-08 2013-02-21 United Biomedical, Inc. Designer peptide-based PCV2 vaccine
TWI508974B (zh) 2010-12-22 2015-11-21 Sbc Virbac Ltd 豬第二型環狀病毒(Porcine Circovirus Type 2)、含彼之免疫組合物、檢測套組及其應用
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
KR102319843B1 (ko) 2013-09-25 2021-10-29 조에티스 서비시즈 엘엘씨 Pcv2b 분지형 백신 조성물 및 사용 방법
MX373884B (es) 2013-10-02 2020-03-26 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína pcv2 orf2 y partículas similares al virus compuestas por ésta.
JP6488304B2 (ja) 2013-12-03 2019-03-20 インターベット インターナショナル ベー. フェー. ローソニア・イントラセルラリス(lawsonia intracellularis)及びブタサーコウイルス(porcine circovirus)2に対するワクチン
ES2771899T3 (es) 2013-12-03 2020-07-07 Intervet Int Bv Vacuna contra circovirus porcino de tipo 2
BR112018007525A2 (pt) * 2015-10-16 2018-10-30 Kansas State University Research Foundation composições imunogênicas de circovírus suíno tipo 3 e métodos de produzir e usar as mesmas
CA3009903C (en) * 2015-12-28 2021-02-23 Agricultural Technology Research Institute Method of preparing porcine circovirus type 2 capsid protein and pharmaceutical composition comprising same
US10953084B2 (en) 2016-03-23 2021-03-23 Intervet Inc. Combination vaccine against PCV2 and PRRS virus infection comprising albumin
US11654191B2 (en) * 2016-03-23 2023-05-23 Intervet Inc. Vaccine for intradermal application against PCV2 and PRRS virus infection
WO2017162741A1 (en) 2016-03-23 2017-09-28 Intervet International B.V. A combination vaccine against pcv2 virus and mycoplasma hyopneumoniae infection
US11622872B2 (en) 2016-05-16 2023-04-11 Elixir Medical Corporation Uncaging stent
CN109561955B (zh) 2016-05-16 2021-04-16 万能医药公司 撑开支架
EA201991041A1 (ru) 2016-11-03 2019-11-29 Вакцина против свиного парвовируса и вируса свиного репродуктивного и респираторного синдрома и способы ее получения
US11311614B2 (en) 2017-04-13 2022-04-26 Intervet Inc. Vaccines containing swine pathogens for associated non-mixed use
CN109010818B (zh) * 2017-06-09 2021-11-09 普莱柯生物工程股份有限公司 一种预防和/或治疗猪圆环病毒感染的二联疫苗组合物及其制备方法和应用
EP3661548B1 (en) 2017-08-03 2024-06-26 Intervet International B.V. A vaccine comprising a pcv2 orf2 protein of genotype 2b
EP3664752B1 (en) 2017-08-11 2024-07-03 Elixir Medical Corporation Uncaging stent
CA3082033A1 (en) 2017-08-24 2019-02-28 Novo Nordisk A\S Glp-1 compositions and uses thereof
JP7162072B2 (ja) 2018-03-26 2022-10-27 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 免疫原性組成物を製造する方法
KR20220004967A (ko) 2019-04-04 2022-01-12 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 돼지 써코바이러스 3형 (pcv3) 백신, 및 이의 제조 및 용도
BR112022004256A2 (pt) 2019-09-12 2022-06-21 Intervet Int Bv Vacina de combinação para administração intradérmica
BR112022013746A2 (pt) 2020-02-18 2022-10-11 Novo Nordisk As Formulação aquosa de cagrilintida, formulação aquosa de semaglutida, dispositivo médico, e, combinação de dose fixa
FR3107454B1 (fr) 2020-02-20 2023-02-10 Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic Adjuvant de vaccin comprenant un microlatex inverse
JP2023523405A (ja) 2020-04-20 2023-06-05 インターベット インターナショナル ベー. フェー. 予防的にブタを治療するワクチンの組み合わせ
BR112023001324A2 (pt) 2020-07-24 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Combinação de vacina de suíno
WO2022090357A1 (en) 2020-10-29 2022-05-05 Intervet International B.V. Combination vaccine for protecting swine against various disorders

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US755016A (en) 1903-06-08 1904-03-22 Charles Herschel Koyl Coal-separating apparatus.
US829809A (en) 1906-04-10 1906-08-28 Arthur H Swan Peel-blade tip.
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US3479705A (en) 1966-12-15 1969-11-25 Miami Brick & Stone Inc Of Mia Molding apparatus
NL7903764A (nl) 1979-05-14 1980-11-18 Shell Int Research Werkwijze ter bereiding van calcium-houdend lood, daarmee verkregen lood en daaruit verkregen accuplaten of -roosters.
CA1247080A (en) 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
ES2052685T3 (es) 1987-03-17 1994-07-16 Akzo Nv Metodo para producir un adyuvante libre.
US5069901A (en) 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
WO1990007935A1 (en) 1989-01-23 1990-07-26 Auspharm International Ltd. Vaccine composition
US5155037A (en) 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
US5202430A (en) 1990-01-16 1993-04-13 University Of Tennessee Transmissible gastroenteritis virus genes
WO1991018627A1 (en) 1990-05-29 1991-12-12 Smithkline Beecham Corporation Swine pneumonia vaccine and method for the preparation thereof
JP3046332B2 (ja) * 1990-08-02 2000-05-29 協和醗酵工業株式会社 発酵法によるアミノ酸の製造法
US5565205A (en) * 1990-08-16 1996-10-15 Solvay Animal Health, Inc. Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof
NL9301272A (nl) 1993-07-20 1995-02-16 Aesculaap Bv Chicken Anemia Virus mutanten en vaccins en toepassingen gebaseerd op de virale eiwitten VP1, VP2 en VP3 of daarvoor coderende sequenties van dat virus.
GB9023111D0 (en) 1990-10-24 1990-12-05 Wellcome Found Expression system
CA2094515C (en) 1990-11-01 1998-09-01 Theodore T. Kramer Bacterial attenuation method and vaccine
MX9204885A (es) 1991-08-26 1994-05-31 Boehringer Animal Health Inc Composicion de vacuna que comprende virus del sindrome de infertilidad y respiratorio de los cerdos.
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US5580557A (en) * 1991-10-09 1996-12-03 Iowa State University Research Foundation, Inc. Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
CN1070078C (zh) * 1993-11-24 2001-08-29 中国农科院兰州兽医研究所 口蹄疫疫苗的生产工艺
EP1820512B1 (en) * 1994-05-10 2013-07-03 Boehringer Ingelheim Vetmedica, Inc. Improved modified live brsv vaccine
US5885823A (en) * 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
AU4231897A (en) 1996-08-16 1998-03-06 Southwest Foundation For Biomedical Research Compositions and methods for delivery of nucleic acids to hepatocytes
EP0835930B1 (en) 1996-10-09 2001-01-31 Akzo Nobel N.V. European vaccine strains of the porcine reproductive and respiratory syndrome virus (PRRSV)
US7211379B2 (en) * 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
AU2002302120B2 (en) * 1997-10-03 2006-01-19 Merial Porcine circoviruses, vaccines and diagnostic reagents
US6391314B1 (en) * 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
US7192594B2 (en) 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
FR2781159B1 (fr) 1998-07-06 2000-10-06 Merial Sas Vaccin circovirus et parvovirus porcin
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
US20060029617A1 (en) 1997-10-03 2006-02-09 Charreyre Catherine E Porcine circovirus and Helicobacter combination vaccines and methods of use
US20040062775A1 (en) * 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
ATE364624T1 (de) 1997-12-11 2007-07-15 Univ Saskatchewan Multisystemisches kümmerwuchssyndrom durch viren in schweine
WO1999045956A1 (en) 1998-03-13 1999-09-16 University Of Georgia Research Foundation, Inc. Vaccines against circovirus infections
US6294176B1 (en) * 1998-07-10 2001-09-25 Schering-Plough Veterinary Corp. Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species
DE19836659A1 (de) 1998-08-13 2000-02-17 Hoechst Schering Agrevo Gmbh Herbizide Mittel für tolerante oder resistente Baumwollkulturen
DE69933647T2 (de) 1998-11-19 2007-08-23 Azwell Inc. Rekombinante lysophosphatidsäure - phosphatase.
FR2789695B1 (fr) * 1999-02-11 2003-03-07 Merial Sas Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
US6943152B1 (en) * 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
US6497883B1 (en) * 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
WO2001017556A1 (fr) 1999-09-07 2001-03-15 Shionogi & Co., Ltd. Préparations vaccinales administrables par les muqueuses
GB9921146D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
GB9921147D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
US6656478B1 (en) 1999-11-12 2003-12-02 Samuel D. Charles Cross-protective salmonella vaccines
JP2003518073A (ja) 1999-12-21 2003-06-03 メリアル クリプトスポリジウムパルヴァムと他の腸内病原体の抗原を含む組成物およびワクチン
US6808900B2 (en) 2000-06-15 2004-10-26 Manitoba, University Of Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof
EP1290016A2 (en) 2000-06-15 2003-03-12 Purdue Research Foundation Vaccine for congenital tremors in pigs
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
MY129765A (en) 2000-12-19 2007-04-30 Wyeth Corp Improved mycoplasma hyopneumoniae bacterin vaccine
JP2002247979A (ja) 2001-02-23 2002-09-03 Nippon Biologicals Inc マレック病ワクチンおよびその製造方法
JP4038127B2 (ja) 2001-03-27 2008-01-23 ユニバーシティ オブ サスカチュワン サーコウイルスの培養方法
US20030096377A1 (en) * 2001-06-28 2003-05-22 Virginia Tech Intellectual Properties, Inc. Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2
DK2027873T3 (da) 2001-07-02 2015-11-09 Zoetis Services Llc Enkeltdosisvaccination med mycoplasma hyopneumoniae
US7361352B2 (en) * 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US6841364B2 (en) 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
WO2003068993A1 (en) 2002-02-14 2003-08-21 Novavax, Inc. Method for isolation and purification of expressed gene products in vitro
US20030199581A1 (en) 2002-03-13 2003-10-23 Seligson Allen L. Boswellin compositions enhanced with 3-beta-acetyl-11-keto-beta-boswellic acid ("AKBA") industrial manufacture and uses
US20030215455A1 (en) * 2002-05-14 2003-11-20 Bailey Reynolds Vaccine stabilizer and method of use
US7194472B2 (en) * 2002-07-05 2007-03-20 Sun Microsystems Inc. Extending role scope in a directory server system
US7335362B2 (en) * 2002-07-19 2008-02-26 Beth Israel Deaconess Medical Center Methods of treating pre-eclampsia or eclampsia
US7223207B1 (en) 2002-09-13 2007-05-29 Simon Basyuk Exercise and massage device
AU2002951692A0 (en) 2002-09-23 2002-10-17 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
EP1599164B1 (en) 2003-02-03 2015-04-08 Cerebus Biologicals, Inc. Methods for treating, preventing and detecting helicobacter infection
US7563449B2 (en) 2003-04-21 2009-07-21 Pfizer Inc, Methods for reducing cattle reproductive diseases
CN1458167A (zh) 2003-06-02 2003-11-26 中国农业科学院哈尔滨兽医研究所 截短表达的猪圆环病毒ⅱ型衣壳蛋白抗原及其应用
US7335361B2 (en) 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
NO321276B1 (no) 2003-07-07 2006-04-18 Elkem Materials Fremgangsmate for fremstilling av triklorsilan og silisium for bruk ved fremstilling av triklorsilan
RU2354399C2 (ru) 2003-07-24 2009-05-10 Мериал Лимитед Вакцинная композиция и способ индуцирования иммунологического ответа у животного
DK1651260T4 (da) 2003-07-25 2018-10-08 Boehringer Ingelheim Vetmedica Inc Lawsonia intracellularis af europæisk oprindelse og vacciner, diagnostiske midler og fremgangsmåder til anvendelse deraf
FR2861731B1 (fr) 2003-10-30 2006-02-24 Centre Nat Rech Scient Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations
WO2005112995A1 (en) 2004-04-26 2005-12-01 Choongang Vaccine Laboratory Co., Ltd. Inactivated mixed vaccine for porcine respiratory disease and the method of manufacturing thereof
CN1579553A (zh) * 2004-05-18 2005-02-16 浙江大学 Ii型猪圆环病毒核酸疫苗的制备方法及其应用
KR100478845B1 (ko) 2004-06-22 2005-03-24 채찬희 돼지 이유자돈 전신성 소모성 증후군 예방 및 치료용 생물학적 조성물
JP2008505114A (ja) 2004-06-30 2008-02-21 アイディー バイオメディカル コーポレイション オブ ケベック コロナウイルス感染を処置するためのワクチン組成物
US7258075B1 (en) * 2004-08-13 2007-08-21 World Factory, Inc. Collapsible bird feeder
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
US7700285B1 (en) 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
CA2587321A1 (en) * 2005-01-13 2006-07-20 Boehringer Ingelheim Vetmedica Gmbh Improved prrs vaccines
US7300785B2 (en) 2005-02-03 2007-11-27 Universiteit Ghent Culturing circular ssDNA viruses for the production of vaccines
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US7358075B2 (en) * 2005-04-13 2008-04-15 Merial Limited Assay for porcine circovirus production
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
AU2006289102C1 (en) * 2005-09-09 2017-11-30 Intervet International B.V. PCV-2 vaccine
MX2008008311A (es) * 2005-12-29 2009-03-04 Boehringer Ingelheim Vetmed Uso de una composicion inmunogenica de pcv2 para reducir los sintomas clinicos en cerdos.
PT2275132T (pt) 2005-12-29 2021-05-21 Boehringer Ingelheim Animal Health Usa Inc Composições imunogénicas de pcv2 multivalentes e métodos para produzir composições deste tipo
WO2007094983A2 (en) 2006-02-03 2007-08-23 Tanox, Inc. Methods and compositions for the inhibition of hiv infection of t cells
US20100136060A1 (en) 2006-11-22 2010-06-03 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
EP2101815A4 (en) 2006-12-11 2010-10-06 Boehringer Ingelheim Vetmed EFFICIENT PROCESS FOR THE TREATMENT OF PORCINE CIRCOVIRUS AND LAWSONIA INTRACELLULARIS INFECTIONS
EP2094872B2 (en) 2006-12-15 2020-02-19 Boehringer Ingelheim Animal Health USA Inc. Treatment of anti-PCV2 antibody seropositive pigs with PCV2 antigen
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
GB0712160D0 (en) 2007-06-22 2007-08-01 Univ Ghent Methods and compositions in the treatment of procine circoviral infection
US20090017064A1 (en) 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
AU2009234345B2 (en) 2008-01-23 2013-08-22 Boehringer Ingelheim Vetmedica, Inc. PCV2 mycoplasma hyopneumoniae immunogenic compositions and methods of producing such compositions
US20110033495A1 (en) 2008-02-15 2011-02-10 Boehringer Ingelheim Vetmedica, Inc. Methods and compositions for reducing the impact of enteric diseases
US8444989B1 (en) 2008-04-18 2013-05-21 Boehringer Ingelheim Vetmedica Gmbh One dose vaccination against mycoplasma infections of pigs
US20100150959A1 (en) 2008-12-15 2010-06-17 Vectogen Pty Ltd. PCV 2-Based Methods and Compositions for the Treatment of Pigs
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
WO2011075379A1 (en) 2009-12-18 2011-06-23 Boehringer Ingelheim Vetmedica, Inc. Multivalent vaccine against porcine teschovirus and other disease causing organisms in swine
ES2773722T3 (es) 2010-03-16 2020-07-14 Virginia Tech Intellectual Properties Inc Vacuna de circovirus porcino quimérico atenuado vivo
US9580474B2 (en) 2010-09-08 2017-02-28 The Johns Hopkins University Polyionic papilloma virus-like particle (VLP) vaccines
CN103122352B (zh) 2012-09-27 2015-02-11 华中农业大学 一种猪圆环病毒2型重组杆状病毒及制备方法和应用
US9624527B2 (en) 2013-03-01 2017-04-18 Boehringer Ingelheim Vetmedica, Inc. Quantification of vaccine compositions
WO2014179200A1 (en) 2013-04-30 2014-11-06 Boehringer Ingelheim Vetmedica, Inc. Orf2 protein of pcv2 subtype a (pcv2a) for use in cross-protection
US20140348874A1 (en) 2013-05-22 2014-11-27 Boehringer Ingelheim Espana, S.A. Method for the reduction of pcv-2 in a herd of swine
CN105451765A (zh) 2013-08-23 2016-03-30 勃林格殷格翰动物保健公司 猪圆环病毒2型(pcv2)亚单位疫苗
MX373884B (es) 2013-10-02 2020-03-26 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína pcv2 orf2 y partículas similares al virus compuestas por ésta.
CN106255554B (zh) 2014-05-07 2021-05-04 勃林格殷格翰国际有限公司 容器、喷雾器及用途
US10555994B2 (en) 2015-03-30 2020-02-11 Boehringer Ingelheim Animal Health USA Inc. PCV2 ORF2 carrier platform

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